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A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity
(Royal Soc Chemistry, Cambridge, 2018)
The anticancer potential of sixteen platinum(II) complexes with general formulae [PtCl(hq)(S-dmso)] (1a-8a) and [PtCl(hq)(pta)] (1b-8b) (where hq is 5-chloro-7-iodo-8-quinolinol (clioquinol; cqH) (1a, 1b), 8-hydroxy-5-ni ...
Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?
(Lippincott Williams & Wilkins, Philadelphia, 2015)
Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, ...
FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle
(Amer Soc Biochemistry Molecular Biology Inc, Rockville, 2000)
We report the identification and characterization of a novel 32-kDa protein expressed in skeletal muscle and located in the Z-disc of the sarcomere. We found that this protein binds to three other Z-disc proteins; therefore, ...
The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis
(Cell Press, Cambridge, 2003)
DSS1 encodes a small acidic protein shown in recent structural studies to interact with the DNA binding domain of BRCA2. Here we report that an ortholog of DSS1 is present in Ustilago maydis and associates with Brh2, the ...
BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis
(Cell Press, Cambridge, 2002)
In a screen for DNA repair-defective mutants in the fungus Ustilago maydis, a gene encoding a BRCA2 family member, designated here as Brh2, was identified. A brh2 null allele was found to be defective in allelic recombination, ...
The Rest Repression of the Neurosecretory Phenotype Is Negatively Modulated by BHC80, a Protein of the BRAF/HDAC Complex
(Soc Neuroscience, Washington, 2009)
Expression of neurosecretion by nerve cells requires the levels of the transcription repressor element-1 silencing transcription factor (REST) to be very low. However, when high-REST clones of PC12 cells, defective of ...
Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics
(Oxford Univ Press, Oxford, 2009)
The 16S ribosomal RNA methyltransferase enzymes that modify nucleosides in the drug binding site to provide self-resistance in aminoglycoside-producing micro-organisms have been proposed to comprise two distinct groups of ...
Managing membrane stress: the phage shock protein (Psp) response, from molecular mechanisms to physiology
(Oxford Univ Press, Oxford, 2010)
The bacterial phage shock protein (Psp) response functions to help cells manage the impacts of agents impairing cell membrane function. The system has relevance to biotechnology and to medicine. Originally discovered in ...
Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion
(Cell Press, Cambridge, 2012)
Shigella infection causes destruction of the human colonic epithelial barrier. The Golgi network and recycling endosomes are essential for maintaining epithelial barrier function. Here we show that Shigella epithelial ...
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
(Nature Publishing Group, New York, 2011)
We developed a series of interrelated locus-specific databases to store all published and unpublished genetic variation related to hemoglobinopathies and thalassemia and implemented microattribution to encourage submission ...