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dc.creatorPetrović, Isidora
dc.creatorMilivojević, Milena
dc.creatorPopović, Jelena
dc.creatorSchwirtlich, Marija
dc.creatorRanković, Branislava
dc.creatorStevanović, Milena
dc.date.accessioned2022-11-15T14:35:10Z
dc.date.available2022-11-15T14:35:10Z
dc.date.issued2015
dc.identifier.issn1932-6203
dc.identifier.urihttps://imagine.imgge.bg.ac.rs/handle/123456789/836
dc.description.abstractAlthough there is much evidence showing functional relationship between Hedgehog pathway, in particular Sonic hedgehog, and SOX transcription factors during embryonic development, scarce data are available regarding their crosstalk in cancer cells. SOX18 protein plays an important role in promoting tumor angiogenesis and therefore emerged as a promising potential target in antiangiogenic tumor therapy. Recently it became evident that expression of SOX18 gene in tumors is not restricted to endothelium of accompanying blood and lymphatic vessels, but in tumor cells as well. In this paper we have identified human SOX18 gene as a novel target gene of Hedgehog signaling in cervical carcinoma cell lines. We have presented data showing that expression of SOX18 gene is regulated by GLI1 and GLI2 transcription factors, final effectors of Hedgehog signaling, and that modulation of Hedgehog signaling activity in considerably influence SOX18 expression. We consider important that Hedgehog pathway inhibitors reduced SOX18 expression, thus showing, for the first time, possibility for manipulationwith SOX18 gene expression. In addition, we analyzed the role of SOX18 in malignant potential of cervical carcinoma cell line, and showed that its overexpression has no influence on cells proliferation and viability, but substantially promotes migration and invasion of cells in vitro. Pro-migratory effect of SOX18 suggests its role in promoting malignant spreading, possibly in response to Hedgehog activation.en
dc.publisherPublic Library Science, San Francisco
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173051/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePLoS One
dc.titleSOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Linesen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue11
dc.citation.other10(11)
dc.citation.rankM21
dc.citation.volume10
dc.identifier.doi10.1371/journal.pone.0143591
dc.identifier.fulltexthttps://imagine.imgge.bg.ac.rs/bitstream/id/751/833.pdf
dc.identifier.pmid26588701
dc.identifier.scopus2-s2.0-84957545982
dc.identifier.wos000365251500065
dc.type.versionpublishedVersion


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