The integrated stress response
Authorized Users Only
2016
Authors
Pakos-Zebrucka, KarolinaKoryga, Izabela
Mnich, Katarzyna
Ljujić, Mila
Samali, Afshin
Gorman, Adrienne M.
Article (Published version)
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Show full item recordAbstract
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by one of four members of the eIF2 alpha kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress.
Keywords:
integrated stress response / eukaryotic translation initiation factor 2 alpha / eIF2 alpha kinase / activating transcription factor 4Source:
EMBO Reports, 2016, 17, 10, 1374-1395Publisher:
- Wiley, Hoboken
Funding / projects:
- Health Research Board [HRA/2009/59, HRA-POR-2014-643]
- Belgian Science Policy Office Interuniversity Attraction Poles program [IAP 7/32]
- Breast Cancer Campaign grant [2010NovPR13]
- Science Foundation Ireland (SFI) grant cofunded under the European Regional Development Fund [13/RC/2073]
- Irish Research Council Scholarship [GOIPG/2014/508]
- Thomas Crawford Hayes Fund
- Irish Research Council Fellowship [GOIPD/2014/53]
- Breast Cancer Campaign [2010NovPR13] Funding Source: researchfish
DOI: 10.15252/embr.201642195
ISSN: 1469-221X
PubMed: 27629041
WoS: 000385710000004
Scopus: 2-s2.0-84989851681
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Pakos-Zebrucka, Karolina AU - Koryga, Izabela AU - Mnich, Katarzyna AU - Ljujić, Mila AU - Samali, Afshin AU - Gorman, Adrienne M. PY - 2016 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/927 AB - In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by one of four members of the eIF2 alpha kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress. PB - Wiley, Hoboken T2 - EMBO Reports T1 - The integrated stress response EP - 1395 IS - 10 SP - 1374 VL - 17 DO - 10.15252/embr.201642195 ER -
@article{ author = "Pakos-Zebrucka, Karolina and Koryga, Izabela and Mnich, Katarzyna and Ljujić, Mila and Samali, Afshin and Gorman, Adrienne M.", year = "2016", abstract = "In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by one of four members of the eIF2 alpha kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress.", publisher = "Wiley, Hoboken", journal = "EMBO Reports", title = "The integrated stress response", pages = "1395-1374", number = "10", volume = "17", doi = "10.15252/embr.201642195" }
Pakos-Zebrucka, K., Koryga, I., Mnich, K., Ljujić, M., Samali, A.,& Gorman, A. M.. (2016). The integrated stress response. in EMBO Reports Wiley, Hoboken., 17(10), 1374-1395. https://doi.org/10.15252/embr.201642195
Pakos-Zebrucka K, Koryga I, Mnich K, Ljujić M, Samali A, Gorman AM. The integrated stress response. in EMBO Reports. 2016;17(10):1374-1395. doi:10.15252/embr.201642195 .
Pakos-Zebrucka, Karolina, Koryga, Izabela, Mnich, Katarzyna, Ljujić, Mila, Samali, Afshin, Gorman, Adrienne M., "The integrated stress response" in EMBO Reports, 17, no. 10 (2016):1374-1395, https://doi.org/10.15252/embr.201642195 . .