TY  - CONF
AU  - Milivojević, Dušan
AU  - Cerović, Bogdan
AU  - Nikodinović-Runić, Jasmina
PY  - 2024
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2384
AB  - Caenorhabditis elegans is a free-living, non-parasitic,
fully transparent, bacteriovorous soil nematode.
Typically found in temperate climates, it
primarily inhabits organic-rich soil and decaying
fruit. Nearly six decades ago, Sydney Brenner
foresaw its potential as an ideal model system
for problems related developmental biology.
Over time, C. elegans has become instrumental
in investigations spanning aging, longevity,
host-pathogen interactions, developmental biology,
evolution, toxicology and ecotoxicology.
With more than 1200 research articles published
each year, today C. elegans is actively studied in
over a thousand laboratories worldwide. Despite
its small size, with adult hermaphrodites possessing
only 959 somatic cells and 302 neurons, C.
elegans exhibits a diverse array of specialized
tissues, including reproductive, digestive, endocrine,
neuromuscular, and sensory systems.
Moreover, this nematode shares a remarkable
number of conserved genes and signalling
pathways with humans, further enhancing its
relevance not only in biomedical research but
also in toxicology and ecotoxicology. In 1998, C.
elegans became the first multicellular organism
whose genome was completely sequenced. This
nematode is an excellent animal model for ecotoxicity
assessment because of its translucent
body, genetic manipulability, ease of cultivation,
rapid and short life cycle that is easily controlled
by temperature changes. The assessment endpoints
for the toxicology researches are various
and include number of live/dead worms, broad
size, number of eggs, embryo hatchability, locomotion
behaviours, germline apoptosis, oxidative
stress and gene expression in C. elegans. In
our laboratory, C. elegans is used in safety and ecotoxicological
evaluations of plastic degradation
products, artificial and natural materials, as well
as antimicrobial substances obtained through
the activity of specific microorganisms and their
chemical modification in the laboratory.
PB  - Serbian Society for Microbiology
C3  - XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health
T1  - FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS
EP  - 173
SP  - 173
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2384
ER  - 

@conference{
author = "Milivojević, Dušan and Cerović, Bogdan and Nikodinović-Runić, Jasmina",
year = "2024",
abstract = "Caenorhabditis elegans is a free-living, non-parasitic,
fully transparent, bacteriovorous soil nematode.
Typically found in temperate climates, it
primarily inhabits organic-rich soil and decaying
fruit. Nearly six decades ago, Sydney Brenner
foresaw its potential as an ideal model system
for problems related developmental biology.
Over time, C. elegans has become instrumental
in investigations spanning aging, longevity,
host-pathogen interactions, developmental biology,
evolution, toxicology and ecotoxicology.
With more than 1200 research articles published
each year, today C. elegans is actively studied in
over a thousand laboratories worldwide. Despite
its small size, with adult hermaphrodites possessing
only 959 somatic cells and 302 neurons, C.
elegans exhibits a diverse array of specialized
tissues, including reproductive, digestive, endocrine,
neuromuscular, and sensory systems.
Moreover, this nematode shares a remarkable
number of conserved genes and signalling
pathways with humans, further enhancing its
relevance not only in biomedical research but
also in toxicology and ecotoxicology. In 1998, C.
elegans became the first multicellular organism
whose genome was completely sequenced. This
nematode is an excellent animal model for ecotoxicity
assessment because of its translucent
body, genetic manipulability, ease of cultivation,
rapid and short life cycle that is easily controlled
by temperature changes. The assessment endpoints
for the toxicology researches are various
and include number of live/dead worms, broad
size, number of eggs, embryo hatchability, locomotion
behaviours, germline apoptosis, oxidative
stress and gene expression in C. elegans. In
our laboratory, C. elegans is used in safety and ecotoxicological
evaluations of plastic degradation
products, artificial and natural materials, as well
as antimicrobial substances obtained through
the activity of specific microorganisms and their
chemical modification in the laboratory.",
publisher = "Serbian Society for Microbiology",
journal = "XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health",
title = "FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS",
pages = "173-173",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2384"
}

Milivojević, D., Cerović, B.,& Nikodinović-Runić, J.. (2024). FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS. in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health
Serbian Society for Microbiology., 173-173.
https://hdl.handle.net/21.15107/rcub_imagine_2384

Milivojević D, Cerović B, Nikodinović-Runić J. FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS. in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health. 2024;:173-173.
https://hdl.handle.net/21.15107/rcub_imagine_2384 .

Milivojević, Dušan, Cerović, Bogdan, Nikodinović-Runić, Jasmina, "FROM SOIL TO LAB: EXPLORING TOXICOLOGY WITH CAENORHABDITIS ELEGANS" in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health (2024):173-173,
https://hdl.handle.net/21.15107/rcub_imagine_2384 .

TY  - DATA
AU  - Pantelić, Brana
AU  - Škaro Bogojević, Sanja
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lončarević, Branka
AU  - Beskoski, Vladimir
AU  - Maslak, Veselin
AU  - Guzik, Maciej
AU  - Makryniotis, Konstantinos
AU  - Taxeidis, George
AU  - Siaperas, Romanos
AU  - Topakas, Evangelos
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://www.mdpi.com/2073-4344/13/2/278
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1792
T2  - Catalysts
T1  - Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278
IS  - 2
SP  - 278
VL  - 13
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1792
ER  - 

@misc{
author = "Pantelić, Brana and Škaro Bogojević, Sanja and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lončarević, Branka and Beskoski, Vladimir and Maslak, Veselin and Guzik, Maciej and Makryniotis, Konstantinos and Taxeidis, George and Siaperas, Romanos and Topakas, Evangelos and Nikodinović-Runić, Jasmina",
year = "2023",
journal = "Catalysts",
title = "Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278",
number = "2",
pages = "278",
volume = "13",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1792"
}

Pantelić, B., Škaro Bogojević, S., Milivojević, D., Ilić-Tomić, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E.,& Nikodinović-Runić, J.. (2023). Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278. in Catalysts, 13(2), 278.
https://hdl.handle.net/21.15107/rcub_imagine_1792

Pantelić B, Škaro Bogojević S, Milivojević D, Ilić-Tomić T, Lončarević B, Beskoski V, Maslak V, Guzik M, Makryniotis K, Taxeidis G, Siaperas R, Topakas E, Nikodinović-Runić J. Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278. in Catalysts. 2023;13(2):278.
https://hdl.handle.net/21.15107/rcub_imagine_1792 .

Pantelić, Brana, Škaro Bogojević, Sanja, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lončarević, Branka, Beskoski, Vladimir, Maslak, Veselin, Guzik, Maciej, Makryniotis, Konstantinos, Taxeidis, George, Siaperas, Romanos, Topakas, Evangelos, Nikodinović-Runić, Jasmina, "Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278" in Catalysts, 13, no. 2 (2023):278,
https://hdl.handle.net/21.15107/rcub_imagine_1792 .

TY  - DATA
AU  - Marković, Zoran
AU  - Budimir, Milica
AU  - Danko, Martin
AU  - Milivojević, Dušan
AU  - Kubat, Pavel
AU  - Zmejkoski, Danica
AU  - Pavlović, Vladimir
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://www.beilstein-journals.org/bjnano/articles/14/17
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1894
AB  - Figure S1: (a) TEM micrograph of CQDs, (b) top view AFM image of CQDs, (c) height profile of CQDs, and (d) particle size distribution of CQDs.
T2  - Beilstein Journal of Nanotechnology
T2  - Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.
T1  - Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17
EP  - 174
IS  - 1
SP  - 165
VL  - 14
DO  - 10.3762/bjnano.14.17
ER  - 

@misc{
author = "Marković, Zoran and Budimir, Milica and Danko, Martin and Milivojević, Dušan and Kubat, Pavel and Zmejkoski, Danica and Pavlović, Vladimir and Mojsin, Marija and Stevanović, Milena and Todorović Marković, Biljana",
year = "2023",
abstract = "Figure S1: (a) TEM micrograph of CQDs, (b) top view AFM image of CQDs, (c) height profile of CQDs, and (d) particle size distribution of CQDs.",
journal = "Beilstein Journal of Nanotechnology, Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.",
title = "Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17",
pages = "174-165",
number = "1",
volume = "14",
doi = "10.3762/bjnano.14.17"
}

Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17. in Beilstein Journal of Nanotechnology, 14(1), 165-174.
https://doi.org/10.3762/bjnano.14.17

Marković Z, Budimir M, Danko M, Milivojević D, Kubat P, Zmejkoski D, Pavlović V, Mojsin M, Stevanović M, Todorović Marković B. Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17. in Beilstein Journal of Nanotechnology. 2023;14(1):165-174.
doi:10.3762/bjnano.14.17 .

Marković, Zoran, Budimir, Milica, Danko, Martin, Milivojević, Dušan, Kubat, Pavel, Zmejkoski, Danica, Pavlović, Vladimir, Mojsin, Marija, Stevanović, Milena, Todorović Marković, Biljana, "Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17" in Beilstein Journal of Nanotechnology, 14, no. 1 (2023):165-174,
https://doi.org/10.3762/bjnano.14.17 . .

TY  - CONF
AU  - Pantelić, Lena
AU  - Lazić, Jelena
AU  - Milivojević, Dušan
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1917
AB  - Industrialization, as well as improper waste management, has led to the accumulation
of a large amount of kitchen and food waste, making it omnipresent in every corner of the
world [1]. This waste stream is considered to be a significant portion of the total
biodegradable waste and a major contributor to greenhouse gases induced pollution [2].
According to the Food and Agriculture Organization official data, an astonishing 1.3 billion
tons of food is wasted annually, emphasizing the need to establish multiple biorefining
strategies in order to minimize waste pollution, whilst producing different valuable products
in a sustainable process [3].
PB  - Beograd : Srpsko hemijsko društvo
C3  - 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023
T1  - Food waste utilization in the production of pyocyanin, a valuable bacterial biopigment
EP  - 172
SP  - 171
VL  - 9
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1917
ER  - 

@conference{
author = "Pantelić, Lena and Lazić, Jelena and Milivojević, Dušan and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Industrialization, as well as improper waste management, has led to the accumulation
of a large amount of kitchen and food waste, making it omnipresent in every corner of the
world [1]. This waste stream is considered to be a significant portion of the total
biodegradable waste and a major contributor to greenhouse gases induced pollution [2].
According to the Food and Agriculture Organization official data, an astonishing 1.3 billion
tons of food is wasted annually, emphasizing the need to establish multiple biorefining
strategies in order to minimize waste pollution, whilst producing different valuable products
in a sustainable process [3].",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023",
title = "Food waste utilization in the production of pyocyanin, a valuable bacterial biopigment",
pages = "172-171",
volume = "9",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1917"
}

Pantelić, L., Lazić, J., Milivojević, D.,& Nikodinović-Runić, J.. (2023). Food waste utilization in the production of pyocyanin, a valuable bacterial biopigment. in 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023
Beograd : Srpsko hemijsko društvo., 9, 171-172.
https://hdl.handle.net/21.15107/rcub_imagine_1917

Pantelić L, Lazić J, Milivojević D, Nikodinović-Runić J. Food waste utilization in the production of pyocyanin, a valuable bacterial biopigment. in 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023. 2023;9:171-172.
https://hdl.handle.net/21.15107/rcub_imagine_1917 .

Pantelić, Lena, Lazić, Jelena, Milivojević, Dušan, Nikodinović-Runić, Jasmina, "Food waste utilization in the production of pyocyanin, a valuable bacterial biopigment" in 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023, 9 (2023):171-172,
https://hdl.handle.net/21.15107/rcub_imagine_1917 .

TY  - DATA
AU  - Snoch, Wojciech
AU  - Jarek, Ewelina
AU  - Milivojević, Dušan
AU  - Nikodinović-Runić, Jasmina
AU  - Guzik, Maciej
PY  - 2023
UR  - https://www.frontiersin.org/articles/10.3389/fbioe.2023.1112053
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1781
T2  - Frontiers in Bioengineering and Biotechnology
T1  - Supplementary information for the article: Snoch, W., Jarek, E., Milivojevic, D., Nikodinovic-Runic, J., & Guzik, M. (2023). Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact. Frontiers in Bioengineering and Biotechnology, 11. https://www.frontiersin.org/articles/10.3389/fbioe.2023.1112053
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1781
ER  - 

@misc{
author = "Snoch, Wojciech and Jarek, Ewelina and Milivojević, Dušan and Nikodinović-Runić, Jasmina and Guzik, Maciej",
year = "2023",
journal = "Frontiers in Bioengineering and Biotechnology",
title = "Supplementary information for the article: Snoch, W., Jarek, E., Milivojevic, D., Nikodinovic-Runic, J., & Guzik, M. (2023). Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact. Frontiers in Bioengineering and Biotechnology, 11. https://www.frontiersin.org/articles/10.3389/fbioe.2023.1112053",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1781"
}

Snoch, W., Jarek, E., Milivojević, D., Nikodinović-Runić, J.,& Guzik, M.. (2023). Supplementary information for the article: Snoch, W., Jarek, E., Milivojevic, D., Nikodinovic-Runic, J., & Guzik, M. (2023). Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact. Frontiers in Bioengineering and Biotechnology, 11. https://www.frontiersin.org/articles/10.3389/fbioe.2023.1112053. in Frontiers in Bioengineering and Biotechnology.
https://hdl.handle.net/21.15107/rcub_imagine_1781

Snoch W, Jarek E, Milivojević D, Nikodinović-Runić J, Guzik M. Supplementary information for the article: Snoch, W., Jarek, E., Milivojevic, D., Nikodinovic-Runic, J., & Guzik, M. (2023). Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact. Frontiers in Bioengineering and Biotechnology, 11. https://www.frontiersin.org/articles/10.3389/fbioe.2023.1112053. in Frontiers in Bioengineering and Biotechnology. 2023;.
https://hdl.handle.net/21.15107/rcub_imagine_1781 .

Snoch, Wojciech, Jarek, Ewelina, Milivojević, Dušan, Nikodinović-Runić, Jasmina, Guzik, Maciej, "Supplementary information for the article: Snoch, W., Jarek, E., Milivojevic, D., Nikodinovic-Runic, J., & Guzik, M. (2023). Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact. Frontiers in Bioengineering and Biotechnology, 11. https://www.frontiersin.org/articles/10.3389/fbioe.2023.1112053" in Frontiers in Bioengineering and Biotechnology (2023),
https://hdl.handle.net/21.15107/rcub_imagine_1781 .

TY  - JOUR
AU  - Marković, Zoran
AU  - Budimir, Milica
AU  - Danko, Martin
AU  - Milivojević, Dušan
AU  - Kubat, Pavel
AU  - Zmejkoski, Danica
AU  - Pavlović, Vladimir
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://www.beilstein-journals.org/bjnano/articles/14/17
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1889
AB  - Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their
unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon
quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared
carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the
results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these
dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark
cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as
probes for bioimaging.
T2  - Beilstein Journal of Nanotechnology
T2  - Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.
T1  - Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine
EP  - 174
IS  - 1
SP  - 165
VL  - 14
DO  - 10.3762/bjnano.14.17
ER  - 

@article{
author = "Marković, Zoran and Budimir, Milica and Danko, Martin and Milivojević, Dušan and Kubat, Pavel and Zmejkoski, Danica and Pavlović, Vladimir and Mojsin, Marija and Stevanović, Milena and Todorović Marković, Biljana",
year = "2023",
abstract = "Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their
unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon
quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared
carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the
results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these
dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark
cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as
probes for bioimaging.",
journal = "Beilstein Journal of Nanotechnology, Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.",
title = "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine",
pages = "174-165",
number = "1",
volume = "14",
doi = "10.3762/bjnano.14.17"
}

Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174.
https://doi.org/10.3762/bjnano.14.17

Marković Z, Budimir M, Danko M, Milivojević D, Kubat P, Zmejkoski D, Pavlović V, Mojsin M, Stevanović M, Todorović Marković B. Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology. 2023;14(1):165-174.
doi:10.3762/bjnano.14.17 .

Marković, Zoran, Budimir, Milica, Danko, Martin, Milivojević, Dušan, Kubat, Pavel, Zmejkoski, Danica, Pavlović, Vladimir, Mojsin, Marija, Stevanović, Milena, Todorović Marković, Biljana, "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine" in Beilstein Journal of Nanotechnology, 14, no. 1 (2023):165-174,
https://doi.org/10.3762/bjnano.14.17 . .

TY  - JOUR
AU  - Snoch, Wojciech
AU  - Jarek, Ewelina
AU  - Milivojević, Dušan
AU  - Nikodinović-Runić, Jasmina
AU  - Guzik, Maciej
PY  - 2023
UR  - https://www.frontiersin.org/articles/10.3389/fbioe.2023.1112053
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1780
AB  - Sugar fatty acids esters are popular compounds widely used in both the nutritional, cosmetic and pharmaceutical industries due to their amphiphilic structure and consequent ability to reduce the surface tension of solutions. Furthermore, an important aspect in the implementation of any additives and formulations is their environmental impact. The properties of the esters depend on the type of sugar used and the hydrophobic component. In this work, selected physicochemical properties of new sugar esters based on lactose, glucose and galactose and hydroxy acids derived from bacterial polyhydroxyalkanoates are shown for the first time. Values for critical aggregation concentration, surface activity and pH make it possible that these esters could compete with other commercially used esters of similar chemical structure. The investigated compounds showed moderate emulsion stabilization abilities presented on the example of water-oil systems containing squalene and body oil. Their potential environmental impact appears to be low, as the esters are not toxic to Caenorhabditis elegans even at concentrations much higher than the critical aggregation concentration.
T2  - Frontiers in Bioengineering and Biotechnology
T2  - Frontiers in Bioengineering and Biotechnology
T1  - Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact
VL  - 11
DO  - 10.3389/fbioe.2023.1112053
ER  - 

@article{
author = "Snoch, Wojciech and Jarek, Ewelina and Milivojević, Dušan and Nikodinović-Runić, Jasmina and Guzik, Maciej",
year = "2023",
abstract = "Sugar fatty acids esters are popular compounds widely used in both the nutritional, cosmetic and pharmaceutical industries due to their amphiphilic structure and consequent ability to reduce the surface tension of solutions. Furthermore, an important aspect in the implementation of any additives and formulations is their environmental impact. The properties of the esters depend on the type of sugar used and the hydrophobic component. In this work, selected physicochemical properties of new sugar esters based on lactose, glucose and galactose and hydroxy acids derived from bacterial polyhydroxyalkanoates are shown for the first time. Values for critical aggregation concentration, surface activity and pH make it possible that these esters could compete with other commercially used esters of similar chemical structure. The investigated compounds showed moderate emulsion stabilization abilities presented on the example of water-oil systems containing squalene and body oil. Their potential environmental impact appears to be low, as the esters are not toxic to Caenorhabditis elegans even at concentrations much higher than the critical aggregation concentration.",
journal = "Frontiers in Bioengineering and Biotechnology, Frontiers in Bioengineering and Biotechnology",
title = "Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact",
volume = "11",
doi = "10.3389/fbioe.2023.1112053"
}

Snoch, W., Jarek, E., Milivojević, D., Nikodinović-Runić, J.,& Guzik, M.. (2023). Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact. in Frontiers in Bioengineering and Biotechnology, 11.
https://doi.org/10.3389/fbioe.2023.1112053

Snoch W, Jarek E, Milivojević D, Nikodinović-Runić J, Guzik M. Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact. in Frontiers in Bioengineering and Biotechnology. 2023;11.
doi:10.3389/fbioe.2023.1112053 .

Snoch, Wojciech, Jarek, Ewelina, Milivojević, Dušan, Nikodinović-Runić, Jasmina, Guzik, Maciej, "Physicochemical studies of novel sugar fatty acid esters based on (R)-3-hydroxylated acids derived from bacterial polyhydroxyalkanoates and their potential environmental impact" in Frontiers in Bioengineering and Biotechnology, 11 (2023),
https://doi.org/10.3389/fbioe.2023.1112053 . .

TY  - JOUR
AU  - Vujinović, Slobodan
AU  - Graber, Hans Ulrich
AU  - Vićić, Ivan
AU  - Vejnović, Branislav
AU  - Stevanović, Oliver
AU  - Krnjaić, Dejan
AU  - Milivojević, Dušan
AU  - Katić, Vera
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0147957123001145
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2172
AB  - This study aimed to determine the prevalence of Staphylococcus aureus subclinical mastitis and to genotype the S. aureus isolates using the 16S–23S rRNA intergenic spacer (RS-PCR) method. In addition, the genes responsible for adherence, biofilm formation, host evasion, tissue necrosis, methicillin resistance, and enterotoxin production of S. aureus were investigated. The overall prevalence of S. aureus subclinical mastitis in lactating cows was 5.4% (95% confidence interval, CI=4.7–6.1%). An increased risk of S. aureus intramammary infection was observed on small family farms (odds ratio, OR=4.2, 95% CI=2.6–6.6, P < 0.001) and medium-sized farms (OR=3.5, 95% CI=2.2–5.7, P < 0.001). The RS-PCR analysis revealed 44 genotypes and genotype variants, of which 15 new genotypes and five new variants were detected within small and medium-sized farms. S. aureus isolates of new genotypes and genotype variants carried the clfA gene responsible for adherence at a lower frequency (64.8%) and enterotoxin-producing genes sea (20.4%), seb (14.8%) and sec (14.8%) at a higher frequency than the other known genotypes (P < 0.001), and were confirmed to carry the sej and sep genes. The spa gene was detected in all S. aureus isolates, whereas none harbored bap, ser, or tsst-1 genes. Methicillin-resistant strains of S. aureus (MRSA) were also detected, with a higher prevalence (19.2%) on large farms with more than 50 cows (P < 0.001). Using molecular techniques as diagnostic tools provides a better understanding of intramammary staphylococcal infections’ occurrence, spread, and eradication.
T2  - Comparative Immunology, Microbiology and Infectious Diseases
T2  - Comparative Immunology, Microbiology and Infectious DiseasesComparative Immunology, Microbiology and Infectious Diseases
T1  - Genotypes and virulence factors in Staphylococcus aureus isolated from dairy cows with subclinical mastitis in Serbia
SP  - 102056
VL  - 101
DO  - 10.1016/j.cimid.2023.102056
ER  - 

@article{
author = "Vujinović, Slobodan and Graber, Hans Ulrich and Vićić, Ivan and Vejnović, Branislav and Stevanović, Oliver and Krnjaić, Dejan and Milivojević, Dušan and Katić, Vera",
year = "2023",
abstract = "This study aimed to determine the prevalence of Staphylococcus aureus subclinical mastitis and to genotype the S. aureus isolates using the 16S–23S rRNA intergenic spacer (RS-PCR) method. In addition, the genes responsible for adherence, biofilm formation, host evasion, tissue necrosis, methicillin resistance, and enterotoxin production of S. aureus were investigated. The overall prevalence of S. aureus subclinical mastitis in lactating cows was 5.4% (95% confidence interval, CI=4.7–6.1%). An increased risk of S. aureus intramammary infection was observed on small family farms (odds ratio, OR=4.2, 95% CI=2.6–6.6, P < 0.001) and medium-sized farms (OR=3.5, 95% CI=2.2–5.7, P < 0.001). The RS-PCR analysis revealed 44 genotypes and genotype variants, of which 15 new genotypes and five new variants were detected within small and medium-sized farms. S. aureus isolates of new genotypes and genotype variants carried the clfA gene responsible for adherence at a lower frequency (64.8%) and enterotoxin-producing genes sea (20.4%), seb (14.8%) and sec (14.8%) at a higher frequency than the other known genotypes (P < 0.001), and were confirmed to carry the sej and sep genes. The spa gene was detected in all S. aureus isolates, whereas none harbored bap, ser, or tsst-1 genes. Methicillin-resistant strains of S. aureus (MRSA) were also detected, with a higher prevalence (19.2%) on large farms with more than 50 cows (P < 0.001). Using molecular techniques as diagnostic tools provides a better understanding of intramammary staphylococcal infections’ occurrence, spread, and eradication.",
journal = "Comparative Immunology, Microbiology and Infectious Diseases, Comparative Immunology, Microbiology and Infectious DiseasesComparative Immunology, Microbiology and Infectious Diseases",
title = "Genotypes and virulence factors in Staphylococcus aureus isolated from dairy cows with subclinical mastitis in Serbia",
pages = "102056",
volume = "101",
doi = "10.1016/j.cimid.2023.102056"
}

Vujinović, S., Graber, H. U., Vićić, I., Vejnović, B., Stevanović, O., Krnjaić, D., Milivojević, D.,& Katić, V.. (2023). Genotypes and virulence factors in Staphylococcus aureus isolated from dairy cows with subclinical mastitis in Serbia. in Comparative Immunology, Microbiology and Infectious Diseases, 101, 102056.
https://doi.org/10.1016/j.cimid.2023.102056

Vujinović S, Graber HU, Vićić I, Vejnović B, Stevanović O, Krnjaić D, Milivojević D, Katić V. Genotypes and virulence factors in Staphylococcus aureus isolated from dairy cows with subclinical mastitis in Serbia. in Comparative Immunology, Microbiology and Infectious Diseases. 2023;101:102056.
doi:10.1016/j.cimid.2023.102056 .

Vujinović, Slobodan, Graber, Hans Ulrich, Vićić, Ivan, Vejnović, Branislav, Stevanović, Oliver, Krnjaić, Dejan, Milivojević, Dušan, Katić, Vera, "Genotypes and virulence factors in Staphylococcus aureus isolated from dairy cows with subclinical mastitis in Serbia" in Comparative Immunology, Microbiology and Infectious Diseases, 101 (2023):102056,
https://doi.org/10.1016/j.cimid.2023.102056 . .

TY  - JOUR
AU  - Pantelić, Brana
AU  - Škaro Bogojević, Sanja
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lončarević, Branka
AU  - Beskoski, Vladimir
AU  - Maslak, Veselin
AU  - Guzik, Maciej
AU  - Makryniotis, Konstantinos
AU  - Taxeidis, George
AU  - Siaperas, Romanos
AU  - Topakas, Evangelos
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://www.mdpi.com/2073-4344/13/2/278
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1790
AB  - Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.
T2  - Catalysts
T2  - Catalysts
T1  - Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts
IS  - 2
SP  - 278
VL  - 13
DO  - 10.3390/catal13020278
ER  - 

@article{
author = "Pantelić, Brana and Škaro Bogojević, Sanja and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lončarević, Branka and Beskoski, Vladimir and Maslak, Veselin and Guzik, Maciej and Makryniotis, Konstantinos and Taxeidis, George and Siaperas, Romanos and Topakas, Evangelos and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.",
journal = "Catalysts, Catalysts",
title = "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts",
number = "2",
pages = "278",
volume = "13",
doi = "10.3390/catal13020278"
}

Pantelić, B., Škaro Bogojević, S., Milivojević, D., Ilić-Tomić, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E.,& Nikodinović-Runić, J.. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts, 13(2), 278.
https://doi.org/10.3390/catal13020278

Pantelić B, Škaro Bogojević S, Milivojević D, Ilić-Tomić T, Lončarević B, Beskoski V, Maslak V, Guzik M, Makryniotis K, Taxeidis G, Siaperas R, Topakas E, Nikodinović-Runić J. Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts. 2023;13(2):278.
doi:10.3390/catal13020278 .

Pantelić, Brana, Škaro Bogojević, Sanja, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lončarević, Branka, Beskoski, Vladimir, Maslak, Veselin, Guzik, Maciej, Makryniotis, Konstantinos, Taxeidis, George, Siaperas, Romanos, Topakas, Evangelos, Nikodinović-Runić, Jasmina, "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts" in Catalysts, 13, no. 2 (2023):278,
https://doi.org/10.3390/catal13020278 . .

TY  - JOUR
AU  - Pantelić, Lena
AU  - Bogojević Škaro, Sanja
AU  - Vojnović, Sandra
AU  - Oliveira, Rui
AU  - Lazić, Jelena
AU  - Ilić-Tomić, Tatjana
AU  - Milivojević, Dušan
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0141022923001308
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2078
AB  - Phenazines, including pyocyanin (PYO) and 1-hydroxyphenazine (1-HP) are extracellular secondary metabolites and multifunctional pigments of Pseudomonas aeruginosa responsible for its blue-green color. These versatile molecules are electrochemically active, involved in significant biological activities giving fitness to the host, but also recognized as antimicrobial and anticancer agents. Their wider application is still limited partly due to the cost of carbon substrate for production, which can be solved by the utilization of carbon from food waste within the biorefinery concept. In this study, a variety of food waste streams (banana peel, potato peel, potato washing, stale bread, yoghurt, processed meat, boiled eggs and mixed canteen waste) was used as sole nutrient source in submerged cultures of P. aeruginosa BK25H. Stale bread was identified as the most suitable substrate to support phenazine biopigments production and bacterial growth. This was further increased in 5-liter fermenter when on average 5.2mgL-1 of PYO and 4.4mgL-1 of 1-HP were purified after 24h batch cultivations from the fermentation medium consisting of homogenized stale bread in tap water. Purified biopigments showed moderate antimicrobial activity, and showed different toxicity profiles, with PYO not being toxic against Caenorhabditis elegans, a free-living soil nematode up to 300µgmL-1 and 1-HP showing lethal effects at 75µgmL-1. Therefore, stale bread waste stream with minimal pretreatment should be considered as suitable biorefinery feedstock, as it can support the production of valuable biopigments such as phenazines.
T2  - Enzyme and Microbial Technology
T1  - Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine
SP  - 110322
VL  - 171
DO  - 10.1016/j.enzmictec.2023.110322
ER  - 

@article{
author = "Pantelić, Lena and Bogojević Škaro, Sanja and Vojnović, Sandra and Oliveira, Rui and Lazić, Jelena and Ilić-Tomić, Tatjana and Milivojević, Dušan and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Phenazines, including pyocyanin (PYO) and 1-hydroxyphenazine (1-HP) are extracellular secondary metabolites and multifunctional pigments of Pseudomonas aeruginosa responsible for its blue-green color. These versatile molecules are electrochemically active, involved in significant biological activities giving fitness to the host, but also recognized as antimicrobial and anticancer agents. Their wider application is still limited partly due to the cost of carbon substrate for production, which can be solved by the utilization of carbon from food waste within the biorefinery concept. In this study, a variety of food waste streams (banana peel, potato peel, potato washing, stale bread, yoghurt, processed meat, boiled eggs and mixed canteen waste) was used as sole nutrient source in submerged cultures of P. aeruginosa BK25H. Stale bread was identified as the most suitable substrate to support phenazine biopigments production and bacterial growth. This was further increased in 5-liter fermenter when on average 5.2mgL-1 of PYO and 4.4mgL-1 of 1-HP were purified after 24h batch cultivations from the fermentation medium consisting of homogenized stale bread in tap water. Purified biopigments showed moderate antimicrobial activity, and showed different toxicity profiles, with PYO not being toxic against Caenorhabditis elegans, a free-living soil nematode up to 300µgmL-1 and 1-HP showing lethal effects at 75µgmL-1. Therefore, stale bread waste stream with minimal pretreatment should be considered as suitable biorefinery feedstock, as it can support the production of valuable biopigments such as phenazines.",
journal = "Enzyme and Microbial Technology",
title = "Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine",
pages = "110322",
volume = "171",
doi = "10.1016/j.enzmictec.2023.110322"
}

Pantelić, L., Bogojević Škaro, S., Vojnović, S., Oliveira, R., Lazić, J., Ilić-Tomić, T., Milivojević, D.,& Nikodinović-Runić, J.. (2023). Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine. in Enzyme and Microbial Technology, 171, 110322.
https://doi.org/10.1016/j.enzmictec.2023.110322

Pantelić L, Bogojević Škaro S, Vojnović S, Oliveira R, Lazić J, Ilić-Tomić T, Milivojević D, Nikodinović-Runić J. Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine. in Enzyme and Microbial Technology. 2023;171:110322.
doi:10.1016/j.enzmictec.2023.110322 .

Pantelić, Lena, Bogojević Škaro, Sanja, Vojnović, Sandra, Oliveira, Rui, Lazić, Jelena, Ilić-Tomić, Tatjana, Milivojević, Dušan, Nikodinović-Runić, Jasmina, "Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine" in Enzyme and Microbial Technology, 171 (2023):110322,
https://doi.org/10.1016/j.enzmictec.2023.110322 . .

TY  - DATA
AU  - Marković, Zoran
AU  - Mišović, Aleksandra
AU  - Zmejkoski, Danica
AU  - Zdravković, Nemanja
AU  - Kovač, Janez
AU  - Bajuk-Bogdanović, Danica
AU  - Milivojević, Dušan
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Pavlović, Vladimir
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1895
AB  - Figure S1. TEM micrographs a) CQD_25, b) CQD_50,c) CQD_100, and d) CQD_200 samples, respectively.
T2  - Antibiotics
T1  - Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919
IS  - 5
SP  - 919
VL  - 12
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1895
ER  - 

@misc{
author = "Marković, Zoran and Mišović, Aleksandra and Zmejkoski, Danica and Zdravković, Nemanja and Kovač, Janez and Bajuk-Bogdanović, Danica and Milivojević, Dušan and Mojsin, Marija and Stevanović, Milena and Pavlović, Vladimir and Todorović Marković, Biljana",
year = "2023",
abstract = "Figure S1. TEM micrographs a) CQD_25, b) CQD_50,c) CQD_100, and d) CQD_200 samples, respectively.",
journal = "Antibiotics",
title = "Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919",
number = "5",
pages = "919",
volume = "12",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1895"
}

Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919. in Antibiotics, 12(5), 919.
https://hdl.handle.net/21.15107/rcub_imagine_1895

Marković Z, Mišović A, Zmejkoski D, Zdravković N, Kovač J, Bajuk-Bogdanović D, Milivojević D, Mojsin M, Stevanović M, Pavlović V, Todorović Marković B. Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919. in Antibiotics. 2023;12(5):919.
https://hdl.handle.net/21.15107/rcub_imagine_1895 .

Marković, Zoran, Mišović, Aleksandra, Zmejkoski, Danica, Zdravković, Nemanja, Kovač, Janez, Bajuk-Bogdanović, Danica, Milivojević, Dušan, Mojsin, Marija, Stevanović, Milena, Pavlović, Vladimir, Todorović Marković, Biljana, "Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919" in Antibiotics, 12, no. 5 (2023):919,
https://hdl.handle.net/21.15107/rcub_imagine_1895 .

TY  - JOUR
AU  - Milzarek, Tobias M.
AU  - Stevanović, Milena
AU  - Milivojević, Dušan
AU  - Vojnović, Sandra
AU  - Iliasov, Denis
AU  - Wolf, Diana
AU  - Mascher, Thorsten
AU  - Nikodinović-Runić, Jasmina
AU  - Gulder, Tobias A. M.
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2077
AB  - The ambigols are cyanobacterial natural products characterized by three polychlorinated aromatic building blocks connected by biaryl and biaryl ether bridges. All ambigols known to date possess promising biological activities. Most significantly, ambigol A was reported to have antibacterial activity against Gram-positive bacteria, such as Bacillus megaterium and B. subtilis. We established a diverse compound library for in-depth biological evaluation building on our previous bio- and total synthetic research on this natural product family. To explore the antimicrobial potential in detail and to determine initial structure–activity relationships of this product class, a large set of dimeric and trimeric compounds were screened against selected bacterial and Candida target strains. Our results reveal exceptional antibiotic activity of the ambigols, especially against challenging clinical isolates.
T2  - ACS Infectious Diseases
T2  - ACS Infectious DiseasesACS Infect. Dis.
T1  - Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs
DO  - 10.1021/acsinfecdis.3c00232
ER  - 

@article{
author = "Milzarek, Tobias M. and Stevanović, Milena and Milivojević, Dušan and Vojnović, Sandra and Iliasov, Denis and Wolf, Diana and Mascher, Thorsten and Nikodinović-Runić, Jasmina and Gulder, Tobias A. M.",
year = "2023",
abstract = "The ambigols are cyanobacterial natural products characterized by three polychlorinated aromatic building blocks connected by biaryl and biaryl ether bridges. All ambigols known to date possess promising biological activities. Most significantly, ambigol A was reported to have antibacterial activity against Gram-positive bacteria, such as Bacillus megaterium and B. subtilis. We established a diverse compound library for in-depth biological evaluation building on our previous bio- and total synthetic research on this natural product family. To explore the antimicrobial potential in detail and to determine initial structure–activity relationships of this product class, a large set of dimeric and trimeric compounds were screened against selected bacterial and Candida target strains. Our results reveal exceptional antibiotic activity of the ambigols, especially against challenging clinical isolates.",
journal = "ACS Infectious Diseases, ACS Infectious DiseasesACS Infect. Dis.",
title = "Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs",
doi = "10.1021/acsinfecdis.3c00232"
}

Milzarek, T. M., Stevanović, M., Milivojević, D., Vojnović, S., Iliasov, D., Wolf, D., Mascher, T., Nikodinović-Runić, J.,& Gulder, T. A. M.. (2023). Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs. in ACS Infectious Diseases.
https://doi.org/10.1021/acsinfecdis.3c00232

Milzarek TM, Stevanović M, Milivojević D, Vojnović S, Iliasov D, Wolf D, Mascher T, Nikodinović-Runić J, Gulder TAM. Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs. in ACS Infectious Diseases. 2023;.
doi:10.1021/acsinfecdis.3c00232 .

Milzarek, Tobias M., Stevanović, Milena, Milivojević, Dušan, Vojnović, Sandra, Iliasov, Denis, Wolf, Diana, Mascher, Thorsten, Nikodinović-Runić, Jasmina, Gulder, Tobias A. M., "Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs" in ACS Infectious Diseases (2023),
https://doi.org/10.1021/acsinfecdis.3c00232 . .

TY  - JOUR
AU  - Duarah, Rituparna
AU  - Aleksić, Ivana
AU  - Milivojević, Dušan
AU  - Rameshkumar, Saranya
AU  - Nikodinović-Runić, Jasmina
AU  - Padamati, Ramesh Babu
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2079
AB  - Novel bio-based, biodegradable packaging material was developed with multi-functional properties of good mechanical strength, potent biocompatibility, and antifungal attributes, predominantly against fungi vital in food spoilage. Biodegradable polymer composites were prepared with a natural antifungal agent, nystatin (Nyst), by melt processing technique for the first time. Initially, Polycaprolactone (PCL) was melt-mixed with various percentages of nystatin to produce nystatin-encapsulated PCL composites (PCL/Nyst). The as-prepared PCL/Nyst composites were melt-mixed with polylactic acid (PLA) to produce nystatin PLA/PCL blend composites. Subsequently, the prepared composites were compression molded in the form of films (1 mm) for further characterization. The composite's structural properties were evaluated by SEM, FTIR, mechanical and thermal studies. In addition, the composites were tested in vitro against a panel of pathogenic fungi and for antibiofilm attributes, specifically against three Candida species (C. albicans ATCC10231, C. parapsilosis ATCC22019, and C. glabrata ATCC2001), and foodborne Penicillium sp. All the composites containing 2 to 20 wt% nystatin displayed good activity and sustained nystatin release for up to 4 days. Thus, the overall study demonstrates the potential application of natural antifungal agents in biodegradable polymers to produce novel composite films for antimicrobial packaging without inducing any toxicity, judged from the toxicity assay using nematode Caenorhabditis elegans.
PB  - Wiley
T2  - Journal of Applied Polymer Science
T1  - Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach
SP  - e54663
DO  - 10.1002/app.54663
ER  - 

@article{
author = "Duarah, Rituparna and Aleksić, Ivana and Milivojević, Dušan and Rameshkumar, Saranya and Nikodinović-Runić, Jasmina and Padamati, Ramesh Babu",
year = "2023",
abstract = "Novel bio-based, biodegradable packaging material was developed with multi-functional properties of good mechanical strength, potent biocompatibility, and antifungal attributes, predominantly against fungi vital in food spoilage. Biodegradable polymer composites were prepared with a natural antifungal agent, nystatin (Nyst), by melt processing technique for the first time. Initially, Polycaprolactone (PCL) was melt-mixed with various percentages of nystatin to produce nystatin-encapsulated PCL composites (PCL/Nyst). The as-prepared PCL/Nyst composites were melt-mixed with polylactic acid (PLA) to produce nystatin PLA/PCL blend composites. Subsequently, the prepared composites were compression molded in the form of films (1 mm) for further characterization. The composite's structural properties were evaluated by SEM, FTIR, mechanical and thermal studies. In addition, the composites were tested in vitro against a panel of pathogenic fungi and for antibiofilm attributes, specifically against three Candida species (C. albicans ATCC10231, C. parapsilosis ATCC22019, and C. glabrata ATCC2001), and foodborne Penicillium sp. All the composites containing 2 to 20 wt% nystatin displayed good activity and sustained nystatin release for up to 4 days. Thus, the overall study demonstrates the potential application of natural antifungal agents in biodegradable polymers to produce novel composite films for antimicrobial packaging without inducing any toxicity, judged from the toxicity assay using nematode Caenorhabditis elegans.",
publisher = "Wiley",
journal = "Journal of Applied Polymer Science",
title = "Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach",
pages = "e54663",
doi = "10.1002/app.54663"
}

Duarah, R., Aleksić, I., Milivojević, D., Rameshkumar, S., Nikodinović-Runić, J.,& Padamati, R. B.. (2023). Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach. in Journal of Applied Polymer Science
Wiley., e54663.
https://doi.org/10.1002/app.54663

Duarah R, Aleksić I, Milivojević D, Rameshkumar S, Nikodinović-Runić J, Padamati RB. Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach. in Journal of Applied Polymer Science. 2023;:e54663.
doi:10.1002/app.54663 .

Duarah, Rituparna, Aleksić, Ivana, Milivojević, Dušan, Rameshkumar, Saranya, Nikodinović-Runić, Jasmina, Padamati, Ramesh Babu, "Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach" in Journal of Applied Polymer Science (2023):e54663,
https://doi.org/10.1002/app.54663 . .

TY  - JOUR
AU  - Vuković, Jovana S.
AU  - Filipović, Vuk V.
AU  - Babić Radić, Marija M.
AU  - Vukomanović, Marija
AU  - Milivojević, Dušan
AU  - Ilic-Tomic, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida Lj
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1669
AB  - Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.
T2  - Polymers
T2  - Polymers
T1  - In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds
IS  - 20
SP  - 4459
VL  - 14
DO  - 10.3390/polym14204459
ER  - 

@article{
author = "Vuković, Jovana S. and Filipović, Vuk V. and Babić Radić, Marija M. and Vukomanović, Marija and Milivojević, Dušan and Ilic-Tomic, Tatjana and Nikodinović-Runić, Jasmina and Tomić, Simonida Lj",
year = "2022",
abstract = "Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.",
journal = "Polymers, Polymers",
title = "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds",
number = "20",
pages = "4459",
volume = "14",
doi = "10.3390/polym14204459"
}

Vuković, J. S., Filipović, V. V., Babić Radić, M. M., Vukomanović, M., Milivojević, D., Ilic-Tomic, T., Nikodinović-Runić, J.,& Tomić, S. L.. (2022). In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers, 14(20), 4459.
https://doi.org/10.3390/polym14204459

Vuković JS, Filipović VV, Babić Radić MM, Vukomanović M, Milivojević D, Ilic-Tomic T, Nikodinović-Runić J, Tomić SL. In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers. 2022;14(20):4459.
doi:10.3390/polym14204459 .

Vuković, Jovana S., Filipović, Vuk V., Babić Radić, Marija M., Vukomanović, Marija, Milivojević, Dušan, Ilic-Tomic, Tatjana, Nikodinović-Runić, Jasmina, Tomić, Simonida Lj, "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds" in Polymers, 14, no. 20 (2022):4459,
https://doi.org/10.3390/polym14204459 . .

TY  - JOUR
AU  - Garcia, Eduardo Lanzagorta
AU  - Mojićević, Marija
AU  - Milivojević, Dušan
AU  - Aleksic, Ivana
AU  - Vojnović, Sandra
AU  - Stevanović, Milena
AU  - Murray, James
AU  - Attallah, Olivia Adly
AU  - Devine, Declan
AU  - Fournet, Margaret Brennan
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1658
AB  - Curcumin and triangular silver nanoplates (TSNP)-incorporated bacterial cellulose (BC) films present an ideal antimicrobial material for biomedical applications as they afford a complete set of requirements, including a broad range of long-lasting potency and superior efficacy antimicrobial activity, combined with low toxicity. Here, BC was produced by Komagataeibacter medellinensis ID13488 strain in the presence of curcumin in the production medium (2 and 10%). TSNP were incorporated in the produced BC/curcumin films using ex situ method (21.34 ppm) and the antimicrobial activity was evaluated against Escherichia coli ATCC95922 and Staphylococcus aureus ATCC25923 bacterial strains. Biological activity of these natural products was assessed in cytotoxicity assay against lung fibroblasts and in vivo using Caenorhabditis elegans and Danio rerio as model organisms. Derived films have shown excellent antimicrobial performance with growth inhibition up to 67% for E. coli and 95% for S. aureus. In a highly positive synergistic interaction, BC films with 10% curcumin and incorporated TSNP have shown reduced toxicity with 80% MRC5 cells survival rate. It was shown that only 100% concentrations of film extracts induce low toxicity effect on model organisms’ development. The combined and synergistic advanced anti-infective functionalities of the curcumin and TSNP incorporated in BC have a high potential for development for application within the clinical setting.
T2  - International Journal of Molecular Sciences
T2  - International Journal of Molecular Sciences
T1  - Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates
IS  - 20
SP  - 12198
VL  - 23
DO  - 10.3390/ijms232012198
ER  - 

@article{
author = "Garcia, Eduardo Lanzagorta and Mojićević, Marija and Milivojević, Dušan and Aleksic, Ivana and Vojnović, Sandra and Stevanović, Milena and Murray, James and Attallah, Olivia Adly and Devine, Declan and Fournet, Margaret Brennan",
year = "2022",
abstract = "Curcumin and triangular silver nanoplates (TSNP)-incorporated bacterial cellulose (BC) films present an ideal antimicrobial material for biomedical applications as they afford a complete set of requirements, including a broad range of long-lasting potency and superior efficacy antimicrobial activity, combined with low toxicity. Here, BC was produced by Komagataeibacter medellinensis ID13488 strain in the presence of curcumin in the production medium (2 and 10%). TSNP were incorporated in the produced BC/curcumin films using ex situ method (21.34 ppm) and the antimicrobial activity was evaluated against Escherichia coli ATCC95922 and Staphylococcus aureus ATCC25923 bacterial strains. Biological activity of these natural products was assessed in cytotoxicity assay against lung fibroblasts and in vivo using Caenorhabditis elegans and Danio rerio as model organisms. Derived films have shown excellent antimicrobial performance with growth inhibition up to 67% for E. coli and 95% for S. aureus. In a highly positive synergistic interaction, BC films with 10% curcumin and incorporated TSNP have shown reduced toxicity with 80% MRC5 cells survival rate. It was shown that only 100% concentrations of film extracts induce low toxicity effect on model organisms’ development. The combined and synergistic advanced anti-infective functionalities of the curcumin and TSNP incorporated in BC have a high potential for development for application within the clinical setting.",
journal = "International Journal of Molecular Sciences, International Journal of Molecular Sciences",
title = "Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates",
number = "20",
pages = "12198",
volume = "23",
doi = "10.3390/ijms232012198"
}

Garcia, E. L., Mojićević, M., Milivojević, D., Aleksic, I., Vojnović, S., Stevanović, M., Murray, J., Attallah, O. A., Devine, D.,& Fournet, M. B.. (2022). Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates. in International Journal of Molecular Sciences, 23(20), 12198.
https://doi.org/10.3390/ijms232012198

Garcia EL, Mojićević M, Milivojević D, Aleksic I, Vojnović S, Stevanović M, Murray J, Attallah OA, Devine D, Fournet MB. Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates. in International Journal of Molecular Sciences. 2022;23(20):12198.
doi:10.3390/ijms232012198 .

Garcia, Eduardo Lanzagorta, Mojićević, Marija, Milivojević, Dušan, Aleksic, Ivana, Vojnović, Sandra, Stevanović, Milena, Murray, James, Attallah, Olivia Adly, Devine, Declan, Fournet, Margaret Brennan, "Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates" in International Journal of Molecular Sciences, 23, no. 20 (2022):12198,
https://doi.org/10.3390/ijms232012198 . .

TY  - JOUR
AU  - Lazić, Jelena
AU  - Škaro Bogojević, Sanja
AU  - Vojnović, Sandra
AU  - Aleksić, Ivana
AU  - Milivojević, Dušan
AU  - Kretzschmar, Martin
AU  - Gulder, Tanja
AU  - Petković, Milos
AU  - Nikodinović-Runić, Jasmina
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1591
AB  - Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, and characterization of prodigiosin (PG) from easily accessible Serratia marcescens ATCC 27117 strain has been achieved to levels of 14 mg/L of culture within 24 h. Furthermore, environmentally friendly bromination of produced PG was used to afford both novel mono- and dibrominated derivatives of PG. PG and its Br derivatives showed anticancer potential with IC50 values range 0.62-17.00 mu g/mL for all tested cancer cell lines and induction of apoptosis but low selectivity against healthy cell lines. All compounds did not affect Caenorhabditis elegans at concentrations up to 50 mu g/mL. However, an improved toxicity profile of Br derivatives in comparison to parent PG was observed in vivo using zebrafish (Danio rerio) model system, when 10 mu g/mL applied at 6 h post fertilization caused death rate of 100%, 30% and 0% by PG, PG-Br, and PG-Br-2,Br- respectively, which is a significant finding for further structural optimizations of bacterial prodigiosins. The drug-likeness of PG and its Br derivatives was examined, and the novel Br derivatives obey the Lipinski's "rule of five", with an exemption of being more lipophilic than PG, which still makes them good targets for further structural optimization.
PB  - MDPI, Basel
T2  - Molecules
T1  - Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117
IS  - 12
VL  - 27
DO  - 10.3390/molecules27123729
ER  - 

@article{
author = "Lazić, Jelena and Škaro Bogojević, Sanja and Vojnović, Sandra and Aleksić, Ivana and Milivojević, Dušan and Kretzschmar, Martin and Gulder, Tanja and Petković, Milos and Nikodinović-Runić, Jasmina",
year = "2022",
abstract = "Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, and characterization of prodigiosin (PG) from easily accessible Serratia marcescens ATCC 27117 strain has been achieved to levels of 14 mg/L of culture within 24 h. Furthermore, environmentally friendly bromination of produced PG was used to afford both novel mono- and dibrominated derivatives of PG. PG and its Br derivatives showed anticancer potential with IC50 values range 0.62-17.00 mu g/mL for all tested cancer cell lines and induction of apoptosis but low selectivity against healthy cell lines. All compounds did not affect Caenorhabditis elegans at concentrations up to 50 mu g/mL. However, an improved toxicity profile of Br derivatives in comparison to parent PG was observed in vivo using zebrafish (Danio rerio) model system, when 10 mu g/mL applied at 6 h post fertilization caused death rate of 100%, 30% and 0% by PG, PG-Br, and PG-Br-2,Br- respectively, which is a significant finding for further structural optimizations of bacterial prodigiosins. The drug-likeness of PG and its Br derivatives was examined, and the novel Br derivatives obey the Lipinski's "rule of five", with an exemption of being more lipophilic than PG, which still makes them good targets for further structural optimization.",
publisher = "MDPI, Basel",
journal = "Molecules",
title = "Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117",
number = "12",
volume = "27",
doi = "10.3390/molecules27123729"
}

Lazić, J., Škaro Bogojević, S., Vojnović, S., Aleksić, I., Milivojević, D., Kretzschmar, M., Gulder, T., Petković, M.,& Nikodinović-Runić, J.. (2022). Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117. in Molecules
MDPI, Basel., 27(12).
https://doi.org/10.3390/molecules27123729

Lazić J, Škaro Bogojević S, Vojnović S, Aleksić I, Milivojević D, Kretzschmar M, Gulder T, Petković M, Nikodinović-Runić J. Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117. in Molecules. 2022;27(12).
doi:10.3390/molecules27123729 .

Lazić, Jelena, Škaro Bogojević, Sanja, Vojnović, Sandra, Aleksić, Ivana, Milivojević, Dušan, Kretzschmar, Martin, Gulder, Tanja, Petković, Milos, Nikodinović-Runić, Jasmina, "Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117" in Molecules, 27, no. 12 (2022),
https://doi.org/10.3390/molecules27123729 . .

TY  - JOUR
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Kljun, Jakob
AU  - Pantović, Bojana, V
AU  - Milivojević, Dušan
AU  - Vojnović, Sandra
AU  - Turel, Iztok
AU  - Djuran, Milos
AU  - Glišić, Biljana
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1589
AB  - Two zinc(II) complexes with dimethyl 2,2 '-bipyridine-4,5-dicarboxylate (py-2py) of the general formula [Zn(py-2py)X-2], X = Cl- (1) and Br- (2) were synthesized and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. Complexes 1 and 2 are isostructural and adopt a slightly distorted tetrahedral geometry with values of tetrahedral indices tau(4) and tau'(4) in the range of 0.80-0.85. The complexes were evaluated for their in vitro antimicrobial activity against two bacterial (Pseudomonas aeruginosa and Staphylococcus aureus) and two fungal strains (Candida albicans and Candida parapsilosis), while their cytotoxicity was tested on the normal human lung fibroblast cell line (MRC-5) and the model organism Caenorhabditis elegans. Complex 1 showed moderate activity against both Candida strains. However, this complex was twofold more cytotoxic compared to complex 2. The complexes tested had no effect on the survival rate of C. elegans. Complex 2 showed the ability to inhibit filamentation of C. albicans, while complex 1 was more effective than complex 2 in inhibiting biofilm formation. The interactions of complexes 1 and 2 with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) were studied to evaluate their binding affinity toward these biomolecules.
PB  - MDPI, Basel
T2  - Inorganics
T1  - Zinc(II) Complexes with Dimethyl 2,2 '-Bipyridine-4,5-dicarboxylate: Structure, Antimicrobial Activity and DNA/BSA Binding Study
IS  - 6
VL  - 10
DO  - 10.3390/inorganics10060071
ER  - 

@article{
author = "Andrejević, Tina P. and Aleksić, Ivana and Kljun, Jakob and Pantović, Bojana, V and Milivojević, Dušan and Vojnović, Sandra and Turel, Iztok and Djuran, Milos and Glišić, Biljana",
year = "2022",
abstract = "Two zinc(II) complexes with dimethyl 2,2 '-bipyridine-4,5-dicarboxylate (py-2py) of the general formula [Zn(py-2py)X-2], X = Cl- (1) and Br- (2) were synthesized and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. Complexes 1 and 2 are isostructural and adopt a slightly distorted tetrahedral geometry with values of tetrahedral indices tau(4) and tau'(4) in the range of 0.80-0.85. The complexes were evaluated for their in vitro antimicrobial activity against two bacterial (Pseudomonas aeruginosa and Staphylococcus aureus) and two fungal strains (Candida albicans and Candida parapsilosis), while their cytotoxicity was tested on the normal human lung fibroblast cell line (MRC-5) and the model organism Caenorhabditis elegans. Complex 1 showed moderate activity against both Candida strains. However, this complex was twofold more cytotoxic compared to complex 2. The complexes tested had no effect on the survival rate of C. elegans. Complex 2 showed the ability to inhibit filamentation of C. albicans, while complex 1 was more effective than complex 2 in inhibiting biofilm formation. The interactions of complexes 1 and 2 with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) were studied to evaluate their binding affinity toward these biomolecules.",
publisher = "MDPI, Basel",
journal = "Inorganics",
title = "Zinc(II) Complexes with Dimethyl 2,2 '-Bipyridine-4,5-dicarboxylate: Structure, Antimicrobial Activity and DNA/BSA Binding Study",
number = "6",
volume = "10",
doi = "10.3390/inorganics10060071"
}

Andrejević, T. P., Aleksić, I., Kljun, J., Pantović, B. V., Milivojević, D., Vojnović, S., Turel, I., Djuran, M.,& Glišić, B.. (2022). Zinc(II) Complexes with Dimethyl 2,2 '-Bipyridine-4,5-dicarboxylate: Structure, Antimicrobial Activity and DNA/BSA Binding Study. in Inorganics
MDPI, Basel., 10(6).
https://doi.org/10.3390/inorganics10060071

Andrejević TP, Aleksić I, Kljun J, Pantović BV, Milivojević D, Vojnović S, Turel I, Djuran M, Glišić B. Zinc(II) Complexes with Dimethyl 2,2 '-Bipyridine-4,5-dicarboxylate: Structure, Antimicrobial Activity and DNA/BSA Binding Study. in Inorganics. 2022;10(6).
doi:10.3390/inorganics10060071 .

Andrejević, Tina P., Aleksić, Ivana, Kljun, Jakob, Pantović, Bojana, V, Milivojević, Dušan, Vojnović, Sandra, Turel, Iztok, Djuran, Milos, Glišić, Biljana, "Zinc(II) Complexes with Dimethyl 2,2 '-Bipyridine-4,5-dicarboxylate: Structure, Antimicrobial Activity and DNA/BSA Binding Study" in Inorganics, 10, no. 6 (2022),
https://doi.org/10.3390/inorganics10060071 . .

TY  - JOUR
AU  - Stevanović, Nevena Lj.
AU  - Kljun, Jakob
AU  - Aleksić, Ivana
AU  - Škaro Bogojević, Sanja
AU  - Milivojević, Dušan
AU  - Veselinović, Aleksandar
AU  - Turel, Iztok
AU  - Djuran, Milos
AU  - Nikodinović-Runić, Jasmina
AU  - Glišić, Biljana
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1568
AB  - In a search for novel antimicrobial metal-based therapeutic agents, mononuclear gold(III) complexes 1-7 of the general formula [AuCl3(azole)], where azole stands for imidazole (im, 1), 1-isopropylimidazole (ipim, 2), 1-phenylimidazole (phim, 3), clotrimazole (ctz, 4), econazole (ecz, 5), tioconazole (tcz, 6) and voriconazole (vcz, 7) were synthesized, characterized and biologically evaluated. In all complexes, the corresponding azole ligand is monodentately coordinated to the Au(III) via the imidazole or triazole nitrogen atom, while the remaining coordination sites are occupied by chloride anions leading to the square-planar arrangement. In vitro antimicrobial assays showed that the complexation of inactive azoles, imidazole, 1-isopropylimidazole and 1-phenylimidazole, to the Au(III) ion led to complexes 1-3, respectively, with moderate activity against the investigated strains and low cytotoxicity on the human normal lung fibroblast cell line (MRC-5). Moreover, gold(III) complexes 4-7 with clinically used antifungal agents clotrimazole, econazole, tioconazole and voriconazole, respectively, have, in most cases, enhanced antimicrobial effectiveness relative to the corresponding azoles, with the best improvement achieved after complexation of tioconazole (6) and voriconazole (7). The complexes 4-7 and the corresponding antifungal azoles inhibited the growth of dermatophyte Microsporum canis at 50 and 25 mu g mL(-1). Gold(III) complexes 1-3 significantly reduced the amount of ergosterol in the cell membrane of Candida albicans at the subinhibitory concentration of 0.5 x MIC (minimal inhibitory concentration), while the corresponding imidazole ligands did not significantly affect the ergosterol content, indicating that the mechanism of action of the gold(III)-azole complexes is associated with inhibition of ergosterol biosynthesis. Finally, complexes 5 and 6 significantly reduced the production of pyocyanin, a virulence factor in Pseudomonas aeruginosa controlled by quorum sensing, and increased cell survival after exposure to this bacterium. These findings could be of importance for the development of novel gold(III)-based antivirulence therapeutic agents that attenuate virulence without pronounced effect on the growth of the pathogens, offering a lower risk for resistance development.
PB  - Royal Soc Chemistry, Cambridge
T2  - Dalton Transactions
T1  - Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex
EP  - 5334
IS  - 13
SP  - 5322
VL  - 51
DO  - 10.1039/d2dt00411a
ER  - 

@article{
author = "Stevanović, Nevena Lj. and Kljun, Jakob and Aleksić, Ivana and Škaro Bogojević, Sanja and Milivojević, Dušan and Veselinović, Aleksandar and Turel, Iztok and Djuran, Milos and Nikodinović-Runić, Jasmina and Glišić, Biljana",
year = "2022",
abstract = "In a search for novel antimicrobial metal-based therapeutic agents, mononuclear gold(III) complexes 1-7 of the general formula [AuCl3(azole)], where azole stands for imidazole (im, 1), 1-isopropylimidazole (ipim, 2), 1-phenylimidazole (phim, 3), clotrimazole (ctz, 4), econazole (ecz, 5), tioconazole (tcz, 6) and voriconazole (vcz, 7) were synthesized, characterized and biologically evaluated. In all complexes, the corresponding azole ligand is monodentately coordinated to the Au(III) via the imidazole or triazole nitrogen atom, while the remaining coordination sites are occupied by chloride anions leading to the square-planar arrangement. In vitro antimicrobial assays showed that the complexation of inactive azoles, imidazole, 1-isopropylimidazole and 1-phenylimidazole, to the Au(III) ion led to complexes 1-3, respectively, with moderate activity against the investigated strains and low cytotoxicity on the human normal lung fibroblast cell line (MRC-5). Moreover, gold(III) complexes 4-7 with clinically used antifungal agents clotrimazole, econazole, tioconazole and voriconazole, respectively, have, in most cases, enhanced antimicrobial effectiveness relative to the corresponding azoles, with the best improvement achieved after complexation of tioconazole (6) and voriconazole (7). The complexes 4-7 and the corresponding antifungal azoles inhibited the growth of dermatophyte Microsporum canis at 50 and 25 mu g mL(-1). Gold(III) complexes 1-3 significantly reduced the amount of ergosterol in the cell membrane of Candida albicans at the subinhibitory concentration of 0.5 x MIC (minimal inhibitory concentration), while the corresponding imidazole ligands did not significantly affect the ergosterol content, indicating that the mechanism of action of the gold(III)-azole complexes is associated with inhibition of ergosterol biosynthesis. Finally, complexes 5 and 6 significantly reduced the production of pyocyanin, a virulence factor in Pseudomonas aeruginosa controlled by quorum sensing, and increased cell survival after exposure to this bacterium. These findings could be of importance for the development of novel gold(III)-based antivirulence therapeutic agents that attenuate virulence without pronounced effect on the growth of the pathogens, offering a lower risk for resistance development.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Dalton Transactions",
title = "Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex",
pages = "5334-5322",
number = "13",
volume = "51",
doi = "10.1039/d2dt00411a"
}

Stevanović, N. Lj., Kljun, J., Aleksić, I., Škaro Bogojević, S., Milivojević, D., Veselinović, A., Turel, I., Djuran, M., Nikodinović-Runić, J.,& Glišić, B.. (2022). Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex. in Dalton Transactions
Royal Soc Chemistry, Cambridge., 51(13), 5322-5334.
https://doi.org/10.1039/d2dt00411a

Stevanović NL, Kljun J, Aleksić I, Škaro Bogojević S, Milivojević D, Veselinović A, Turel I, Djuran M, Nikodinović-Runić J, Glišić B. Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex. in Dalton Transactions. 2022;51(13):5322-5334.
doi:10.1039/d2dt00411a .

Stevanović, Nevena Lj., Kljun, Jakob, Aleksić, Ivana, Škaro Bogojević, Sanja, Milivojević, Dušan, Veselinović, Aleksandar, Turel, Iztok, Djuran, Milos, Nikodinović-Runić, Jasmina, Glišić, Biljana, "Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex" in Dalton Transactions, 51, no. 13 (2022):5322-5334,
https://doi.org/10.1039/d2dt00411a . .

TY  - CONF
AU  - Janković, Vukašin
AU  - Nikodinović-Runić, Jasmina
AU  - Milivojević, Dušan
AU  - Stevanović, Milena
AU  - Ilić-Tomić, Tatjana
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1843
AB  - BACKGROUND
Pigments from microbial origin have promising applications in food, cosmetics, textiles and therapeutics.
Compared to other natural sources pigments from bacteria are more stable, safer, and could be cheaper to
produce and extract. Bacterial genus Streptomyces has been known as a source of biologicaly active pigments
that exhibit several effects such as antimicrobial and cytotoxic.
OBJECTIVES
The aim of this study was the isolation of pigment-producing Streptomyces strain from soil, optimization of
growth parametres for pigment production and evaluation of antimicrobial and cytotoxic activity of extracted
bacterial pigments.
METHODS
Isolation and characterization of pigment-producing Streptomyces strain from soil was done following the
standard microbiological protocol, using four different growth media. The pigments were extracted by solvent
extraction using ethyl acetate. Antimicrobial activity was analyzed using the disc diffusion test. Cytotoxic activity
was tested on the HaCaT cell line following the standard protocol.
RESULTS
Extraction of pigments by solvent extraction resulted in crude pigment extracts with antimicrobial activities.
In total pigments from 14 bacterial strains have been extracted. Antimicrobial activity was evident on Gram +
bacteria Staphylococcus aureus (6 mm of inhibition zone at concentration 8.4 μg/ml and 4 mm of inhibition
zone at concentration 1.1 μg/ml) as well as on the fungus Candida albicans (4 mm of inhibition zone at concentration
13 μg/ml). Pigments showed dose-dependent inhibiton of proliferation of HaCaT cells, with the
lowest concentration at 25 μg/ml.
C3  - FEMS Conference on Microbiology
T1  - Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts
EP  - 622
SP  - 621
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1843
ER  - 

@conference{
author = "Janković, Vukašin and Nikodinović-Runić, Jasmina and Milivojević, Dušan and Stevanović, Milena and Ilić-Tomić, Tatjana",
year = "2022",
abstract = "BACKGROUND
Pigments from microbial origin have promising applications in food, cosmetics, textiles and therapeutics.
Compared to other natural sources pigments from bacteria are more stable, safer, and could be cheaper to
produce and extract. Bacterial genus Streptomyces has been known as a source of biologicaly active pigments
that exhibit several effects such as antimicrobial and cytotoxic.
OBJECTIVES
The aim of this study was the isolation of pigment-producing Streptomyces strain from soil, optimization of
growth parametres for pigment production and evaluation of antimicrobial and cytotoxic activity of extracted
bacterial pigments.
METHODS
Isolation and characterization of pigment-producing Streptomyces strain from soil was done following the
standard microbiological protocol, using four different growth media. The pigments were extracted by solvent
extraction using ethyl acetate. Antimicrobial activity was analyzed using the disc diffusion test. Cytotoxic activity
was tested on the HaCaT cell line following the standard protocol.
RESULTS
Extraction of pigments by solvent extraction resulted in crude pigment extracts with antimicrobial activities.
In total pigments from 14 bacterial strains have been extracted. Antimicrobial activity was evident on Gram +
bacteria Staphylococcus aureus (6 mm of inhibition zone at concentration 8.4 μg/ml and 4 mm of inhibition
zone at concentration 1.1 μg/ml) as well as on the fungus Candida albicans (4 mm of inhibition zone at concentration
13 μg/ml). Pigments showed dose-dependent inhibiton of proliferation of HaCaT cells, with the
lowest concentration at 25 μg/ml.",
journal = "FEMS Conference on Microbiology",
title = "Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts",
pages = "622-621",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1843"
}

Janković, V., Nikodinović-Runić, J., Milivojević, D., Stevanović, M.,& Ilić-Tomić, T.. (2022). Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts. in FEMS Conference on Microbiology, 621-622.
https://hdl.handle.net/21.15107/rcub_imagine_1843

Janković V, Nikodinović-Runić J, Milivojević D, Stevanović M, Ilić-Tomić T. Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts. in FEMS Conference on Microbiology. 2022;:621-622.
https://hdl.handle.net/21.15107/rcub_imagine_1843 .

Janković, Vukašin, Nikodinović-Runić, Jasmina, Milivojević, Dušan, Stevanović, Milena, Ilić-Tomić, Tatjana, "Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts" in FEMS Conference on Microbiology (2022):621-622,
https://hdl.handle.net/21.15107/rcub_imagine_1843 .

TY  - JOUR
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lješević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0045653521004744
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1732
AB  - Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.
PB  - Elsevier
T2  - Chemosphere
T2  - ChemosphereChemosphere
T1  - Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases
SP  - 130005
VL  - 275
DO  - 10.1016/j.chemosphere.2021.130005
ER  - 

@article{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lješević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
abstract = "Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.",
publisher = "Elsevier",
journal = "Chemosphere, ChemosphereChemosphere",
title = "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases",
pages = "130005",
volume = "275",
doi = "10.1016/j.chemosphere.2021.130005"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Lješević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere
Elsevier., 275, 130005.
https://doi.org/10.1016/j.chemosphere.2021.130005

Đapović M, Milivojević D, Ilić-Tomić T, Lješević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere. 2021;275:130005.
doi:10.1016/j.chemosphere.2021.130005 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lješević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases" in Chemosphere, 275 (2021):130005,
https://doi.org/10.1016/j.chemosphere.2021.130005 . .

TY  - JOUR
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Ljesević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1415
AB  - Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 mg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 mg/mL with inhibiting concentration (IC50) values of 30 mg/mL and 50 mg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 mg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Chemosphere
T1  - Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases
SP  - 130005
VL  - 275
DO  - 10.1016/j.chemosphere.2021.130005
ER  - 

@article{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Ljesević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
abstract = "Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 mg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 mg/mL with inhibiting concentration (IC50) values of 30 mg/mL and 50 mg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 mg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Chemosphere",
title = "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases",
pages = "130005",
volume = "275",
doi = "10.1016/j.chemosphere.2021.130005"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Ljesević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere
Pergamon-Elsevier Science Ltd, Oxford., 275, 130005.
https://doi.org/10.1016/j.chemosphere.2021.130005

Đapović M, Milivojević D, Ilić-Tomić T, Ljesević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere. 2021;275:130005.
doi:10.1016/j.chemosphere.2021.130005 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Ljesević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases" in Chemosphere, 275 (2021):130005,
https://doi.org/10.1016/j.chemosphere.2021.130005 . .

TY  - DATA
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lješević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0045653521004744
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1733
PB  - Elsevier
T2  - Chemosphere
T1  - Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1733
ER  - 

@misc{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lješević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
publisher = "Elsevier",
journal = "Chemosphere",
title = "Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1733"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Lješević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.. in Chemosphere
Elsevier..
https://hdl.handle.net/21.15107/rcub_imagine_1733

Đapović M, Milivojević D, Ilić-Tomić T, Lješević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.. in Chemosphere. 2021;.
https://hdl.handle.net/21.15107/rcub_imagine_1733 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lješević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005." in Chemosphere (2021),
https://hdl.handle.net/21.15107/rcub_imagine_1733 .

TY  - JOUR
AU  - Andrejević, Tina P.
AU  - Aleksić, Ivana
AU  - Pockaj, Marta
AU  - Kljun, Jakob
AU  - Milivojević, Dušan
AU  - Stevanović, Nevena Lj.
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Djuran, Milos
AU  - Glišić, Biljana
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1492
AB  - Five novel copper(ii) complexes with pyridine-4,5-dicarboxylate esters as ligands, [Cu(NO3)(py-2tz)(H2O)(3)]NO3 (1), [Cu(NO3)(2)(py-2metz)(H2O)] (2), [Cu(NO3)(2)(py-2py)(H2O)]center dot H2O (3), [CuCl2(py-2tz)](2) (4) and [CuCl2(py-2metz)](n) (5) (py-2tz is dimethyl 2-(thiazol-2-yl)pyridine-4,5-dicarboxylate, py-2metz is dimethyl 2-(4-methylthiazol-2-yl)pyridine-4,5-dicarboxylate and py-2py is dimethyl 2,2 '-bipyridine-4,5-dicarboxylate), were synthesized and structurally characterized by different spectroscopic and electrochemical methods. The structure of these complexes was determined by single-crystal X-ray diffraction analysis, confirming the bidentate coordination mode of the corresponding pyridine-4,5-dicarboxylate ester to the Cu(ii) ion through the nitrogen atoms. The antimicrobial potential of copper(ii) complexes 1-5 was assessed against two bacterial and two Candida species. These complexes showed better growth inhibiting activity against Candida spp. with respect to the tested bacterial species, also being moderately toxic towards normal human lung fibroblast cells (MRC-5). Complexes 1 and 4 showed the greatest ability to inhibit the filamentation of C. albicans, which is an important process during fungal infection, and these two complexes efficiently inhibited the biofilm formation of C. albicans at subinhibitory concentrations. Complex 4 also successfully prevented the adhesion of C. albicans in an in vitro epithelial cell model. The mechanism of the antifungal activity of copper(ii) complexes 1-5 was studied through their interaction with ct-DNA, as one of the possible target biomolecules, by fluorescence spectroscopy and gel electrophoresis. Finally, the ability of these complexes to bind to bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy.
PB  - Royal Soc Chemistry, Cambridge
T2  - Dalton Transactions
T1  - Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity
EP  - 2638
IS  - 7
SP  - 2627
VL  - 50
DO  - 10.1039/d0dt04061d
ER  - 

@article{
author = "Andrejević, Tina P. and Aleksić, Ivana and Pockaj, Marta and Kljun, Jakob and Milivojević, Dušan and Stevanović, Nevena Lj. and Nikodinović-Runić, Jasmina and Turel, Iztok and Djuran, Milos and Glišić, Biljana",
year = "2021",
abstract = "Five novel copper(ii) complexes with pyridine-4,5-dicarboxylate esters as ligands, [Cu(NO3)(py-2tz)(H2O)(3)]NO3 (1), [Cu(NO3)(2)(py-2metz)(H2O)] (2), [Cu(NO3)(2)(py-2py)(H2O)]center dot H2O (3), [CuCl2(py-2tz)](2) (4) and [CuCl2(py-2metz)](n) (5) (py-2tz is dimethyl 2-(thiazol-2-yl)pyridine-4,5-dicarboxylate, py-2metz is dimethyl 2-(4-methylthiazol-2-yl)pyridine-4,5-dicarboxylate and py-2py is dimethyl 2,2 '-bipyridine-4,5-dicarboxylate), were synthesized and structurally characterized by different spectroscopic and electrochemical methods. The structure of these complexes was determined by single-crystal X-ray diffraction analysis, confirming the bidentate coordination mode of the corresponding pyridine-4,5-dicarboxylate ester to the Cu(ii) ion through the nitrogen atoms. The antimicrobial potential of copper(ii) complexes 1-5 was assessed against two bacterial and two Candida species. These complexes showed better growth inhibiting activity against Candida spp. with respect to the tested bacterial species, also being moderately toxic towards normal human lung fibroblast cells (MRC-5). Complexes 1 and 4 showed the greatest ability to inhibit the filamentation of C. albicans, which is an important process during fungal infection, and these two complexes efficiently inhibited the biofilm formation of C. albicans at subinhibitory concentrations. Complex 4 also successfully prevented the adhesion of C. albicans in an in vitro epithelial cell model. The mechanism of the antifungal activity of copper(ii) complexes 1-5 was studied through their interaction with ct-DNA, as one of the possible target biomolecules, by fluorescence spectroscopy and gel electrophoresis. Finally, the ability of these complexes to bind to bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Dalton Transactions",
title = "Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity",
pages = "2638-2627",
number = "7",
volume = "50",
doi = "10.1039/d0dt04061d"
}

Andrejević, T. P., Aleksić, I., Pockaj, M., Kljun, J., Milivojević, D., Stevanović, N. Lj., Nikodinović-Runić, J., Turel, I., Djuran, M.,& Glišić, B.. (2021). Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity. in Dalton Transactions
Royal Soc Chemistry, Cambridge., 50(7), 2627-2638.
https://doi.org/10.1039/d0dt04061d

Andrejević TP, Aleksić I, Pockaj M, Kljun J, Milivojević D, Stevanović NL, Nikodinović-Runić J, Turel I, Djuran M, Glišić B. Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity. in Dalton Transactions. 2021;50(7):2627-2638.
doi:10.1039/d0dt04061d .

Andrejević, Tina P., Aleksić, Ivana, Pockaj, Marta, Kljun, Jakob, Milivojević, Dušan, Stevanović, Nevena Lj., Nikodinović-Runić, Jasmina, Turel, Iztok, Djuran, Milos, Glišić, Biljana, "Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity" in Dalton Transactions, 50, no. 7 (2021):2627-2638,
https://doi.org/10.1039/d0dt04061d . .

TY  - JOUR
AU  - Ašanin, Darko P.
AU  - Škaro Bogojević, Sanja
AU  - Perdih, Franc
AU  - Andrejević, Tina P.
AU  - Milivojević, Dušan
AU  - Aleksić, Ivana
AU  - Nikodinović-Runić, Jasmina
AU  - Glišić, Biljana
AU  - Turel, Iztok
AU  - Djuran, Milos
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1420
AB  - Three new silver(I) complexes [Ag(NO3)(tia)(H2O)](n) (Ag1), [Ag(CF3SO3)(1,8-naph)](n) (Ag2) and [Ag-2(1,8-naph)(2)(H2O)(1.2)](PF6)(2) (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochemical methods and their crystal structures were determined by single-crystal X-ray diffraction analysis. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56-7.81 mu g/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds. Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomolecules for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1-3 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids.
PB  - Basel : MDPI
T2  - Molecules
T1  - Structural Characterization, Antimicrobial Activity and BSA/DNA Binding Affinity of New Silver(I) Complexes with Thianthrene and 1,8-Naphthyridine
IS  - 7
VL  - 26
DO  - 10.3390/molecules26071871
ER  - 

@article{
author = "Ašanin, Darko P. and Škaro Bogojević, Sanja and Perdih, Franc and Andrejević, Tina P. and Milivojević, Dušan and Aleksić, Ivana and Nikodinović-Runić, Jasmina and Glišić, Biljana and Turel, Iztok and Djuran, Milos",
year = "2021",
abstract = "Three new silver(I) complexes [Ag(NO3)(tia)(H2O)](n) (Ag1), [Ag(CF3SO3)(1,8-naph)](n) (Ag2) and [Ag-2(1,8-naph)(2)(H2O)(1.2)](PF6)(2) (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochemical methods and their crystal structures were determined by single-crystal X-ray diffraction analysis. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56-7.81 mu g/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds. Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomolecules for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1-3 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids.",
publisher = "Basel : MDPI",
journal = "Molecules",
title = "Structural Characterization, Antimicrobial Activity and BSA/DNA Binding Affinity of New Silver(I) Complexes with Thianthrene and 1,8-Naphthyridine",
number = "7",
volume = "26",
doi = "10.3390/molecules26071871"
}

Ašanin, D. P., Škaro Bogojević, S., Perdih, F., Andrejević, T. P., Milivojević, D., Aleksić, I., Nikodinović-Runić, J., Glišić, B., Turel, I.,& Djuran, M.. (2021). Structural Characterization, Antimicrobial Activity and BSA/DNA Binding Affinity of New Silver(I) Complexes with Thianthrene and 1,8-Naphthyridine. in Molecules
Basel : MDPI., 26(7).
https://doi.org/10.3390/molecules26071871

Ašanin DP, Škaro Bogojević S, Perdih F, Andrejević TP, Milivojević D, Aleksić I, Nikodinović-Runić J, Glišić B, Turel I, Djuran M. Structural Characterization, Antimicrobial Activity and BSA/DNA Binding Affinity of New Silver(I) Complexes with Thianthrene and 1,8-Naphthyridine. in Molecules. 2021;26(7).
doi:10.3390/molecules26071871 .

Ašanin, Darko P., Škaro Bogojević, Sanja, Perdih, Franc, Andrejević, Tina P., Milivojević, Dušan, Aleksić, Ivana, Nikodinović-Runić, Jasmina, Glišić, Biljana, Turel, Iztok, Djuran, Milos, "Structural Characterization, Antimicrobial Activity and BSA/DNA Binding Affinity of New Silver(I) Complexes with Thianthrene and 1,8-Naphthyridine" in Molecules, 26, no. 7 (2021),
https://doi.org/10.3390/molecules26071871 . .

TY  - CHAP
AU  - Šenerović, Lidija
AU  - Morić, Ivana
AU  - Milivojević, Dušan
AU  - Opsenica, Dejan
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1639
AB  - The rapid emergence of antibiotic-resistant pathogens presents a global healthcare challenge. Bacteria control their virulence, motility, and biofilm formation, all of them being required for establishing pathogenicity, through a cell density-dependent communication system known as quorum sensing (QS). QS comprises production of extracellular signaling molecules, their detection, and population-wide response involving regulation of the virulence genes expression. Inhibition of QS affects virulence and reduces harmful effects to the host and as such presents a promising strategy to fight antibiotic-resistant infections. Multiresistant Pseudomonas aeruginosa belogns to the group of most critical pathogens for which the introduction of new therapeutics is imperative. In the search for novel therapeutics nature continues to be inexhaustible source of bioactive scaffolds, which provide the bases for structure-based rational drug design enabling further exploitation of diverse natural structures. This review describes bacterial QS systems, highlights strategies for their manipulation, overviews nature-inspired antivirulence molecules primarily against P. aeruginosa, and discusses their perspectives.
PB  - Academic Press
T2  - Biodiversity and Biomedicine
T2  - Biodiversity and Biomedicine
T1  - Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections
EP  - 523
SP  - 497
DO  - 10.1016/B978-0-12-819541-3.00025-6
ER  - 

@inbook{
author = "Šenerović, Lidija and Morić, Ivana and Milivojević, Dušan and Opsenica, Dejan",
year = "2020",
abstract = "The rapid emergence of antibiotic-resistant pathogens presents a global healthcare challenge. Bacteria control their virulence, motility, and biofilm formation, all of them being required for establishing pathogenicity, through a cell density-dependent communication system known as quorum sensing (QS). QS comprises production of extracellular signaling molecules, their detection, and population-wide response involving regulation of the virulence genes expression. Inhibition of QS affects virulence and reduces harmful effects to the host and as such presents a promising strategy to fight antibiotic-resistant infections. Multiresistant Pseudomonas aeruginosa belogns to the group of most critical pathogens for which the introduction of new therapeutics is imperative. In the search for novel therapeutics nature continues to be inexhaustible source of bioactive scaffolds, which provide the bases for structure-based rational drug design enabling further exploitation of diverse natural structures. This review describes bacterial QS systems, highlights strategies for their manipulation, overviews nature-inspired antivirulence molecules primarily against P. aeruginosa, and discusses their perspectives.",
publisher = "Academic Press",
journal = "Biodiversity and Biomedicine, Biodiversity and Biomedicine",
booktitle = "Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections",
pages = "523-497",
doi = "10.1016/B978-0-12-819541-3.00025-6"
}

Šenerović, L., Morić, I., Milivojević, D.,& Opsenica, D.. (2020). Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections. in Biodiversity and Biomedicine
Academic Press., 497-523.
https://doi.org/10.1016/B978-0-12-819541-3.00025-6

Šenerović L, Morić I, Milivojević D, Opsenica D. Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections. in Biodiversity and Biomedicine. 2020;:497-523.
doi:10.1016/B978-0-12-819541-3.00025-6 .

Šenerović, Lidija, Morić, Ivana, Milivojević, Dušan, Opsenica, Dejan, "Nature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infections" in Biodiversity and Biomedicine (2020):497-523,
https://doi.org/10.1016/B978-0-12-819541-3.00025-6 . .