The 3 ' End Prothrombin Gene Variants in Patients With Different Thrombotic Events
2014
Аутори
Đorđević, ValentinaPruner, Iva
Tomić, Branko
Nestorović, Aleksandra
Gvozdenov, Maja
Kovač, Mirjana
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Prothrombin (FII) A19911G and C20221T gene variants are associated with increased prothrombin levels and potentially represent thrombotic risk factors. Objective: To determine the frequency of A19911G and C20221T FII gene variants in patients with thrombotic disorders and in women who have experienced pregnancy loss (PL). Methods: We determined the frequency of these variants in 133 patients with deep venous thrombosis (DVT), 80 patients with isolated pulmonary embolism (PE), 101 patients with idiopathic PL, and 180 control individuals. Results: The FII A19911G variant was more prevalent in patients with DVT and with PL compared with controls; however, these differences were not statistically significant. The 19911GG genotype was associated with increased risk of PE (odds ratio, 1.91; 95% confidence interval, 1.04-3.51). We did not detect carriers of the FII C20221T gene variant in this study. Conclusions: This is the first study, to our knowledge, that demonstrates the FII... 1991199 genotype may represent a risk factor for isolated PE. Also, our results show that the FII C20221T is a rare variant in this population and therefore, routine thrombophilia screening should not include screening for this genotype.
Кључне речи:
venous thrombosis / pulmonary embolism / pregnancy loss / FII C20221T / FII A19911G / 3 ' end of the prothrombin geneИзвор:
Laboratory Medicine, 2014, 45, 4, 307-311Издавач:
- Amer Soc Clinical Pathology, Chicago
Финансирање / пројекти:
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.1309/LM8E84ZSLPDMWZCM
ISSN: 0007-5027
PubMed: 25316662
WoS: 000343954700005
Scopus: 2-s2.0-84926488493
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Đorđević, Valentina AU - Pruner, Iva AU - Tomić, Branko AU - Nestorović, Aleksandra AU - Gvozdenov, Maja AU - Kovač, Mirjana AU - Radojković, Dragica PY - 2014 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/739 AB - Background: Prothrombin (FII) A19911G and C20221T gene variants are associated with increased prothrombin levels and potentially represent thrombotic risk factors. Objective: To determine the frequency of A19911G and C20221T FII gene variants in patients with thrombotic disorders and in women who have experienced pregnancy loss (PL). Methods: We determined the frequency of these variants in 133 patients with deep venous thrombosis (DVT), 80 patients with isolated pulmonary embolism (PE), 101 patients with idiopathic PL, and 180 control individuals. Results: The FII A19911G variant was more prevalent in patients with DVT and with PL compared with controls; however, these differences were not statistically significant. The 19911GG genotype was associated with increased risk of PE (odds ratio, 1.91; 95% confidence interval, 1.04-3.51). We did not detect carriers of the FII C20221T gene variant in this study. Conclusions: This is the first study, to our knowledge, that demonstrates the FII 1991199 genotype may represent a risk factor for isolated PE. Also, our results show that the FII C20221T is a rare variant in this population and therefore, routine thrombophilia screening should not include screening for this genotype. PB - Amer Soc Clinical Pathology, Chicago T2 - Laboratory Medicine T1 - The 3 ' End Prothrombin Gene Variants in Patients With Different Thrombotic Events EP - 311 IS - 4 SP - 307 VL - 45 DO - 10.1309/LM8E84ZSLPDMWZCM ER -
@article{ author = "Đorđević, Valentina and Pruner, Iva and Tomić, Branko and Nestorović, Aleksandra and Gvozdenov, Maja and Kovač, Mirjana and Radojković, Dragica", year = "2014", abstract = "Background: Prothrombin (FII) A19911G and C20221T gene variants are associated with increased prothrombin levels and potentially represent thrombotic risk factors. Objective: To determine the frequency of A19911G and C20221T FII gene variants in patients with thrombotic disorders and in women who have experienced pregnancy loss (PL). Methods: We determined the frequency of these variants in 133 patients with deep venous thrombosis (DVT), 80 patients with isolated pulmonary embolism (PE), 101 patients with idiopathic PL, and 180 control individuals. Results: The FII A19911G variant was more prevalent in patients with DVT and with PL compared with controls; however, these differences were not statistically significant. The 19911GG genotype was associated with increased risk of PE (odds ratio, 1.91; 95% confidence interval, 1.04-3.51). We did not detect carriers of the FII C20221T gene variant in this study. Conclusions: This is the first study, to our knowledge, that demonstrates the FII 1991199 genotype may represent a risk factor for isolated PE. Also, our results show that the FII C20221T is a rare variant in this population and therefore, routine thrombophilia screening should not include screening for this genotype.", publisher = "Amer Soc Clinical Pathology, Chicago", journal = "Laboratory Medicine", title = "The 3 ' End Prothrombin Gene Variants in Patients With Different Thrombotic Events", pages = "311-307", number = "4", volume = "45", doi = "10.1309/LM8E84ZSLPDMWZCM" }
Đorđević, V., Pruner, I., Tomić, B., Nestorović, A., Gvozdenov, M., Kovač, M.,& Radojković, D.. (2014). The 3 ' End Prothrombin Gene Variants in Patients With Different Thrombotic Events. in Laboratory Medicine Amer Soc Clinical Pathology, Chicago., 45(4), 307-311. https://doi.org/10.1309/LM8E84ZSLPDMWZCM
Đorđević V, Pruner I, Tomić B, Nestorović A, Gvozdenov M, Kovač M, Radojković D. The 3 ' End Prothrombin Gene Variants in Patients With Different Thrombotic Events. in Laboratory Medicine. 2014;45(4):307-311. doi:10.1309/LM8E84ZSLPDMWZCM .
Đorđević, Valentina, Pruner, Iva, Tomić, Branko, Nestorović, Aleksandra, Gvozdenov, Maja, Kovač, Mirjana, Radojković, Dragica, "The 3 ' End Prothrombin Gene Variants in Patients With Different Thrombotic Events" in Laboratory Medicine, 45, no. 4 (2014):307-311, https://doi.org/10.1309/LM8E84ZSLPDMWZCM . .