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Thrombin generation, D-dimer and protein S in uncomplicated pregnancy
dc.creator | Kovač, Mirjana | |
dc.creator | Lalić-Cosić, Sanja Z. | |
dc.creator | Dmitrović, Jelena M. | |
dc.creator | Đorđević, Valentina | |
dc.creator | Radojković, Dragica | |
dc.date.accessioned | 2022-11-15T14:34:45Z | |
dc.date.available | 2022-11-15T14:34:45Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1434-6621 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/831 | |
dc.description.abstract | Background: Gestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy. Methods: Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22-40) years; the subjects were followed in order to establish the gestational age dependent values for endogenous thrombin potential (ETP), D-dimer and protein S (activity and free). Results: During the first trimester 50% of studied women had ETP gt 100% (reference values out of pregnancy); in the second trimester an ETP over 100% was observed in all women; ETP values remained unchanged during the third trimester. In the first trimester, the median D-dimer concentration of 0.30 mg/L, in the second 0.91 mg/L and in the third of 1.45 mg/L were observed. During the first trimester 14/40 subjects had protein S activity below reference range ( lt 59%, out of pregnancy); the median value of 61.35; interquartile range (IQR) 20.38; in the second 21/37; the median value of 53.1 (IQR 15.65); in the third trimester 28/37 had low level of protein S activity with the median value of 49.0 (IQR 18.8). Free protein S showed a slight decrease from the first trimester; it remained almost stable during the rest of pregnancy, with the equal number of pregnant women with reduced free protein S. Conclusions: Related to the gestational age, a significant increase of ETP and D-dimer, from the second trimester was observed; the decrease of protein S was observed already from the early pregnancy, with more pronounced variability of protein S activity. | en |
dc.publisher | Walter De Gruyter Gmbh, Berlin | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Chemistry and Laboratory Medicine | |
dc.subject | protein S | en |
dc.subject | pregnancy | en |
dc.subject | global coagulation test | en |
dc.subject | D-dimer | en |
dc.title | Thrombin generation, D-dimer and protein S in uncomplicated pregnancy | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1979 | |
dc.citation.issue | 12 | |
dc.citation.other | 53(12): 1975-1979 | |
dc.citation.rank | M21 | |
dc.citation.spage | 1975 | |
dc.citation.volume | 53 | |
dc.identifier.doi | 10.1515/cclm-2014-1030 | |
dc.identifier.pmid | 25945720 | |
dc.identifier.scopus | 2-s2.0-84946824366 | |
dc.identifier.wos | 000364312800025 | |
dc.type.version | publishedVersion |