Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases
Аутори
Vukotić, GoranMatić, Ivana
Begović, Jelena
Besu, Irina
Kojić, Milan
Đokić, Jelena
Juranić, Zorica
Strahinić, Ivana
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
The level of humoral immunoreactivity to total cows' milk proteins (TCMP) in sera of patients suffering from recurrent oral ulcerations, gastrointestinal diseases or haematological malignancies was investigated. TCMP were also hydrolysed with two different species of lactobacilli and dramatic changes in the levels of specific IgG and IgE were found with statistically significant decreases in the levels of specific antibodies in sera from all patient groups. The levels below cut-off values of IgG specific for TCMP hydrolysates were detected in sera from all patients, while values of IgE for hydrolysates obtained with Lactobacillus helveticus BGRA43 and Lactobacillus zeae LMG17315were below cut-off in 85% and 97% of patients, respectively. Competitive ELISA confirmed the specificity of antibodies for immunogenic TCMP epitopes, demonstrating that lactobacilli hydrolyse TCMP by degrading immunogenic epitopes, and could therefore be used in processing of milk proteins to obtain products sui...table for patients with altered immune response on TCMP.
Извор:
International Dairy Journal, 2016, 63, 1-7Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Изучавање гена и молекуларних механизама у основи пробиотичке активности бактерија млечне киселине изолованих са подручја западног Балкана (RS-MESTD-Basic Research (BR or ON)-173019)
Напомена:
- This is the peer reviewed version of the paper: Vukotic, G., Matic, I., Begovic, J., Besu, I., Kojic, M., Djokic, J., Juranic, Z., & Strahinic, I. (2016). Lactobacilli hydrolysis of cows’ milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases. International Dairy Journal, 63, 1–7. https://doi.org/10.1016/j.idairyj.2016.07.009
Повезане информације:
- Друга верзија
https://doi.org/10.1016/j.idairyj.2016.07.009
DOI: 10.1016/j.idairyj.2016.07.009
ISSN: 0958-6946
WoS: 000385606500001
Scopus: 2-s2.0-84983756965
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Vukotić, Goran AU - Matić, Ivana AU - Begović, Jelena AU - Besu, Irina AU - Kojić, Milan AU - Đokić, Jelena AU - Juranić, Zorica AU - Strahinić, Ivana PY - 2016 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/928 AB - The level of humoral immunoreactivity to total cows' milk proteins (TCMP) in sera of patients suffering from recurrent oral ulcerations, gastrointestinal diseases or haematological malignancies was investigated. TCMP were also hydrolysed with two different species of lactobacilli and dramatic changes in the levels of specific IgG and IgE were found with statistically significant decreases in the levels of specific antibodies in sera from all patient groups. The levels below cut-off values of IgG specific for TCMP hydrolysates were detected in sera from all patients, while values of IgE for hydrolysates obtained with Lactobacillus helveticus BGRA43 and Lactobacillus zeae LMG17315were below cut-off in 85% and 97% of patients, respectively. Competitive ELISA confirmed the specificity of antibodies for immunogenic TCMP epitopes, demonstrating that lactobacilli hydrolyse TCMP by degrading immunogenic epitopes, and could therefore be used in processing of milk proteins to obtain products suitable for patients with altered immune response on TCMP. PB - Elsevier Sci Ltd, Oxford T2 - International Dairy Journal T1 - Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases EP - 7 SP - 1 VL - 63 DO - 10.1016/j.idairyj.2016.07.009 ER -
@article{ author = "Vukotić, Goran and Matić, Ivana and Begović, Jelena and Besu, Irina and Kojić, Milan and Đokić, Jelena and Juranić, Zorica and Strahinić, Ivana", year = "2016", abstract = "The level of humoral immunoreactivity to total cows' milk proteins (TCMP) in sera of patients suffering from recurrent oral ulcerations, gastrointestinal diseases or haematological malignancies was investigated. TCMP were also hydrolysed with two different species of lactobacilli and dramatic changes in the levels of specific IgG and IgE were found with statistically significant decreases in the levels of specific antibodies in sera from all patient groups. The levels below cut-off values of IgG specific for TCMP hydrolysates were detected in sera from all patients, while values of IgE for hydrolysates obtained with Lactobacillus helveticus BGRA43 and Lactobacillus zeae LMG17315were below cut-off in 85% and 97% of patients, respectively. Competitive ELISA confirmed the specificity of antibodies for immunogenic TCMP epitopes, demonstrating that lactobacilli hydrolyse TCMP by degrading immunogenic epitopes, and could therefore be used in processing of milk proteins to obtain products suitable for patients with altered immune response on TCMP.", publisher = "Elsevier Sci Ltd, Oxford", journal = "International Dairy Journal", title = "Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases", pages = "7-1", volume = "63", doi = "10.1016/j.idairyj.2016.07.009" }
Vukotić, G., Matić, I., Begović, J., Besu, I., Kojić, M., Đokić, J., Juranić, Z.,& Strahinić, I.. (2016). Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases. in International Dairy Journal Elsevier Sci Ltd, Oxford., 63, 1-7. https://doi.org/10.1016/j.idairyj.2016.07.009
Vukotić G, Matić I, Begović J, Besu I, Kojić M, Đokić J, Juranić Z, Strahinić I. Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases. in International Dairy Journal. 2016;63:1-7. doi:10.1016/j.idairyj.2016.07.009 .
Vukotić, Goran, Matić, Ivana, Begović, Jelena, Besu, Irina, Kojić, Milan, Đokić, Jelena, Juranić, Zorica, Strahinić, Ivana, "Lactobacilli hydrolysis of cows' milk proteins abrogates their humoral immunoreactivity in patients with immune-mediated diseases" in International Dairy Journal, 63 (2016):1-7, https://doi.org/10.1016/j.idairyj.2016.07.009 . .