Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease
Samo za registrovane korisnike
2013
Autori
Rodić, PredragPavlović, Sonja
Kostić, Tatjana
Suvajdžić-Vuković, Nada
Đorđević, Maja
Sumarac, Zorica
Dajak, Marijana
Bonaci-Nikolić, Branka
Janić, Dragana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Introduction: We evaluated a novel approach for investigation of lymphocyte dysregulation in Gaucher patients by including determination of IgH and TCR gene rearrangements together with levels of immunoglobulins, natural autoantibodies as well as presence of monoclonal protein. Materials and methods: Measurement of serum immunoglobulins, monoclonal immunoglobulins, selected autoantibodies, as well as analysis of immunoglobulin heavy chain and T cell receptor gene rearrangements. Results: Immunoglobulin disorder was detected in 29.6% patients, 40.7% demonstrated presence of B cell clonality and 44.4% demonstrated presence of autoantibodies. In five patients in our series, the presence of IgH gene rearrangement was the only detectable indicator of B cell dysfunction. TCR gene rearrangements were not found in any of the patients. Conclusion: Based on our results, we propose IgH gene rearrangements as a new biomarker for investigation of B cell dysfunction occurring as a complication of Ga...ucher disease.
Ključne reči:
Lymphocytes / IgH gene rearrangement / Gaucher disease / Gammopathy / B cell clonalityIzvor:
Blood Cells Molecules and Diseases, 2013, 50, 3, 222-225Izdavač:
- Academic Press Inc Elsevier Science, San Diego
Finansiranje / projekti:
- Retke bolesti: molekularna patofiziologija, dijagnostički i terapijski modaliteti i socijalni, etički i pravni aspekti (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
- Genzyme Corporation
DOI: 10.1016/j.bcmd.2012.11.012
ISSN: 1079-9796
PubMed: 23265739
WoS: 000315074500016
Scopus: 2-s2.0-84873275123
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Rodić, Predrag AU - Pavlović, Sonja AU - Kostić, Tatjana AU - Suvajdžić-Vuković, Nada AU - Đorđević, Maja AU - Sumarac, Zorica AU - Dajak, Marijana AU - Bonaci-Nikolić, Branka AU - Janić, Dragana PY - 2013 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/621 AB - Introduction: We evaluated a novel approach for investigation of lymphocyte dysregulation in Gaucher patients by including determination of IgH and TCR gene rearrangements together with levels of immunoglobulins, natural autoantibodies as well as presence of monoclonal protein. Materials and methods: Measurement of serum immunoglobulins, monoclonal immunoglobulins, selected autoantibodies, as well as analysis of immunoglobulin heavy chain and T cell receptor gene rearrangements. Results: Immunoglobulin disorder was detected in 29.6% patients, 40.7% demonstrated presence of B cell clonality and 44.4% demonstrated presence of autoantibodies. In five patients in our series, the presence of IgH gene rearrangement was the only detectable indicator of B cell dysfunction. TCR gene rearrangements were not found in any of the patients. Conclusion: Based on our results, we propose IgH gene rearrangements as a new biomarker for investigation of B cell dysfunction occurring as a complication of Gaucher disease. PB - Academic Press Inc Elsevier Science, San Diego T2 - Blood Cells Molecules and Diseases T1 - Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease EP - 225 IS - 3 SP - 222 VL - 50 DO - 10.1016/j.bcmd.2012.11.012 ER -
@article{ author = "Rodić, Predrag and Pavlović, Sonja and Kostić, Tatjana and Suvajdžić-Vuković, Nada and Đorđević, Maja and Sumarac, Zorica and Dajak, Marijana and Bonaci-Nikolić, Branka and Janić, Dragana", year = "2013", abstract = "Introduction: We evaluated a novel approach for investigation of lymphocyte dysregulation in Gaucher patients by including determination of IgH and TCR gene rearrangements together with levels of immunoglobulins, natural autoantibodies as well as presence of monoclonal protein. Materials and methods: Measurement of serum immunoglobulins, monoclonal immunoglobulins, selected autoantibodies, as well as analysis of immunoglobulin heavy chain and T cell receptor gene rearrangements. Results: Immunoglobulin disorder was detected in 29.6% patients, 40.7% demonstrated presence of B cell clonality and 44.4% demonstrated presence of autoantibodies. In five patients in our series, the presence of IgH gene rearrangement was the only detectable indicator of B cell dysfunction. TCR gene rearrangements were not found in any of the patients. Conclusion: Based on our results, we propose IgH gene rearrangements as a new biomarker for investigation of B cell dysfunction occurring as a complication of Gaucher disease.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Blood Cells Molecules and Diseases", title = "Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease", pages = "225-222", number = "3", volume = "50", doi = "10.1016/j.bcmd.2012.11.012" }
Rodić, P., Pavlović, S., Kostić, T., Suvajdžić-Vuković, N., Đorđević, M., Sumarac, Z., Dajak, M., Bonaci-Nikolić, B.,& Janić, D.. (2013). Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. in Blood Cells Molecules and Diseases Academic Press Inc Elsevier Science, San Diego., 50(3), 222-225. https://doi.org/10.1016/j.bcmd.2012.11.012
Rodić P, Pavlović S, Kostić T, Suvajdžić-Vuković N, Đorđević M, Sumarac Z, Dajak M, Bonaci-Nikolić B, Janić D. Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. in Blood Cells Molecules and Diseases. 2013;50(3):222-225. doi:10.1016/j.bcmd.2012.11.012 .
Rodić, Predrag, Pavlović, Sonja, Kostić, Tatjana, Suvajdžić-Vuković, Nada, Đorđević, Maja, Sumarac, Zorica, Dajak, Marijana, Bonaci-Nikolić, Branka, Janić, Dragana, "Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease" in Blood Cells Molecules and Diseases, 50, no. 3 (2013):222-225, https://doi.org/10.1016/j.bcmd.2012.11.012 . .