Heart rate dynamics in doxorubicin-induced cardiomyopathy
Само за регистроване кориснике
2015
Аутори
Loncar-Turukalo, T.Vasić, Marko
Tasić, T.
Mijatović, G.
Glumac, S.
Bajić, Dragana
Japunzic-Zigon, N.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy.
Кључне речи:
MSC 92C30 physiology / Hilbert-Huang transform / heart rate variability / doxorubicin / cardiotoxicity / 37M10 time series analysisИзвор:
Physiological Measurement, 2015, 36, 4, 727-739Издавач:
- IOP Publishing Ltd, Bristol
Финансирање / пројекти:
- Функционална геномика хипоталамуса и медуле у хипертензији индукованој хроничним стресом (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41013)
- Развој мултиваријабилних метода за аналитичку подршку биомедицинској дијагностици (RS-MESTD-Technological Development (TD or TR)-32040)
DOI: 10.1088/0967-3334/36/4/727
ISSN: 0967-3334
PubMed: 25798626
WoS: 000354773300009
Scopus: 2-s2.0-84925686118
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Loncar-Turukalo, T. AU - Vasić, Marko AU - Tasić, T. AU - Mijatović, G. AU - Glumac, S. AU - Bajić, Dragana AU - Japunzic-Zigon, N. PY - 2015 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/813 AB - The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy. PB - IOP Publishing Ltd, Bristol T2 - Physiological Measurement T1 - Heart rate dynamics in doxorubicin-induced cardiomyopathy EP - 739 IS - 4 SP - 727 VL - 36 DO - 10.1088/0967-3334/36/4/727 ER -
@article{ author = "Loncar-Turukalo, T. and Vasić, Marko and Tasić, T. and Mijatović, G. and Glumac, S. and Bajić, Dragana and Japunzic-Zigon, N.", year = "2015", abstract = "The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy.", publisher = "IOP Publishing Ltd, Bristol", journal = "Physiological Measurement", title = "Heart rate dynamics in doxorubicin-induced cardiomyopathy", pages = "739-727", number = "4", volume = "36", doi = "10.1088/0967-3334/36/4/727" }
Loncar-Turukalo, T., Vasić, M., Tasić, T., Mijatović, G., Glumac, S., Bajić, D.,& Japunzic-Zigon, N.. (2015). Heart rate dynamics in doxorubicin-induced cardiomyopathy. in Physiological Measurement IOP Publishing Ltd, Bristol., 36(4), 727-739. https://doi.org/10.1088/0967-3334/36/4/727
Loncar-Turukalo T, Vasić M, Tasić T, Mijatović G, Glumac S, Bajić D, Japunzic-Zigon N. Heart rate dynamics in doxorubicin-induced cardiomyopathy. in Physiological Measurement. 2015;36(4):727-739. doi:10.1088/0967-3334/36/4/727 .
Loncar-Turukalo, T., Vasić, Marko, Tasić, T., Mijatović, G., Glumac, S., Bajić, Dragana, Japunzic-Zigon, N., "Heart rate dynamics in doxorubicin-induced cardiomyopathy" in Physiological Measurement, 36, no. 4 (2015):727-739, https://doi.org/10.1088/0967-3334/36/4/727 . .