Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing
Само за регистроване кориснике
2013
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing.
Кључне речи:
tyrosine hydroxylase / rats / noradrenaline / noradrenaline transporters / isolation stress / hypothalamusИзвор:
Neurochemical Journal, 2013, 7, 2, 139-143Издавач:
- Maik Nauka/Interperiodica/Springer, New York
Финансирање / пројекти:
- Молекуларни механизми патофизиолошких промена у ћелијама централног нервног система и периферног ткива код сисара (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.1134/S1819712413020050
ISSN: 1819-7124
WoS: 000320338500008
Scopus: 2-s2.0-84878787997
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Spasojević, N. AU - Jovanović, P. AU - Stanisavljević, D. AU - Stefanović, B. AU - Dronjak, S. PY - 2013 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/662 AB - The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing. PB - Maik Nauka/Interperiodica/Springer, New York T2 - Neurochemical Journal T1 - Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing EP - 143 IS - 2 SP - 139 VL - 7 DO - 10.1134/S1819712413020050 ER -
@article{ author = "Spasojević, N. and Jovanović, P. and Stanisavljević, D. and Stefanović, B. and Dronjak, S.", year = "2013", abstract = "The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing.", publisher = "Maik Nauka/Interperiodica/Springer, New York", journal = "Neurochemical Journal", title = "Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing", pages = "143-139", number = "2", volume = "7", doi = "10.1134/S1819712413020050" }
Spasojević, N., Jovanović, P., Stanisavljević, D., Stefanović, B.,& Dronjak, S.. (2013). Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing. in Neurochemical Journal Maik Nauka/Interperiodica/Springer, New York., 7(2), 139-143. https://doi.org/10.1134/S1819712413020050
Spasojević N, Jovanović P, Stanisavljević D, Stefanović B, Dronjak S. Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing. in Neurochemical Journal. 2013;7(2):139-143. doi:10.1134/S1819712413020050 .
Spasojević, N., Jovanović, P., Stanisavljević, D., Stefanović, B., Dronjak, S., "Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing" in Neurochemical Journal, 7, no. 2 (2013):139-143, https://doi.org/10.1134/S1819712413020050 . .