Origin of rat β-globin haplotypes containing three and five genes
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We have reported in rat three adult β-gene haplotypes containing either five or three genes. Detailed sequence analysis reveals that the leftmost gene is the major gene and that at the opposite end downstream lies the minor gene. All of the genes lying between them are minor-major hybrids indicating their origin by unequal crossing-over. In two haplotypes β-globin genes were found with an L1 element inserted directly into IVS2. The described results allow the formulation of a pathway of mutational events leading from the ancient two-β-gene rodent ancestor through a three-gene haplotype to five-gene haplotypes, one of which is postulated to have arisen in common laboratory strains since their capture in the wild.
Кључне речи:
rat haplotypes / numerous β-globin genes / minor-major hybrid genes / globin genesИзвор:
Molecular Biology and Evolution, 1990, 7, 5, 407-422
DOI: 10.1093/oxfordjournals.molbev.a040616 Abstract
ISSN: 0737-4038
PubMed: 2263193
Scopus: 2-s2.0-0025150965
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Paunesku, T. AU - Stevanović, Milena AU - Radosavljević, D. AU - Drmanac, R. AU - Crkvenjakov, R. PY - 1990 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/73 AB - We have reported in rat three adult β-gene haplotypes containing either five or three genes. Detailed sequence analysis reveals that the leftmost gene is the major gene and that at the opposite end downstream lies the minor gene. All of the genes lying between them are minor-major hybrids indicating their origin by unequal crossing-over. In two haplotypes β-globin genes were found with an L1 element inserted directly into IVS2. The described results allow the formulation of a pathway of mutational events leading from the ancient two-β-gene rodent ancestor through a three-gene haplotype to five-gene haplotypes, one of which is postulated to have arisen in common laboratory strains since their capture in the wild. T2 - Molecular Biology and Evolution T1 - Origin of rat β-globin haplotypes containing three and five genes EP - 422 IS - 5 SP - 407 VL - 7 DO - 10.1093/oxfordjournals.molbev.a040616 Abstract ER -
@article{ author = "Paunesku, T. and Stevanović, Milena and Radosavljević, D. and Drmanac, R. and Crkvenjakov, R.", year = "1990", abstract = "We have reported in rat three adult β-gene haplotypes containing either five or three genes. Detailed sequence analysis reveals that the leftmost gene is the major gene and that at the opposite end downstream lies the minor gene. All of the genes lying between them are minor-major hybrids indicating their origin by unequal crossing-over. In two haplotypes β-globin genes were found with an L1 element inserted directly into IVS2. The described results allow the formulation of a pathway of mutational events leading from the ancient two-β-gene rodent ancestor through a three-gene haplotype to five-gene haplotypes, one of which is postulated to have arisen in common laboratory strains since their capture in the wild.", journal = "Molecular Biology and Evolution", title = "Origin of rat β-globin haplotypes containing three and five genes", pages = "422-407", number = "5", volume = "7", doi = "10.1093/oxfordjournals.molbev.a040616 Abstract" }
Paunesku, T., Stevanović, M., Radosavljević, D., Drmanac, R.,& Crkvenjakov, R.. (1990). Origin of rat β-globin haplotypes containing three and five genes. in Molecular Biology and Evolution, 7(5), 407-422. https://doi.org/10.1093/oxfordjournals.molbev.a040616 Abstract
Paunesku T, Stevanović M, Radosavljević D, Drmanac R, Crkvenjakov R. Origin of rat β-globin haplotypes containing three and five genes. in Molecular Biology and Evolution. 1990;7(5):407-422. doi:10.1093/oxfordjournals.molbev.a040616 Abstract .
Paunesku, T., Stevanović, Milena, Radosavljević, D., Drmanac, R., Crkvenjakov, R., "Origin of rat β-globin haplotypes containing three and five genes" in Molecular Biology and Evolution, 7, no. 5 (1990):407-422, https://doi.org/10.1093/oxfordjournals.molbev.a040616 Abstract . .