Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia
Abstract
Central nervous system (CNS) involvement in acute promyelocytic leukemia (APL) is rare and tends to be seen mostly following treatment with all-trans retinoic acid (ATRA), due to prolonged patient survival and poor penetration of the drug in the CNS. At least 10% of extramedullary relapses in APL involve the CNS, and associated factors include an increased age, the BCR isoform, the development of differentiation syndrome, a high white cell count at presentation and hemorrhage into the CNS during induction therapy. We present the case of a patient with high-risk APL, CD56+, CD2+ in whom a CNS relapse was diagnosed through the presence of a PML/RAR alpha rearrangement on PCR of the cerebrospinal fluid (CSF).
Source:
Medical Oncology, 2012, 29, 1, 260-262Publisher:
- Humana Press Inc, Totowa
Funding / projects:
- Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
DOI: 10.1007/s12032-011-9834-y
ISSN: 1357-0560
PubMed: 21298367
WoS: 000300317200040
Scopus: 2-s2.0-84864031957
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Čolović, Nataša AU - Tomin, D. AU - Vidović, A. AU - Tošić, Nataša AU - Atkinson, H. D. AU - Colović, Milica D. PY - 2012 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/587 AB - Central nervous system (CNS) involvement in acute promyelocytic leukemia (APL) is rare and tends to be seen mostly following treatment with all-trans retinoic acid (ATRA), due to prolonged patient survival and poor penetration of the drug in the CNS. At least 10% of extramedullary relapses in APL involve the CNS, and associated factors include an increased age, the BCR isoform, the development of differentiation syndrome, a high white cell count at presentation and hemorrhage into the CNS during induction therapy. We present the case of a patient with high-risk APL, CD56+, CD2+ in whom a CNS relapse was diagnosed through the presence of a PML/RAR alpha rearrangement on PCR of the cerebrospinal fluid (CSF). PB - Humana Press Inc, Totowa T2 - Medical Oncology T1 - Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia EP - 262 IS - 1 SP - 260 VL - 29 DO - 10.1007/s12032-011-9834-y ER -
@article{ author = "Čolović, Nataša and Tomin, D. and Vidović, A. and Tošić, Nataša and Atkinson, H. D. and Colović, Milica D.", year = "2012", abstract = "Central nervous system (CNS) involvement in acute promyelocytic leukemia (APL) is rare and tends to be seen mostly following treatment with all-trans retinoic acid (ATRA), due to prolonged patient survival and poor penetration of the drug in the CNS. At least 10% of extramedullary relapses in APL involve the CNS, and associated factors include an increased age, the BCR isoform, the development of differentiation syndrome, a high white cell count at presentation and hemorrhage into the CNS during induction therapy. We present the case of a patient with high-risk APL, CD56+, CD2+ in whom a CNS relapse was diagnosed through the presence of a PML/RAR alpha rearrangement on PCR of the cerebrospinal fluid (CSF).", publisher = "Humana Press Inc, Totowa", journal = "Medical Oncology", title = "Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia", pages = "262-260", number = "1", volume = "29", doi = "10.1007/s12032-011-9834-y" }
Čolović, N., Tomin, D., Vidović, A., Tošić, N., Atkinson, H. D.,& Colović, M. D.. (2012). Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia. in Medical Oncology Humana Press Inc, Totowa., 29(1), 260-262. https://doi.org/10.1007/s12032-011-9834-y
Čolović N, Tomin D, Vidović A, Tošić N, Atkinson HD, Colović MD. Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia. in Medical Oncology. 2012;29(1):260-262. doi:10.1007/s12032-011-9834-y .
Čolović, Nataša, Tomin, D., Vidović, A., Tošić, Nataša, Atkinson, H. D., Colović, Milica D., "Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia" in Medical Oncology, 29, no. 1 (2012):260-262, https://doi.org/10.1007/s12032-011-9834-y . .