Pretraživanje
Prikaz rezultata 1-10 od 11
Predictive genetic markers of coagulation, inflammation and apoptosis in Perthes disease-Serbian experience
(Springer, New York, 2015)
Perthes disease is one of the most common forms of pediatric femoral head osteonecrosis with an unknown etiology. Coagulation factors were the first genetic factors suspected to have a role in the pathogenesis of this ...
Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy
(Elsevier Ireland Ltd, Clare, 2014)
Ethnopharmacological relevance: Reseda lutea L (Resedaceae) or Wild Mignonette is a widely distributed plant species. Pliny the Elder (AD 23-AD 79), a Roman scholar and naturalist, reported the use of R. lutea for reducing ...
Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO
(Elsevier Science Inc, New York, 2010)
The new chemical entity GIT-27NO was created by the covalent linkage of a NO moiety to the antiinflammatory isoxazoline VGX-1027 The compound has been shown to possess powerful anticancer effects both in vitro and in vivo ...
Cell-type dependent response of melanoma cells to aloe emodin
(Pergamon-Elsevier Science Ltd, Oxford, 2012)
Intrinsic characteristics of melanoma cells such as expression of inducible nitric oxide synthase (iNOS), redox status, and activity of signaling pathways involved in proliferation, differentiation and cell death define ...
The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate
(Elsevier Sci Ltd, Oxford, 2013)
The biodegradable polymer medium chain length polyhydroxyalkanoate (mclPHA), produced by Pseudomonas putida CA-3, was depolymerised and the predominant monomer (R)-3-hydroxydecanoic acid (R10) purified. R10 was conjugated ...
Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells
(Springer, New York, 2017)
Autophagy is linked to multiple cancer-related signaling pathways, and represents a defense mechanism for cancer cells under therapeutic stress. The crosstalk between apoptosis and autophagy is essential for both tumorigenesis ...
Cardiac transcription factor Nkx2.5 interacts with p53 and modulates its activity
(Elsevier Science Inc, New York, 2015)
Transcription factor Nkx2.5, essential for heart development, regulates cardiomyocyte-specific gene expression through combinatorial interactions with other cardiac-restricted (GATA4 and dHAND) or ubiquitous (p300) ...
Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia
(Pergamon-Elsevier Science Ltd, Oxford, 2012)
Objectives: BCL2L12 is a recently discovered and cloned gene from members of our research team. It is a novel member of the BCL2 gene family, members of which are implicated in different hematological malignancies. In the ...
Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification
(Elsevier Science Inc, New York, 2019)
Anticancer activity of Pd complexes 1-5 with bidentate N-heteroaromatic hydrazone ligands was investigated on human acute monocytic leukemia (THP-1; cells in a suspension) and human mammary adenocarcinoma (MCF-7; two-dimensional ...
Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2022)
The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The ...