Cellular role of DNA polymerase I
Abstract
Escherichia coli possesses three well‐established DNA polymerases, I, II and III. DNA polymerase I (Pol 1) is the main repair polymerase in E. coli and also has a minor but important role in chromosomal replication. A major advantage of Pol I as an experimental system is its simplicity: unlike other replication enzymes, it is active as a single subunit. To a large extent, mutagenesis appears to be the result of (dis) functions of the DNA replication machinery. It is the purpose of this review to provide an integrated view of this relationship with particular emphasis on the role of Pol I in mutagenic events. Copyright
Source:
Journal of Basic Microbiology, 1990, 30, 10, 769-784
DOI: 10.1002/jobm.3620301017
ISSN: 0233-111X
PubMed: 2090806
Scopus: 2-s2.0-0025621293
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Savić, D.J. AU - Janković, M. AU - Kostić, Tatjana PY - 1990 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/70 AB - Escherichia coli possesses three well‐established DNA polymerases, I, II and III. DNA polymerase I (Pol 1) is the main repair polymerase in E. coli and also has a minor but important role in chromosomal replication. A major advantage of Pol I as an experimental system is its simplicity: unlike other replication enzymes, it is active as a single subunit. To a large extent, mutagenesis appears to be the result of (dis) functions of the DNA replication machinery. It is the purpose of this review to provide an integrated view of this relationship with particular emphasis on the role of Pol I in mutagenic events. Copyright T2 - Journal of Basic Microbiology T1 - Cellular role of DNA polymerase I EP - 784 IS - 10 SP - 769 VL - 30 DO - 10.1002/jobm.3620301017 ER -
@article{ author = "Savić, D.J. and Janković, M. and Kostić, Tatjana ", year = "1990", abstract = "Escherichia coli possesses three well‐established DNA polymerases, I, II and III. DNA polymerase I (Pol 1) is the main repair polymerase in E. coli and also has a minor but important role in chromosomal replication. A major advantage of Pol I as an experimental system is its simplicity: unlike other replication enzymes, it is active as a single subunit. To a large extent, mutagenesis appears to be the result of (dis) functions of the DNA replication machinery. It is the purpose of this review to provide an integrated view of this relationship with particular emphasis on the role of Pol I in mutagenic events. Copyright", journal = "Journal of Basic Microbiology", title = "Cellular role of DNA polymerase I", pages = "784-769", number = "10", volume = "30", doi = "10.1002/jobm.3620301017" }
Savić, D.J., Janković, M.,& Kostić, T.. (1990). Cellular role of DNA polymerase I. in Journal of Basic Microbiology, 30(10), 769-784. https://doi.org/10.1002/jobm.3620301017
Savić D, Janković M, Kostić T. Cellular role of DNA polymerase I. in Journal of Basic Microbiology. 1990;30(10):769-784. doi:10.1002/jobm.3620301017 .
Savić, D.J., Janković, M., Kostić, Tatjana , "Cellular role of DNA polymerase I" in Journal of Basic Microbiology, 30, no. 10 (1990):769-784, https://doi.org/10.1002/jobm.3620301017 . .