The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas
Authorized Users Only
2016
Authors
Jelicić, JelenaTodorovic-Balint, Milena
Perunicić-Jovanović, Maja
Boricić, Novica
Micev, Marjan
Stojsić, Jelena
Antić, Darko
Anđelić, Boško
Bila, Jelena
Balint, Bela
Pavlović, Sonja
Mihaljević, Biljana
Article (Published version)
Metadata
Show full item recordAbstract
Prognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in tumour tissue and expression of CD44s as adhesive molecule on tumour cells in diffuse large B cell lymphoma-DLBCL, primary central nervous system DLBCL-CNS DLBCL and follicular lymphoma-FL. A total of 202 histopathological samples (115 DLBCL/65 FL/22 CNS DLBCL) were evaluated. Overall response (complete/partial remission) was achieved in 81.3 % DLBCL patients, 81.8 % primary CNS DLBCL and 92.3 % FL. Absolute lymphocyte count-ALC/Absolute monocyte count-AMC gt 2.6 in DLBCL and ALC/AMC a parts per thousand yenaEuro parts per thousand 4.7 in FL were associated with better event-free survival (EFS) and overall survival (OS) (p lt 0.05). In DLBCL, MVD gt 42 blood vessels/0.36 mm(2) correl...ated with primary resistant disease (p lt 0.0001), poorer EFS and OS (p = 0.014). High CD44s expression in FL correlated with inferior EFS and OS (p lt 0.01). In DLBCL, multivariate Cox regression analysis showed that ALC/AMC was independent parameter that affected OS (HR 3.27, 95 % CI 1.51-7.09, p = 0.003) along with the NCCN-IPI (HR 1.39, 95 % CI 1.08-1.79, p = 0.01). Furthermore, in FL, ALC/AMC mostly influenced OS (HR 5.21, 95 % CI 1.17-23.21, p = 0.03), followed with the FLIPI (HR 3.98, 95 % CI 1.06-14.95, p = 0.041). In DLBCL and FL, ALC/AMC is simple and robust tool that is, with current prognostic scores, able to define long-term survival and identify patients with inferior outcome. The introduction of immunochemotherapy might altered the prognostic significance of microenvionmental biomarkers (MVD and CD44s).
Keywords:
Lymphoma / Lymphocyte-to-monocyte count / Angiogenesis / AdhesionSource:
Pathology & Oncology Research, 2016, 22, 3, 567-577Publisher:
- Springer, Dordrecht
Funding / projects:
- Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
DOI: 10.1007/s12253-015-0032-7
ISSN: 1219-4956
PubMed: 26750138
WoS: 000377427500017
Scopus: 2-s2.0-84959095549
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jelicić, Jelena AU - Todorovic-Balint, Milena AU - Perunicić-Jovanović, Maja AU - Boricić, Novica AU - Micev, Marjan AU - Stojsić, Jelena AU - Antić, Darko AU - Anđelić, Boško AU - Bila, Jelena AU - Balint, Bela AU - Pavlović, Sonja AU - Mihaljević, Biljana PY - 2016 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/944 AB - Prognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in tumour tissue and expression of CD44s as adhesive molecule on tumour cells in diffuse large B cell lymphoma-DLBCL, primary central nervous system DLBCL-CNS DLBCL and follicular lymphoma-FL. A total of 202 histopathological samples (115 DLBCL/65 FL/22 CNS DLBCL) were evaluated. Overall response (complete/partial remission) was achieved in 81.3 % DLBCL patients, 81.8 % primary CNS DLBCL and 92.3 % FL. Absolute lymphocyte count-ALC/Absolute monocyte count-AMC gt 2.6 in DLBCL and ALC/AMC a parts per thousand yenaEuro parts per thousand 4.7 in FL were associated with better event-free survival (EFS) and overall survival (OS) (p lt 0.05). In DLBCL, MVD gt 42 blood vessels/0.36 mm(2) correlated with primary resistant disease (p lt 0.0001), poorer EFS and OS (p = 0.014). High CD44s expression in FL correlated with inferior EFS and OS (p lt 0.01). In DLBCL, multivariate Cox regression analysis showed that ALC/AMC was independent parameter that affected OS (HR 3.27, 95 % CI 1.51-7.09, p = 0.003) along with the NCCN-IPI (HR 1.39, 95 % CI 1.08-1.79, p = 0.01). Furthermore, in FL, ALC/AMC mostly influenced OS (HR 5.21, 95 % CI 1.17-23.21, p = 0.03), followed with the FLIPI (HR 3.98, 95 % CI 1.06-14.95, p = 0.041). In DLBCL and FL, ALC/AMC is simple and robust tool that is, with current prognostic scores, able to define long-term survival and identify patients with inferior outcome. The introduction of immunochemotherapy might altered the prognostic significance of microenvionmental biomarkers (MVD and CD44s). PB - Springer, Dordrecht T2 - Pathology & Oncology Research T1 - The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas EP - 577 IS - 3 SP - 567 VL - 22 DO - 10.1007/s12253-015-0032-7 ER -
@article{ author = "Jelicić, Jelena and Todorovic-Balint, Milena and Perunicić-Jovanović, Maja and Boricić, Novica and Micev, Marjan and Stojsić, Jelena and Antić, Darko and Anđelić, Boško and Bila, Jelena and Balint, Bela and Pavlović, Sonja and Mihaljević, Biljana", year = "2016", abstract = "Prognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in tumour tissue and expression of CD44s as adhesive molecule on tumour cells in diffuse large B cell lymphoma-DLBCL, primary central nervous system DLBCL-CNS DLBCL and follicular lymphoma-FL. A total of 202 histopathological samples (115 DLBCL/65 FL/22 CNS DLBCL) were evaluated. Overall response (complete/partial remission) was achieved in 81.3 % DLBCL patients, 81.8 % primary CNS DLBCL and 92.3 % FL. Absolute lymphocyte count-ALC/Absolute monocyte count-AMC gt 2.6 in DLBCL and ALC/AMC a parts per thousand yenaEuro parts per thousand 4.7 in FL were associated with better event-free survival (EFS) and overall survival (OS) (p lt 0.05). In DLBCL, MVD gt 42 blood vessels/0.36 mm(2) correlated with primary resistant disease (p lt 0.0001), poorer EFS and OS (p = 0.014). High CD44s expression in FL correlated with inferior EFS and OS (p lt 0.01). In DLBCL, multivariate Cox regression analysis showed that ALC/AMC was independent parameter that affected OS (HR 3.27, 95 % CI 1.51-7.09, p = 0.003) along with the NCCN-IPI (HR 1.39, 95 % CI 1.08-1.79, p = 0.01). Furthermore, in FL, ALC/AMC mostly influenced OS (HR 5.21, 95 % CI 1.17-23.21, p = 0.03), followed with the FLIPI (HR 3.98, 95 % CI 1.06-14.95, p = 0.041). In DLBCL and FL, ALC/AMC is simple and robust tool that is, with current prognostic scores, able to define long-term survival and identify patients with inferior outcome. The introduction of immunochemotherapy might altered the prognostic significance of microenvionmental biomarkers (MVD and CD44s).", publisher = "Springer, Dordrecht", journal = "Pathology & Oncology Research", title = "The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas", pages = "577-567", number = "3", volume = "22", doi = "10.1007/s12253-015-0032-7" }
Jelicić, J., Todorovic-Balint, M., Perunicić-Jovanović, M., Boricić, N., Micev, M., Stojsić, J., Antić, D., Anđelić, B., Bila, J., Balint, B., Pavlović, S.,& Mihaljević, B.. (2016). The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas. in Pathology & Oncology Research Springer, Dordrecht., 22(3), 567-577. https://doi.org/10.1007/s12253-015-0032-7
Jelicić J, Todorovic-Balint M, Perunicić-Jovanović M, Boricić N, Micev M, Stojsić J, Antić D, Anđelić B, Bila J, Balint B, Pavlović S, Mihaljević B. The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas. in Pathology & Oncology Research. 2016;22(3):567-577. doi:10.1007/s12253-015-0032-7 .
Jelicić, Jelena, Todorovic-Balint, Milena, Perunicić-Jovanović, Maja, Boricić, Novica, Micev, Marjan, Stojsić, Jelena, Antić, Darko, Anđelić, Boško, Bila, Jelena, Balint, Bela, Pavlović, Sonja, Mihaljević, Biljana, "The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas" in Pathology & Oncology Research, 22, no. 3 (2016):567-577, https://doi.org/10.1007/s12253-015-0032-7 . .