@inbook{
author = "Bubić, Maja and Živković, Maja",
year = "2023",
abstract = "Povećana konzumacija fruktoze kroz industrijsku hranu doprinosi razvoju metaboličkog sindroma (MetS)
koji prati hronična inflamacija niskog intenziteta, oksidativni stres i aktivacija renin-angiotenzin sistema (RAS).
Orasi su bogat izvor antioksidanasa i polinezasićenih n-3 masnih kiselina sa antiinflamatornim efektima.
Na životinjskom modelu MetS-a je pokazano da suplementacija orasima ima zaštitni efekat na srce kroz
smanjenje odnosa n-6/n-3 masnih kiselina i povećanje nivoa angiotenzin konvertujućeg enzima 2 (ACE2),
kardioprotektivne komponente RAS-a. Orasi u srcu deluju protektivno i na antioksidativnu osu SIRT1-
FoxO3a-MnSOD/katalaza, koja je kompromitovana ishranom bogatom fruktozom. Ulogu negativnih regulatora
ove ose, Nox4 i ChREBP, u srcu treba dodatno ispitati kako bi se utvrdio njihov potencijal u nutritivnoj
terapiji.
Dosadašnja istraživanja su potvrdila korisne efekte konzumacije oraha na kardiometaboličko zdravlje i
predložila molekularne mehanizme u srcu koji leže u osnovi njihovih antiinflamatornih i antioksidativnih
efekata koji mogu poništiti štetne efekte ishrane bogate fruktozom. Translacioni potencijal istraživanja
ukazuje na mogućnost razvoja novih, nefarmakoloških pristupa u terapiji kardiometaboličkih bolesti., Increased fructose intake via industrial food is associated with metabolic syndrome (MetS) which is characterized
by chronic low-intensity inflammation, oxidative stress and activation of the renin-angiotensin
system (RAS). Walnuts are a rich source of antioxidants and polyunsaturated n-3 fatty acids that exert antiinflammatory
effects.
Walnut supplementation in an animal model of MetS has been shown to have a protective effect on the
heart through a reduction of n-6/n-3 fatty acid ratio and an increase of angiotensin-converting enzyme 2
(ACE2) level, a cardioprotective component of the RAS. Walnut consumption also showed a protective effect
on the antioxidative axis SIRT1-FoxO3a-MnSOD/catalase in the heart, which was compromised by
fructose-rich diet. The role of the negative regulators of this axis, Nox4 and ChREBP, in the heart should be
further investigated to determine their nutritional therapy potential.
Previous studies confirmed the beneficial effects of walnut consumption on cardiometabolic health and
proposed the molecular mechanisms underlying their anti-inflammatory and antioxidative effects in the
heart, which could reverse the harmful effects of fructose-rich diet. The translational potential of the research
indicates the possibility for development of novel, nutritional, non-pharmacological approaches in
cardiometabolic disease therapy.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj Biologiji",
booktitle = "Antioksidativni i antiinflamatorni efekti suplementacije orasima (Juglans regia L.) na srce u metaboličkom sindromu izazvanom ishranom bogatom fruktozom, Antioxidative and antiinflamatory effects of walnut supplementation (Juglans regia L.)on heart with fructose-rich diet-induced metabolic syndrome",
pages = "121-106",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2250"
}
