Heart rate dynamics in doxorubicin-induced cardiomyopathy
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2015
Authors
Loncar-Turukalo, T.Vasić, Marko
Tasić, T.
Mijatović, G.
Glumac, S.
Bajić, Dragana
Japunzic-Zigon, N.
Article (Published version)
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Show full item recordAbstract
The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy.
Keywords:
MSC 92C30 physiology / Hilbert-Huang transform / heart rate variability / doxorubicin / cardiotoxicity / 37M10 time series analysisSource:
Physiological Measurement, 2015, 36, 4, 727-739Publisher:
- IOP Publishing Ltd, Bristol
Funding / projects:
- Hypothalamic and medullary functional genomics in stress-induced hypertension (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41013)
- Development of multivariable methods for analytical support to biomedical diagnostics (RS-MESTD-Technological Development (TD or TR)-32040)
DOI: 10.1088/0967-3334/36/4/727
ISSN: 0967-3334
PubMed: 25798626
WoS: 000354773300009
Scopus: 2-s2.0-84925686118
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Loncar-Turukalo, T. AU - Vasić, Marko AU - Tasić, T. AU - Mijatović, G. AU - Glumac, S. AU - Bajić, Dragana AU - Japunzic-Zigon, N. PY - 2015 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/813 AB - The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy. PB - IOP Publishing Ltd, Bristol T2 - Physiological Measurement T1 - Heart rate dynamics in doxorubicin-induced cardiomyopathy EP - 739 IS - 4 SP - 727 VL - 36 DO - 10.1088/0967-3334/36/4/727 ER -
@article{ author = "Loncar-Turukalo, T. and Vasić, Marko and Tasić, T. and Mijatović, G. and Glumac, S. and Bajić, Dragana and Japunzic-Zigon, N.", year = "2015", abstract = "The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy.", publisher = "IOP Publishing Ltd, Bristol", journal = "Physiological Measurement", title = "Heart rate dynamics in doxorubicin-induced cardiomyopathy", pages = "739-727", number = "4", volume = "36", doi = "10.1088/0967-3334/36/4/727" }
Loncar-Turukalo, T., Vasić, M., Tasić, T., Mijatović, G., Glumac, S., Bajić, D.,& Japunzic-Zigon, N.. (2015). Heart rate dynamics in doxorubicin-induced cardiomyopathy. in Physiological Measurement IOP Publishing Ltd, Bristol., 36(4), 727-739. https://doi.org/10.1088/0967-3334/36/4/727
Loncar-Turukalo T, Vasić M, Tasić T, Mijatović G, Glumac S, Bajić D, Japunzic-Zigon N. Heart rate dynamics in doxorubicin-induced cardiomyopathy. in Physiological Measurement. 2015;36(4):727-739. doi:10.1088/0967-3334/36/4/727 .
Loncar-Turukalo, T., Vasić, Marko, Tasić, T., Mijatović, G., Glumac, S., Bajić, Dragana, Japunzic-Zigon, N., "Heart rate dynamics in doxorubicin-induced cardiomyopathy" in Physiological Measurement, 36, no. 4 (2015):727-739, https://doi.org/10.1088/0967-3334/36/4/727 . .