Reversal of FLT3 Mutational Status and Sustained Expression of NPM1 Mutation in Paired Presentation, and Relapse Samples in a Patient with Acute Myeloid Leukemia
Autori
Radojković, MilicaTošić, Nataša
Čolović, Nataša
Ristić, Slobodan
Pavlović, Sonja
Colović, Milica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We report a case of de novo acute myeloid leukemia (AML) with unstable FLT3 gene mutations and stable NPM1 mutation. FLT3/D835 and NPM1 (Type A) mutations were detected upon diagnosis. During the relapse, the FLT3/D835 mutation changed to an FLT3/ITD mutation while the NPM1 (Type A) mutation was retained. Cytogenetic analyses showed the normal karyotype at diagnosis and relapse. Our findings raise interesting questions about the significance of these mutations in the leukemogenic process, about their stability during the evolution of the disease, and regarding the selection of appropriate molecular markers for the monitoring of minimal residual disease.
Ključne reči:
relapse / NPM1 / FLT3 / acute myeloid leukemiaIzvor:
Annals of Clinical and Laboratory Science, 2012, 42, 2, 186-190Finansiranje / projekti:
- Retke bolesti: molekularna patofiziologija, dijagnostički i terapijski modaliteti i socijalni, etički i pravni aspekti (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Radojković, Milica AU - Tošić, Nataša AU - Čolović, Nataša AU - Ristić, Slobodan AU - Pavlović, Sonja AU - Colović, Milica PY - 2012 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/582 AB - We report a case of de novo acute myeloid leukemia (AML) with unstable FLT3 gene mutations and stable NPM1 mutation. FLT3/D835 and NPM1 (Type A) mutations were detected upon diagnosis. During the relapse, the FLT3/D835 mutation changed to an FLT3/ITD mutation while the NPM1 (Type A) mutation was retained. Cytogenetic analyses showed the normal karyotype at diagnosis and relapse. Our findings raise interesting questions about the significance of these mutations in the leukemogenic process, about their stability during the evolution of the disease, and regarding the selection of appropriate molecular markers for the monitoring of minimal residual disease. T2 - Annals of Clinical and Laboratory Science T1 - Reversal of FLT3 Mutational Status and Sustained Expression of NPM1 Mutation in Paired Presentation, and Relapse Samples in a Patient with Acute Myeloid Leukemia EP - 190 IS - 2 SP - 186 VL - 42 UR - https://hdl.handle.net/21.15107/rcub_imagine_582 ER -
@article{ author = "Radojković, Milica and Tošić, Nataša and Čolović, Nataša and Ristić, Slobodan and Pavlović, Sonja and Colović, Milica", year = "2012", abstract = "We report a case of de novo acute myeloid leukemia (AML) with unstable FLT3 gene mutations and stable NPM1 mutation. FLT3/D835 and NPM1 (Type A) mutations were detected upon diagnosis. During the relapse, the FLT3/D835 mutation changed to an FLT3/ITD mutation while the NPM1 (Type A) mutation was retained. Cytogenetic analyses showed the normal karyotype at diagnosis and relapse. Our findings raise interesting questions about the significance of these mutations in the leukemogenic process, about their stability during the evolution of the disease, and regarding the selection of appropriate molecular markers for the monitoring of minimal residual disease.", journal = "Annals of Clinical and Laboratory Science", title = "Reversal of FLT3 Mutational Status and Sustained Expression of NPM1 Mutation in Paired Presentation, and Relapse Samples in a Patient with Acute Myeloid Leukemia", pages = "190-186", number = "2", volume = "42", url = "https://hdl.handle.net/21.15107/rcub_imagine_582" }
Radojković, M., Tošić, N., Čolović, N., Ristić, S., Pavlović, S.,& Colović, M.. (2012). Reversal of FLT3 Mutational Status and Sustained Expression of NPM1 Mutation in Paired Presentation, and Relapse Samples in a Patient with Acute Myeloid Leukemia. in Annals of Clinical and Laboratory Science, 42(2), 186-190. https://hdl.handle.net/21.15107/rcub_imagine_582
Radojković M, Tošić N, Čolović N, Ristić S, Pavlović S, Colović M. Reversal of FLT3 Mutational Status and Sustained Expression of NPM1 Mutation in Paired Presentation, and Relapse Samples in a Patient with Acute Myeloid Leukemia. in Annals of Clinical and Laboratory Science. 2012;42(2):186-190. https://hdl.handle.net/21.15107/rcub_imagine_582 .
Radojković, Milica, Tošić, Nataša, Čolović, Nataša, Ristić, Slobodan, Pavlović, Sonja, Colović, Milica, "Reversal of FLT3 Mutational Status and Sustained Expression of NPM1 Mutation in Paired Presentation, and Relapse Samples in a Patient with Acute Myeloid Leukemia" in Annals of Clinical and Laboratory Science, 42, no. 2 (2012):186-190, https://hdl.handle.net/21.15107/rcub_imagine_582 .