TY  - JOUR
AU  - Dragičević, Sandra
AU  - Kosnik, Mitja
AU  - Divac Rankov, Aleksandra
AU  - Rijavec, Matija
AU  - Milosević, Katarina
AU  - Korosec, Peter
AU  - Kavalar, Maja Skerbinjek
AU  - Nikolić, Aleksandra
PY  - 2018
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1180
AB  - Purpose The maintaining of asthma control is difficult due to high variability in response to therapy among patients. Since matrix metalloproteinase 9 (MMP9) is implicated in inflammation and remodeling of asthmatic airways, it could be associated with adequate response to asthma therapy. The aim of this study was to investigate whether variants in 3' end of the MMP9 gene are associated with clinical phenotype and responsiveness to treatment in children with asthma. Methods The study included 127 asthmatic children from Slovenia. Variants in the 3' end of the MMP9 gene were analyzed by direct DNA sequencing and the obtained results were correlated with clinical parameters. Results Two variants were detected, rs13925 and rs20544. For the variant rs20544, statistically significant difference in airway hyperresponsiveness (p = 0.011) and asthma control (p = 0.049) between genotypes was found. Patients with TT genotype had lower airway sensitivity, and after 12 months of treatment showed significant improvement in Asthma Control Test (ACT) scores compared to CC and CT genotype. For the variant rs13925, the association with lung function was observed. The carriers of A allele showed noticeable improvement of lung function after the first 6 months of treatment in comparison to the carriers of G allele (p = 0.046). Conclusion The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment. Based on these results, MMP9 deserves further research as a potential predictive biomarker for asthma.
PB  - Springer, New York
T2  - Lung
T1  - The Variants in the 3 ' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma
EP  - 303
IS  - 3
SP  - 297
VL  - 196
DO  - 10.1007/s00408-018-0113-y
ER  - 

@article{
author = "Dragičević, Sandra and Kosnik, Mitja and Divac Rankov, Aleksandra and Rijavec, Matija and Milosević, Katarina and Korosec, Peter and Kavalar, Maja Skerbinjek and Nikolić, Aleksandra",
year = "2018",
abstract = "Purpose The maintaining of asthma control is difficult due to high variability in response to therapy among patients. Since matrix metalloproteinase 9 (MMP9) is implicated in inflammation and remodeling of asthmatic airways, it could be associated with adequate response to asthma therapy. The aim of this study was to investigate whether variants in 3' end of the MMP9 gene are associated with clinical phenotype and responsiveness to treatment in children with asthma. Methods The study included 127 asthmatic children from Slovenia. Variants in the 3' end of the MMP9 gene were analyzed by direct DNA sequencing and the obtained results were correlated with clinical parameters. Results Two variants were detected, rs13925 and rs20544. For the variant rs20544, statistically significant difference in airway hyperresponsiveness (p = 0.011) and asthma control (p = 0.049) between genotypes was found. Patients with TT genotype had lower airway sensitivity, and after 12 months of treatment showed significant improvement in Asthma Control Test (ACT) scores compared to CC and CT genotype. For the variant rs13925, the association with lung function was observed. The carriers of A allele showed noticeable improvement of lung function after the first 6 months of treatment in comparison to the carriers of G allele (p = 0.046). Conclusion The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment. Based on these results, MMP9 deserves further research as a potential predictive biomarker for asthma.",
publisher = "Springer, New York",
journal = "Lung",
title = "The Variants in the 3 ' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma",
pages = "303-297",
number = "3",
volume = "196",
doi = "10.1007/s00408-018-0113-y"
}

Dragičević, S., Kosnik, M., Divac Rankov, A., Rijavec, M., Milosević, K., Korosec, P., Kavalar, M. S.,& Nikolić, A.. (2018). The Variants in the 3 ' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma. in Lung
Springer, New York., 196(3), 297-303.
https://doi.org/10.1007/s00408-018-0113-y

Dragičević S, Kosnik M, Divac Rankov A, Rijavec M, Milosević K, Korosec P, Kavalar MS, Nikolić A. The Variants in the 3 ' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma. in Lung. 2018;196(3):297-303.
doi:10.1007/s00408-018-0113-y .

Dragičević, Sandra, Kosnik, Mitja, Divac Rankov, Aleksandra, Rijavec, Matija, Milosević, Katarina, Korosec, Peter, Kavalar, Maja Skerbinjek, Nikolić, Aleksandra, "The Variants in the 3 ' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma" in Lung, 196, no. 3 (2018):297-303,
https://doi.org/10.1007/s00408-018-0113-y . .