Risk factors for thrombosis in Serbian children
Само за регистроване кориснике
2014
Аутори
Serbić-Nonković, Olivera M.Kuzmanović, Milos B.
Rakićević, Ljiljana
Đorđević, Valentina
Veljković, Dobrila K.
Prijić, Sergej M.
Kovacević, Gordana S.
Rakonjac, Zorica M.
Kosutić, Jovan Lj
Vujić, Dragana S.
Micić, Dragan V.
Janković, Borisav Z.
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Venous and arterial thromboses are increasingly encountered in the pediatric population. We present results of a case-control study of inherited and acquired risk factors for thrombosis in 129 pediatric patients from the first day of life to 18 years. The aims of study were to determine the importance of thrombophilic risk factors and comorbidity as a cause of thrombosis in children. Single thrombophilic risk factor was found in 24.4% (n=21), whereas combined thrombophilic factors were found in 15.1% (n=13) patients. A total of 87.2% of the children had recognized thrombophilic risk factors for thrombosis and/or additional comorbid risk factors. The single independent risk factors for thrombosis were mutation of factor V Leiden (P=0.021), lupus anticoagulant antibodies (P=0.028), and comorbidity (P=0.000). Mutation of factor V Leiden [odds ratio (OR), 6.2 (95% confidence interval, CI 1.1-38.1, P=0.048] was found to be a risk factor for venous thrombosis. Lupus anticoagulant antibodies ...were related to both venous (P=0.008) and arterial thrombosis (P=0.016). The frequency of inherited thrombophilic factors were the same in neonates and adolescents (23%). The prothrombotic gene mutations were present in 18.6% (n=8) of asymptomatic children. Our study confirms that thrombosis in children is a multifactorial disorder, and associated most with the underlying medical disease (comorbidity) for vein thrombosis [OR, 18.6 (95% CI 3.7-93.4), P=0.000] and for arterial thrombosis [OR, 10.5 (95% CI 2.2-49.9) P=0.003]. Inherited thrombophilic disorders contributed to the development of thrombosis in children.
Кључне речи:
thrombosis / thrombophilia / risk factors / childrenИзвор:
Blood Coagulation & Fibrinolysis, 2014, 25, 1, 25-32Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.1097/MBC.0b013e328364c217
ISSN: 0957-5235
PubMed: 24030120
WoS: 000334920800006
Scopus: 2-s2.0-84893706918
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Serbić-Nonković, Olivera M. AU - Kuzmanović, Milos B. AU - Rakićević, Ljiljana AU - Đorđević, Valentina AU - Veljković, Dobrila K. AU - Prijić, Sergej M. AU - Kovacević, Gordana S. AU - Rakonjac, Zorica M. AU - Kosutić, Jovan Lj AU - Vujić, Dragana S. AU - Micić, Dragan V. AU - Janković, Borisav Z. AU - Radojković, Dragica PY - 2014 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/772 AB - Venous and arterial thromboses are increasingly encountered in the pediatric population. We present results of a case-control study of inherited and acquired risk factors for thrombosis in 129 pediatric patients from the first day of life to 18 years. The aims of study were to determine the importance of thrombophilic risk factors and comorbidity as a cause of thrombosis in children. Single thrombophilic risk factor was found in 24.4% (n=21), whereas combined thrombophilic factors were found in 15.1% (n=13) patients. A total of 87.2% of the children had recognized thrombophilic risk factors for thrombosis and/or additional comorbid risk factors. The single independent risk factors for thrombosis were mutation of factor V Leiden (P=0.021), lupus anticoagulant antibodies (P=0.028), and comorbidity (P=0.000). Mutation of factor V Leiden [odds ratio (OR), 6.2 (95% confidence interval, CI 1.1-38.1, P=0.048] was found to be a risk factor for venous thrombosis. Lupus anticoagulant antibodies were related to both venous (P=0.008) and arterial thrombosis (P=0.016). The frequency of inherited thrombophilic factors were the same in neonates and adolescents (23%). The prothrombotic gene mutations were present in 18.6% (n=8) of asymptomatic children. Our study confirms that thrombosis in children is a multifactorial disorder, and associated most with the underlying medical disease (comorbidity) for vein thrombosis [OR, 18.6 (95% CI 3.7-93.4), P=0.000] and for arterial thrombosis [OR, 10.5 (95% CI 2.2-49.9) P=0.003]. Inherited thrombophilic disorders contributed to the development of thrombosis in children. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Blood Coagulation & Fibrinolysis T1 - Risk factors for thrombosis in Serbian children EP - 32 IS - 1 SP - 25 VL - 25 DO - 10.1097/MBC.0b013e328364c217 ER -
@article{ author = "Serbić-Nonković, Olivera M. and Kuzmanović, Milos B. and Rakićević, Ljiljana and Đorđević, Valentina and Veljković, Dobrila K. and Prijić, Sergej M. and Kovacević, Gordana S. and Rakonjac, Zorica M. and Kosutić, Jovan Lj and Vujić, Dragana S. and Micić, Dragan V. and Janković, Borisav Z. and Radojković, Dragica", year = "2014", abstract = "Venous and arterial thromboses are increasingly encountered in the pediatric population. We present results of a case-control study of inherited and acquired risk factors for thrombosis in 129 pediatric patients from the first day of life to 18 years. The aims of study were to determine the importance of thrombophilic risk factors and comorbidity as a cause of thrombosis in children. Single thrombophilic risk factor was found in 24.4% (n=21), whereas combined thrombophilic factors were found in 15.1% (n=13) patients. A total of 87.2% of the children had recognized thrombophilic risk factors for thrombosis and/or additional comorbid risk factors. The single independent risk factors for thrombosis were mutation of factor V Leiden (P=0.021), lupus anticoagulant antibodies (P=0.028), and comorbidity (P=0.000). Mutation of factor V Leiden [odds ratio (OR), 6.2 (95% confidence interval, CI 1.1-38.1, P=0.048] was found to be a risk factor for venous thrombosis. Lupus anticoagulant antibodies were related to both venous (P=0.008) and arterial thrombosis (P=0.016). The frequency of inherited thrombophilic factors were the same in neonates and adolescents (23%). The prothrombotic gene mutations were present in 18.6% (n=8) of asymptomatic children. Our study confirms that thrombosis in children is a multifactorial disorder, and associated most with the underlying medical disease (comorbidity) for vein thrombosis [OR, 18.6 (95% CI 3.7-93.4), P=0.000] and for arterial thrombosis [OR, 10.5 (95% CI 2.2-49.9) P=0.003]. Inherited thrombophilic disorders contributed to the development of thrombosis in children.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Blood Coagulation & Fibrinolysis", title = "Risk factors for thrombosis in Serbian children", pages = "32-25", number = "1", volume = "25", doi = "10.1097/MBC.0b013e328364c217" }
Serbić-Nonković, O. M., Kuzmanović, M. B., Rakićević, L., Đorđević, V., Veljković, D. K., Prijić, S. M., Kovacević, G. S., Rakonjac, Z. M., Kosutić, J. L., Vujić, D. S., Micić, D. V., Janković, B. Z.,& Radojković, D.. (2014). Risk factors for thrombosis in Serbian children. in Blood Coagulation & Fibrinolysis Lippincott Williams & Wilkins, Philadelphia., 25(1), 25-32. https://doi.org/10.1097/MBC.0b013e328364c217
Serbić-Nonković OM, Kuzmanović MB, Rakićević L, Đorđević V, Veljković DK, Prijić SM, Kovacević GS, Rakonjac ZM, Kosutić JL, Vujić DS, Micić DV, Janković BZ, Radojković D. Risk factors for thrombosis in Serbian children. in Blood Coagulation & Fibrinolysis. 2014;25(1):25-32. doi:10.1097/MBC.0b013e328364c217 .
Serbić-Nonković, Olivera M., Kuzmanović, Milos B., Rakićević, Ljiljana, Đorđević, Valentina, Veljković, Dobrila K., Prijić, Sergej M., Kovacević, Gordana S., Rakonjac, Zorica M., Kosutić, Jovan Lj, Vujić, Dragana S., Micić, Dragan V., Janković, Borisav Z., Radojković, Dragica, "Risk factors for thrombosis in Serbian children" in Blood Coagulation & Fibrinolysis, 25, no. 1 (2014):25-32, https://doi.org/10.1097/MBC.0b013e328364c217 . .