Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat
dc.creator | Savković, S | |
dc.creator | Pavlović, Sonja | |
dc.creator | Mitrović, T | |
dc.creator | Joksimović, M | |
dc.creator | Marjanović, J | |
dc.creator | Glisin, V | |
dc.creator | Popović, Z | |
dc.date.accessioned | 2022-11-15T13:29:47Z | |
dc.date.available | 2022-11-15T13:29:47Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0014-4754 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/97 | |
dc.description.abstract | The splenomegaly and the appearance of a significant number of CFU-E (erythroid colony-forming units) and BFU-E(1) (erythroid burst-forming units) in the Belgrade laboratory rat (b/b) spleen prompted us to analyse further the molecular evidence for increased hematopoietic proliferation in the b/b spleen. Messenger RNAs (mRNAs) specific for globins, proteins for iron transport and deposition and the band 3 protein were used in rat erythropoietic tissues as markers for proliferation and erythroid differentiation. In the b/b spleen, all mRNAs analysed display an erythroid-specific pattern of expression. This analysis also revealed an enhanced level of mRNA for ferritin in the +/b spleen, whereas erythrocyte-specific mRNA production was normal. | en |
dc.publisher | Birkhauser Verlag AG | |
dc.rights | restrictedAccess | |
dc.source | Experientia | |
dc.subject | transferrin receptor | en |
dc.subject | ferritin | en |
dc.subject | beta-globin | en |
dc.subject | band 3 protein | en |
dc.subject | b/b rat | en |
dc.subject | alpha-globin | en |
dc.subject | +/b rat | en |
dc.title | Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 811 | |
dc.citation.issue | 8 | |
dc.citation.other | 52(8): 807-811 | |
dc.citation.spage | 807 | |
dc.citation.volume | 52 | |
dc.identifier.doi | 10.1007/BF01923994 | |
dc.identifier.pmid | 8774753 | |
dc.identifier.scopus | 2-s2.0-0029741692 | |
dc.identifier.wos | A1996VC25600011 | |
dc.type.version | publishedVersion |