From waste streams to biotherapeutics: making a connection using bacteria
Abstract
Microorganisms, our planet’s original inhabitants discovered with the invention of the
first microscope in the 17th century, have consistently facilitated our daily life. However,
our modern life generates enormous amounts of wastes, such as plastic, food, and
chemicals from the pharmaceutical industry. Bacterial natural products hold an
important position in this industry, as drug leads in synthetic chemistry and biology,
essential for the discovery of effective agents against a variety of human diseases. If the
existing waste is used as a nutrient source for microbial production of valuable
biomolecules, that concept is called “waste to value” or “upcycling”.
This concept was explored using bacterial biopigment prodigiosin (PG, Fig. 1) as part of
the BioECOLogics project. This proof of concept demonstrates how the bacteria Serratia
marcescens ATCC 27117 can use a waste stream from the food industry as a carbon
source to grow and produce its bioactive secondary metabolite P...G. The unique structure
of this molecule was changed through green chemical [1] and biopolymer formulation
[2] approaches, as well as metal complexation. Finally, these sustainable biotherapeutics
were validated in vitro (antimicrobial, anticancer) and in vivo (nematode Caenorhabditis
elegans and zebrafish Danio rerio).
Keywords:
bacteriaSource:
9th Conference of Young Chemists of Serbia, 2023, 6-6Publisher:
- Belgrade : Serbian Chemical Society and Serbian Young Chemists’ Club
Funding / projects:
- BioECOLogics - Value-added biologics through eco-sustainable routes (RS-ScienceFundRS-Ideje-7730810)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
Note:
- Book of Abstracts: 9th Conference of Young Chemists of Serbia Novi Sad, 4th November 2023
URI
https://www.chem.bg.ac.rs/pz/news1.py?q=3820&l=1https://imagine.imgge.bg.ac.rs/handle/123456789/2205
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Lazić, Jelena AU - Nikodinović-Runić, Jasmina PY - 2023 UR - https://www.chem.bg.ac.rs/pz/news1.py?q=3820&l=1 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2205 AB - Microorganisms, our planet’s original inhabitants discovered with the invention of the first microscope in the 17th century, have consistently facilitated our daily life. However, our modern life generates enormous amounts of wastes, such as plastic, food, and chemicals from the pharmaceutical industry. Bacterial natural products hold an important position in this industry, as drug leads in synthetic chemistry and biology, essential for the discovery of effective agents against a variety of human diseases. If the existing waste is used as a nutrient source for microbial production of valuable biomolecules, that concept is called “waste to value” or “upcycling”. This concept was explored using bacterial biopigment prodigiosin (PG, Fig. 1) as part of the BioECOLogics project. This proof of concept demonstrates how the bacteria Serratia marcescens ATCC 27117 can use a waste stream from the food industry as a carbon source to grow and produce its bioactive secondary metabolite PG. The unique structure of this molecule was changed through green chemical [1] and biopolymer formulation [2] approaches, as well as metal complexation. Finally, these sustainable biotherapeutics were validated in vitro (antimicrobial, anticancer) and in vivo (nematode Caenorhabditis elegans and zebrafish Danio rerio). PB - Belgrade : Serbian Chemical Society and Serbian Young Chemists’ Club C3 - 9th Conference of Young Chemists of Serbia T1 - From waste streams to biotherapeutics: making a connection using bacteria EP - 6 SP - 6 UR - https://hdl.handle.net/21.15107/rcub_imagine_2205 ER -
@conference{ author = "Lazić, Jelena and Nikodinović-Runić, Jasmina", year = "2023", abstract = "Microorganisms, our planet’s original inhabitants discovered with the invention of the first microscope in the 17th century, have consistently facilitated our daily life. However, our modern life generates enormous amounts of wastes, such as plastic, food, and chemicals from the pharmaceutical industry. Bacterial natural products hold an important position in this industry, as drug leads in synthetic chemistry and biology, essential for the discovery of effective agents against a variety of human diseases. If the existing waste is used as a nutrient source for microbial production of valuable biomolecules, that concept is called “waste to value” or “upcycling”. This concept was explored using bacterial biopigment prodigiosin (PG, Fig. 1) as part of the BioECOLogics project. This proof of concept demonstrates how the bacteria Serratia marcescens ATCC 27117 can use a waste stream from the food industry as a carbon source to grow and produce its bioactive secondary metabolite PG. The unique structure of this molecule was changed through green chemical [1] and biopolymer formulation [2] approaches, as well as metal complexation. Finally, these sustainable biotherapeutics were validated in vitro (antimicrobial, anticancer) and in vivo (nematode Caenorhabditis elegans and zebrafish Danio rerio).", publisher = "Belgrade : Serbian Chemical Society and Serbian Young Chemists’ Club", journal = "9th Conference of Young Chemists of Serbia", title = "From waste streams to biotherapeutics: making a connection using bacteria", pages = "6-6", url = "https://hdl.handle.net/21.15107/rcub_imagine_2205" }
Lazić, J.,& Nikodinović-Runić, J.. (2023). From waste streams to biotherapeutics: making a connection using bacteria. in 9th Conference of Young Chemists of Serbia Belgrade : Serbian Chemical Society and Serbian Young Chemists’ Club., 6-6. https://hdl.handle.net/21.15107/rcub_imagine_2205
Lazić J, Nikodinović-Runić J. From waste streams to biotherapeutics: making a connection using bacteria. in 9th Conference of Young Chemists of Serbia. 2023;:6-6. https://hdl.handle.net/21.15107/rcub_imagine_2205 .
Lazić, Jelena, Nikodinović-Runić, Jasmina, "From waste streams to biotherapeutics: making a connection using bacteria" in 9th Conference of Young Chemists of Serbia (2023):6-6, https://hdl.handle.net/21.15107/rcub_imagine_2205 .