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dc.creatorKrivokuca, Marija
dc.creatorNiketić, Marjan
dc.creatorMilenković, Marina
dc.creatorGolić, Nataša
dc.creatorMasia, Carla
dc.creatorScaltrito, Maria Maddalena
dc.creatorSisto, Francesca
dc.creatorKundaković, Tatjana
dc.date.accessioned2022-11-15T14:37:17Z
dc.date.available2022-11-15T14:37:17Z
dc.date.issued2015
dc.identifier.issn1934-578X
dc.identifier.urihttps://imagine.imgge.bg.ac.rs/handle/123456789/863
dc.description.abstractThe present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Frohner), A. fissa Gunther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-beta-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 mu g/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 mu g/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 mu g/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 mu g/mL), while the second identified compound, quercetin-3-O-beta-D-glucoside, was also very active in concentration of 2-16 mu g/mL.en
dc.publisherNatural Product Incorporation
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//
dc.rightsrestrictedAccess
dc.sourceNatural Product Communications
dc.subjectQuercetin-3-O-beta-D-glucosideen
dc.subjectHelicobacter pylorien
dc.subjectEllagic aciden
dc.subjectAlchemilla sp.en
dc.titleAnti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)en
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1371
dc.citation.issue8
dc.citation.other10(8): 1369-1371
dc.citation.rankM23
dc.citation.spage1369
dc.citation.volume10
dc.identifier.doi10.1177/1934578x1501000814
dc.identifier.pmid26434119
dc.identifier.scopus2-s2.0-84945989702
dc.identifier.wos000359095800014
dc.type.versionpublishedVersion


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