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Using whole exome sequencing to explore genetic basis of unicuspid aortic valve disease
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Normal aortic valve consists of three cusps that develop in the embryonic stage. Unicuspid
aortic valve (UAV) is a rare congenital anomaly resulting in only one cusp with estimated
prevalence of 0.02% in general population. ...
Deciphering the reward-related impulsivity domains in rats: The big data study of historical control
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Impulsivity is a lack of ability to control own impulses, and encompasses many subdomains.
The variable-delay-to-signal (VDS) paradigm is behavioral procedure for assessing motor
impulsivity and delay intolerance in rats, ...
Impact of different mapping tools on detection of small RNAs in bacterial outer membrane vesicles
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Bacterial small RNAs (sRNAs) represent a highly diverse RNA class ranging from 8 to 200
nucleotides in length, originating from the bacterial chromosome, plasmids or phages.
After syntheses sRNAs can remain inside the ...
Pathway analysis of CD8+ T cell transcriptome in glioblastoma patients reveales multiple sclerosis signaling pathway as the top rated upregulated disease pathway in tumor infiltrating cells
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
The significance of CD8+ T cell central nervous system migration and activation in the
progression of glioblastoma is well documented. However, molecular signaling pathways
regulation related to migration and activation ...
Genomic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Variants in Serbia: Insights into Evolutionary Dynamics and Genetic Diversity
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic, resulting in significant morbidity and mortality worldwide. Understanding the evolutionary
dynamics and genetic diversity of ...
Analysis of nucleotide sequence repeats in coronaviruses
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Repeats in nucleotide sequences are connected with various genome characteristics.
RNA secondary structures are related to repeats at the primary structure level. Four
different types of nucleotide repeats may be identified: ...
Online in silico validation of disease and gene sets, clusterings or subnetworks with DIGEST
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Given the constraints faced in the development of new drugs, the importance of drug repurposing
has reached unprecedented levels. A key aspect of effective drug repurposing lies in the discovery
of disease mechanisms and ...
AI-powered framework to predict the toxicity of microplastics
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Numerous articles have been published investigating the health effects of exposure
to micro- and nanoplastics (MNPs). However, these studies have yielded inconclusive
findings due to the lack of comparability between ...
A New Framework for the Use of Variant Interpretation Tools in Clinical Practice
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Current ACMG/AMP guidelines for the use of sequence variants for genetic diagnosis
and treatment permit the use of in silico predictors as Supporting evidence (PP3 and
BP4 criteria). These criteria, however, lack ...
Deciphering key regulatory networks and drug repurposing candidates through scRNAseq data analysis using SCANet
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Differences in co-expression networks between two or multiple cell (sub)types across
conditions is a pressing problem in single-cell RNA sequencing (scRNA-seq). A key
challenge is to define those co-variations that differ ...