Učestalost polimorfizma PAI-1 4G/5G kod žena sa spontanim pobačajem - prvi podaci za srpsku populaciju
The prevalence of PAI-1 4G/5G polymorphism in women with fetal loss: First data for a Serbian population
2014
Autori
Đorđević, ValentinaGvozdenov, Maja
Pruner, Iva
Kovač, Mirjana
Tomić, Branko
Stanković, Marija
Radojković, Dragica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Uvod: Inhibitor aktivatora plazminogena 1 (PAI-1) igra značajnu ulogu u procesu inhibicije fibrinolize. Pokazano je da je PAI-1 4G/5G polimorfizam povezan sa povišenim nivoom PAI-1 proteina u plazmi. Povećana ekspresija PAI-1 i smanjena fibrinoliza kod homozigotnih nosilaca PAI-1 4G/5G polimorfizma može dovesti do poremećaja tokom formiranja placente i povećanja rizika za spontane pobačaje (SP). U okviru ove studije analizirali smo učestalost PAI-1 4G/5G polimorfizma kod pacijentkinja sa spontanim pobačajima. Metode: Studija je obuhvatila grupu od 203 žene (91 u kontrolnoj grupi i 112 žena sa SP). Prisustvo PAI-1 4G/5G polimorfizama je detektovano PCR-RFLP analizom. Rezultati: Detektovana učestalost homozigotnih nosilaca PAI-1 4G/5G polimorfizma je bila nešto visa u grupi pacijentkinja u odnosu na kontrolnu grupu (32,1% vs. 30,8%). Najviša učestalost je detektovana kod žena koje su imale SP u drugom trimestru trudnoće (50%), ali ova razlika nije bila statistički značajna. Zaključak Rez...ultati naše studije ukazuju da PAI-1 4G/4G može biti faktor rizika za pojavu SP u drugom trimestru trudnoće. Potrebna su dalja ispitivanja u cilju određivanja uloge PAI-1 4G/4G polimorfizma u etiologiji spontanih pobačaja.
Background: Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis. The PAI-1 4G/5G polymorphism is associated with elevated plasma levels of PAI-1. Overexpression of PAI-1 and impaired fibrinolysis in homozygous carriers of the 4G/4G PAI polymorphism may lead to abnormal placental formation and increased risk of fetal loss (FL). The aim of our study was to determine the frequency of this polymorphism in patients with FL in a Serbian population. Methods: The study was carried out in a group of 203 women (91 controls and 112 women with FL). The presence of PAI-1 4G/5G polymorphism was detected by PCR-RFLP analysis. Results: Slightly increased frequency of the PAI-1 4G/4G genotype was observed in the study group compared to the controls (32.1% vs. 30.8%). The frequency of PAI-1 was highest in women experiencing FL in the second trimester of pregnancy (50%), but this difference was not statistically significant. Conclusions: Our findings suggest that PAI-1 4G/4G might b...e a risk factor for FL occurring in the second trimester of pregnancy. Further studies are required in order to determine the role of PAI-1 4G/5G polymorphism in the etiology of FL.
Ključne reči:
spontani pobačaj / PAI-1 4G/5G polimorfizam / inhibitor aktivatora plazminogena / plasminogen activator inhibitor-1 / PAI-1 4G/5G polymorphism / fetal lossIzvor:
Journal of Medical Biochemistry, 2014, 33, 2, 203-207Izdavač:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Finansiranje / projekti:
- Kompleksne bolesti kao model sistem za proučavanje modulacije fenotipa-strukturna i funkcionalna analiza molekularnih biomarkera (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.2478/jomb-2013-0040
ISSN: 1452-8258
WoS: 000332683700011
Scopus: 2-s2.0-84896850981
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Đorđević, Valentina AU - Gvozdenov, Maja AU - Pruner, Iva AU - Kovač, Mirjana AU - Tomić, Branko AU - Stanković, Marija AU - Radojković, Dragica PY - 2014 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/788 AB - Uvod: Inhibitor aktivatora plazminogena 1 (PAI-1) igra značajnu ulogu u procesu inhibicije fibrinolize. Pokazano je da je PAI-1 4G/5G polimorfizam povezan sa povišenim nivoom PAI-1 proteina u plazmi. Povećana ekspresija PAI-1 i smanjena fibrinoliza kod homozigotnih nosilaca PAI-1 4G/5G polimorfizma može dovesti do poremećaja tokom formiranja placente i povećanja rizika za spontane pobačaje (SP). U okviru ove studije analizirali smo učestalost PAI-1 4G/5G polimorfizma kod pacijentkinja sa spontanim pobačajima. Metode: Studija je obuhvatila grupu od 203 žene (91 u kontrolnoj grupi i 112 žena sa SP). Prisustvo PAI-1 4G/5G polimorfizama je detektovano PCR-RFLP analizom. Rezultati: Detektovana učestalost homozigotnih nosilaca PAI-1 4G/5G polimorfizma je bila nešto visa u grupi pacijentkinja u odnosu na kontrolnu grupu (32,1% vs. 30,8%). Najviša učestalost je detektovana kod žena koje su imale SP u drugom trimestru trudnoće (50%), ali ova razlika nije bila statistički značajna. Zaključak Rezultati naše studije ukazuju da PAI-1 4G/4G može biti faktor rizika za pojavu SP u drugom trimestru trudnoće. Potrebna su dalja ispitivanja u cilju određivanja uloge PAI-1 4G/4G polimorfizma u etiologiji spontanih pobačaja. AB - Background: Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis. The PAI-1 4G/5G polymorphism is associated with elevated plasma levels of PAI-1. Overexpression of PAI-1 and impaired fibrinolysis in homozygous carriers of the 4G/4G PAI polymorphism may lead to abnormal placental formation and increased risk of fetal loss (FL). The aim of our study was to determine the frequency of this polymorphism in patients with FL in a Serbian population. Methods: The study was carried out in a group of 203 women (91 controls and 112 women with FL). The presence of PAI-1 4G/5G polymorphism was detected by PCR-RFLP analysis. Results: Slightly increased frequency of the PAI-1 4G/4G genotype was observed in the study group compared to the controls (32.1% vs. 30.8%). The frequency of PAI-1 was highest in women experiencing FL in the second trimester of pregnancy (50%), but this difference was not statistically significant. Conclusions: Our findings suggest that PAI-1 4G/4G might be a risk factor for FL occurring in the second trimester of pregnancy. Further studies are required in order to determine the role of PAI-1 4G/5G polymorphism in the etiology of FL. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Učestalost polimorfizma PAI-1 4G/5G kod žena sa spontanim pobačajem - prvi podaci za srpsku populaciju T1 - The prevalence of PAI-1 4G/5G polymorphism in women with fetal loss: First data for a Serbian population EP - 207 IS - 2 SP - 203 VL - 33 DO - 10.2478/jomb-2013-0040 ER -
@article{ author = "Đorđević, Valentina and Gvozdenov, Maja and Pruner, Iva and Kovač, Mirjana and Tomić, Branko and Stanković, Marija and Radojković, Dragica", year = "2014", abstract = "Uvod: Inhibitor aktivatora plazminogena 1 (PAI-1) igra značajnu ulogu u procesu inhibicije fibrinolize. Pokazano je da je PAI-1 4G/5G polimorfizam povezan sa povišenim nivoom PAI-1 proteina u plazmi. Povećana ekspresija PAI-1 i smanjena fibrinoliza kod homozigotnih nosilaca PAI-1 4G/5G polimorfizma može dovesti do poremećaja tokom formiranja placente i povećanja rizika za spontane pobačaje (SP). U okviru ove studije analizirali smo učestalost PAI-1 4G/5G polimorfizma kod pacijentkinja sa spontanim pobačajima. Metode: Studija je obuhvatila grupu od 203 žene (91 u kontrolnoj grupi i 112 žena sa SP). Prisustvo PAI-1 4G/5G polimorfizama je detektovano PCR-RFLP analizom. Rezultati: Detektovana učestalost homozigotnih nosilaca PAI-1 4G/5G polimorfizma je bila nešto visa u grupi pacijentkinja u odnosu na kontrolnu grupu (32,1% vs. 30,8%). Najviša učestalost je detektovana kod žena koje su imale SP u drugom trimestru trudnoće (50%), ali ova razlika nije bila statistički značajna. Zaključak Rezultati naše studije ukazuju da PAI-1 4G/4G može biti faktor rizika za pojavu SP u drugom trimestru trudnoće. Potrebna su dalja ispitivanja u cilju određivanja uloge PAI-1 4G/4G polimorfizma u etiologiji spontanih pobačaja., Background: Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis. The PAI-1 4G/5G polymorphism is associated with elevated plasma levels of PAI-1. Overexpression of PAI-1 and impaired fibrinolysis in homozygous carriers of the 4G/4G PAI polymorphism may lead to abnormal placental formation and increased risk of fetal loss (FL). The aim of our study was to determine the frequency of this polymorphism in patients with FL in a Serbian population. Methods: The study was carried out in a group of 203 women (91 controls and 112 women with FL). The presence of PAI-1 4G/5G polymorphism was detected by PCR-RFLP analysis. Results: Slightly increased frequency of the PAI-1 4G/4G genotype was observed in the study group compared to the controls (32.1% vs. 30.8%). The frequency of PAI-1 was highest in women experiencing FL in the second trimester of pregnancy (50%), but this difference was not statistically significant. Conclusions: Our findings suggest that PAI-1 4G/4G might be a risk factor for FL occurring in the second trimester of pregnancy. Further studies are required in order to determine the role of PAI-1 4G/5G polymorphism in the etiology of FL.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Učestalost polimorfizma PAI-1 4G/5G kod žena sa spontanim pobačajem - prvi podaci za srpsku populaciju, The prevalence of PAI-1 4G/5G polymorphism in women with fetal loss: First data for a Serbian population", pages = "207-203", number = "2", volume = "33", doi = "10.2478/jomb-2013-0040" }
Đorđević, V., Gvozdenov, M., Pruner, I., Kovač, M., Tomić, B., Stanković, M.,& Radojković, D.. (2014). Učestalost polimorfizma PAI-1 4G/5G kod žena sa spontanim pobačajem - prvi podaci za srpsku populaciju. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 33(2), 203-207. https://doi.org/10.2478/jomb-2013-0040
Đorđević V, Gvozdenov M, Pruner I, Kovač M, Tomić B, Stanković M, Radojković D. Učestalost polimorfizma PAI-1 4G/5G kod žena sa spontanim pobačajem - prvi podaci za srpsku populaciju. in Journal of Medical Biochemistry. 2014;33(2):203-207. doi:10.2478/jomb-2013-0040 .
Đorđević, Valentina, Gvozdenov, Maja, Pruner, Iva, Kovač, Mirjana, Tomić, Branko, Stanković, Marija, Radojković, Dragica, "Učestalost polimorfizma PAI-1 4G/5G kod žena sa spontanim pobačajem - prvi podaci za srpsku populaciju" in Journal of Medical Biochemistry, 33, no. 2 (2014):203-207, https://doi.org/10.2478/jomb-2013-0040 . .