Kliničke karakteristike prve venske tromboze kod mladih žena i onih starijih od 45 godina
Clinical characteristics of first venous thrombosis among women under and over 45 years of age
2014
Аутори
Kovač, MirjanaMiković, Željko
Mandić, Vesna
Radojković, Dragica
Đorđević, Valentina
Mitić, Gorana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Uvod. Venski tromboembolizam je multifaktorijalna bolest koja nastaje u interakciji genetskog i stečenog faktora rizika. Nakon bolesti koronarnih krvnih sudova i moždanog udara, najčešći je razlog kardiovaskularne smrti ili onesposobljenosti. Materijal i metode. Sa ciljem da se utvrde kliničke krakteristike prvog venskog tromboembolizma, u studiju je uključeno 447 žena mlađih od 45 i 174 žene starije od 45 godina, koje su testirane na prisustvo trombofilije u periodu 1998-2012. godine. Rezultati. Proksimalna duboka venska tromboza češće je zastupljena kod mladih žena, dok je distalna učestalija u grupi starijih. Najčešći faktor rizika za trombozu, koji je utvrđen kod 49,8% mladih žena je trudnoća i stanje posle porođaja, dok se kod 25,2% tromboza razvila bez jasno prepoznatljivog faktora rizika. U grupi starijih žena, tromboza nastaje kod 38,5% bez faktora rizika, dok je malignitet kao najznačajniji faktor rizika utvrđen kod 23%. Prisustvo trombofilije zabeleženo je kod 48,7% mladih, o...dnosno kod 28,7% starijih žena, p lt 0,001. Razlika se beleži i u odnosu na ponavljane venske tromboze koje su zabeležene kod 26,3% mladih, odnosno kod 17,8% starijih žena, p = 0,03. Zaključak. Kod mladih žena se razvijaju klinički teže venske tromboze nego kod starijih. Urođeni faktor rizika otkriven je kod skoro polovine mladih ispitanica, odnosno kod svake četvrte starije žene. Sa izuzetkom faktora V Leiden mutacije ostali tipovi urođene trombofilije su gotovo zanemarljivi u grupi starijih žena. Stoga je testiranje na prisustvo trombofilije u slučaju prve tromboze, u potpunosti opravdano samo kod mlađih žena.
Introduction. Venous thromboembolism is a multifactorial disease defined by multiple interactions between genetic and acquired risk factors. After coronary heart disease and stroke, venous thromboembolism is the most common cause of cardiovascular death and disability. Material and Methods. In order to investigate the clinical characteristics of first venous thromboembolism, 447 women younger than 45 and 174 over 45 years of age with confirmed venous thromboembolism, who had been tested for the presence of thrombophilia in the period 1998-2012, were included in the study. Results. Proximal deep vein thrombosis occurred most often among young women, while distal deep vein thrombosis was the most frequent in the older group. The most common reported risk for venous thromboembolism observed in 49.8% of the young women was pregnancy and puerperium, while 25.2% of them developed venous thromboembolism without any obvious cause. Among women over the age of 45, venous thromboembolism develope...d without an obvious cause in 38.5%, while malignant disease was identified as the most important risk factor in 23% of them. Thrombophilia was observed in 48.7% of the young women in comparison to 28.7% of the older ones (p lt 0.0001). As for venous thromboembolism recurrence, it developed in 26.3% of young women and 17.8% of the older ones (p = 0.03). Conclusion. Younger women developed more severe forms of thrombosis than the older ones. Inherited risk factor for thrombosis was detected in almost half of all young women, and in every fourth elderly women. With the exception of factor V Leiden mutation, other types of congenital thrombophilia are almost negligible among older women. Therefore, thrombophilia testing in case of first thrombosis is fully justified only in young women.
Кључне речи:
Znaci i simptomi / Žensko / Venska tromboza / Tromboembolije / Stari / Odrasli / Faktori rizika / Dijagnostičke tehnike i procedure / Venous Thrombosis / Thromboembolism / Signs and Symptoms / Risk Factors / Female / Diagnostic Techniques and Procedures / Aged / AdultИзвор:
Medicinski pregled, 2014, 67, 9-10, 328-333Издавач:
- Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kovač, Mirjana AU - Miković, Željko AU - Mandić, Vesna AU - Radojković, Dragica AU - Đorđević, Valentina AU - Mitić, Gorana PY - 2014 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/728 AB - Uvod. Venski tromboembolizam je multifaktorijalna bolest koja nastaje u interakciji genetskog i stečenog faktora rizika. Nakon bolesti koronarnih krvnih sudova i moždanog udara, najčešći je razlog kardiovaskularne smrti ili onesposobljenosti. Materijal i metode. Sa ciljem da se utvrde kliničke krakteristike prvog venskog tromboembolizma, u studiju je uključeno 447 žena mlađih od 45 i 174 žene starije od 45 godina, koje su testirane na prisustvo trombofilije u periodu 1998-2012. godine. Rezultati. Proksimalna duboka venska tromboza češće je zastupljena kod mladih žena, dok je distalna učestalija u grupi starijih. Najčešći faktor rizika za trombozu, koji je utvrđen kod 49,8% mladih žena je trudnoća i stanje posle porođaja, dok se kod 25,2% tromboza razvila bez jasno prepoznatljivog faktora rizika. U grupi starijih žena, tromboza nastaje kod 38,5% bez faktora rizika, dok je malignitet kao najznačajniji faktor rizika utvrđen kod 23%. Prisustvo trombofilije zabeleženo je kod 48,7% mladih, odnosno kod 28,7% starijih žena, p lt 0,001. Razlika se beleži i u odnosu na ponavljane venske tromboze koje su zabeležene kod 26,3% mladih, odnosno kod 17,8% starijih žena, p = 0,03. Zaključak. Kod mladih žena se razvijaju klinički teže venske tromboze nego kod starijih. Urođeni faktor rizika otkriven je kod skoro polovine mladih ispitanica, odnosno kod svake četvrte starije žene. Sa izuzetkom faktora V Leiden mutacije ostali tipovi urođene trombofilije su gotovo zanemarljivi u grupi starijih žena. Stoga je testiranje na prisustvo trombofilije u slučaju prve tromboze, u potpunosti opravdano samo kod mlađih žena. AB - Introduction. Venous thromboembolism is a multifactorial disease defined by multiple interactions between genetic and acquired risk factors. After coronary heart disease and stroke, venous thromboembolism is the most common cause of cardiovascular death and disability. Material and Methods. In order to investigate the clinical characteristics of first venous thromboembolism, 447 women younger than 45 and 174 over 45 years of age with confirmed venous thromboembolism, who had been tested for the presence of thrombophilia in the period 1998-2012, were included in the study. Results. Proximal deep vein thrombosis occurred most often among young women, while distal deep vein thrombosis was the most frequent in the older group. The most common reported risk for venous thromboembolism observed in 49.8% of the young women was pregnancy and puerperium, while 25.2% of them developed venous thromboembolism without any obvious cause. Among women over the age of 45, venous thromboembolism developed without an obvious cause in 38.5%, while malignant disease was identified as the most important risk factor in 23% of them. Thrombophilia was observed in 48.7% of the young women in comparison to 28.7% of the older ones (p lt 0.0001). As for venous thromboembolism recurrence, it developed in 26.3% of young women and 17.8% of the older ones (p = 0.03). Conclusion. Younger women developed more severe forms of thrombosis than the older ones. Inherited risk factor for thrombosis was detected in almost half of all young women, and in every fourth elderly women. With the exception of factor V Leiden mutation, other types of congenital thrombophilia are almost negligible among older women. Therefore, thrombophilia testing in case of first thrombosis is fully justified only in young women. PB - Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad T2 - Medicinski pregled T1 - Kliničke karakteristike prve venske tromboze kod mladih žena i onih starijih od 45 godina T1 - Clinical characteristics of first venous thrombosis among women under and over 45 years of age EP - 333 IS - 9-10 SP - 328 VL - 67 DO - 10.2298/MPNS1410328K ER -
@article{ author = "Kovač, Mirjana and Miković, Željko and Mandić, Vesna and Radojković, Dragica and Đorđević, Valentina and Mitić, Gorana", year = "2014", abstract = "Uvod. Venski tromboembolizam je multifaktorijalna bolest koja nastaje u interakciji genetskog i stečenog faktora rizika. Nakon bolesti koronarnih krvnih sudova i moždanog udara, najčešći je razlog kardiovaskularne smrti ili onesposobljenosti. Materijal i metode. Sa ciljem da se utvrde kliničke krakteristike prvog venskog tromboembolizma, u studiju je uključeno 447 žena mlađih od 45 i 174 žene starije od 45 godina, koje su testirane na prisustvo trombofilije u periodu 1998-2012. godine. Rezultati. Proksimalna duboka venska tromboza češće je zastupljena kod mladih žena, dok je distalna učestalija u grupi starijih. Najčešći faktor rizika za trombozu, koji je utvrđen kod 49,8% mladih žena je trudnoća i stanje posle porođaja, dok se kod 25,2% tromboza razvila bez jasno prepoznatljivog faktora rizika. U grupi starijih žena, tromboza nastaje kod 38,5% bez faktora rizika, dok je malignitet kao najznačajniji faktor rizika utvrđen kod 23%. Prisustvo trombofilije zabeleženo je kod 48,7% mladih, odnosno kod 28,7% starijih žena, p lt 0,001. Razlika se beleži i u odnosu na ponavljane venske tromboze koje su zabeležene kod 26,3% mladih, odnosno kod 17,8% starijih žena, p = 0,03. Zaključak. Kod mladih žena se razvijaju klinički teže venske tromboze nego kod starijih. Urođeni faktor rizika otkriven je kod skoro polovine mladih ispitanica, odnosno kod svake četvrte starije žene. Sa izuzetkom faktora V Leiden mutacije ostali tipovi urođene trombofilije su gotovo zanemarljivi u grupi starijih žena. Stoga je testiranje na prisustvo trombofilije u slučaju prve tromboze, u potpunosti opravdano samo kod mlađih žena., Introduction. Venous thromboembolism is a multifactorial disease defined by multiple interactions between genetic and acquired risk factors. After coronary heart disease and stroke, venous thromboembolism is the most common cause of cardiovascular death and disability. Material and Methods. In order to investigate the clinical characteristics of first venous thromboembolism, 447 women younger than 45 and 174 over 45 years of age with confirmed venous thromboembolism, who had been tested for the presence of thrombophilia in the period 1998-2012, were included in the study. Results. Proximal deep vein thrombosis occurred most often among young women, while distal deep vein thrombosis was the most frequent in the older group. The most common reported risk for venous thromboembolism observed in 49.8% of the young women was pregnancy and puerperium, while 25.2% of them developed venous thromboembolism without any obvious cause. Among women over the age of 45, venous thromboembolism developed without an obvious cause in 38.5%, while malignant disease was identified as the most important risk factor in 23% of them. Thrombophilia was observed in 48.7% of the young women in comparison to 28.7% of the older ones (p lt 0.0001). As for venous thromboembolism recurrence, it developed in 26.3% of young women and 17.8% of the older ones (p = 0.03). Conclusion. Younger women developed more severe forms of thrombosis than the older ones. Inherited risk factor for thrombosis was detected in almost half of all young women, and in every fourth elderly women. With the exception of factor V Leiden mutation, other types of congenital thrombophilia are almost negligible among older women. Therefore, thrombophilia testing in case of first thrombosis is fully justified only in young women.", publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad", journal = "Medicinski pregled", title = "Kliničke karakteristike prve venske tromboze kod mladih žena i onih starijih od 45 godina, Clinical characteristics of first venous thrombosis among women under and over 45 years of age", pages = "333-328", number = "9-10", volume = "67", doi = "10.2298/MPNS1410328K" }
Kovač, M., Miković, Ž., Mandić, V., Radojković, D., Đorđević, V.,& Mitić, G.. (2014). Kliničke karakteristike prve venske tromboze kod mladih žena i onih starijih od 45 godina. in Medicinski pregled Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad., 67(9-10), 328-333. https://doi.org/10.2298/MPNS1410328K
Kovač M, Miković Ž, Mandić V, Radojković D, Đorđević V, Mitić G. Kliničke karakteristike prve venske tromboze kod mladih žena i onih starijih od 45 godina. in Medicinski pregled. 2014;67(9-10):328-333. doi:10.2298/MPNS1410328K .
Kovač, Mirjana, Miković, Željko, Mandić, Vesna, Radojković, Dragica, Đorđević, Valentina, Mitić, Gorana, "Kliničke karakteristike prve venske tromboze kod mladih žena i onih starijih od 45 godina" in Medicinski pregled, 67, no. 9-10 (2014):328-333, https://doi.org/10.2298/MPNS1410328K . .