Thrombin generation, D-dimer and protein S in uncomplicated pregnancy
Authorized Users Only
2015
Authors
Kovač, MirjanaLalić-Cosić, Sanja Z.
Dmitrović, Jelena M.
Đorđević, Valentina
Radojković, Dragica
Article (Published version)
Metadata
Show full item recordAbstract
Background: Gestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy. Methods: Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22-40) years; the subjects were followed in order to establish the gestational age dependent values for endogenous thrombin potential (ETP), D-dimer and protein S (activity and free). Results: During the first trimester 50% of studied women had ETP gt 100% (reference values out of pregnancy); in the second trimester an ETP over 100% was observed in all women; ETP values remained unchanged during the third trimester. In the first trimester, the median D-dimer concentration of 0.30 mg/L, in the second 0.91 mg/L and in the third of 1.45 mg/L were observed. During the first trimester 14/40 subjects had protein S activity below reference range ( lt 59%, out of pregnancy); the median value of 61.35; interquartile range (IQR) 20.38; in the second 21/37;... the median value of 53.1 (IQR 15.65); in the third trimester 28/37 had low level of protein S activity with the median value of 49.0 (IQR 18.8). Free protein S showed a slight decrease from the first trimester; it remained almost stable during the rest of pregnancy, with the equal number of pregnant women with reduced free protein S. Conclusions: Related to the gestational age, a significant increase of ETP and D-dimer, from the second trimester was observed; the decrease of protein S was observed already from the early pregnancy, with more pronounced variability of protein S activity.
Keywords:
protein S / pregnancy / global coagulation test / D-dimerSource:
Clinical Chemistry and Laboratory Medicine, 2015, 53, 12, 1975-1979Publisher:
- Walter De Gruyter Gmbh, Berlin
Funding / projects:
- Complex diseases as a model system for phenotype modulation- structural and functional analysis of molecular biomarkers (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.1515/cclm-2014-1030
ISSN: 1434-6621
PubMed: 25945720
WoS: 000364312800025
Scopus: 2-s2.0-84946824366
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kovač, Mirjana AU - Lalić-Cosić, Sanja Z. AU - Dmitrović, Jelena M. AU - Đorđević, Valentina AU - Radojković, Dragica PY - 2015 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/831 AB - Background: Gestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy. Methods: Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22-40) years; the subjects were followed in order to establish the gestational age dependent values for endogenous thrombin potential (ETP), D-dimer and protein S (activity and free). Results: During the first trimester 50% of studied women had ETP gt 100% (reference values out of pregnancy); in the second trimester an ETP over 100% was observed in all women; ETP values remained unchanged during the third trimester. In the first trimester, the median D-dimer concentration of 0.30 mg/L, in the second 0.91 mg/L and in the third of 1.45 mg/L were observed. During the first trimester 14/40 subjects had protein S activity below reference range ( lt 59%, out of pregnancy); the median value of 61.35; interquartile range (IQR) 20.38; in the second 21/37; the median value of 53.1 (IQR 15.65); in the third trimester 28/37 had low level of protein S activity with the median value of 49.0 (IQR 18.8). Free protein S showed a slight decrease from the first trimester; it remained almost stable during the rest of pregnancy, with the equal number of pregnant women with reduced free protein S. Conclusions: Related to the gestational age, a significant increase of ETP and D-dimer, from the second trimester was observed; the decrease of protein S was observed already from the early pregnancy, with more pronounced variability of protein S activity. PB - Walter De Gruyter Gmbh, Berlin T2 - Clinical Chemistry and Laboratory Medicine T1 - Thrombin generation, D-dimer and protein S in uncomplicated pregnancy EP - 1979 IS - 12 SP - 1975 VL - 53 DO - 10.1515/cclm-2014-1030 ER -
@article{ author = "Kovač, Mirjana and Lalić-Cosić, Sanja Z. and Dmitrović, Jelena M. and Đorđević, Valentina and Radojković, Dragica", year = "2015", abstract = "Background: Gestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy. Methods: Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22-40) years; the subjects were followed in order to establish the gestational age dependent values for endogenous thrombin potential (ETP), D-dimer and protein S (activity and free). Results: During the first trimester 50% of studied women had ETP gt 100% (reference values out of pregnancy); in the second trimester an ETP over 100% was observed in all women; ETP values remained unchanged during the third trimester. In the first trimester, the median D-dimer concentration of 0.30 mg/L, in the second 0.91 mg/L and in the third of 1.45 mg/L were observed. During the first trimester 14/40 subjects had protein S activity below reference range ( lt 59%, out of pregnancy); the median value of 61.35; interquartile range (IQR) 20.38; in the second 21/37; the median value of 53.1 (IQR 15.65); in the third trimester 28/37 had low level of protein S activity with the median value of 49.0 (IQR 18.8). Free protein S showed a slight decrease from the first trimester; it remained almost stable during the rest of pregnancy, with the equal number of pregnant women with reduced free protein S. Conclusions: Related to the gestational age, a significant increase of ETP and D-dimer, from the second trimester was observed; the decrease of protein S was observed already from the early pregnancy, with more pronounced variability of protein S activity.", publisher = "Walter De Gruyter Gmbh, Berlin", journal = "Clinical Chemistry and Laboratory Medicine", title = "Thrombin generation, D-dimer and protein S in uncomplicated pregnancy", pages = "1979-1975", number = "12", volume = "53", doi = "10.1515/cclm-2014-1030" }
Kovač, M., Lalić-Cosić, S. Z., Dmitrović, J. M., Đorđević, V.,& Radojković, D.. (2015). Thrombin generation, D-dimer and protein S in uncomplicated pregnancy. in Clinical Chemistry and Laboratory Medicine Walter De Gruyter Gmbh, Berlin., 53(12), 1975-1979. https://doi.org/10.1515/cclm-2014-1030
Kovač M, Lalić-Cosić SZ, Dmitrović JM, Đorđević V, Radojković D. Thrombin generation, D-dimer and protein S in uncomplicated pregnancy. in Clinical Chemistry and Laboratory Medicine. 2015;53(12):1975-1979. doi:10.1515/cclm-2014-1030 .
Kovač, Mirjana, Lalić-Cosić, Sanja Z., Dmitrović, Jelena M., Đorđević, Valentina, Radojković, Dragica, "Thrombin generation, D-dimer and protein S in uncomplicated pregnancy" in Clinical Chemistry and Laboratory Medicine, 53, no. 12 (2015):1975-1979, https://doi.org/10.1515/cclm-2014-1030 . .