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Investigation of the role of the glucose-6-phosphate translocase in the activation of autophagy and glycogen-selective autophagy in glycogen storage disease type IB patients
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Glycogen storage disease type Ib (GSD-Ib) is characterized by a deficiency of glucose-6-
phosphate translocase (G6PT) encoded by the SLC37A4 gene, affecting glucose homeostasis and disrupting autophagy. ...
Precision medicine and COVID-19: Importance of host genome profiling
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: The clinical picture and the course of the disease in COVID-19 patients, caused by coronavirus SARS-CoV-2, vary from asymptomatic to fatal outcome. As the same agent cause the disease, the
individual genomic ...
Prothrombin influences proliferation and migration of colon cancer in vitro
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Thrombin, crucial member of the coagulation cascade, can influence growth and development of different types of cancer. Prothrombin, thrombin precursor, although predominantly secreted
from the liver into ...
Influence of amino acid substitution on the antimicrobial activity of bacteriocin lactolisterin BU
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Lactolisterin BU (LBU) is a potent bacteriocin derived from Lactococcuslactis subsp. lactisbv. diacetylactis BGBU1-4. It exhibits antimicrobial properties against Gram-positive food spoilage andfoodborne ...
The role of MIR-34 family members on the mucociliary process in the cellular respiratory model system
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Primary ciliary dyskinesia is a rare and heterogeneous disorder primarily affecting the respiratory organs, with impaired mucociliary clearance being a common characteristic. Recently, the importance of the ...
Can pharmacogenetic variants in TPMT, MTHFR and SLCO1B1 genes be used as potential markers of outcome prediction in systemic sclerosis patients?
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Systemic sclerosis(SSc) is a rare autoimmune disorder that affects connective tissues and
hasthe highest morbidity and mortality among rheumatologic diseases. Clinical presentations as well as
disease ...
Neurofilament as a biomarker of response to genetically designed therapies for spinal muscular atrophy
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Considering the substantial impact of genetic therapies for spinal muscular atrophy (SMA), longitudinal
follow-up of patients undergoing treatment is crucial to effectively monitor treatment response. While
functional ...
Determination of muscle fiber types expressing ANKRD2
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Ankyrin Repeat Domain 2 (ANKRD2) is expressed in skeletal muscle, where plays a role in
muscle development, differentiation and adaptation to stress. Human skeletal muscle consists of three
major fiber ...
Drying without dying: revealing the role of late embryogenesis abundant proteins during desiccation in Ramonda serbica
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Resurrection plants (such as Ramonda serbica) can survive a long desiccation period and
fully resume their metabolism upon watering. The hallmark of desiccation tolerance (DT) is the accumulation of protective, ...
Reconstitution of non-carrier, heterozygous and homozygous prothrombin belgrade mutation carrier plasma using recombinant proteins
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: The prothrombin Belgrade variant (c.1787G>A, p.Arg596Gln) is a rare mutation found in
Serbia, Japan, China, America, India and leads to antithrombin resistance. Prothrombin Belgrade mutation influencesthro ...