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Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation
dc.creator | Lippert, Rainer | |
dc.creator | Vojnović, Sandra | |
dc.creator | Mitrović, Aleksandra | |
dc.creator | Jux, Norbert | |
dc.creator | Ivanović-Burmazović, Ivana | |
dc.creator | Vasiljević, Branka | |
dc.creator | Stanković, Nada | |
dc.date.accessioned | 2022-11-15T14:24:53Z | |
dc.date.available | 2022-11-15T14:24:53Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/705 | |
dc.description.abstract | Ferrocene-substituted porphyrin RL-91 exhibits antifungal activity against opportune human pathogen Candida albicans. RL-91 efficiently inhibits growth of both planktonic C albicans cells and cells within biofilms without photoactivation. The minimal inhibitory concentration for plankton form (PMIC) was established to be 100 mu g/mL and the same concentration killed 80% of sessile cells in the mature biofilm (SMIC80). Furthermore PMIC of RL-91 efficiently prevents C albicans biofilm formation. RL-91 is cytotoxic for human fibroblasts in vitro in concentration of 10 mu g/mL, however it does not cause hemolysis in concentrations of up to 50 mu g/mL. These findings open possibility for application of RL-91 as an antifungal agent for external antibiofilm treatment of medical devices as well as a scaffold for further development of porphyrin based systemic antifungals. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS// | |
dc.relation | University Erlangen-Nurnberg (Emerging Field Initiative: Medicinal Redox Inorganic Chemistry) | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic & Medicinal Chemistry Letters | |
dc.subject | Porphyrins | en |
dc.subject | Ferrocene | en |
dc.subject | Candida albicans | en |
dc.subject | Biofilm | en |
dc.subject | Antifungal | en |
dc.title | Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 3511 | |
dc.citation.issue | 15 | |
dc.citation.other | 24(15): 3506-3511 | |
dc.citation.rank | M22 | |
dc.citation.spage | 3506 | |
dc.citation.volume | 24 | |
dc.identifier.doi | 10.1016/j.bmcl.2014.05.061 | |
dc.identifier.pmid | 24929472 | |
dc.identifier.scopus | 2-s2.0-84904066359 | |
dc.identifier.wos | 000339228700058 | |
dc.type.version | publishedVersion |