Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation
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2016
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Stomatin-like protein 2 (SLP-2), a member of the stomatin protein family, has emerged as a potential molecular hallmark of tumor progression in several human malignancies. The aim of this study was to analyze SLP-2 expression pattern in benign and malignant thyroid tumors (n = 210) and to examine its relationship with clinicopathological parameters and BRAFV600E mutation in thyroid cancer. SLP-2 immunohistochemical expression was not detected in benign adenomas and was absent/weak in follicular and anaplastic carcinomas. High expression levels of SLP-2, found only in papillary thyroid carcinoma (PTC), particularly in the classical variant, were significantly associated with adverse clinicopathological parameters: lymph node metastasis (p = 0.002), extrathyroid invasion (p lt 0.001), pT status (p lt 0.001), and advanced tumor stage (p = 0.001). Additional genotyping of PTC cases for the BRAFV600E mutation revealed for the first time a close relation between SLP-2 overexpression and ...the presence of BRAF mutation (p = 0.02) with high positive rates of lymph node metastasis (70%) and extrathyroid invasion (80%) in these cases. The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated PTC and that SLP-2 evaluation could be clinically useful in identification of high-risk PTC patients.
Ključne reči:
tumor progression / thyroid / Stomatin-like protein 2 / papillary thyroid carcinoma / BRAFV600E mutationIzvor:
APMIS, 2016, 124, 4, 271-277Izdavač:
- Wiley-Blackwell, Hoboken
Finansiranje / projekti:
- Molekularna karakterizacija tumora štitaste žlezde: biološki i klinički aspekti (RS-MESTD-Basic Research (BR or ON)-173050)
DOI: 10.1111/apm.12505
ISSN: 0903-4641
PubMed: 26750533
WoS: 000372895700005
Scopus: 2-s2.0-84954100159
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Bartolome, Aleksandar AU - Bošković, Srđan AU - Paunović, Ivan AU - Bozić, Vesna AU - Cvejić, Dubravka PY - 2016 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/987 AB - Stomatin-like protein 2 (SLP-2), a member of the stomatin protein family, has emerged as a potential molecular hallmark of tumor progression in several human malignancies. The aim of this study was to analyze SLP-2 expression pattern in benign and malignant thyroid tumors (n = 210) and to examine its relationship with clinicopathological parameters and BRAFV600E mutation in thyroid cancer. SLP-2 immunohistochemical expression was not detected in benign adenomas and was absent/weak in follicular and anaplastic carcinomas. High expression levels of SLP-2, found only in papillary thyroid carcinoma (PTC), particularly in the classical variant, were significantly associated with adverse clinicopathological parameters: lymph node metastasis (p = 0.002), extrathyroid invasion (p lt 0.001), pT status (p lt 0.001), and advanced tumor stage (p = 0.001). Additional genotyping of PTC cases for the BRAFV600E mutation revealed for the first time a close relation between SLP-2 overexpression and the presence of BRAF mutation (p = 0.02) with high positive rates of lymph node metastasis (70%) and extrathyroid invasion (80%) in these cases. The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated PTC and that SLP-2 evaluation could be clinically useful in identification of high-risk PTC patients. PB - Wiley-Blackwell, Hoboken T2 - APMIS T1 - Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation EP - 277 IS - 4 SP - 271 VL - 124 DO - 10.1111/apm.12505 ER -
@article{ author = "Bartolome, Aleksandar and Bošković, Srđan and Paunović, Ivan and Bozić, Vesna and Cvejić, Dubravka", year = "2016", abstract = "Stomatin-like protein 2 (SLP-2), a member of the stomatin protein family, has emerged as a potential molecular hallmark of tumor progression in several human malignancies. The aim of this study was to analyze SLP-2 expression pattern in benign and malignant thyroid tumors (n = 210) and to examine its relationship with clinicopathological parameters and BRAFV600E mutation in thyroid cancer. SLP-2 immunohistochemical expression was not detected in benign adenomas and was absent/weak in follicular and anaplastic carcinomas. High expression levels of SLP-2, found only in papillary thyroid carcinoma (PTC), particularly in the classical variant, were significantly associated with adverse clinicopathological parameters: lymph node metastasis (p = 0.002), extrathyroid invasion (p lt 0.001), pT status (p lt 0.001), and advanced tumor stage (p = 0.001). Additional genotyping of PTC cases for the BRAFV600E mutation revealed for the first time a close relation between SLP-2 overexpression and the presence of BRAF mutation (p = 0.02) with high positive rates of lymph node metastasis (70%) and extrathyroid invasion (80%) in these cases. The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated PTC and that SLP-2 evaluation could be clinically useful in identification of high-risk PTC patients.", publisher = "Wiley-Blackwell, Hoboken", journal = "APMIS", title = "Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation", pages = "277-271", number = "4", volume = "124", doi = "10.1111/apm.12505" }
Bartolome, A., Bošković, S., Paunović, I., Bozić, V.,& Cvejić, D.. (2016). Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation. in APMIS Wiley-Blackwell, Hoboken., 124(4), 271-277. https://doi.org/10.1111/apm.12505
Bartolome A, Bošković S, Paunović I, Bozić V, Cvejić D. Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation. in APMIS. 2016;124(4):271-277. doi:10.1111/apm.12505 .
Bartolome, Aleksandar, Bošković, Srđan, Paunović, Ivan, Bozić, Vesna, Cvejić, Dubravka, "Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation" in APMIS, 124, no. 4 (2016):271-277, https://doi.org/10.1111/apm.12505 . .