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Methoxy-Substituted Hydroxychalcone Reduces Biofilm Production, Adhesion and Surface Motility of Acinetobacter baumannii by Inhibiting ompA Gene Expression
(Wiley-V C H Verlag Gmbh, Weinheim, 2021)
An increasing lack of available therapeutic options against Acinetobacter baumannii urged researchers to seek alternative ways to fight this extremely resistant nosocomial pathogen. Targeting its virulence appears to be a ...
Effects of Chemotherapy for Metastatic Colorectal Cancer on the TGF-beta Signaling and Related miRNAs hsa-miR-17-5p, hsa-miR-21-5p and hsa-miR-93-5p
(Humana Press Inc, Totowa, 2021)
Metastatic colorectal cancer (mCRC) patients are treated with standard chemotherapeutic drugs in the form of FOLFOX and FOLFIRI regimens. There are no reliable markers that could predict response to chemotherapy for mCRC. ...
Biotransformation of Perrottetin F by Aspergillus niger: New Bioactive Secondary Metabolites
(ACG Publications, Gebze-Kocaeli, 2021)
Biotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have been isolated using reversed phase semipreparative ...
Complex transcriptional regulation of the BCL2L12 gene: Novel, active promoter in K562 cells
(Elsevier, Amsterdam, 2020)
The BCL2L12, one of the latest discovered members of the BCL2 family, has both pro- and anti-apoptotic roles that are cell-type-dependent. Its role in tumorigenesis is highly implicated. Sixty-three splice variants of this ...
Association of SLC28A3 Gene Expression and CYP2B6*6 Allele with the Response to Fludarabine Plus Cyclophosphamide in Chronic Lymphocytic Leukemia Patients
(Frontiers Media Sa, Lausanne, 2020)
Fludarabine plus cyclophosphamide (FC) chemotherapy is the basis of treatment protocols used in management of chronic lymphocytic leukemia (CLL). In some patients, response to therapy may be affected by aberrant function ...
Bisaurones - enzymatic production and biological evaluation
(Royal Soc Chemistry, Cambridge, 2020)
TheTrametes versicolorlaccase catalyzed oxidation of chalcone butein afforded four dimers of aurone sulfuretin (i.e.two regioisomeric pairs of diasteromers,1-4) as the major products. The formation of the dimers was explained ...
Optimization of extraction yield and chemical characterization of optimal extract from Juglans nigra L. leaves
(Elsevier, Amsterdam, 2020)
The extraction yield of Juglans nigra L. leaves was assessed at different ethanol concentrations (0-96% (v/v)) and solvent-to-solid ratios (5-20 kg kg(-1)). The response surface methodology (RSM) and artificial neural ...
Machine Learning Modeling from Omics Data as Prospective Tool for Improvement of Inflammatory Bowel Disease Diagnosis and Clinical Classifications
(MDPI, Basel, 2021)
Research of inflammatory bowel disease (IBD) has identified numerous molecular players involved in the disease development. Even so, the understanding of IBD is incomplete, while disease treatment is still far from the ...
Intrinsically disordered protein AtDSS1(V) participates in plant defense response to oxidative stress
(Springer Wien, Wien, 2021)
DSS1 is a small protein, highly conserved across different species. As a member of the intrinsically disordered protein family, DSS1 interacts with different protein partners, thus forming complexes involved in diverse ...
Burkholderia cepacia YtnP and Y2-aiiA lactonases inhibit virulence of Pseudomonas aeruginosa via quorum quenching activity
(Academic Press Ltd- Elsevier Science Ltd, London, 2020)
Burkholderia cepacia is well known as the causative agent of infections in humans where often shares niche with other pathogens, like Pseudomonas aeruginosa. Clinical isolate Burkholderia sp. BCC4135 was selected due to ...