TY  - CHAP
AU  - Dobrijević, Zorana
AU  - Matijašević-Joković, Suzana
AU  - Branković, Ana
AU  - Djordjević, Ana
AU  - Popović, Milica
AU  - Brajušković, Goran
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1813
AB  - U ovom radu preglednog tipa prikazano je desetogodišnje iskustvo istraživačkog tima PROSTATSERBIA
koji za temu svog istraživanja ima molekularnu osnovu karcinoma prostate (KP). Centar
za humanu molekularnu genetiku Biološkog fakulteta Univerziteta u Beogradu poseduje kolekciju
uzoraka i banku podataka za gotovo 1000 muškaraca sa bolestima prostate (KP i benigna hiperplazija
prostate) i preko 350 muškaraca bez znakova bolesti prostate iz populacije Republike Srbije. Najveći
broj studija bio je dizajniran kao studije asocijacije odabranih genetičkih varijanti sa rizikom za
razvoj i progresiju KP. U ovim studijama slučajeva i kontola ispitivane su genetičke varijente kako u genima
za proteine i nekodirajuće molekule RNK, tako i u nekodirajućim regionima genoma (tzv. „genskim
pustinjama“). Pored studija slučajeva i kontrola, sprovođene su i meta-analize kao i analize
statističkih epistatičkih interakcija analiziranih genetičkih varijanti. Krajnji cilj ovih studija je kreiranje
algoritma za procenu rizika za progresiju bolesti koji bi se koristio u fazi aktivnog praćenja bolesnika
sa ranodijagnostikovanim KP. U poslednje vreme, istraživanja su usmerena na egzozome i njihov makromolekulski
sadržaj (proteine i nekodirajuće molekule RNK) kao potencijalne biološke markere
tečne biopsije KP. Pored toga, biološki makromolekuli na površini egzozoma predstavljaju i ciljane
molekule u novim strategijama lečenja KP.
AB  - This review-type paper will present the ten-year experience of the PROSTATSERBIA research team,
which has the molecular basis of prostate cancer (PCa) as its research topic. The Center for Human Molecular
Genetics of the Faculty of Biology, University of Belgrade has a collection of samples and a
data bank for almost 1000 men with prostate diseases (PCa and benign prostatic hyperplasia) and for
over 350 men without signs of prostate diseases, all from Serbian population. Most of the studies
were designed as studies of association of selected genetic variants with the risk for development
and progression of PCa. In these case-control studies, genetic variants were examined both in genes
for proteins and non-coding RNAs, as well as in non-coding regions of the genome (so-called gene
deserts). In addition to case control studies, both meta-analyses and the analysis of statistical epistatic
interactions of the analyzed genetic variants were conducted. The main goal of all these studies was
to create an algorithm for risk assessment for disease progression that would be used in the phase of
active monitoring of patients with early diagnosed PCa. Recently, we shifted our research focus on
exosomes and their macromolecular content (proteins and microRNAs) as potential biological markers
of liquid prostate cancer biopsy. In addition, macromolecules at the exosome surface represent
target molecules for new PCa treatment strategies.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - Trendovi u molekularnoj Biologiji
T1  - Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate
T1  - Modern approaches in research of the molecular basis of prostate cancer
EP  - 74
IS  - 2
SP  - 63
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1813
ER  - 

@inbook{
author = "Dobrijević, Zorana and Matijašević-Joković, Suzana and Branković, Ana and Djordjević, Ana and Popović, Milica and Brajušković, Goran",
year = "2022",
abstract = "U ovom radu preglednog tipa prikazano je desetogodišnje iskustvo istraživačkog tima PROSTATSERBIA
koji za temu svog istraživanja ima molekularnu osnovu karcinoma prostate (KP). Centar
za humanu molekularnu genetiku Biološkog fakulteta Univerziteta u Beogradu poseduje kolekciju
uzoraka i banku podataka za gotovo 1000 muškaraca sa bolestima prostate (KP i benigna hiperplazija
prostate) i preko 350 muškaraca bez znakova bolesti prostate iz populacije Republike Srbije. Najveći
broj studija bio je dizajniran kao studije asocijacije odabranih genetičkih varijanti sa rizikom za
razvoj i progresiju KP. U ovim studijama slučajeva i kontola ispitivane su genetičke varijente kako u genima
za proteine i nekodirajuće molekule RNK, tako i u nekodirajućim regionima genoma (tzv. „genskim
pustinjama“). Pored studija slučajeva i kontrola, sprovođene su i meta-analize kao i analize
statističkih epistatičkih interakcija analiziranih genetičkih varijanti. Krajnji cilj ovih studija je kreiranje
algoritma za procenu rizika za progresiju bolesti koji bi se koristio u fazi aktivnog praćenja bolesnika
sa ranodijagnostikovanim KP. U poslednje vreme, istraživanja su usmerena na egzozome i njihov makromolekulski
sadržaj (proteine i nekodirajuće molekule RNK) kao potencijalne biološke markere
tečne biopsije KP. Pored toga, biološki makromolekuli na površini egzozoma predstavljaju i ciljane
molekule u novim strategijama lečenja KP., This review-type paper will present the ten-year experience of the PROSTATSERBIA research team,
which has the molecular basis of prostate cancer (PCa) as its research topic. The Center for Human Molecular
Genetics of the Faculty of Biology, University of Belgrade has a collection of samples and a
data bank for almost 1000 men with prostate diseases (PCa and benign prostatic hyperplasia) and for
over 350 men without signs of prostate diseases, all from Serbian population. Most of the studies
were designed as studies of association of selected genetic variants with the risk for development
and progression of PCa. In these case-control studies, genetic variants were examined both in genes
for proteins and non-coding RNAs, as well as in non-coding regions of the genome (so-called gene
deserts). In addition to case control studies, both meta-analyses and the analysis of statistical epistatic
interactions of the analyzed genetic variants were conducted. The main goal of all these studies was
to create an algorithm for risk assessment for disease progression that would be used in the phase of
active monitoring of patients with early diagnosed PCa. Recently, we shifted our research focus on
exosomes and their macromolecular content (proteins and microRNAs) as potential biological markers
of liquid prostate cancer biopsy. In addition, macromolecules at the exosome surface represent
target molecules for new PCa treatment strategies.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj Biologiji",
booktitle = "Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate, Modern approaches in research of the molecular basis of prostate cancer",
pages = "74-63",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1813"
}

Dobrijević, Z., Matijašević-Joković, S., Branković, A., Djordjević, A., Popović, M.,& Brajušković, G.. (2022). Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate. in Trendovi u molekularnoj Biologiji
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(2), 63-74.
https://hdl.handle.net/21.15107/rcub_imagine_1813

Dobrijević Z, Matijašević-Joković S, Branković A, Djordjević A, Popović M, Brajušković G. Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate. in Trendovi u molekularnoj Biologiji. 2022;(2):63-74.
https://hdl.handle.net/21.15107/rcub_imagine_1813 .

Dobrijević, Zorana, Matijašević-Joković, Suzana, Branković, Ana, Djordjević, Ana, Popović, Milica, Brajušković, Goran, "Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate" in Trendovi u molekularnoj Biologiji, no. 2 (2022):63-74,
https://hdl.handle.net/21.15107/rcub_imagine_1813 .