TY  - JOUR
AU  - Krkobabić, Ana
AU  - Radetić, Maja
AU  - Zille, Andrea
AU  - Ribeiro, Ana Isabel
AU  - Tadić, Vanja
AU  - Ilić-Tomić, Tatjana
AU  - Marković, Darka
PY  - 2024
UR  - https://www.mdpi.com/1420-3049/29/7/1447
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2335
AB  - The syntheses of Ag-based nanoparticles (NPs) with the assistance of plant extracts have been shown to be environmentally benign and cost-effective alternatives to conventional chemical syntheses. This study discusses the application of Paliurus spina-christi, Juglans regia, Humulus lupulus, and Sambucus nigra leaf extracts for in situ synthesis of Ag-based NPs on cotton fabric modified with citric acid. The presence of NPs with an average size ranging from 57 to 99 nm on the fiber surface was confirmed by FESEM. XPS analysis indicated that metallic (Ag0) and/or ionic silver (Ag2O and AgO) appeared on the surface of the modified cotton. The chemical composition, size, shape, and amounts of synthesized NPs were strongly dependent on the applied plant extract. All fabricated nanocomposites exhibited excellent antifungal activity against yeast Candida albicans. Antibacterial activity was significantly stronger against Gram-positive bacteria Staphylococcus aureus than Gram-negative bacteria Escherichia coli. In addition, 99% of silver was retained on the samples after 24 h of contact with physiological saline solution, implying a high stability of nanoparticles. Cytotoxic activity towards HaCaT and MRC5 cells was only observed for the sample synthetized in the presence of H. lupulus extract. Excellent antimicrobial activity and non-cytotoxicity make the developed composites efficient candidates for medicinal applications.
PB  - MDPI
T2  - Molecules
T2  - Molecules
T1  - Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies
IS  - 7
SP  - 1447
VL  - 29
DO  - 10.3390/molecules29071447
ER  - 

@article{
author = "Krkobabić, Ana and Radetić, Maja and Zille, Andrea and Ribeiro, Ana Isabel and Tadić, Vanja and Ilić-Tomić, Tatjana and Marković, Darka",
year = "2024",
abstract = "The syntheses of Ag-based nanoparticles (NPs) with the assistance of plant extracts have been shown to be environmentally benign and cost-effective alternatives to conventional chemical syntheses. This study discusses the application of Paliurus spina-christi, Juglans regia, Humulus lupulus, and Sambucus nigra leaf extracts for in situ synthesis of Ag-based NPs on cotton fabric modified with citric acid. The presence of NPs with an average size ranging from 57 to 99 nm on the fiber surface was confirmed by FESEM. XPS analysis indicated that metallic (Ag0) and/or ionic silver (Ag2O and AgO) appeared on the surface of the modified cotton. The chemical composition, size, shape, and amounts of synthesized NPs were strongly dependent on the applied plant extract. All fabricated nanocomposites exhibited excellent antifungal activity against yeast Candida albicans. Antibacterial activity was significantly stronger against Gram-positive bacteria Staphylococcus aureus than Gram-negative bacteria Escherichia coli. In addition, 99% of silver was retained on the samples after 24 h of contact with physiological saline solution, implying a high stability of nanoparticles. Cytotoxic activity towards HaCaT and MRC5 cells was only observed for the sample synthetized in the presence of H. lupulus extract. Excellent antimicrobial activity and non-cytotoxicity make the developed composites efficient candidates for medicinal applications.",
publisher = "MDPI",
journal = "Molecules, Molecules",
title = "Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies",
number = "7",
pages = "1447",
volume = "29",
doi = "10.3390/molecules29071447"
}

Krkobabić, A., Radetić, M., Zille, A., Ribeiro, A. I., Tadić, V., Ilić-Tomić, T.,& Marković, D.. (2024). Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies. in Molecules
MDPI., 29(7), 1447.
https://doi.org/10.3390/molecules29071447

Krkobabić A, Radetić M, Zille A, Ribeiro AI, Tadić V, Ilić-Tomić T, Marković D. Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies. in Molecules. 2024;29(7):1447.
doi:10.3390/molecules29071447 .

Krkobabić, Ana, Radetić, Maja, Zille, Andrea, Ribeiro, Ana Isabel, Tadić, Vanja, Ilić-Tomić, Tatjana, Marković, Darka, "Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies" in Molecules, 29, no. 7 (2024):1447,
https://doi.org/10.3390/molecules29071447 . .

TY  - JOUR
AU  - Vojnović, Sandra
AU  - Aleksić, Ivana
AU  - Ilić-Tomić, Tatjana
AU  - Stevanović, Milena
AU  - Nikodinović-Runić, Jasmina
PY  - 2024
UR  - https://doi.org/10.1007/s00253-023-12900-x
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2314
AB  - The application of enzymes is expanding across diverse industries due to their nontoxic and biodegradable characteristics. Another advantage is their cost-effectiveness, reflected in reduced processing time, water, and energy consumption. Although Gram-positive bacteria, Bacillus, and Streptomyces spp. are successfully used for production of industrially relevant enzymes, they still lag far behind Escherichia coli as hosts for recombinant protein production. Generally, proteins secreted by Bacillus and Streptomyces hosts are released into the culture medium; their native conformation is preserved and easier recovery process enabled. Given the resilience of both hosts in harsh environmental conditions and their spore-forming capability, a deeper understanding and broader use of Bacillus and Streptomyces as expression hosts could significantly enhance the robustness of industrial bioprocesses. This mini-review aims to compare two expression hosts, emphasizing their specific advantages in industrial surroundings such are chemical, detergent, textile, food, animal feed, leather, and paper industries. The homologous sources, heterologous hosts, and molecular tools used for the production of recombinant proteins in these hosts are discussed. The potential to use both hosts as biocatalysts is also evaluated. Undoubtedly, Bacillus and Streptomyces spp. as production hosts possess the potential to take on a more substantial role, providing superior (bio-based) process robustness and flexibility.
PB  - Springer Nature
T2  - Applied Microbiology and Biotechnology
T1  - Bacillus and Streptomyces spp. as hosts for production of industrially relevant enzymes
IS  - 1
SP  - 185
VL  - 108
DO  - 10.1007/s00253-023-12900-x
ER  - 

@article{
author = "Vojnović, Sandra and Aleksić, Ivana and Ilić-Tomić, Tatjana and Stevanović, Milena and Nikodinović-Runić, Jasmina",
year = "2024",
abstract = "The application of enzymes is expanding across diverse industries due to their nontoxic and biodegradable characteristics. Another advantage is their cost-effectiveness, reflected in reduced processing time, water, and energy consumption. Although Gram-positive bacteria, Bacillus, and Streptomyces spp. are successfully used for production of industrially relevant enzymes, they still lag far behind Escherichia coli as hosts for recombinant protein production. Generally, proteins secreted by Bacillus and Streptomyces hosts are released into the culture medium; their native conformation is preserved and easier recovery process enabled. Given the resilience of both hosts in harsh environmental conditions and their spore-forming capability, a deeper understanding and broader use of Bacillus and Streptomyces as expression hosts could significantly enhance the robustness of industrial bioprocesses. This mini-review aims to compare two expression hosts, emphasizing their specific advantages in industrial surroundings such are chemical, detergent, textile, food, animal feed, leather, and paper industries. The homologous sources, heterologous hosts, and molecular tools used for the production of recombinant proteins in these hosts are discussed. The potential to use both hosts as biocatalysts is also evaluated. Undoubtedly, Bacillus and Streptomyces spp. as production hosts possess the potential to take on a more substantial role, providing superior (bio-based) process robustness and flexibility.",
publisher = "Springer Nature",
journal = "Applied Microbiology and Biotechnology",
title = "Bacillus and Streptomyces spp. as hosts for production of industrially relevant enzymes",
number = "1",
pages = "185",
volume = "108",
doi = "10.1007/s00253-023-12900-x"
}

Vojnović, S., Aleksić, I., Ilić-Tomić, T., Stevanović, M.,& Nikodinović-Runić, J.. (2024). Bacillus and Streptomyces spp. as hosts for production of industrially relevant enzymes. in Applied Microbiology and Biotechnology
Springer Nature., 108(1), 185.
https://doi.org/10.1007/s00253-023-12900-x

Vojnović S, Aleksić I, Ilić-Tomić T, Stevanović M, Nikodinović-Runić J. Bacillus and Streptomyces spp. as hosts for production of industrially relevant enzymes. in Applied Microbiology and Biotechnology. 2024;108(1):185.
doi:10.1007/s00253-023-12900-x .

Vojnović, Sandra, Aleksić, Ivana, Ilić-Tomić, Tatjana, Stevanović, Milena, Nikodinović-Runić, Jasmina, "Bacillus and Streptomyces spp. as hosts for production of industrially relevant enzymes" in Applied Microbiology and Biotechnology, 108, no. 1 (2024):185,
https://doi.org/10.1007/s00253-023-12900-x . .

TY  - DATA
AU  - Pantelić, Brana
AU  - Škaro Bogojević, Sanja
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lončarević, Branka
AU  - Beskoski, Vladimir
AU  - Maslak, Veselin
AU  - Guzik, Maciej
AU  - Makryniotis, Konstantinos
AU  - Taxeidis, George
AU  - Siaperas, Romanos
AU  - Topakas, Evangelos
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://www.mdpi.com/2073-4344/13/2/278
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1792
T2  - Catalysts
T1  - Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278
IS  - 2
SP  - 278
VL  - 13
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1792
ER  - 

@misc{
author = "Pantelić, Brana and Škaro Bogojević, Sanja and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lončarević, Branka and Beskoski, Vladimir and Maslak, Veselin and Guzik, Maciej and Makryniotis, Konstantinos and Taxeidis, George and Siaperas, Romanos and Topakas, Evangelos and Nikodinović-Runić, Jasmina",
year = "2023",
journal = "Catalysts",
title = "Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278",
number = "2",
pages = "278",
volume = "13",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1792"
}

Pantelić, B., Škaro Bogojević, S., Milivojević, D., Ilić-Tomić, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E.,& Nikodinović-Runić, J.. (2023). Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278. in Catalysts, 13(2), 278.
https://hdl.handle.net/21.15107/rcub_imagine_1792

Pantelić B, Škaro Bogojević S, Milivojević D, Ilić-Tomić T, Lončarević B, Beskoski V, Maslak V, Guzik M, Makryniotis K, Taxeidis G, Siaperas R, Topakas E, Nikodinović-Runić J. Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278. in Catalysts. 2023;13(2):278.
https://hdl.handle.net/21.15107/rcub_imagine_1792 .

Pantelić, Brana, Škaro Bogojević, Sanja, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lončarević, Branka, Beskoski, Vladimir, Maslak, Veselin, Guzik, Maciej, Makryniotis, Konstantinos, Taxeidis, George, Siaperas, Romanos, Topakas, Evangelos, Nikodinović-Runić, Jasmina, "Supporting information: Pantelic, B., Skaro Bogojevic, S., Milivojevic, D., Ilic-Tomic, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E., & Nikodinovic-Runic, J. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. Catalysts, 13(2), Art. 2. https://doi.org/10.3390/catal13020278" in Catalysts, 13, no. 2 (2023):278,
https://hdl.handle.net/21.15107/rcub_imagine_1792 .

TY  - JOUR
AU  - Aksić, Jelena
AU  - Genčić, Marija
AU  - Radulović, Niko
AU  - Dimitrijević, Marina
AU  - Stojanović-Radić, Zorica
AU  - Ilić Tomić, Tatjana
AU  - Rodić, Marko
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0045206823003693
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2068
AB  - To improve the antiproliferative effect of ALC67 (diastereomeric mixture of ethyl 2-phenyl-3-propioloyl-1,3-thiazolidine-4-carboxylate), its structure was modified via (i) bioisosteric substitution of the phenyl ring by the ferrocene unit and (ii) replacing the propiolamide side-chain in ACL67 with other acyl groups having differing electrophilicities. In this way, a small library of methyl N-acyl-2-ferrocenyl-1,3-thiazolidine-4-carboxylates (13 compounds in total) was created and characterized by spectral and crystallographic means. The last N-acylation step was highly diastereoselective toward the cis-diastereomer. In solution, most of the obtained compounds existed as a mixture of two rotamers and displayed a preference for the syn-orientation around the CN bond. A twisted 5T4 envelope conformation was adopted by the derivative containing the N-phenoxyacetyl group in the crystalline state. Two derivatives with chloroacetyl and bromoacetyl groups in the N-3 side chain were cytotoxic to fibroblasts and hepatocellular cancer cells in the low micromolar range (IC50(MRC5) = 9.0 and 11.8 μM, respectively, and IC50(HepG2) = 10.6 and 18.4 μM, respectively) causing an effect similar to the lead compound (IC50(HepG2) = 10.0 μM) and cisplatin (IC50(MRC5) = 4.0 μM and IC50(HepG2) = 7.7 μM). Several derivatives also manifested modest antimicrobial effects against the studied microbial strains (MICs in the range from 0.44 to 4.0 μmol/mL). Our findings demonstrated that the introduction of a ferrocene core facilitated the preparation of optically pure analogs of ALC67 and that the cytotoxicity of compounds may be enhanced by adding proper electrophilic centers to the N-acyl side-chain.
T2  - Bioorganic Chemistry
T1  - Bioisosteric ferrocenyl 1,3-thiazolidine-4-carboxylic acid derivatives: In vitro antiproliferative and antimicrobial evaluations
SP  - 106708
VL  - 139
DO  - 10.1016/j.bioorg.2023.106708
ER  - 

@article{
author = "Aksić, Jelena and Genčić, Marija and Radulović, Niko and Dimitrijević, Marina and Stojanović-Radić, Zorica and Ilić Tomić, Tatjana and Rodić, Marko",
year = "2023",
abstract = "To improve the antiproliferative effect of ALC67 (diastereomeric mixture of ethyl 2-phenyl-3-propioloyl-1,3-thiazolidine-4-carboxylate), its structure was modified via (i) bioisosteric substitution of the phenyl ring by the ferrocene unit and (ii) replacing the propiolamide side-chain in ACL67 with other acyl groups having differing electrophilicities. In this way, a small library of methyl N-acyl-2-ferrocenyl-1,3-thiazolidine-4-carboxylates (13 compounds in total) was created and characterized by spectral and crystallographic means. The last N-acylation step was highly diastereoselective toward the cis-diastereomer. In solution, most of the obtained compounds existed as a mixture of two rotamers and displayed a preference for the syn-orientation around the CN bond. A twisted 5T4 envelope conformation was adopted by the derivative containing the N-phenoxyacetyl group in the crystalline state. Two derivatives with chloroacetyl and bromoacetyl groups in the N-3 side chain were cytotoxic to fibroblasts and hepatocellular cancer cells in the low micromolar range (IC50(MRC5) = 9.0 and 11.8 μM, respectively, and IC50(HepG2) = 10.6 and 18.4 μM, respectively) causing an effect similar to the lead compound (IC50(HepG2) = 10.0 μM) and cisplatin (IC50(MRC5) = 4.0 μM and IC50(HepG2) = 7.7 μM). Several derivatives also manifested modest antimicrobial effects against the studied microbial strains (MICs in the range from 0.44 to 4.0 μmol/mL). Our findings demonstrated that the introduction of a ferrocene core facilitated the preparation of optically pure analogs of ALC67 and that the cytotoxicity of compounds may be enhanced by adding proper electrophilic centers to the N-acyl side-chain.",
journal = "Bioorganic Chemistry",
title = "Bioisosteric ferrocenyl 1,3-thiazolidine-4-carboxylic acid derivatives: In vitro antiproliferative and antimicrobial evaluations",
pages = "106708",
volume = "139",
doi = "10.1016/j.bioorg.2023.106708"
}

Aksić, J., Genčić, M., Radulović, N., Dimitrijević, M., Stojanović-Radić, Z., Ilić Tomić, T.,& Rodić, M.. (2023). Bioisosteric ferrocenyl 1,3-thiazolidine-4-carboxylic acid derivatives: In vitro antiproliferative and antimicrobial evaluations. in Bioorganic Chemistry, 139, 106708.
https://doi.org/10.1016/j.bioorg.2023.106708

Aksić J, Genčić M, Radulović N, Dimitrijević M, Stojanović-Radić Z, Ilić Tomić T, Rodić M. Bioisosteric ferrocenyl 1,3-thiazolidine-4-carboxylic acid derivatives: In vitro antiproliferative and antimicrobial evaluations. in Bioorganic Chemistry. 2023;139:106708.
doi:10.1016/j.bioorg.2023.106708 .

Aksić, Jelena, Genčić, Marija, Radulović, Niko, Dimitrijević, Marina, Stojanović-Radić, Zorica, Ilić Tomić, Tatjana, Rodić, Marko, "Bioisosteric ferrocenyl 1,3-thiazolidine-4-carboxylic acid derivatives: In vitro antiproliferative and antimicrobial evaluations" in Bioorganic Chemistry, 139 (2023):106708,
https://doi.org/10.1016/j.bioorg.2023.106708 . .

TY  - CONF
AU  - Glišić, Biljana
AU  - Andrejević, Tina
AU  - Lazić, Jelena
AU  - Ilić-Tomić, Tatjana
AU  - Ašanin, Darko
AU  - Pantović, Bojana
AU  - Djuran, Miloš
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://isabc2023.com/
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1926
AB  - Prodigiosin (PG) is a red biopigment produced as a secondary metabolite by
microorganisms such as Serratia marcescens and Streptomyces. In recent years, this tripyrrole
compound has attracted an increasing attention due to its antibacterial, antimalarial, and
immunosuppressive activities [1]. It is also known for its antitumor activity, inducing the cell
death by apoptosis in different human cancer cell lines [2]. Considering this, in the present
study, we investigated the interactions of prodigiosin and its copper(II) complex (CuPG; the
structural formula is presented below), whose crystal structure was determined previously [2],
with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) by fluorescence emission
spectroscopy to clarify their binding affinities toward these biomolecules. The antimicrobial
activity of the synthesized CuPG complex and PG ligand was evaluated in vitro against various
microorganisms that can lead to many infections. Moreover, CuPG and PG were evaluated in
a cell viability assay on a healthy MRC-5 cell line, as well as a panel of MDA-MB-231, A549,
A375, and HCT116 cancer cell lines.
PB  - Greece : University of Ioannina
C3  - 16th International Symposium on Applied Bioinorganic Chemistry
T1  - DNA/BSA interactions and biological activity of prodigiosin and its
copper(II) complex
SP  - 264
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1926
ER  - 

@conference{
author = "Glišić, Biljana and Andrejević, Tina and Lazić, Jelena and Ilić-Tomić, Tatjana and Ašanin, Darko and Pantović, Bojana and Djuran, Miloš and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Prodigiosin (PG) is a red biopigment produced as a secondary metabolite by
microorganisms such as Serratia marcescens and Streptomyces. In recent years, this tripyrrole
compound has attracted an increasing attention due to its antibacterial, antimalarial, and
immunosuppressive activities [1]. It is also known for its antitumor activity, inducing the cell
death by apoptosis in different human cancer cell lines [2]. Considering this, in the present
study, we investigated the interactions of prodigiosin and its copper(II) complex (CuPG; the
structural formula is presented below), whose crystal structure was determined previously [2],
with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) by fluorescence emission
spectroscopy to clarify their binding affinities toward these biomolecules. The antimicrobial
activity of the synthesized CuPG complex and PG ligand was evaluated in vitro against various
microorganisms that can lead to many infections. Moreover, CuPG and PG were evaluated in
a cell viability assay on a healthy MRC-5 cell line, as well as a panel of MDA-MB-231, A549,
A375, and HCT116 cancer cell lines.",
publisher = "Greece : University of Ioannina",
journal = "16th International Symposium on Applied Bioinorganic Chemistry",
title = "DNA/BSA interactions and biological activity of prodigiosin and its
copper(II) complex",
pages = "264",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1926"
}

Glišić, B., Andrejević, T., Lazić, J., Ilić-Tomić, T., Ašanin, D., Pantović, B., Djuran, M.,& Nikodinović-Runić, J.. (2023). DNA/BSA interactions and biological activity of prodigiosin and its
copper(II) complex. in 16th International Symposium on Applied Bioinorganic Chemistry
Greece : University of Ioannina., 264.
https://hdl.handle.net/21.15107/rcub_imagine_1926

Glišić B, Andrejević T, Lazić J, Ilić-Tomić T, Ašanin D, Pantović B, Djuran M, Nikodinović-Runić J. DNA/BSA interactions and biological activity of prodigiosin and its
copper(II) complex. in 16th International Symposium on Applied Bioinorganic Chemistry. 2023;:264.
https://hdl.handle.net/21.15107/rcub_imagine_1926 .

Glišić, Biljana, Andrejević, Tina, Lazić, Jelena, Ilić-Tomić, Tatjana, Ašanin, Darko, Pantović, Bojana, Djuran, Miloš, Nikodinović-Runić, Jasmina, "DNA/BSA interactions and biological activity of prodigiosin and its
copper(II) complex" in 16th International Symposium on Applied Bioinorganic Chemistry (2023):264,
https://hdl.handle.net/21.15107/rcub_imagine_1926 .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Ilić-Tomić, Tatjana
AU  - Đorđević, Iris
AU  - Anđelković, Boban
AU  - Tesević, Vele
AU  - Milosavljević, Slobodan
AU  - Asakawa, Yoshinori
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0031942223001358
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1862
AB  - Bisbibenzyls are specialized metabolites found exclusively in liverworts, until recently; they represent chemical markers of liverworts. Their occurrence in vascular plants was noticed in 2007, when they were found in Primula veris subsp. macrocalyx from Russia. This report prompted us to chemically analyze the two most common Serbian Primula species, P. veris subsp. columnae and P. acaulis, in order to determine the presence of bisbibenzyls in them. Our study revealed nine structurally distinct bisbibenzyls (1–9), identified based on 1D and 2D NMR, IR, UV and HRESIMS data. Among them were five previously undescribed compounds (2–6). The remaining compounds found and previously described in the literature were: the bisbibenzyls riccardin C (1), isoperrottetin A (7), isoplagiochin E (8) and 11-O-demethylmarchantin I (9), as well as 4-hydroxyphenylmethylketone (10) and 4-hydroxy-3-methoxyphenylmethylketone (11). Riccardin C was the most dominant bisbibenzyl in both species studied. Previously, it was the first bisbibenzyl found in vascular plants (P. veris subsp. macrocalyx). An assessment of the cytotoxic activity of the isolated compounds against A549 lung cancer and healthy MRC5 cell lines was also the subject of our study. Compounds 6 and 9 exhibited significant cytotoxic activity expressed by IC50 values of 12 μM, but the selectivity was not satisfactory.
T2  - Phytochemistry
T2  - PhytochemistryPhytochemistry
T1  - Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L
SP  - 113719
VL  - 212
DO  - 10.1016/j.phytochem.2023.113719
ER  - 

@article{
author = "Novaković, Miroslav and Ilić-Tomić, Tatjana and Đorđević, Iris and Anđelković, Boban and Tesević, Vele and Milosavljević, Slobodan and Asakawa, Yoshinori",
year = "2023",
abstract = "Bisbibenzyls are specialized metabolites found exclusively in liverworts, until recently; they represent chemical markers of liverworts. Their occurrence in vascular plants was noticed in 2007, when they were found in Primula veris subsp. macrocalyx from Russia. This report prompted us to chemically analyze the two most common Serbian Primula species, P. veris subsp. columnae and P. acaulis, in order to determine the presence of bisbibenzyls in them. Our study revealed nine structurally distinct bisbibenzyls (1–9), identified based on 1D and 2D NMR, IR, UV and HRESIMS data. Among them were five previously undescribed compounds (2–6). The remaining compounds found and previously described in the literature were: the bisbibenzyls riccardin C (1), isoperrottetin A (7), isoplagiochin E (8) and 11-O-demethylmarchantin I (9), as well as 4-hydroxyphenylmethylketone (10) and 4-hydroxy-3-methoxyphenylmethylketone (11). Riccardin C was the most dominant bisbibenzyl in both species studied. Previously, it was the first bisbibenzyl found in vascular plants (P. veris subsp. macrocalyx). An assessment of the cytotoxic activity of the isolated compounds against A549 lung cancer and healthy MRC5 cell lines was also the subject of our study. Compounds 6 and 9 exhibited significant cytotoxic activity expressed by IC50 values of 12 μM, but the selectivity was not satisfactory.",
journal = "Phytochemistry, PhytochemistryPhytochemistry",
title = "Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L",
pages = "113719",
volume = "212",
doi = "10.1016/j.phytochem.2023.113719"
}

Novaković, M., Ilić-Tomić, T., Đorđević, I., Anđelković, B., Tesević, V., Milosavljević, S.,& Asakawa, Y.. (2023). Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L. in Phytochemistry, 212, 113719.
https://doi.org/10.1016/j.phytochem.2023.113719

Novaković M, Ilić-Tomić T, Đorđević I, Anđelković B, Tesević V, Milosavljević S, Asakawa Y. Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L. in Phytochemistry. 2023;212:113719.
doi:10.1016/j.phytochem.2023.113719 .

Novaković, Miroslav, Ilić-Tomić, Tatjana, Đorđević, Iris, Anđelković, Boban, Tesević, Vele, Milosavljević, Slobodan, Asakawa, Yoshinori, "Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L" in Phytochemistry, 212 (2023):113719,
https://doi.org/10.1016/j.phytochem.2023.113719 . .

TY  - JOUR
AU  - Marković, Darka
AU  - Petkovska, Jovana
AU  - Mladenović, Nina
AU  - Radoičić, Marija
AU  - Rodriguez-Melendez, Danixa
AU  - Ilić-Tomić, Tatjana
AU  - Radetić, Maja
AU  - Grunlan, Jaime
AU  - Jordanov, Igor
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1794
AB  - Poor antimicrobial activity and lack of protection against UV irradiation are weaknesses of cotton

textiles. In an attempt to impart superior antimicrobial and UV-protective properties to cotton, layer-by-
layer deposition of chitosan and magnesium lignosulfonate, and in situ synthesis of silver (Ag)

nanoparticles (NPs), was performed. Lignin, in a chitosan/lignin multilayer, simultaneously acts as a UV
protective macromolecule and natural reducing and stabilizing agent, allowing formation of Ag NPs. Four
bilayers of this coating is sufficient for fabrication of a chitosan/lignin/Ag-NP textile nanocomposite

treatment with 50+ UV protection. 100% reduction of Gram-negative bacteria Escherichia coli, gram-
positive bacteria Staphylococcus aureus, and yeast Candida albicans can be achieved with a 12-bilayer

coating, when 20 mM silver nitrate solution and sodium borohydride are applied. On the other hand,
four bilayers impregnated with Ag NPs, using 10 mM silver nitrate solution, provides sufficient
antimicrobial activity independent of an added reducing agent. This treatment exhibits no inhibition of
human keratinocyte cells growth on the skin, indicating low cytotoxicity.
PB  - Wiley Periodicals, LLC.
T2  - Journal of Applied Polymer Science
T1  - Antimicrobial and UV protective chitosan/lignin multilayer nanocoating with immobilized silver nanoparticles
DO  - 10.1002/app.53823
ER  - 

@article{
author = "Marković, Darka and Petkovska, Jovana and Mladenović, Nina and Radoičić, Marija and Rodriguez-Melendez, Danixa and Ilić-Tomić, Tatjana and Radetić, Maja and Grunlan, Jaime and Jordanov, Igor",
year = "2023",
abstract = "Poor antimicrobial activity and lack of protection against UV irradiation are weaknesses of cotton

textiles. In an attempt to impart superior antimicrobial and UV-protective properties to cotton, layer-by-
layer deposition of chitosan and magnesium lignosulfonate, and in situ synthesis of silver (Ag)

nanoparticles (NPs), was performed. Lignin, in a chitosan/lignin multilayer, simultaneously acts as a UV
protective macromolecule and natural reducing and stabilizing agent, allowing formation of Ag NPs. Four
bilayers of this coating is sufficient for fabrication of a chitosan/lignin/Ag-NP textile nanocomposite

treatment with 50+ UV protection. 100% reduction of Gram-negative bacteria Escherichia coli, gram-
positive bacteria Staphylococcus aureus, and yeast Candida albicans can be achieved with a 12-bilayer

coating, when 20 mM silver nitrate solution and sodium borohydride are applied. On the other hand,
four bilayers impregnated with Ag NPs, using 10 mM silver nitrate solution, provides sufficient
antimicrobial activity independent of an added reducing agent. This treatment exhibits no inhibition of
human keratinocyte cells growth on the skin, indicating low cytotoxicity.",
publisher = "Wiley Periodicals, LLC.",
journal = "Journal of Applied Polymer Science",
title = "Antimicrobial and UV protective chitosan/lignin multilayer nanocoating with immobilized silver nanoparticles",
doi = "10.1002/app.53823"
}

Marković, D., Petkovska, J., Mladenović, N., Radoičić, M., Rodriguez-Melendez, D., Ilić-Tomić, T., Radetić, M., Grunlan, J.,& Jordanov, I.. (2023). Antimicrobial and UV protective chitosan/lignin multilayer nanocoating with immobilized silver nanoparticles. in Journal of Applied Polymer Science
Wiley Periodicals, LLC...
https://doi.org/10.1002/app.53823

Marković D, Petkovska J, Mladenović N, Radoičić M, Rodriguez-Melendez D, Ilić-Tomić T, Radetić M, Grunlan J, Jordanov I. Antimicrobial and UV protective chitosan/lignin multilayer nanocoating with immobilized silver nanoparticles. in Journal of Applied Polymer Science. 2023;.
doi:10.1002/app.53823 .

Marković, Darka, Petkovska, Jovana, Mladenović, Nina, Radoičić, Marija, Rodriguez-Melendez, Danixa, Ilić-Tomić, Tatjana, Radetić, Maja, Grunlan, Jaime, Jordanov, Igor, "Antimicrobial and UV protective chitosan/lignin multilayer nanocoating with immobilized silver nanoparticles" in Journal of Applied Polymer Science (2023),
https://doi.org/10.1002/app.53823 . .

TY  - CONF
AU  - Lazić, Jelena
AU  - Milovanović, Jelena
AU  - Anejević, Tina
AU  - Ašanin, Darko
AU  - Ilić-Tomić, Tatjana
AU  - Glišić, Biljana
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://afea.eventsair.com/10th-conference-of-mikrobiokosmos/abstract-book
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2235
AB  - Prodigiosin (PG, Fig. 1a) is a biologically active
pyrrolylpyrromethene alkaloid whose structure was
first confirmed in 1962 [1]. PG is commonly
produced by Gram-negative bacteria, such as
Serratia spp. and has an eco-physiological role [2].
Its biological activities were extensively researched,
and numerous pharmacological properties were
established, including anticancer and
immunosuppressive However, high cost of extraction and purification
still represent the bottleneck in the microbial
production of PG. Meat and fish processing wastes have high potential as raw materials for conversion
into useful products of higher value. In this study,
meat offcuts were assessed as the sole nutrient for
the fermentative production of PG from S.
marcescens. Using this substrate lowered the
cultivation medium cost and shortened the
fermentation time to 12 h, while allowing a
satisfying PG yield of 83.1 mg/L. The isolated PG
was used in one-step reactions with CuCl₂ or ZnCl₂
in terc-BuOH at 25 °C. The obtained [Cu(PG)Cl] (Fig.
1b) and [Zn(PG)₂] (Fig. 1c) complexes were
characterized by UV-Vis and IR spectroscopy and
their bioactivity potential was assessed.
Antimicrobial activity was assessed in a disc assay
against 4 human pathogens: Escherichia coli NCTC
9001, Pseudomonas aeruginosa ATCC 10332,
Staphylococcus aureus NCTC 6571, Candida
albicans ATCC 10231, but no effect was observed
for the tested concentrations of 200 μg per disc and
lower. However, the anticancer potential of the new
derivatives is promising and the bovine serum
albumin (BSA) binding study revealed that
complexes bind to BSA tightly and reversibly [4].
C3  - 10th Conference of Mikrobiokosmos
T1  - Biotechnological production of bacterial pigment prodigiosin and bioactive properties of its metal complexes with Cu(II) and Zn(II)
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2235
ER  - 

@conference{
author = "Lazić, Jelena and Milovanović, Jelena and Anejević, Tina and Ašanin, Darko and Ilić-Tomić, Tatjana and Glišić, Biljana and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Prodigiosin (PG, Fig. 1a) is a biologically active
pyrrolylpyrromethene alkaloid whose structure was
first confirmed in 1962 [1]. PG is commonly
produced by Gram-negative bacteria, such as
Serratia spp. and has an eco-physiological role [2].
Its biological activities were extensively researched,
and numerous pharmacological properties were
established, including anticancer and
immunosuppressive However, high cost of extraction and purification
still represent the bottleneck in the microbial
production of PG. Meat and fish processing wastes have high potential as raw materials for conversion
into useful products of higher value. In this study,
meat offcuts were assessed as the sole nutrient for
the fermentative production of PG from S.
marcescens. Using this substrate lowered the
cultivation medium cost and shortened the
fermentation time to 12 h, while allowing a
satisfying PG yield of 83.1 mg/L. The isolated PG
was used in one-step reactions with CuCl₂ or ZnCl₂
in terc-BuOH at 25 °C. The obtained [Cu(PG)Cl] (Fig.
1b) and [Zn(PG)₂] (Fig. 1c) complexes were
characterized by UV-Vis and IR spectroscopy and
their bioactivity potential was assessed.
Antimicrobial activity was assessed in a disc assay
against 4 human pathogens: Escherichia coli NCTC
9001, Pseudomonas aeruginosa ATCC 10332,
Staphylococcus aureus NCTC 6571, Candida
albicans ATCC 10231, but no effect was observed
for the tested concentrations of 200 μg per disc and
lower. However, the anticancer potential of the new
derivatives is promising and the bovine serum
albumin (BSA) binding study revealed that
complexes bind to BSA tightly and reversibly [4].",
journal = "10th Conference of Mikrobiokosmos",
title = "Biotechnological production of bacterial pigment prodigiosin and bioactive properties of its metal complexes with Cu(II) and Zn(II)",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2235"
}

Lazić, J., Milovanović, J., Anejević, T., Ašanin, D., Ilić-Tomić, T., Glišić, B.,& Nikodinović-Runić, J.. (2023). Biotechnological production of bacterial pigment prodigiosin and bioactive properties of its metal complexes with Cu(II) and Zn(II). in 10th Conference of Mikrobiokosmos.
https://hdl.handle.net/21.15107/rcub_imagine_2235

Lazić J, Milovanović J, Anejević T, Ašanin D, Ilić-Tomić T, Glišić B, Nikodinović-Runić J. Biotechnological production of bacterial pigment prodigiosin and bioactive properties of its metal complexes with Cu(II) and Zn(II). in 10th Conference of Mikrobiokosmos. 2023;.
https://hdl.handle.net/21.15107/rcub_imagine_2235 .

Lazić, Jelena, Milovanović, Jelena, Anejević, Tina, Ašanin, Darko, Ilić-Tomić, Tatjana, Glišić, Biljana, Nikodinović-Runić, Jasmina, "Biotechnological production of bacterial pigment prodigiosin and bioactive properties of its metal complexes with Cu(II) and Zn(II)" in 10th Conference of Mikrobiokosmos (2023),
https://hdl.handle.net/21.15107/rcub_imagine_2235 .

TY  - JOUR
AU  - Babić Radić, Marija
AU  - Filipović, Vuk
AU  - Vuković, Jovana
AU  - Vukomanović, Marija
AU  - Ilić-Tomić, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2023
UR  - https://www.mdpi.com/2073-4360/15/7/1643
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1799
AB  - The idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33–65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.
T2  - Polymers
T2  - Polymers
T1  - 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform
IS  - 7
SP  - 1643
VL  - 15
DO  - 10.3390/polym15071643
ER  - 

@article{
author = "Babić Radić, Marija and Filipović, Vuk and Vuković, Jovana and Vukomanović, Marija and Ilić-Tomić, Tatjana and Nikodinović-Runić, Jasmina and Tomić, Simonida",
year = "2023",
abstract = "The idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33–65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.",
journal = "Polymers, Polymers",
title = "2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform",
number = "7",
pages = "1643",
volume = "15",
doi = "10.3390/polym15071643"
}

Babić Radić, M., Filipović, V., Vuković, J., Vukomanović, M., Ilić-Tomić, T., Nikodinović-Runić, J.,& Tomić, S.. (2023). 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform. in Polymers, 15(7), 1643.
https://doi.org/10.3390/polym15071643

Babić Radić M, Filipović V, Vuković J, Vukomanović M, Ilić-Tomić T, Nikodinović-Runić J, Tomić S. 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform. in Polymers. 2023;15(7):1643.
doi:10.3390/polym15071643 .

Babić Radić, Marija, Filipović, Vuk, Vuković, Jovana, Vukomanović, Marija, Ilić-Tomić, Tatjana, Nikodinović-Runić, Jasmina, Tomić, Simonida, "2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform" in Polymers, 15, no. 7 (2023):1643,
https://doi.org/10.3390/polym15071643 . .

TY  - CONF
AU  - Stevanović, Milena
AU  - Janković, Vukašin
AU  - Filipović, Vuk
AU  - Ilić-Tomić, Tatjana
AU  - Vojnović, Sandra
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1915
AB  - The genus Streptomyces has been studied for the vast secondary metabolite
production, biological activity of crude extracts, as well as colouring properties on textile
materials [1, 2]. Streptomyces sp. BV365 is a potent producer of yellow pigments, used to
efficiently colour different natural textiles [3]. Utilization of food waste for bacterial growth
and production of pigments and antifungals [4] could contribute to conversion of waste to
valuable molecules, providing more economically acceptable and more eco-friendly
generated biotherapeutics, enzymes and pigments.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023
T1  - Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365
EP  - 168
SP  - 167
VL  - 9
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1915
ER  - 

@conference{
author = "Stevanović, Milena and Janković, Vukašin and Filipović, Vuk and Ilić-Tomić, Tatjana and Vojnović, Sandra",
year = "2023",
abstract = "The genus Streptomyces has been studied for the vast secondary metabolite
production, biological activity of crude extracts, as well as colouring properties on textile
materials [1, 2]. Streptomyces sp. BV365 is a potent producer of yellow pigments, used to
efficiently colour different natural textiles [3]. Utilization of food waste for bacterial growth
and production of pigments and antifungals [4] could contribute to conversion of waste to
valuable molecules, providing more economically acceptable and more eco-friendly
generated biotherapeutics, enzymes and pigments.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023",
title = "Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365",
pages = "168-167",
volume = "9",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1915"
}

Stevanović, M., Janković, V., Filipović, V., Ilić-Tomić, T.,& Vojnović, S.. (2023). Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365. in 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023
Beograd : Srpsko hemijsko društvo., 9, 167-168.
https://hdl.handle.net/21.15107/rcub_imagine_1915

Stevanović M, Janković V, Filipović V, Ilić-Tomić T, Vojnović S. Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365. in 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023. 2023;9:167-168.
https://hdl.handle.net/21.15107/rcub_imagine_1915 .

Stevanović, Milena, Janković, Vukašin, Filipović, Vuk, Ilić-Tomić, Tatjana, Vojnović, Sandra, "Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365" in 9. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, EnviroChem2023, 9 (2023):167-168,
https://hdl.handle.net/21.15107/rcub_imagine_1915 .

TY  - JOUR
AU  - Pantelić, Brana
AU  - Škaro Bogojević, Sanja
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lončarević, Branka
AU  - Beskoski, Vladimir
AU  - Maslak, Veselin
AU  - Guzik, Maciej
AU  - Makryniotis, Konstantinos
AU  - Taxeidis, George
AU  - Siaperas, Romanos
AU  - Topakas, Evangelos
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://www.mdpi.com/2073-4344/13/2/278
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1790
AB  - Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.
T2  - Catalysts
T2  - Catalysts
T1  - Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts
IS  - 2
SP  - 278
VL  - 13
DO  - 10.3390/catal13020278
ER  - 

@article{
author = "Pantelić, Brana and Škaro Bogojević, Sanja and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lončarević, Branka and Beskoski, Vladimir and Maslak, Veselin and Guzik, Maciej and Makryniotis, Konstantinos and Taxeidis, George and Siaperas, Romanos and Topakas, Evangelos and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.",
journal = "Catalysts, Catalysts",
title = "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts",
number = "2",
pages = "278",
volume = "13",
doi = "10.3390/catal13020278"
}

Pantelić, B., Škaro Bogojević, S., Milivojević, D., Ilić-Tomić, T., Lončarević, B., Beskoski, V., Maslak, V., Guzik, M., Makryniotis, K., Taxeidis, G., Siaperas, R., Topakas, E.,& Nikodinović-Runić, J.. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts, 13(2), 278.
https://doi.org/10.3390/catal13020278

Pantelić B, Škaro Bogojević S, Milivojević D, Ilić-Tomić T, Lončarević B, Beskoski V, Maslak V, Guzik M, Makryniotis K, Taxeidis G, Siaperas R, Topakas E, Nikodinović-Runić J. Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts. 2023;13(2):278.
doi:10.3390/catal13020278 .

Pantelić, Brana, Škaro Bogojević, Sanja, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lončarević, Branka, Beskoski, Vladimir, Maslak, Veselin, Guzik, Maciej, Makryniotis, Konstantinos, Taxeidis, George, Siaperas, Romanos, Topakas, Evangelos, Nikodinović-Runić, Jasmina, "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts" in Catalysts, 13, no. 2 (2023):278,
https://doi.org/10.3390/catal13020278 . .

TY  - JOUR
AU  - Pantelić, Lena
AU  - Bogojević Škaro, Sanja
AU  - Vojnović, Sandra
AU  - Oliveira, Rui
AU  - Lazić, Jelena
AU  - Ilić-Tomić, Tatjana
AU  - Milivojević, Dušan
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0141022923001308
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2078
AB  - Phenazines, including pyocyanin (PYO) and 1-hydroxyphenazine (1-HP) are extracellular secondary metabolites and multifunctional pigments of Pseudomonas aeruginosa responsible for its blue-green color. These versatile molecules are electrochemically active, involved in significant biological activities giving fitness to the host, but also recognized as antimicrobial and anticancer agents. Their wider application is still limited partly due to the cost of carbon substrate for production, which can be solved by the utilization of carbon from food waste within the biorefinery concept. In this study, a variety of food waste streams (banana peel, potato peel, potato washing, stale bread, yoghurt, processed meat, boiled eggs and mixed canteen waste) was used as sole nutrient source in submerged cultures of P. aeruginosa BK25H. Stale bread was identified as the most suitable substrate to support phenazine biopigments production and bacterial growth. This was further increased in 5-liter fermenter when on average 5.2mgL-1 of PYO and 4.4mgL-1 of 1-HP were purified after 24h batch cultivations from the fermentation medium consisting of homogenized stale bread in tap water. Purified biopigments showed moderate antimicrobial activity, and showed different toxicity profiles, with PYO not being toxic against Caenorhabditis elegans, a free-living soil nematode up to 300µgmL-1 and 1-HP showing lethal effects at 75µgmL-1. Therefore, stale bread waste stream with minimal pretreatment should be considered as suitable biorefinery feedstock, as it can support the production of valuable biopigments such as phenazines.
T2  - Enzyme and Microbial Technology
T1  - Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine
SP  - 110322
VL  - 171
DO  - 10.1016/j.enzmictec.2023.110322
ER  - 

@article{
author = "Pantelić, Lena and Bogojević Škaro, Sanja and Vojnović, Sandra and Oliveira, Rui and Lazić, Jelena and Ilić-Tomić, Tatjana and Milivojević, Dušan and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Phenazines, including pyocyanin (PYO) and 1-hydroxyphenazine (1-HP) are extracellular secondary metabolites and multifunctional pigments of Pseudomonas aeruginosa responsible for its blue-green color. These versatile molecules are electrochemically active, involved in significant biological activities giving fitness to the host, but also recognized as antimicrobial and anticancer agents. Their wider application is still limited partly due to the cost of carbon substrate for production, which can be solved by the utilization of carbon from food waste within the biorefinery concept. In this study, a variety of food waste streams (banana peel, potato peel, potato washing, stale bread, yoghurt, processed meat, boiled eggs and mixed canteen waste) was used as sole nutrient source in submerged cultures of P. aeruginosa BK25H. Stale bread was identified as the most suitable substrate to support phenazine biopigments production and bacterial growth. This was further increased in 5-liter fermenter when on average 5.2mgL-1 of PYO and 4.4mgL-1 of 1-HP were purified after 24h batch cultivations from the fermentation medium consisting of homogenized stale bread in tap water. Purified biopigments showed moderate antimicrobial activity, and showed different toxicity profiles, with PYO not being toxic against Caenorhabditis elegans, a free-living soil nematode up to 300µgmL-1 and 1-HP showing lethal effects at 75µgmL-1. Therefore, stale bread waste stream with minimal pretreatment should be considered as suitable biorefinery feedstock, as it can support the production of valuable biopigments such as phenazines.",
journal = "Enzyme and Microbial Technology",
title = "Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine",
pages = "110322",
volume = "171",
doi = "10.1016/j.enzmictec.2023.110322"
}

Pantelić, L., Bogojević Škaro, S., Vojnović, S., Oliveira, R., Lazić, J., Ilić-Tomić, T., Milivojević, D.,& Nikodinović-Runić, J.. (2023). Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine. in Enzyme and Microbial Technology, 171, 110322.
https://doi.org/10.1016/j.enzmictec.2023.110322

Pantelić L, Bogojević Škaro S, Vojnović S, Oliveira R, Lazić J, Ilić-Tomić T, Milivojević D, Nikodinović-Runić J. Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine. in Enzyme and Microbial Technology. 2023;171:110322.
doi:10.1016/j.enzmictec.2023.110322 .

Pantelić, Lena, Bogojević Škaro, Sanja, Vojnović, Sandra, Oliveira, Rui, Lazić, Jelena, Ilić-Tomić, Tatjana, Milivojević, Dušan, Nikodinović-Runić, Jasmina, "Upcycling of food waste streams to valuable biopigments pyocyanin and 1-hydroxyphenazine" in Enzyme and Microbial Technology, 171 (2023):110322,
https://doi.org/10.1016/j.enzmictec.2023.110322 . .

TY  - CONF
AU  - Janković, Vukašin
AU  - Nikodinović-Runić, Jasmina
AU  - Radetić, Maja
AU  - Marković, Darka
AU  - Stevanović, Milena
AU  - Nenadović, Marija
AU  - Ilić-Tomić, Tatjana
PY  - 2023
UR  - https://www.fems2023.org/
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2026
AB  - Microorganisms, especially soil-dwelling Streptomyces, have the potential to both degrade
and colour a variety of textiles. Pigments from Streptomycetes could serve as colouring
agents for different natural and synthetic fabrics. Apart from pigments, Streptomyces can
produce a variety of enzymes. Several of these enzymes show favourable application in the
depolymerization of synthetic materials such as polyamide and polyurethane.
The aim of this study was the assessment of live interactions of pigmented Streptomyces
strains from the lab collection using polyamide (PA) and Polyamide/Elastane (PA/EA) knits
as substrates.
Cultivation of pigment-producing Streptomyces strains was done following the standard
microbiological protocols, using two different growth media with the addition of PA and
PA/EA knits into flasks. Cultures were incubated at 30°C for 7 and 14 days under static and
dynamic conditions. Materials were recovered and their colour coordinates, colour difference
(ΔE), and fastness were determined, and their surface changes were examined by Scanning
Electron Microscopy (SEM).
The incubation of knits with living bacterial cultures resulted in both live dyeing and
degradation, depending on the strain used. The intensity of color yield was larger under
dynamic culture conditions. Therefore, Streptomyces strains could be successfully applied in
the development of greener dyeing and degradation bioprocesses.
C3  - FEMS2023 Congress of European Microbiologists
T1  - Microbial live interactions with textiles
EP  - 835
EP  - 835
SP  - 835
VL  - 10
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2026
ER  - 

@conference{
author = "Janković, Vukašin and Nikodinović-Runić, Jasmina and Radetić, Maja and Marković, Darka and Stevanović, Milena and Nenadović, Marija and Ilić-Tomić, Tatjana",
year = "2023",
abstract = "Microorganisms, especially soil-dwelling Streptomyces, have the potential to both degrade
and colour a variety of textiles. Pigments from Streptomycetes could serve as colouring
agents for different natural and synthetic fabrics. Apart from pigments, Streptomyces can
produce a variety of enzymes. Several of these enzymes show favourable application in the
depolymerization of synthetic materials such as polyamide and polyurethane.
The aim of this study was the assessment of live interactions of pigmented Streptomyces
strains from the lab collection using polyamide (PA) and Polyamide/Elastane (PA/EA) knits
as substrates.
Cultivation of pigment-producing Streptomyces strains was done following the standard
microbiological protocols, using two different growth media with the addition of PA and
PA/EA knits into flasks. Cultures were incubated at 30°C for 7 and 14 days under static and
dynamic conditions. Materials were recovered and their colour coordinates, colour difference
(ΔE), and fastness were determined, and their surface changes were examined by Scanning
Electron Microscopy (SEM).
The incubation of knits with living bacterial cultures resulted in both live dyeing and
degradation, depending on the strain used. The intensity of color yield was larger under
dynamic culture conditions. Therefore, Streptomyces strains could be successfully applied in
the development of greener dyeing and degradation bioprocesses.",
journal = "FEMS2023 Congress of European Microbiologists",
title = "Microbial live interactions with textiles",
pages = "835-835-835",
volume = "10",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2026"
}

Janković, V., Nikodinović-Runić, J., Radetić, M., Marković, D., Stevanović, M., Nenadović, M.,& Ilić-Tomić, T.. (2023). Microbial live interactions with textiles. in FEMS2023 Congress of European Microbiologists, 10, 835-835.
https://hdl.handle.net/21.15107/rcub_imagine_2026

Janković V, Nikodinović-Runić J, Radetić M, Marković D, Stevanović M, Nenadović M, Ilić-Tomić T. Microbial live interactions with textiles. in FEMS2023 Congress of European Microbiologists. 2023;10:835-835.
https://hdl.handle.net/21.15107/rcub_imagine_2026 .

Janković, Vukašin, Nikodinović-Runić, Jasmina, Radetić, Maja, Marković, Darka, Stevanović, Milena, Nenadović, Marija, Ilić-Tomić, Tatjana, "Microbial live interactions with textiles" in FEMS2023 Congress of European Microbiologists, 10 (2023):835-835,
https://hdl.handle.net/21.15107/rcub_imagine_2026 .

TY  - JOUR
AU  - Krkobabić, Ana
AU  - Radetić, Maja
AU  - Tseng, Hsiang-Han
AU  - Nunney, Tim S.
AU  - Tadić, Vanja
AU  - Ilic-Tomic, Tatjana
AU  - Marković, Darka
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1668
AB  - The demand for medical textiles in various forms with strong antimicrobial activity drastically increased during the COVID19 pandemic. In an attempt to tackle this issue and to develop antimicrobial textiles in more environmentally benign manner, a viscose fabric after coating with biopolymer chitosan has been impregnated with Ag- and Cu-based nanoparticles. Chitosan was applied in the presence and absence of cross-linker 1,2,3,4-butanetetracarboxylic acid (BTCA). In situ green synthesis of nanoparticles was performed using a Punica granatum (pomegranate) peel extract as a reducing and stabilizing agent. Formation of nanoparticles on the fiber surface was confirmed by FESEM. Elemental analysis by XPS showed the synthesized nanoparticles exist as AgCl and a mixture of Cu/CuO/Cu2O in the modified samples. Moreover, these nanoparticles appeared to be present not only on the sample surface but also buried within the fibers, as indicated by XPS mapping and depth profiling measurements. All impregnated fabrics exhibited excellent antifungal activity providing the maximum reduction of yeast Candida albicans colonies. Antibacterial activity was stronger against Gram-negative bacteria Escherichia coli than Gram-positive bacteria Staphylococcus aureus, and it was highly influenced by metal content. The fabrics impregnated with AgCl nanoparticles showed lower cytotoxicity towards human keratinocyte cells.
T2  - Applied Surface Science
T2  - Applied Surface ScienceApplied Surface Science
T1  - Green in situ synthesis of Ag- and Cu-based nanoparticles on viscose fabric using a Punica granatum peel extract
SP  - 155612
VL  - 611
DO  - 10.1016/j.apsusc.2022.155612
ER  - 

@article{
author = "Krkobabić, Ana and Radetić, Maja and Tseng, Hsiang-Han and Nunney, Tim S. and Tadić, Vanja and Ilic-Tomic, Tatjana and Marković, Darka",
year = "2023",
abstract = "The demand for medical textiles in various forms with strong antimicrobial activity drastically increased during the COVID19 pandemic. In an attempt to tackle this issue and to develop antimicrobial textiles in more environmentally benign manner, a viscose fabric after coating with biopolymer chitosan has been impregnated with Ag- and Cu-based nanoparticles. Chitosan was applied in the presence and absence of cross-linker 1,2,3,4-butanetetracarboxylic acid (BTCA). In situ green synthesis of nanoparticles was performed using a Punica granatum (pomegranate) peel extract as a reducing and stabilizing agent. Formation of nanoparticles on the fiber surface was confirmed by FESEM. Elemental analysis by XPS showed the synthesized nanoparticles exist as AgCl and a mixture of Cu/CuO/Cu2O in the modified samples. Moreover, these nanoparticles appeared to be present not only on the sample surface but also buried within the fibers, as indicated by XPS mapping and depth profiling measurements. All impregnated fabrics exhibited excellent antifungal activity providing the maximum reduction of yeast Candida albicans colonies. Antibacterial activity was stronger against Gram-negative bacteria Escherichia coli than Gram-positive bacteria Staphylococcus aureus, and it was highly influenced by metal content. The fabrics impregnated with AgCl nanoparticles showed lower cytotoxicity towards human keratinocyte cells.",
journal = "Applied Surface Science, Applied Surface ScienceApplied Surface Science",
title = "Green in situ synthesis of Ag- and Cu-based nanoparticles on viscose fabric using a Punica granatum peel extract",
pages = "155612",
volume = "611",
doi = "10.1016/j.apsusc.2022.155612"
}

Krkobabić, A., Radetić, M., Tseng, H., Nunney, T. S., Tadić, V., Ilic-Tomic, T.,& Marković, D.. (2023). Green in situ synthesis of Ag- and Cu-based nanoparticles on viscose fabric using a Punica granatum peel extract. in Applied Surface Science, 611, 155612.
https://doi.org/10.1016/j.apsusc.2022.155612

Krkobabić A, Radetić M, Tseng H, Nunney TS, Tadić V, Ilic-Tomic T, Marković D. Green in situ synthesis of Ag- and Cu-based nanoparticles on viscose fabric using a Punica granatum peel extract. in Applied Surface Science. 2023;611:155612.
doi:10.1016/j.apsusc.2022.155612 .

Krkobabić, Ana, Radetić, Maja, Tseng, Hsiang-Han, Nunney, Tim S., Tadić, Vanja, Ilic-Tomic, Tatjana, Marković, Darka, "Green in situ synthesis of Ag- and Cu-based nanoparticles on viscose fabric using a Punica granatum peel extract" in Applied Surface Science, 611 (2023):155612,
https://doi.org/10.1016/j.apsusc.2022.155612 . .

TY  - JOUR
AU  - Vuković, Jovana S.
AU  - Filipović, Vuk V.
AU  - Babić Radić, Marija M.
AU  - Vukomanović, Marija
AU  - Milivojević, Dušan
AU  - Ilic-Tomic, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida Lj
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1669
AB  - Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.
T2  - Polymers
T2  - Polymers
T1  - In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds
IS  - 20
SP  - 4459
VL  - 14
DO  - 10.3390/polym14204459
ER  - 

@article{
author = "Vuković, Jovana S. and Filipović, Vuk V. and Babić Radić, Marija M. and Vukomanović, Marija and Milivojević, Dušan and Ilic-Tomic, Tatjana and Nikodinović-Runić, Jasmina and Tomić, Simonida Lj",
year = "2022",
abstract = "Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.",
journal = "Polymers, Polymers",
title = "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds",
number = "20",
pages = "4459",
volume = "14",
doi = "10.3390/polym14204459"
}

Vuković, J. S., Filipović, V. V., Babić Radić, M. M., Vukomanović, M., Milivojević, D., Ilic-Tomic, T., Nikodinović-Runić, J.,& Tomić, S. L.. (2022). In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers, 14(20), 4459.
https://doi.org/10.3390/polym14204459

Vuković JS, Filipović VV, Babić Radić MM, Vukomanović M, Milivojević D, Ilic-Tomic T, Nikodinović-Runić J, Tomić SL. In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers. 2022;14(20):4459.
doi:10.3390/polym14204459 .

Vuković, Jovana S., Filipović, Vuk V., Babić Radić, Marija M., Vukomanović, Marija, Milivojević, Dušan, Ilic-Tomic, Tatjana, Nikodinović-Runić, Jasmina, Tomić, Simonida Lj, "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds" in Polymers, 14, no. 20 (2022):4459,
https://doi.org/10.3390/polym14204459 . .

TY  - CONF
AU  - Vojnović, Sandra
AU  - Stevanović, Milena
AU  - Lazić, Jelena
AU  - Pantelić, Lena
AU  - Milojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Nikodinović-Runić, Jasmina
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1751
AB  - Iako su bioterapeutici doveli do revolucionarnih promena u lečenju raka,
dokazali svoju efikasnost u saniranju mikrobnih infekcija i lečenju ljudi sa
retkim bolestima, zbog visoke cene nisu svima dostupni. Inovativni pristup gde
otpad ulazi u sastav hranjivih podloga za gajenje bakterija bi mogao dovesti do
smanjenja cene bioterapeutika. Fermentacijom na skali od 5 L je dobijeno
nekoliko bioaktivnih prirodnih proizvoda, pri čemu je različit otpad bio izvor
hranjivih materija za gajenje mikroorganizama proizvođača. Prodigiozin,
sekundarni metabolit bakterije Serratia marcescens, dobijen je gajenjem S.
marcescens u tečnoj podlozi sa homogenizovanim mesnim nareskom, a prinos
prodigiozina je poboljšan čak 10 puta u poređenju sa standardnom podlogom.1
Kada je Pseudomonas sp. BK25H gajen u podlozi sa komponentama kuhinjskog otpada
dobijen je odličan prinos piocijanina od 12,5 mg L-1. Slično, aktinomicin D i
staurosporin, sekundarni metaboliti Streptomyces sp. BV365 i 410, su dobijeni
gajenjem proizvođača u hranjivim podlogama sa komponentama poljoprivrednog
otpada ili otpada dobijenog preradom lignoceluloze. S obzirom da neka od
navedenih jedinjenja dostižu komercijalnu vrednost od 2.500,00 evra za 1 mg
(https://www.sigmaaldrich.com/RS/en/product/sigma/s5921), dobijeni rezultati idu u
prilog ideji da bi se otpadne materije mogle koristiti kao jeftine sirovine za
proizvodnju vrednih hemikalija, uz istovremeno smanjenje njihove cene, pri čemu
bi se i količina otpadnih tokova redukovala.
AB  - Иако су биотерапеутици довели до револуционарних промена у лечењу рака,
доказали своју ефикасност у санирању микробних инфекција и лечењу људи са
ретким болестима, због високе цене нису свима доступни. Иновативни приступ где
отпад улази у састав храњивих подлога за гајење бактерија би могао довести до
смањења цене биотерапеутика. Ферментацијом на скали од 5 L је добијено
неколико биоактивних природних производа, при чему је различит отпад био извор
храњивих материја за гајење микроорганизама произвођача. Продигиозин,
секундарни метаболит бактерије Serratia marcescens, добијен је гајењем S.
marcescens у течној подлози са хомогенизованим месним нареском, а принос
продигиозина је побољшан чак 10 пута у поређењу са стандардном подлогом.1
Када је Pseudomonas sp. BK25H гајен у подлози са компонентама кухињског отпада
добијен је одличан принос пиоцијанина од 12,5 mg L-1. Слично, актиномицин Д и
стауроспорин, секундарни метаболити Streptomyces sp. BV365 и 410, су добијени
гајењем произвођача у храњивим подлогама са компонентама пољопривредног
отпада или отпада добијеног прерадом лигноцелулозе. С обзиром да нека од
наведених једињења достижу комерцијалну вредност од 2.500,00 евра за 1 mg
(https://www.sigmaaldrich.com/RS/en/product/sigma/s5921), добијени резултати иду у
прилог идеји да би се отпадне материје могле користити као јефтине сировине за
производњу вредних хемикалија, уз истовремено смањење њихове цене, при чему
би се и количина отпадних токова редуковала.
PB  - Beograd : Srpsko biološko društvo
C3  - Treći kongres biologa Srbije
T1  - Od otpada do bioterapeutika
T1  - Од отпада до биотерапеутика
SP  - 253
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1751
ER  - 

@conference{
author = "Vojnović, Sandra and Stevanović, Milena and Lazić, Jelena and Pantelić, Lena and Milojević, Dušan and Ilić-Tomić, Tatjana and Nikodinović-Runić, Jasmina",
year = "2022",
abstract = "Iako su bioterapeutici doveli do revolucionarnih promena u lečenju raka,
dokazali svoju efikasnost u saniranju mikrobnih infekcija i lečenju ljudi sa
retkim bolestima, zbog visoke cene nisu svima dostupni. Inovativni pristup gde
otpad ulazi u sastav hranjivih podloga za gajenje bakterija bi mogao dovesti do
smanjenja cene bioterapeutika. Fermentacijom na skali od 5 L je dobijeno
nekoliko bioaktivnih prirodnih proizvoda, pri čemu je različit otpad bio izvor
hranjivih materija za gajenje mikroorganizama proizvođača. Prodigiozin,
sekundarni metabolit bakterije Serratia marcescens, dobijen je gajenjem S.
marcescens u tečnoj podlozi sa homogenizovanim mesnim nareskom, a prinos
prodigiozina je poboljšan čak 10 puta u poređenju sa standardnom podlogom.1
Kada je Pseudomonas sp. BK25H gajen u podlozi sa komponentama kuhinjskog otpada
dobijen je odličan prinos piocijanina od 12,5 mg L-1. Slično, aktinomicin D i
staurosporin, sekundarni metaboliti Streptomyces sp. BV365 i 410, su dobijeni
gajenjem proizvođača u hranjivim podlogama sa komponentama poljoprivrednog
otpada ili otpada dobijenog preradom lignoceluloze. S obzirom da neka od
navedenih jedinjenja dostižu komercijalnu vrednost od 2.500,00 evra za 1 mg
(https://www.sigmaaldrich.com/RS/en/product/sigma/s5921), dobijeni rezultati idu u
prilog ideji da bi se otpadne materije mogle koristiti kao jeftine sirovine za
proizvodnju vrednih hemikalija, uz istovremeno smanjenje njihove cene, pri čemu
bi se i količina otpadnih tokova redukovala., Иако су биотерапеутици довели до револуционарних промена у лечењу рака,
доказали своју ефикасност у санирању микробних инфекција и лечењу људи са
ретким болестима, због високе цене нису свима доступни. Иновативни приступ где
отпад улази у састав храњивих подлога за гајење бактерија би могао довести до
смањења цене биотерапеутика. Ферментацијом на скали од 5 L је добијено
неколико биоактивних природних производа, при чему је различит отпад био извор
храњивих материја за гајење микроорганизама произвођача. Продигиозин,
секундарни метаболит бактерије Serratia marcescens, добијен је гајењем S.
marcescens у течној подлози са хомогенизованим месним нареском, а принос
продигиозина је побољшан чак 10 пута у поређењу са стандардном подлогом.1
Када је Pseudomonas sp. BK25H гајен у подлози са компонентама кухињског отпада
добијен је одличан принос пиоцијанина од 12,5 mg L-1. Слично, актиномицин Д и
стауроспорин, секундарни метаболити Streptomyces sp. BV365 и 410, су добијени
гајењем произвођача у храњивим подлогама са компонентама пољопривредног
отпада или отпада добијеног прерадом лигноцелулозе. С обзиром да нека од
наведених једињења достижу комерцијалну вредност од 2.500,00 евра за 1 mg
(https://www.sigmaaldrich.com/RS/en/product/sigma/s5921), добијени резултати иду у
прилог идеји да би се отпадне материје могле користити као јефтине сировине за
производњу вредних хемикалија, уз истовремено смањење њихове цене, при чему
би се и количина отпадних токова редуковала.",
publisher = "Beograd : Srpsko biološko društvo",
journal = "Treći kongres biologa Srbije",
title = "Od otpada do bioterapeutika, Од отпада до биотерапеутика",
pages = "253",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1751"
}

Vojnović, S., Stevanović, M., Lazić, J., Pantelić, L., Milojević, D., Ilić-Tomić, T.,& Nikodinović-Runić, J.. (2022). Od otpada do bioterapeutika. in Treći kongres biologa Srbije
Beograd : Srpsko biološko društvo., 253.
https://hdl.handle.net/21.15107/rcub_imagine_1751

Vojnović S, Stevanović M, Lazić J, Pantelić L, Milojević D, Ilić-Tomić T, Nikodinović-Runić J. Od otpada do bioterapeutika. in Treći kongres biologa Srbije. 2022;:253.
https://hdl.handle.net/21.15107/rcub_imagine_1751 .

Vojnović, Sandra, Stevanović, Milena, Lazić, Jelena, Pantelić, Lena, Milojević, Dušan, Ilić-Tomić, Tatjana, Nikodinović-Runić, Jasmina, "Od otpada do bioterapeutika" in Treći kongres biologa Srbije (2022):253,
https://hdl.handle.net/21.15107/rcub_imagine_1751 .

TY  - JOUR
AU  - Tomsić, Brigita
AU  - Marković, Darka
AU  - Janković, Vukašin
AU  - Simoncić, Barbara
AU  - Nikodinović-Runić, Jasmina
AU  - Ilić-Tomić, Tatjana
AU  - Radetić, Maja
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1539
AB  - Sustainable biodegradation of cellulose fibers is critical for composting after the end of a product's life. In this study, we aimed at investigating the effect of in situ synthesized CuO/Cu2O nanoparticles (NPs) with biocidal concentration on the biodegradation behavior of cotton fibers pretreated with 1,2,3,4-butanetetracarboxylic acid (BTCA) and succinic acid (SUC). Biodegradation of the fibers was evaluated by soil burial tests in garden soil and in model compost after different soil burial times. The results showed that the application of BTCA, SUC, and CuO/Cu2O NPs did not affect the hydrophilicity of the samples and allowed a smooth biodegradation process. The morphological and chemical changes during biodegradation, evaluated by FESEM and FTIR analyses, showed that the presence of CuO/Cu2O NPs slightly hindered biodegradation of the fibers after 18 days in soil. However, biodegradation was much faster in the model compost, where all samples, regardless of their chemical modification, almost completely degraded after only 11 days. Intense microbial growth on the surface of all samples after nine days of burial in garden soil and model compost was confirmed by the presence of proteins produced by the microorganisms. The total number of microorganisms in the garden soil remained almost unchanged and increased in the model compost after the burial test. The only exception was the sample with the highest concentration of CuO/Cu2O NPs, which caused a reduction in microbial growth but not complete growth inhibition. These results clearly showed that during material degradation, the cellulosic material supporting microbial growth prevailed over the suppression of microbial growth by CuO/Cu2O NPs.
PB  - Springer, Dordrecht
T2  - Cellulose
T1  - Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids
EP  - 302
IS  - 1
SP  - 287
VL  - 29
DO  - 10.1007/s10570-021-04296-6
ER  - 

@article{
author = "Tomsić, Brigita and Marković, Darka and Janković, Vukašin and Simoncić, Barbara and Nikodinović-Runić, Jasmina and Ilić-Tomić, Tatjana and Radetić, Maja",
year = "2022",
abstract = "Sustainable biodegradation of cellulose fibers is critical for composting after the end of a product's life. In this study, we aimed at investigating the effect of in situ synthesized CuO/Cu2O nanoparticles (NPs) with biocidal concentration on the biodegradation behavior of cotton fibers pretreated with 1,2,3,4-butanetetracarboxylic acid (BTCA) and succinic acid (SUC). Biodegradation of the fibers was evaluated by soil burial tests in garden soil and in model compost after different soil burial times. The results showed that the application of BTCA, SUC, and CuO/Cu2O NPs did not affect the hydrophilicity of the samples and allowed a smooth biodegradation process. The morphological and chemical changes during biodegradation, evaluated by FESEM and FTIR analyses, showed that the presence of CuO/Cu2O NPs slightly hindered biodegradation of the fibers after 18 days in soil. However, biodegradation was much faster in the model compost, where all samples, regardless of their chemical modification, almost completely degraded after only 11 days. Intense microbial growth on the surface of all samples after nine days of burial in garden soil and model compost was confirmed by the presence of proteins produced by the microorganisms. The total number of microorganisms in the garden soil remained almost unchanged and increased in the model compost after the burial test. The only exception was the sample with the highest concentration of CuO/Cu2O NPs, which caused a reduction in microbial growth but not complete growth inhibition. These results clearly showed that during material degradation, the cellulosic material supporting microbial growth prevailed over the suppression of microbial growth by CuO/Cu2O NPs.",
publisher = "Springer, Dordrecht",
journal = "Cellulose",
title = "Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids",
pages = "302-287",
number = "1",
volume = "29",
doi = "10.1007/s10570-021-04296-6"
}

Tomsić, B., Marković, D., Janković, V., Simoncić, B., Nikodinović-Runić, J., Ilić-Tomić, T.,& Radetić, M.. (2022). Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids. in Cellulose
Springer, Dordrecht., 29(1), 287-302.
https://doi.org/10.1007/s10570-021-04296-6

Tomsić B, Marković D, Janković V, Simoncić B, Nikodinović-Runić J, Ilić-Tomić T, Radetić M. Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids. in Cellulose. 2022;29(1):287-302.
doi:10.1007/s10570-021-04296-6 .

Tomsić, Brigita, Marković, Darka, Janković, Vukašin, Simoncić, Barbara, Nikodinović-Runić, Jasmina, Ilić-Tomić, Tatjana, Radetić, Maja, "Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids" in Cellulose, 29, no. 1 (2022):287-302,
https://doi.org/10.1007/s10570-021-04296-6 . .

TY  - CONF
AU  - Janković, Vukašin
AU  - Nikodinović-Runić, Jasmina
AU  - Milivojević, Dušan
AU  - Stevanović, Milena
AU  - Ilić-Tomić, Tatjana
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1843
AB  - BACKGROUND
Pigments from microbial origin have promising applications in food, cosmetics, textiles and therapeutics.
Compared to other natural sources pigments from bacteria are more stable, safer, and could be cheaper to
produce and extract. Bacterial genus Streptomyces has been known as a source of biologicaly active pigments
that exhibit several effects such as antimicrobial and cytotoxic.
OBJECTIVES
The aim of this study was the isolation of pigment-producing Streptomyces strain from soil, optimization of
growth parametres for pigment production and evaluation of antimicrobial and cytotoxic activity of extracted
bacterial pigments.
METHODS
Isolation and characterization of pigment-producing Streptomyces strain from soil was done following the
standard microbiological protocol, using four different growth media. The pigments were extracted by solvent
extraction using ethyl acetate. Antimicrobial activity was analyzed using the disc diffusion test. Cytotoxic activity
was tested on the HaCaT cell line following the standard protocol.
RESULTS
Extraction of pigments by solvent extraction resulted in crude pigment extracts with antimicrobial activities.
In total pigments from 14 bacterial strains have been extracted. Antimicrobial activity was evident on Gram +
bacteria Staphylococcus aureus (6 mm of inhibition zone at concentration 8.4 μg/ml and 4 mm of inhibition
zone at concentration 1.1 μg/ml) as well as on the fungus Candida albicans (4 mm of inhibition zone at concentration
13 μg/ml). Pigments showed dose-dependent inhibiton of proliferation of HaCaT cells, with the
lowest concentration at 25 μg/ml.
C3  - FEMS Conference on Microbiology
T1  - Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts
EP  - 622
SP  - 621
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1843
ER  - 

@conference{
author = "Janković, Vukašin and Nikodinović-Runić, Jasmina and Milivojević, Dušan and Stevanović, Milena and Ilić-Tomić, Tatjana",
year = "2022",
abstract = "BACKGROUND
Pigments from microbial origin have promising applications in food, cosmetics, textiles and therapeutics.
Compared to other natural sources pigments from bacteria are more stable, safer, and could be cheaper to
produce and extract. Bacterial genus Streptomyces has been known as a source of biologicaly active pigments
that exhibit several effects such as antimicrobial and cytotoxic.
OBJECTIVES
The aim of this study was the isolation of pigment-producing Streptomyces strain from soil, optimization of
growth parametres for pigment production and evaluation of antimicrobial and cytotoxic activity of extracted
bacterial pigments.
METHODS
Isolation and characterization of pigment-producing Streptomyces strain from soil was done following the
standard microbiological protocol, using four different growth media. The pigments were extracted by solvent
extraction using ethyl acetate. Antimicrobial activity was analyzed using the disc diffusion test. Cytotoxic activity
was tested on the HaCaT cell line following the standard protocol.
RESULTS
Extraction of pigments by solvent extraction resulted in crude pigment extracts with antimicrobial activities.
In total pigments from 14 bacterial strains have been extracted. Antimicrobial activity was evident on Gram +
bacteria Staphylococcus aureus (6 mm of inhibition zone at concentration 8.4 μg/ml and 4 mm of inhibition
zone at concentration 1.1 μg/ml) as well as on the fungus Candida albicans (4 mm of inhibition zone at concentration
13 μg/ml). Pigments showed dose-dependent inhibiton of proliferation of HaCaT cells, with the
lowest concentration at 25 μg/ml.",
journal = "FEMS Conference on Microbiology",
title = "Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts",
pages = "622-621",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1843"
}

Janković, V., Nikodinović-Runić, J., Milivojević, D., Stevanović, M.,& Ilić-Tomić, T.. (2022). Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts. in FEMS Conference on Microbiology, 621-622.
https://hdl.handle.net/21.15107/rcub_imagine_1843

Janković V, Nikodinović-Runić J, Milivojević D, Stevanović M, Ilić-Tomić T. Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts. in FEMS Conference on Microbiology. 2022;:621-622.
https://hdl.handle.net/21.15107/rcub_imagine_1843 .

Janković, Vukašin, Nikodinović-Runić, Jasmina, Milivojević, Dušan, Stevanović, Milena, Ilić-Tomić, Tatjana, "Antimicrobial and cytotoxic activity of pigmented Streptomyces spp. culture extracts" in FEMS Conference on Microbiology (2022):621-622,
https://hdl.handle.net/21.15107/rcub_imagine_1843 .

TY  - JOUR
AU  - Krkobabić, Ana
AU  - Marković, Darka
AU  - Kovacević, Aleksandar
AU  - Tadić, Vanja
AU  - Radoicić, Marija
AU  - Barudzija, Tatjana
AU  - Ilić-Tomić, Tatjana
AU  - Radetić, Maja
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1552
AB  - The aim of this study was to develop antimicrobial nanocomposite textile material comprising of Cu-based nanostructures synthesized on oxidized cotton fabric using Arctostaphylos uva-ursi (L.) Spreng., Ericaceae (bearberry leaves) as a green reducing agent for adsorbed Cu2+-ions. In order to provide sufficient number of carboxyl groups for complexation with Cu2+-ions a two-step oxidation process with NaIO4 and NaClO2 was carried out. The influence of NaIO4 concentration on content of carboxyl groups and Cu-based nanoparticles was studied by FTIR and AAS. HPLC analysis identified the gallic acid known as a reducing agent in bearberry leaves extract. FESEM and XRD analyses revealed that using bearberry leaves extract and gallic acid solution as reducing agents led to a formation of spherical Cu2O/CuO nanoparticles and CuO nanosheets, respectively. These nanoparticles and nanosheets provided excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. Cytotoxicity on human keratinocyte cells was shown to depend on their copper content.
PB  - Korean Fiber Soc, Seoul
T2  - Fibers and Polymers
T1  - Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract
EP  - 966
IS  - 4
SP  - 954
VL  - 23
DO  - 10.1007/s12221-022-4639-5
ER  - 

@article{
author = "Krkobabić, Ana and Marković, Darka and Kovacević, Aleksandar and Tadić, Vanja and Radoicić, Marija and Barudzija, Tatjana and Ilić-Tomić, Tatjana and Radetić, Maja",
year = "2022",
abstract = "The aim of this study was to develop antimicrobial nanocomposite textile material comprising of Cu-based nanostructures synthesized on oxidized cotton fabric using Arctostaphylos uva-ursi (L.) Spreng., Ericaceae (bearberry leaves) as a green reducing agent for adsorbed Cu2+-ions. In order to provide sufficient number of carboxyl groups for complexation with Cu2+-ions a two-step oxidation process with NaIO4 and NaClO2 was carried out. The influence of NaIO4 concentration on content of carboxyl groups and Cu-based nanoparticles was studied by FTIR and AAS. HPLC analysis identified the gallic acid known as a reducing agent in bearberry leaves extract. FESEM and XRD analyses revealed that using bearberry leaves extract and gallic acid solution as reducing agents led to a formation of spherical Cu2O/CuO nanoparticles and CuO nanosheets, respectively. These nanoparticles and nanosheets provided excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. Cytotoxicity on human keratinocyte cells was shown to depend on their copper content.",
publisher = "Korean Fiber Soc, Seoul",
journal = "Fibers and Polymers",
title = "Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract",
pages = "966-954",
number = "4",
volume = "23",
doi = "10.1007/s12221-022-4639-5"
}

Krkobabić, A., Marković, D., Kovacević, A., Tadić, V., Radoicić, M., Barudzija, T., Ilić-Tomić, T.,& Radetić, M.. (2022). Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract. in Fibers and Polymers
Korean Fiber Soc, Seoul., 23(4), 954-966.
https://doi.org/10.1007/s12221-022-4639-5

Krkobabić A, Marković D, Kovacević A, Tadić V, Radoicić M, Barudzija T, Ilić-Tomić T, Radetić M. Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract. in Fibers and Polymers. 2022;23(4):954-966.
doi:10.1007/s12221-022-4639-5 .

Krkobabić, Ana, Marković, Darka, Kovacević, Aleksandar, Tadić, Vanja, Radoicić, Marija, Barudzija, Tatjana, Ilić-Tomić, Tatjana, Radetić, Maja, "Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract" in Fibers and Polymers, 23, no. 4 (2022):954-966,
https://doi.org/10.1007/s12221-022-4639-5 . .

TY  - JOUR
AU  - Janković, Vukašin
AU  - Marković, Darka
AU  - Nikodinović-Runić, Jasmina
AU  - Radetić, Maja
AU  - Ilic-Tomic, Tatjana
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1665
AB  - Given the environmental burden of textile industry, especially of dyeing processes and the volume of synthetic dyes and surfactants, the intensive development of the greener approaches is under way. Herein, an environmentaly-friendly dyeing of polyamide (PA) and PA/Elastane (PA/EA) knits using live bacterial approach in water environment, completely eliminating usage of textile auxiliaries is described. A total of 12 pigment-producing Streptomyces strains were isolated and purified from soil and rizoshere or bark of smoke tree Cotinus coggygria samples. The antibacterial, antifungal and cytotoxic effects of crude bacterial extracts were tested. Antimicrobial effect was obtained by the majority of extracts but only two streptomycetes extracts, 11–5 and BPS51, showed moderate cytotoxicity against HaCaT human cell line. This was the reason to select 11–5 and BPS51 strains for the dyeing of the textile materials. Excellent properties of dyeing wool, silk and PA are achieved initially using live cultures, and the bioprocess is optimized on commercial PA and PA/EA knits used for stockings production. Satisfactory coloration of both knits is achieved with dynamic conditions (culture shaking at 180 rpm over 5–14 days at 30 ºC) giving the best coloration results, except in the case of the PA sample dyed with a bacterial strain 11–5. The prolongation of dyeing time leads to higher color yields independently of fabric and bacteria strain. Although the color differences between the samples before and after washing are observed, washing fastness after three washing cycles can be considered as satisfactory.
T2  - World Journal of Microbiology and Biotechnology
T2  - World Journal of Microbiology and BiotechnologyWorld J Microbiol Biotechnol
T1  - Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains
IS  - 1
SP  - 32
VL  - 39
DO  - 10.1007/s11274-022-03473-4
ER  - 

@article{
author = "Janković, Vukašin and Marković, Darka and Nikodinović-Runić, Jasmina and Radetić, Maja and Ilic-Tomic, Tatjana",
year = "2022",
abstract = "Given the environmental burden of textile industry, especially of dyeing processes and the volume of synthetic dyes and surfactants, the intensive development of the greener approaches is under way. Herein, an environmentaly-friendly dyeing of polyamide (PA) and PA/Elastane (PA/EA) knits using live bacterial approach in water environment, completely eliminating usage of textile auxiliaries is described. A total of 12 pigment-producing Streptomyces strains were isolated and purified from soil and rizoshere or bark of smoke tree Cotinus coggygria samples. The antibacterial, antifungal and cytotoxic effects of crude bacterial extracts were tested. Antimicrobial effect was obtained by the majority of extracts but only two streptomycetes extracts, 11–5 and BPS51, showed moderate cytotoxicity against HaCaT human cell line. This was the reason to select 11–5 and BPS51 strains for the dyeing of the textile materials. Excellent properties of dyeing wool, silk and PA are achieved initially using live cultures, and the bioprocess is optimized on commercial PA and PA/EA knits used for stockings production. Satisfactory coloration of both knits is achieved with dynamic conditions (culture shaking at 180 rpm over 5–14 days at 30 ºC) giving the best coloration results, except in the case of the PA sample dyed with a bacterial strain 11–5. The prolongation of dyeing time leads to higher color yields independently of fabric and bacteria strain. Although the color differences between the samples before and after washing are observed, washing fastness after three washing cycles can be considered as satisfactory.",
journal = "World Journal of Microbiology and Biotechnology, World Journal of Microbiology and BiotechnologyWorld J Microbiol Biotechnol",
title = "Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains",
number = "1",
pages = "32",
volume = "39",
doi = "10.1007/s11274-022-03473-4"
}

Janković, V., Marković, D., Nikodinović-Runić, J., Radetić, M.,& Ilic-Tomic, T.. (2022). Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains. in World Journal of Microbiology and Biotechnology, 39(1), 32.
https://doi.org/10.1007/s11274-022-03473-4

Janković V, Marković D, Nikodinović-Runić J, Radetić M, Ilic-Tomic T. Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains. in World Journal of Microbiology and Biotechnology. 2022;39(1):32.
doi:10.1007/s11274-022-03473-4 .

Janković, Vukašin, Marković, Darka, Nikodinović-Runić, Jasmina, Radetić, Maja, Ilic-Tomic, Tatjana, "Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains" in World Journal of Microbiology and Biotechnology, 39, no. 1 (2022):32,
https://doi.org/10.1007/s11274-022-03473-4 . .

TY  - JOUR
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lješević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0045653521004744
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1732
AB  - Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.
PB  - Elsevier
T2  - Chemosphere
T2  - ChemosphereChemosphere
T1  - Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases
SP  - 130005
VL  - 275
DO  - 10.1016/j.chemosphere.2021.130005
ER  - 

@article{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lješević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
abstract = "Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.",
publisher = "Elsevier",
journal = "Chemosphere, ChemosphereChemosphere",
title = "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases",
pages = "130005",
volume = "275",
doi = "10.1016/j.chemosphere.2021.130005"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Lješević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere
Elsevier., 275, 130005.
https://doi.org/10.1016/j.chemosphere.2021.130005

Đapović M, Milivojević D, Ilić-Tomić T, Lješević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere. 2021;275:130005.
doi:10.1016/j.chemosphere.2021.130005 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lješević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases" in Chemosphere, 275 (2021):130005,
https://doi.org/10.1016/j.chemosphere.2021.130005 . .

TY  - JOUR
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Ljesević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1415
AB  - Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 mg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 mg/mL with inhibiting concentration (IC50) values of 30 mg/mL and 50 mg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 mg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Chemosphere
T1  - Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases
SP  - 130005
VL  - 275
DO  - 10.1016/j.chemosphere.2021.130005
ER  - 

@article{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Ljesević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
abstract = "Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 mg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 mg/mL with inhibiting concentration (IC50) values of 30 mg/mL and 50 mg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 mg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Chemosphere",
title = "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases",
pages = "130005",
volume = "275",
doi = "10.1016/j.chemosphere.2021.130005"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Ljesević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere
Pergamon-Elsevier Science Ltd, Oxford., 275, 130005.
https://doi.org/10.1016/j.chemosphere.2021.130005

Đapović M, Milivojević D, Ilić-Tomić T, Ljesević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases. in Chemosphere. 2021;275:130005.
doi:10.1016/j.chemosphere.2021.130005 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Ljesević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases" in Chemosphere, 275 (2021):130005,
https://doi.org/10.1016/j.chemosphere.2021.130005 . .

TY  - DATA
AU  - Đapović, Milica
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Lješević, Marija
AU  - Nikolaivits, Efstratios
AU  - Topakas, Evangelos
AU  - Maslak, Veselin
AU  - Nikodinović-Runić, Jasmina
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0045653521004744
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1733
PB  - Elsevier
T2  - Chemosphere
T1  - Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1733
ER  - 

@misc{
author = "Đapović, Milica and Milivojević, Dušan and Ilić-Tomić, Tatjana and Lješević, Marija and Nikolaivits, Efstratios and Topakas, Evangelos and Maslak, Veselin and Nikodinović-Runić, Jasmina",
year = "2021",
publisher = "Elsevier",
journal = "Chemosphere",
title = "Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1733"
}

Đapović, M., Milivojević, D., Ilić-Tomić, T., Lješević, M., Nikolaivits, E., Topakas, E., Maslak, V.,& Nikodinović-Runić, J.. (2021). Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.. in Chemosphere
Elsevier..
https://hdl.handle.net/21.15107/rcub_imagine_1733

Đapović M, Milivojević D, Ilić-Tomić T, Lješević M, Nikolaivits E, Topakas E, Maslak V, Nikodinović-Runić J. Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005.. in Chemosphere. 2021;.
https://hdl.handle.net/21.15107/rcub_imagine_1733 .

Đapović, Milica, Milivojević, Dušan, Ilić-Tomić, Tatjana, Lješević, Marija, Nikolaivits, Efstratios, Topakas, Evangelos, Maslak, Veselin, Nikodinović-Runić, Jasmina, "Supplementary data for the article: Djapovic, M.; Milivojevic, D.; Ilic-Tomic, T.; Lješević, M.; Nikolaivits, E.; Topakas, E.; Maslak, V.; Nikodinovic-Runic, J. Synthesis and Characterization of Polyethylene Terephthalate (PET) Precursors and Potential Degradation Products: Toxicity Study and Application in Discovery of Novel PETases. Chemosphere 2021, 275, 130005. https://doi.org/10.1016/j.chemosphere.2021.130005." in Chemosphere (2021),
https://hdl.handle.net/21.15107/rcub_imagine_1733 .

TY  - JOUR
AU  - Pavić, Aleksandar
AU  - Ilić-Tomić, Tatjana
AU  - Glamoclija, Jasmina
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1474
AB  - Severe drawbacks associated with the topical use of depigmenting agents in treatments of skin hyperigmentations impose a great demand for novel, effective, and safe melanogenesis inhibitors. Edible and medicinal mushrooms, known for numerous health-promoting properties, represent a rich reservoir of anti-melanogenic compounds, with the potential to be applied in preventing excessive skin pigmentation. Herein, using zebrafish (Danio rerio) as a preclinical animal model, we have demonstrated that ethanol extract of Laetiporus sulphureus (LSE) and Agaricus silvaticus (ASE) are not toxic at high doses up to 400-500 mu g/mL while effectively inhibit melanogenesis in a dose-dependent manner. At depigmenting doses, the explored extracts showed no adverse effects on zebrafish embryos melanocytes. Even more, they did not provoke inflammation or neutropenia when applied at the highest dose ensuring almost complete the cells depigmentation. Since LSE and ASE have demonstrated significantly higher the therapeutic potential than kojic acid and hydroquinone, two well-known depigmenting agents, overall results of this study strongly suggest that the explored mushrooms extracts could be used as efficient and safe topical agents in treatments of skin hyperpigmentation disorders.
PB  - MDPI, Basel
T2  - Journal of Fungi
T1  - Unravelling Anti-Melanogenic Potency of Edible Mushrooms Laetiporus sulphureus and Agaricus silvaticus In Vivo Using the Zebrafish Model
IS  - 10
VL  - 7
DO  - 10.3390/jof7100834
ER  - 

@article{
author = "Pavić, Aleksandar and Ilić-Tomić, Tatjana and Glamoclija, Jasmina",
year = "2021",
abstract = "Severe drawbacks associated with the topical use of depigmenting agents in treatments of skin hyperigmentations impose a great demand for novel, effective, and safe melanogenesis inhibitors. Edible and medicinal mushrooms, known for numerous health-promoting properties, represent a rich reservoir of anti-melanogenic compounds, with the potential to be applied in preventing excessive skin pigmentation. Herein, using zebrafish (Danio rerio) as a preclinical animal model, we have demonstrated that ethanol extract of Laetiporus sulphureus (LSE) and Agaricus silvaticus (ASE) are not toxic at high doses up to 400-500 mu g/mL while effectively inhibit melanogenesis in a dose-dependent manner. At depigmenting doses, the explored extracts showed no adverse effects on zebrafish embryos melanocytes. Even more, they did not provoke inflammation or neutropenia when applied at the highest dose ensuring almost complete the cells depigmentation. Since LSE and ASE have demonstrated significantly higher the therapeutic potential than kojic acid and hydroquinone, two well-known depigmenting agents, overall results of this study strongly suggest that the explored mushrooms extracts could be used as efficient and safe topical agents in treatments of skin hyperpigmentation disorders.",
publisher = "MDPI, Basel",
journal = "Journal of Fungi",
title = "Unravelling Anti-Melanogenic Potency of Edible Mushrooms Laetiporus sulphureus and Agaricus silvaticus In Vivo Using the Zebrafish Model",
number = "10",
volume = "7",
doi = "10.3390/jof7100834"
}

Pavić, A., Ilić-Tomić, T.,& Glamoclija, J.. (2021). Unravelling Anti-Melanogenic Potency of Edible Mushrooms Laetiporus sulphureus and Agaricus silvaticus In Vivo Using the Zebrafish Model. in Journal of Fungi
MDPI, Basel., 7(10).
https://doi.org/10.3390/jof7100834

Pavić A, Ilić-Tomić T, Glamoclija J. Unravelling Anti-Melanogenic Potency of Edible Mushrooms Laetiporus sulphureus and Agaricus silvaticus In Vivo Using the Zebrafish Model. in Journal of Fungi. 2021;7(10).
doi:10.3390/jof7100834 .

Pavić, Aleksandar, Ilić-Tomić, Tatjana, Glamoclija, Jasmina, "Unravelling Anti-Melanogenic Potency of Edible Mushrooms Laetiporus sulphureus and Agaricus silvaticus In Vivo Using the Zebrafish Model" in Journal of Fungi, 7, no. 10 (2021),
https://doi.org/10.3390/jof7100834 . .

TY  - JOUR
AU  - Kramar, Ana D.
AU  - Ilić-Tomić, Tatjana
AU  - Ladarević, Jelena M.
AU  - Nikodinović-Runić, Jasmina
AU  - Kostić, Mirjana M.
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1497
AB  - Halochromic (pH-responsive) material was obtained by dyeing functionalized viscose fabric with a crude extract from Streptomyces sp. strain NP4. The functionalization of the fabric before dyeing was performed to make cellulose susceptible to coloration with NP4 extract. Two combined pre-treatment steps were used, oxidation to obtain dialdehyde cellulose and chitosan deposition after oxidation. Chitosan was deposited onto untreated fabric as well, while only oxidized viscose was also investigated for dyeing. Functionalization by both protocols made viscose susceptible to dyeing with the notion that the deposition of chitosan onto oxidized viscose produced the darkest shade on the material. Dyed fabrics showed visual pH responsiveness in the range pH 4-10, with a color change from pink to red (pH 4-pH 7) and a major color change from red to blue (pH 7-pH 10) whereby fabric was tested and could withstand 10 color-changing cycles. Cytotoxicity assay confirmed the non-toxic nature of dyed material, which indicates its possible use as wound dressing's indicators.
PB  - Springer, Dordrecht
T2  - Cellulose
T1  - Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4
EP  - 8784
IS  - 13
SP  - 8771
VL  - 28
DO  - 10.1007/s10570-021-04071-7
ER  - 

@article{
author = "Kramar, Ana D. and Ilić-Tomić, Tatjana and Ladarević, Jelena M. and Nikodinović-Runić, Jasmina and Kostić, Mirjana M.",
year = "2021",
abstract = "Halochromic (pH-responsive) material was obtained by dyeing functionalized viscose fabric with a crude extract from Streptomyces sp. strain NP4. The functionalization of the fabric before dyeing was performed to make cellulose susceptible to coloration with NP4 extract. Two combined pre-treatment steps were used, oxidation to obtain dialdehyde cellulose and chitosan deposition after oxidation. Chitosan was deposited onto untreated fabric as well, while only oxidized viscose was also investigated for dyeing. Functionalization by both protocols made viscose susceptible to dyeing with the notion that the deposition of chitosan onto oxidized viscose produced the darkest shade on the material. Dyed fabrics showed visual pH responsiveness in the range pH 4-10, with a color change from pink to red (pH 4-pH 7) and a major color change from red to blue (pH 7-pH 10) whereby fabric was tested and could withstand 10 color-changing cycles. Cytotoxicity assay confirmed the non-toxic nature of dyed material, which indicates its possible use as wound dressing's indicators.",
publisher = "Springer, Dordrecht",
journal = "Cellulose",
title = "Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4",
pages = "8784-8771",
number = "13",
volume = "28",
doi = "10.1007/s10570-021-04071-7"
}

Kramar, A. D., Ilić-Tomić, T., Ladarević, J. M., Nikodinović-Runić, J.,& Kostić, M. M.. (2021). Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4. in Cellulose
Springer, Dordrecht., 28(13), 8771-8784.
https://doi.org/10.1007/s10570-021-04071-7

Kramar AD, Ilić-Tomić T, Ladarević JM, Nikodinović-Runić J, Kostić MM. Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4. in Cellulose. 2021;28(13):8771-8784.
doi:10.1007/s10570-021-04071-7 .

Kramar, Ana D., Ilić-Tomić, Tatjana, Ladarević, Jelena M., Nikodinović-Runić, Jasmina, Kostić, Mirjana M., "Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4" in Cellulose, 28, no. 13 (2021):8771-8784,
https://doi.org/10.1007/s10570-021-04071-7 . .