Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action
Апстракт
Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.
Кључне речи:
mushrooms / molecular mechanisms / extracts / compounds / Antitumor propertiesИзвор:
Current Topics in Medicinal Chemistry, 2013, 13, 21, 2791-2806Издавач:
- Bentham Science Publ Ltd, Sharjah
Финансирање / пројекти:
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-Basic Research (BR or ON)-173021)
- Проучавање сигналних путева и епигенетичких механизама укључених у контролу експресије хуманих SOX гена: даље расветљавање њихове улоге у одређивању судбине и диференцијацији ћелија (RS-MESTD-Basic Research (BR or ON)-173051)
- Етногенеза Срба у средњем веку: Упоредна анализа историјско-културног наслеђа, генетичког материјала и предмета материјалне културе са аспекта аналитичке хемије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-47025)
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.2174/15680266113136660198
ISSN: 1568-0266
PubMed: 24083788
WoS: 000326986900009
Scopus: 2-s2.0-84903293666
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Popović, Visnja AU - Zivković, Jelena AU - Davidović, Slobodan AU - Stevanović, Milena AU - Stojković, Dejan PY - 2013 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/664 AB - Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously. PB - Bentham Science Publ Ltd, Sharjah T2 - Current Topics in Medicinal Chemistry T1 - Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action EP - 2806 IS - 21 SP - 2791 VL - 13 DO - 10.2174/15680266113136660198 ER -
@article{ author = "Popović, Visnja and Zivković, Jelena and Davidović, Slobodan and Stevanović, Milena and Stojković, Dejan", year = "2013", abstract = "Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current Topics in Medicinal Chemistry", title = "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action", pages = "2806-2791", number = "21", volume = "13", doi = "10.2174/15680266113136660198" }
Popović, V., Zivković, J., Davidović, S., Stevanović, M.,& Stojković, D.. (2013). Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 13(21), 2791-2806. https://doi.org/10.2174/15680266113136660198
Popović V, Zivković J, Davidović S, Stevanović M, Stojković D. Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry. 2013;13(21):2791-2806. doi:10.2174/15680266113136660198 .
Popović, Visnja, Zivković, Jelena, Davidović, Slobodan, Stevanović, Milena, Stojković, Dejan, "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action" in Current Topics in Medicinal Chemistry, 13, no. 21 (2013):2791-2806, https://doi.org/10.2174/15680266113136660198 . .