The c20068t gene variant in the 3 ' end of the prothrombin gene and recurrent pregnancy loss: a pilot study
2015
Autori
Pruner, IvaĐorđević, Valentina
Gvozdenov, Maja
Tomić, Branko
Kovač, Mirjana
Miljić, Predrag
Radojković, Dragica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Recurrent pregnancy loss (RPL) is a health problem affecting up to 5% of women of reproductive age. Several thrombophilic risk factors might contribute to RPL. To investigate relationship between a novel C20068T gene variant in the 3' end of prothrombin gene and RPL, we tested 153 women with RPL and 111 controls for the presence of this gene variant. In patients, we have detected four heterozygous (2.61%) and no homozygous carriers. In controls, no carriers were detected. Our results indicate higher prevalence of C20068T gene variant in women with RPL but this difference was not statistically significant. However, in patients who suffered 5 or more RPL, frequency of C20068T gene variant was significantly increased compared to controls (12.5% vs. 0%, P = 0.02). This is the first study which points out a possible role of C20068T gene variant in etiology of RPL, but larger studies should be carried out to confirm our findings.
Ključne reči:
thrombophilia / synonymous gene variant / recurrent pregnancy loss / 3 ' end of the prothrombin geneIzvor:
Genetika-Belgrade, 2015, 47, 2, 469-476Izdavač:
- Društvo genetičara Srbije, Beograd
Finansiranje / projekti:
- Kompleksne bolesti kao model sistem za proučavanje modulacije fenotipa-strukturna i funkcionalna analiza molekularnih biomarkera (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.2298/GENSR1502469P
ISSN: 0534-0012
WoS: 000363055800009
Scopus: 2-s2.0-84945973115
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Pruner, Iva AU - Đorđević, Valentina AU - Gvozdenov, Maja AU - Tomić, Branko AU - Kovač, Mirjana AU - Miljić, Predrag AU - Radojković, Dragica PY - 2015 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/830 AB - Recurrent pregnancy loss (RPL) is a health problem affecting up to 5% of women of reproductive age. Several thrombophilic risk factors might contribute to RPL. To investigate relationship between a novel C20068T gene variant in the 3' end of prothrombin gene and RPL, we tested 153 women with RPL and 111 controls for the presence of this gene variant. In patients, we have detected four heterozygous (2.61%) and no homozygous carriers. In controls, no carriers were detected. Our results indicate higher prevalence of C20068T gene variant in women with RPL but this difference was not statistically significant. However, in patients who suffered 5 or more RPL, frequency of C20068T gene variant was significantly increased compared to controls (12.5% vs. 0%, P = 0.02). This is the first study which points out a possible role of C20068T gene variant in etiology of RPL, but larger studies should be carried out to confirm our findings. PB - Društvo genetičara Srbije, Beograd T2 - Genetika-Belgrade T1 - The c20068t gene variant in the 3 ' end of the prothrombin gene and recurrent pregnancy loss: a pilot study EP - 476 IS - 2 SP - 469 VL - 47 DO - 10.2298/GENSR1502469P ER -
@article{ author = "Pruner, Iva and Đorđević, Valentina and Gvozdenov, Maja and Tomić, Branko and Kovač, Mirjana and Miljić, Predrag and Radojković, Dragica", year = "2015", abstract = "Recurrent pregnancy loss (RPL) is a health problem affecting up to 5% of women of reproductive age. Several thrombophilic risk factors might contribute to RPL. To investigate relationship between a novel C20068T gene variant in the 3' end of prothrombin gene and RPL, we tested 153 women with RPL and 111 controls for the presence of this gene variant. In patients, we have detected four heterozygous (2.61%) and no homozygous carriers. In controls, no carriers were detected. Our results indicate higher prevalence of C20068T gene variant in women with RPL but this difference was not statistically significant. However, in patients who suffered 5 or more RPL, frequency of C20068T gene variant was significantly increased compared to controls (12.5% vs. 0%, P = 0.02). This is the first study which points out a possible role of C20068T gene variant in etiology of RPL, but larger studies should be carried out to confirm our findings.", publisher = "Društvo genetičara Srbije, Beograd", journal = "Genetika-Belgrade", title = "The c20068t gene variant in the 3 ' end of the prothrombin gene and recurrent pregnancy loss: a pilot study", pages = "476-469", number = "2", volume = "47", doi = "10.2298/GENSR1502469P" }
Pruner, I., Đorđević, V., Gvozdenov, M., Tomić, B., Kovač, M., Miljić, P.,& Radojković, D.. (2015). The c20068t gene variant in the 3 ' end of the prothrombin gene and recurrent pregnancy loss: a pilot study. in Genetika-Belgrade Društvo genetičara Srbije, Beograd., 47(2), 469-476. https://doi.org/10.2298/GENSR1502469P
Pruner I, Đorđević V, Gvozdenov M, Tomić B, Kovač M, Miljić P, Radojković D. The c20068t gene variant in the 3 ' end of the prothrombin gene and recurrent pregnancy loss: a pilot study. in Genetika-Belgrade. 2015;47(2):469-476. doi:10.2298/GENSR1502469P .
Pruner, Iva, Đorđević, Valentina, Gvozdenov, Maja, Tomić, Branko, Kovač, Mirjana, Miljić, Predrag, Radojković, Dragica, "The c20068t gene variant in the 3 ' end of the prothrombin gene and recurrent pregnancy loss: a pilot study" in Genetika-Belgrade, 47, no. 2 (2015):469-476, https://doi.org/10.2298/GENSR1502469P . .