TY  - JOUR
AU  - Ilić, M.
AU  - Samardžić, S.
AU  - Kotur-Stevuljević, J.
AU  - Ušjak, D.
AU  - Milenković, M.
AU  - Kovačević, N.
AU  - Drobac, M.
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1771
AB  - OBJECTIVE: Plants and plant extracts are of great scientific interest due to the
chemical diversity and pharmacological properties of present bioactive molecules. The Geranium L. species are widely used in ethnomedicine. In the current study, the total phenolic and
tannin content, antioxidant and antimicrobial
activity of methanol extracts of eight Geranium
species were investigated.
MATERIALS AND METHODS: The total phenolic and tannin content were determined by the
FC method. Antioxidant capacity was evaluated
in FRAP, DPPH, and biochemical assays, while
antimicrobial activity was examined using the
broth microdilution method.
RESULTS: The high total phenolic (170.64-
636.32 mg GAE/g dry extract) and tannin content (37.80-414.02 mg GAE/g DE), along with significant total antioxidant (FRAP values 1.13-8.80
mmol Fe2+/g) and DPPH radical scavenging activity (SC50 values 4.24-34.52 µg/mL) were observed. The prominent antioxidant capacity was
confirmed in biochemical assays (OS values -1.47
– -13.02). The extracts exhibited significant antimicrobial activity against ATTC strains (MICs
dominantly in the range of 12.5-200 µg/mL) as
well as against clinical isolates of E. coli (MICs
mostly 50 and 100 µg/mL). The pronounced antioxidant and antimicrobial activity can be due to
the high phenolic content, particularly due to the
presence of hydrolyzable tannins.
CONCLUSIONS: Based on the high content of
polyphenols, pronounced antioxidant and antimicrobial activities, the examined extracts are
promising natural antioxidant and antimicrobial
agents with the potential medicinal purpose and
use as a functional food.
PB  - Roma : Verduci Editore
T2  - European Review for Medical and Pharmacological Sciences
T1  - Polyphenol rich extracts of Geranium L. species as potential natural antioxidant and antimicrobial agents
EP  - 6294
IS  - 20
SP  - 6283
VL  - 25
DO  - 10.26355/eurrev_202110_26998
ER  - 

@article{
author = "Ilić, M. and Samardžić, S. and Kotur-Stevuljević, J. and Ušjak, D. and Milenković, M. and Kovačević, N. and Drobac, M.",
year = "2021",
abstract = "OBJECTIVE: Plants and plant extracts are of great scientific interest due to the
chemical diversity and pharmacological properties of present bioactive molecules. The Geranium L. species are widely used in ethnomedicine. In the current study, the total phenolic and
tannin content, antioxidant and antimicrobial
activity of methanol extracts of eight Geranium
species were investigated.
MATERIALS AND METHODS: The total phenolic and tannin content were determined by the
FC method. Antioxidant capacity was evaluated
in FRAP, DPPH, and biochemical assays, while
antimicrobial activity was examined using the
broth microdilution method.
RESULTS: The high total phenolic (170.64-
636.32 mg GAE/g dry extract) and tannin content (37.80-414.02 mg GAE/g DE), along with significant total antioxidant (FRAP values 1.13-8.80
mmol Fe2+/g) and DPPH radical scavenging activity (SC50 values 4.24-34.52 µg/mL) were observed. The prominent antioxidant capacity was
confirmed in biochemical assays (OS values -1.47
– -13.02). The extracts exhibited significant antimicrobial activity against ATTC strains (MICs
dominantly in the range of 12.5-200 µg/mL) as
well as against clinical isolates of E. coli (MICs
mostly 50 and 100 µg/mL). The pronounced antioxidant and antimicrobial activity can be due to
the high phenolic content, particularly due to the
presence of hydrolyzable tannins.
CONCLUSIONS: Based on the high content of
polyphenols, pronounced antioxidant and antimicrobial activities, the examined extracts are
promising natural antioxidant and antimicrobial
agents with the potential medicinal purpose and
use as a functional food.",
publisher = "Roma : Verduci Editore",
journal = "European Review for Medical and Pharmacological Sciences",
title = "Polyphenol rich extracts of Geranium L. species as potential natural antioxidant and antimicrobial agents",
pages = "6294-6283",
number = "20",
volume = "25",
doi = "10.26355/eurrev_202110_26998"
}

Ilić, M., Samardžić, S., Kotur-Stevuljević, J., Ušjak, D., Milenković, M., Kovačević, N.,& Drobac, M.. (2021). Polyphenol rich extracts of Geranium L. species as potential natural antioxidant and antimicrobial agents. in European Review for Medical and Pharmacological Sciences
Roma : Verduci Editore., 25(20), 6283-6294.
https://doi.org/10.26355/eurrev_202110_26998

Ilić M, Samardžić S, Kotur-Stevuljević J, Ušjak D, Milenković M, Kovačević N, Drobac M. Polyphenol rich extracts of Geranium L. species as potential natural antioxidant and antimicrobial agents. in European Review for Medical and Pharmacological Sciences. 2021;25(20):6283-6294.
doi:10.26355/eurrev_202110_26998 .

Ilić, M., Samardžić, S., Kotur-Stevuljević, J., Ušjak, D., Milenković, M., Kovačević, N., Drobac, M., "Polyphenol rich extracts of Geranium L. species as potential natural antioxidant and antimicrobial agents" in European Review for Medical and Pharmacological Sciences, 25, no. 20 (2021):6283-6294,
https://doi.org/10.26355/eurrev_202110_26998 . .