Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling
Samo za registrovane korisnike
2014
Autori
Mojsin, MarijaVicentić, Jelena Marjanovic
Schwirtlich, Marija
Topalović, Vladanka
Stevanović, Milena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Quercetin, a bioflavonoid found in plant foods, has a wide range of therapeutic effects. In order to examine the therapeutic potential of quercetin in teratocarcinoma, we used the human teratocarcinoma cell line NT2/D1 as an in vitro model. We have shown that quercetin inhibits the proliferation, adhesion and migration of NT2/D1 cells and downregulates the expression of pluripotency factors SOX2, Oct4 and Nanog. Our results further suggest that the anticancer effect of quercetin against human teratocarcinoma cells is mediated by targeting the canonical Wnt signaling pathway. Quercetin antagonized the Wnt/beta-catenin signaling pathway in NT2/D1 cells by inhibiting beta-catenin nuclear translocation and the consequent downregulation of beta-catenin-dependent transcription. These data suggest that quercetin as a potent inhibitor of Wnt signaling may be an effective therapeutic agent in cancers with aberrant activation of the Wnt pathway.
Izvor:
Food & Function, 2014, 5, 10, 2564-2573Izdavač:
- Royal Soc Chemistry, Cambridge
Finansiranje / projekti:
- Proučavanje signalnih puteva i epigenetičkih mehanizama uključenih u kontrolu ekspresije humanih SOX gena: dalje rasvetljavanje njihove uloge u određivanju sudbine i diferencijaciji ćelija (RS-MESTD-Basic Research (BR or ON)-173051)
DOI: 10.1039/c4fo00484a
ISSN: 2042-6496
PubMed: 25138740
WoS: 000343023300022
Scopus: 2-s2.0-84907856552
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Mojsin, Marija AU - Vicentić, Jelena Marjanovic AU - Schwirtlich, Marija AU - Topalović, Vladanka AU - Stevanović, Milena PY - 2014 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/743 AB - Quercetin, a bioflavonoid found in plant foods, has a wide range of therapeutic effects. In order to examine the therapeutic potential of quercetin in teratocarcinoma, we used the human teratocarcinoma cell line NT2/D1 as an in vitro model. We have shown that quercetin inhibits the proliferation, adhesion and migration of NT2/D1 cells and downregulates the expression of pluripotency factors SOX2, Oct4 and Nanog. Our results further suggest that the anticancer effect of quercetin against human teratocarcinoma cells is mediated by targeting the canonical Wnt signaling pathway. Quercetin antagonized the Wnt/beta-catenin signaling pathway in NT2/D1 cells by inhibiting beta-catenin nuclear translocation and the consequent downregulation of beta-catenin-dependent transcription. These data suggest that quercetin as a potent inhibitor of Wnt signaling may be an effective therapeutic agent in cancers with aberrant activation of the Wnt pathway. PB - Royal Soc Chemistry, Cambridge T2 - Food & Function T1 - Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling EP - 2573 IS - 10 SP - 2564 VL - 5 DO - 10.1039/c4fo00484a ER -
@article{ author = "Mojsin, Marija and Vicentić, Jelena Marjanovic and Schwirtlich, Marija and Topalović, Vladanka and Stevanović, Milena", year = "2014", abstract = "Quercetin, a bioflavonoid found in plant foods, has a wide range of therapeutic effects. In order to examine the therapeutic potential of quercetin in teratocarcinoma, we used the human teratocarcinoma cell line NT2/D1 as an in vitro model. We have shown that quercetin inhibits the proliferation, adhesion and migration of NT2/D1 cells and downregulates the expression of pluripotency factors SOX2, Oct4 and Nanog. Our results further suggest that the anticancer effect of quercetin against human teratocarcinoma cells is mediated by targeting the canonical Wnt signaling pathway. Quercetin antagonized the Wnt/beta-catenin signaling pathway in NT2/D1 cells by inhibiting beta-catenin nuclear translocation and the consequent downregulation of beta-catenin-dependent transcription. These data suggest that quercetin as a potent inhibitor of Wnt signaling may be an effective therapeutic agent in cancers with aberrant activation of the Wnt pathway.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Food & Function", title = "Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling", pages = "2573-2564", number = "10", volume = "5", doi = "10.1039/c4fo00484a" }
Mojsin, M., Vicentić, J. M., Schwirtlich, M., Topalović, V.,& Stevanović, M.. (2014). Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling. in Food & Function Royal Soc Chemistry, Cambridge., 5(10), 2564-2573. https://doi.org/10.1039/c4fo00484a
Mojsin M, Vicentić JM, Schwirtlich M, Topalović V, Stevanović M. Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling. in Food & Function. 2014;5(10):2564-2573. doi:10.1039/c4fo00484a .
Mojsin, Marija, Vicentić, Jelena Marjanovic, Schwirtlich, Marija, Topalović, Vladanka, Stevanović, Milena, "Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling" in Food & Function, 5, no. 10 (2014):2564-2573, https://doi.org/10.1039/c4fo00484a . .