Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis
Samo za registrovane korisnike
2013
Autori
Saksida, TamaraMiljković, Djordje
Timotijević, Gordana
Stojanović, Ivana
Mijatović, Sanja
Fagone, Paolo
Mangano, Katia
Mammana, Santa
Farina, Claudio
Ascione, Ester
Maiello, Valentina
Nicoletti, Ferdinando
Stošić-Grujičić, Stanislava
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Transferrin (Tf) has a major role in T cell activation and proliferation. Here, we investigated whether Tf exerts immunomodulatory effects on T cells and in development of T-cell driven experimental autoimmune encephalomyelitis (EAE). While treatment of concanavalin A-stimulated splenocytes with apotransferrin (ApoTf) did not affect release of IL-1 beta, TNF, INF-gamma, IL-17, IL-4, and IL-10, it markedly and dose-dependently down-regulated synthesis of IL-2 in these cells. ApoTf also inhibited IL-2 generation in purified CD3(+) T cells and the effect was accompanied with down-regulation of MAPK p44/42 and NF kappa B signaling. Despite impeded IL-2 release, proliferation of splenocytes was not inhibited by ApoTf. Importantly, ApoTf ameliorated EAE in mice and significantly reduced ex vivo IL-2 production in proteolipid protein-specific lymphocytes. Thus ApoTf may be a promising beneficial agent for multiple sclerosis.
Ključne reči:
T cell activation / IL-2 / Experimental autoimmune encephalomyelitis / ApotransferrinIzvor:
Journal of Neuroimmunology, 2013, 262, 1-2, 72-78Izdavač:
- Elsevier, Amsterdam
Finansiranje / projekti:
- MIUR (Ministry of Education, University, Research) [795]
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Ćelijski i molekulski mehanizmi oporavka pacova od eksperimentalnog autoimunskog encefalomijelitisa (RS-MESTD-Basic Research (BR or ON)-173035)
DOI: 10.1016/j.jneuroim.2013.07.001
ISSN: 0165-5728
PubMed: 23890777
WoS: 000324970400010
Scopus: 2-s2.0-84884138712
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Saksida, Tamara AU - Miljković, Djordje AU - Timotijević, Gordana AU - Stojanović, Ivana AU - Mijatović, Sanja AU - Fagone, Paolo AU - Mangano, Katia AU - Mammana, Santa AU - Farina, Claudio AU - Ascione, Ester AU - Maiello, Valentina AU - Nicoletti, Ferdinando AU - Stošić-Grujičić, Stanislava PY - 2013 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/627 AB - Transferrin (Tf) has a major role in T cell activation and proliferation. Here, we investigated whether Tf exerts immunomodulatory effects on T cells and in development of T-cell driven experimental autoimmune encephalomyelitis (EAE). While treatment of concanavalin A-stimulated splenocytes with apotransferrin (ApoTf) did not affect release of IL-1 beta, TNF, INF-gamma, IL-17, IL-4, and IL-10, it markedly and dose-dependently down-regulated synthesis of IL-2 in these cells. ApoTf also inhibited IL-2 generation in purified CD3(+) T cells and the effect was accompanied with down-regulation of MAPK p44/42 and NF kappa B signaling. Despite impeded IL-2 release, proliferation of splenocytes was not inhibited by ApoTf. Importantly, ApoTf ameliorated EAE in mice and significantly reduced ex vivo IL-2 production in proteolipid protein-specific lymphocytes. Thus ApoTf may be a promising beneficial agent for multiple sclerosis. PB - Elsevier, Amsterdam T2 - Journal of Neuroimmunology T1 - Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis EP - 78 IS - 1-2 SP - 72 VL - 262 DO - 10.1016/j.jneuroim.2013.07.001 ER -
@article{ author = "Saksida, Tamara and Miljković, Djordje and Timotijević, Gordana and Stojanović, Ivana and Mijatović, Sanja and Fagone, Paolo and Mangano, Katia and Mammana, Santa and Farina, Claudio and Ascione, Ester and Maiello, Valentina and Nicoletti, Ferdinando and Stošić-Grujičić, Stanislava", year = "2013", abstract = "Transferrin (Tf) has a major role in T cell activation and proliferation. Here, we investigated whether Tf exerts immunomodulatory effects on T cells and in development of T-cell driven experimental autoimmune encephalomyelitis (EAE). While treatment of concanavalin A-stimulated splenocytes with apotransferrin (ApoTf) did not affect release of IL-1 beta, TNF, INF-gamma, IL-17, IL-4, and IL-10, it markedly and dose-dependently down-regulated synthesis of IL-2 in these cells. ApoTf also inhibited IL-2 generation in purified CD3(+) T cells and the effect was accompanied with down-regulation of MAPK p44/42 and NF kappa B signaling. Despite impeded IL-2 release, proliferation of splenocytes was not inhibited by ApoTf. Importantly, ApoTf ameliorated EAE in mice and significantly reduced ex vivo IL-2 production in proteolipid protein-specific lymphocytes. Thus ApoTf may be a promising beneficial agent for multiple sclerosis.", publisher = "Elsevier, Amsterdam", journal = "Journal of Neuroimmunology", title = "Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis", pages = "78-72", number = "1-2", volume = "262", doi = "10.1016/j.jneuroim.2013.07.001" }
Saksida, T., Miljković, D., Timotijević, G., Stojanović, I., Mijatović, S., Fagone, P., Mangano, K., Mammana, S., Farina, C., Ascione, E., Maiello, V., Nicoletti, F.,& Stošić-Grujičić, S.. (2013). Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis. in Journal of Neuroimmunology Elsevier, Amsterdam., 262(1-2), 72-78. https://doi.org/10.1016/j.jneuroim.2013.07.001
Saksida T, Miljković D, Timotijević G, Stojanović I, Mijatović S, Fagone P, Mangano K, Mammana S, Farina C, Ascione E, Maiello V, Nicoletti F, Stošić-Grujičić S. Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis. in Journal of Neuroimmunology. 2013;262(1-2):72-78. doi:10.1016/j.jneuroim.2013.07.001 .
Saksida, Tamara, Miljković, Djordje, Timotijević, Gordana, Stojanović, Ivana, Mijatović, Sanja, Fagone, Paolo, Mangano, Katia, Mammana, Santa, Farina, Claudio, Ascione, Ester, Maiello, Valentina, Nicoletti, Ferdinando, Stošić-Grujičić, Stanislava, "Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis" in Journal of Neuroimmunology, 262, no. 1-2 (2013):72-78, https://doi.org/10.1016/j.jneuroim.2013.07.001 . .