Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion
2012
Аутори
Mounier, JoelleBoncompain, Gaelle
Šenerović, Lidija
Lagache, Thibault
Chretien, Fabrice
Perez, Franck
Kolbe, Michael
Olivo-Marin, Jean-Christophe
Sansonetti, Philippe J.
Sauvonnet, Nathalie
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Shigella infection causes destruction of the human colonic epithelial barrier. The Golgi network and recycling endosomes are essential for maintaining epithelial barrier function. Here we show that Shigella epithelial invasion induces fragmentation of the Golgi complex with consequent inhibition of both secretion and retrograde transport in the infected host cell. Shigella induces tubulation of the Rab11-positive compartment, thereby affecting cell surface receptor recycling. The molecular process underlying the observed damage to the Golgi complex and receptor recycling is a massive redistribution of plasma membrane cholesterol to the sites of Shigella entry. IpaB, a virulence factor of Shigella that is known to bind cholesterol, is necessary and sufficient to induce Golgi fragmentation and reorganization of the recycling compartment. Shigella infection-induced Golgi disorganization was also observed in vivo, suggesting that this mechanism affecting the sorting of cell surface molecul...es likely contributes to host epithelial barrier disruption associated with Shigella pathogenesis.
Извор:
Cell Host & Microbe, 2012, 12, 3, 381-389Издавач:
- Cell Press, Cambridge
Финансирање / пројекти:
- Programme Transversal de Recherche from Institut Pasteur [387]
- ERC
- PR2 bilateral French-German grant of the French Ministry of Foreign Affairs
- ANR "Blanc"
DOI: 10.1016/j.chom.2012.07.010
ISSN: 1931-3128
PubMed: 22980334
WoS: 000309947900014
Scopus: 2-s2.0-84866431810
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Mounier, Joelle AU - Boncompain, Gaelle AU - Šenerović, Lidija AU - Lagache, Thibault AU - Chretien, Fabrice AU - Perez, Franck AU - Kolbe, Michael AU - Olivo-Marin, Jean-Christophe AU - Sansonetti, Philippe J. AU - Sauvonnet, Nathalie PY - 2012 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/588 AB - Shigella infection causes destruction of the human colonic epithelial barrier. The Golgi network and recycling endosomes are essential for maintaining epithelial barrier function. Here we show that Shigella epithelial invasion induces fragmentation of the Golgi complex with consequent inhibition of both secretion and retrograde transport in the infected host cell. Shigella induces tubulation of the Rab11-positive compartment, thereby affecting cell surface receptor recycling. The molecular process underlying the observed damage to the Golgi complex and receptor recycling is a massive redistribution of plasma membrane cholesterol to the sites of Shigella entry. IpaB, a virulence factor of Shigella that is known to bind cholesterol, is necessary and sufficient to induce Golgi fragmentation and reorganization of the recycling compartment. Shigella infection-induced Golgi disorganization was also observed in vivo, suggesting that this mechanism affecting the sorting of cell surface molecules likely contributes to host epithelial barrier disruption associated with Shigella pathogenesis. PB - Cell Press, Cambridge T2 - Cell Host & Microbe T1 - Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion EP - 389 IS - 3 SP - 381 VL - 12 DO - 10.1016/j.chom.2012.07.010 ER -
@article{ author = "Mounier, Joelle and Boncompain, Gaelle and Šenerović, Lidija and Lagache, Thibault and Chretien, Fabrice and Perez, Franck and Kolbe, Michael and Olivo-Marin, Jean-Christophe and Sansonetti, Philippe J. and Sauvonnet, Nathalie", year = "2012", abstract = "Shigella infection causes destruction of the human colonic epithelial barrier. The Golgi network and recycling endosomes are essential for maintaining epithelial barrier function. Here we show that Shigella epithelial invasion induces fragmentation of the Golgi complex with consequent inhibition of both secretion and retrograde transport in the infected host cell. Shigella induces tubulation of the Rab11-positive compartment, thereby affecting cell surface receptor recycling. The molecular process underlying the observed damage to the Golgi complex and receptor recycling is a massive redistribution of plasma membrane cholesterol to the sites of Shigella entry. IpaB, a virulence factor of Shigella that is known to bind cholesterol, is necessary and sufficient to induce Golgi fragmentation and reorganization of the recycling compartment. Shigella infection-induced Golgi disorganization was also observed in vivo, suggesting that this mechanism affecting the sorting of cell surface molecules likely contributes to host epithelial barrier disruption associated with Shigella pathogenesis.", publisher = "Cell Press, Cambridge", journal = "Cell Host & Microbe", title = "Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion", pages = "389-381", number = "3", volume = "12", doi = "10.1016/j.chom.2012.07.010" }
Mounier, J., Boncompain, G., Šenerović, L., Lagache, T., Chretien, F., Perez, F., Kolbe, M., Olivo-Marin, J., Sansonetti, P. J.,& Sauvonnet, N.. (2012). Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion. in Cell Host & Microbe Cell Press, Cambridge., 12(3), 381-389. https://doi.org/10.1016/j.chom.2012.07.010
Mounier J, Boncompain G, Šenerović L, Lagache T, Chretien F, Perez F, Kolbe M, Olivo-Marin J, Sansonetti PJ, Sauvonnet N. Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion. in Cell Host & Microbe. 2012;12(3):381-389. doi:10.1016/j.chom.2012.07.010 .
Mounier, Joelle, Boncompain, Gaelle, Šenerović, Lidija, Lagache, Thibault, Chretien, Fabrice, Perez, Franck, Kolbe, Michael, Olivo-Marin, Jean-Christophe, Sansonetti, Philippe J., Sauvonnet, Nathalie, "Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion" in Cell Host & Microbe, 12, no. 3 (2012):381-389, https://doi.org/10.1016/j.chom.2012.07.010 . .