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Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2018)
Mononuclear silver(I) complexes with 1,7-phenanthroline (1,7-phen), [Ag(NO3-O,O') (1,7-phen-N7)(2)] (1) and [Ag(1,7-phen-N7)(2)]X, X = ClO4- (2), CF3SO3- (3), BF4- (4) and SbF6- (5) were synthesized and structurally ...
Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2019)
Ebola virus (EBOV) causes a deadly hemorrhagic fever in humans and non-human primates. There is currently no FDA-approved vaccine or medication to counter this disease. Here, we report on the design, synthesis and anti-viral ...
Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2020)
We have prepared a series of ten 3-arylcoumarin molecules, their respective fac-[Re(CO)(3)(bpy)L](+) and fac-[Re(CO)(3)(L(sic)L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ...
Combatting AMR: A molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2021)
Antimicrobial resistance (AMR) is a major emerging threat to public health, causing serious issues in the successful prevention and treatment of persistent diseases. While the problem escalates, lack of financial incentive ...
Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2022)
Candida albicans remains the main causal agent of candidiasis, the most common fungal infection with disturbingly high mortality rates worldwide. The limited diversity and efficacy of clinical antifungal drugs, exacerbated ...
4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2019)
Among neglected tropical diseases, leishmaniasis is one of the most relevant with an estimated 30,000 deaths annually. Existing therapies have serious drawbacks in safety, drug resistance, field-adapted application and ...
Identification of novel potent and non-toxic anticancer, anti-angiogenic and antimetastatic rhenium complexes against colorectal carcinoma
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2020)
Combination therapy targeting both tumor growth and vascularization is considered to be a cornerstone for colorectal carcinomas (CRC) treatment. However, the major obstacles of most clinical anticancer drugs are their weak ...
Benzothiazole carbamates and amides as antiproliferative species
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2018)
A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible ...
Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2018)
Mononuclear silver(I) complexes with 1,7-phenanthroline (1,7-phen), [Ag(NO3-O,O') (1,7-phen-N7)(2)] (1) and [Ag(1,7-phen-N7)(2)]X, X = ClO4- (2), CF3SO3- (3), BF4- (4) and SbF6- (5) were synthesized and structurally ...
Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2022)
The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The ...