Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
2013
Authors
Stojković, Dejan S.Davidović, Slobodan
Zivković, Jelena
Glamoclija, Jasmina
Cirić, Ana
Stevanović, Milena
Ferreira, Isabel C. F. R.
Soković, Marina
Article (Published version)
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Show full item recordAbstract
Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mito...tic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.
Keywords:
protocatechuic acid / Morchella esculenta / antimutagenic / antimitotic / Ames test / Allium cepa assaySource:
Frontiers in Life Science, 2013, 7, 3-4, 218-223Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Foundation for Science and Technology (FCT, Portugal)
- COMPETE/QREN/EU [PTDC/AGR-ALI/110062/2009, PEst-OE/AGR/UI0690/2011]
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-MESTD-Basic Research (BR or ON)-173032)
- Studying signal transduction pathways and epigenetic mechanisms that control human SOX genes expression: further insight into their roles in cell fate determination and differentiation (RS-MESTD-Basic Research (BR or ON)-173051)
- Ethnogenesis of the Serbs during the middle ages: a comparative analysis of the historical-cultural heritage, genetic material and artefacts of material culture from the aspect of analytical chemistry (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-47025)
DOI: 10.1080/21553769.2014.901925
ISSN: 2155-3769
WoS: 000334827900015
Scopus: 2-s2.0-84899570972
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stojković, Dejan S. AU - Davidović, Slobodan AU - Zivković, Jelena AU - Glamoclija, Jasmina AU - Cirić, Ana AU - Stevanović, Milena AU - Ferreira, Isabel C. F. R. AU - Soković, Marina PY - 2013 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/658 AB - Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score. PB - Taylor & Francis Ltd, Abingdon T2 - Frontiers in Life Science T1 - Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid EP - 223 IS - 3-4 SP - 218 VL - 7 DO - 10.1080/21553769.2014.901925 ER -
@article{ author = "Stojković, Dejan S. and Davidović, Slobodan and Zivković, Jelena and Glamoclija, Jasmina and Cirić, Ana and Stevanović, Milena and Ferreira, Isabel C. F. R. and Soković, Marina", year = "2013", abstract = "Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Frontiers in Life Science", title = "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid", pages = "223-218", number = "3-4", volume = "7", doi = "10.1080/21553769.2014.901925" }
Stojković, D. S., Davidović, S., Zivković, J., Glamoclija, J., Cirić, A., Stevanović, M., Ferreira, I. C. F. R.,& Soković, M.. (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science Taylor & Francis Ltd, Abingdon., 7(3-4), 218-223. https://doi.org/10.1080/21553769.2014.901925
Stojković DS, Davidović S, Zivković J, Glamoclija J, Cirić A, Stevanović M, Ferreira ICFR, Soković M. Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science. 2013;7(3-4):218-223. doi:10.1080/21553769.2014.901925 .
Stojković, Dejan S., Davidović, Slobodan, Zivković, Jelena, Glamoclija, Jasmina, Cirić, Ana, Stevanović, Milena, Ferreira, Isabel C. F. R., Soković, Marina, "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid" in Frontiers in Life Science, 7, no. 3-4 (2013):218-223, https://doi.org/10.1080/21553769.2014.901925 . .