TY  - JOUR
AU  - Jovanović, Ljubiša
AU  - Nikolić, Aleksandra
AU  - Dragičević, Sandra
AU  - Jović, Milena
AU  - Janković, Radmila
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2300
AB  - Aim To analyze the expression of autophagy markers p62,
LC3, and Beclin1 in ovarian cancer tissue and evaluate the
prognostic potential of these markers.
Methods The study enrolled 328 patients: 122 with epithelial ovarian carcinoma, 42 with atypical proliferative tumor, and 164 with benign epithelial ovarian tumor. The expression of p62, LC3, and Beclin1 was analyzed in central
and invasive tumor segments with immunohistochemistry
combined with tissue microarray. The expression levels of
the analyzed markers were correlated with relevant histopathology parameters.
Results The expression of all analyzed markers was most
remarkable in epithelial ovarian carcinoma. There was a
strong positive correlation between the expressions of p62
and LC3, while these two markers negatively correlated
with Beclin1. High-grade serous carcinoma had higher p62
and LC3 levels, and lower Beclin1 levels than other tumor
types. This expression profile was also observed in more
advanced tumor stages.
Conclusion Prominent p62 and LC3 expression in combination with weak Beclin1 expression in high-grade serous
carcinoma indicates potential for the application of autophagy inhibitors in patients with this tumor subtype.
PB  - Medicinska naklada (Croatia)
T2  - Croatian Medical Journal
T1  - Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer
EP  - 460
IS  - 5
SP  - 453
VL  - 63
DO  - 10.3325/cmj.2022.63.453
ER  - 

@article{
author = "Jovanović, Ljubiša and Nikolić, Aleksandra and Dragičević, Sandra and Jović, Milena and Janković, Radmila",
year = "2022",
abstract = "Aim To analyze the expression of autophagy markers p62,
LC3, and Beclin1 in ovarian cancer tissue and evaluate the
prognostic potential of these markers.
Methods The study enrolled 328 patients: 122 with epithelial ovarian carcinoma, 42 with atypical proliferative tumor, and 164 with benign epithelial ovarian tumor. The expression of p62, LC3, and Beclin1 was analyzed in central
and invasive tumor segments with immunohistochemistry
combined with tissue microarray. The expression levels of
the analyzed markers were correlated with relevant histopathology parameters.
Results The expression of all analyzed markers was most
remarkable in epithelial ovarian carcinoma. There was a
strong positive correlation between the expressions of p62
and LC3, while these two markers negatively correlated
with Beclin1. High-grade serous carcinoma had higher p62
and LC3 levels, and lower Beclin1 levels than other tumor
types. This expression profile was also observed in more
advanced tumor stages.
Conclusion Prominent p62 and LC3 expression in combination with weak Beclin1 expression in high-grade serous
carcinoma indicates potential for the application of autophagy inhibitors in patients with this tumor subtype.",
publisher = "Medicinska naklada (Croatia)",
journal = "Croatian Medical Journal",
title = "Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer",
pages = "460-453",
number = "5",
volume = "63",
doi = "10.3325/cmj.2022.63.453"
}

Jovanović, L., Nikolić, A., Dragičević, S., Jović, M.,& Janković, R.. (2022). Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer. in Croatian Medical Journal
Medicinska naklada (Croatia)., 63(5), 453-460.
https://doi.org/10.3325/cmj.2022.63.453

Jovanović L, Nikolić A, Dragičević S, Jović M, Janković R. Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer. in Croatian Medical Journal. 2022;63(5):453-460.
doi:10.3325/cmj.2022.63.453 .

Jovanović, Ljubiša, Nikolić, Aleksandra, Dragičević, Sandra, Jović, Milena, Janković, Radmila, "Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer" in Croatian Medical Journal, 63, no. 5 (2022):453-460,
https://doi.org/10.3325/cmj.2022.63.453 . .