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Now showing items 101-110 of 110
Combined experimental and theoretical study of Type-II toxin-antitoxin system response to antibiotics
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Bacterial Type-II toxin-antitoxin (TA) systems, including kacAT in Klebsiella pneumoniae,
respond to antibiotics. We investigated kacAT’s regulation relevant to antibiotic
persistence, which refers to the survival of ...
Genome-wide association analysis for severe COVID-19 in Serbian population
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Host genetics, an important contributor to the COVID-19 clinical susceptibility and severity,
currently is the focus of multiple genome-wide association studies (GWAS) in populations
affected by the pandemic. This is the ...
PACSIN2 modifies miRNAs in extracellular vesicles, modulating thiopurine response
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Thiopurines, such as mercaptopurine, are antimetabolites, used in the treatment of acute
lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD). PACSIN2 rs2413739
is associated with gastrointestinal toxicity ...
Single cell 3’ transcriptome profiling
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Whole 3’ transcriptome profiling at the single cell level opens up new abilities for researchers to
answer complex questions. Thousands of individual cells per sample are Barcoded separately to
index the transcriptome ...
Uncovering resistance to microtubule targeting drugs
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Drugs that alter microtubule dynamics have been used for decades for treating different
types of cancers. Such drugs arrest cell cycle progression in mitosis, and induce apoptosis.
However, a fraction of cells manages ...
Computational tools and repositories for precision therapeutics in the post-genomic era
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
In the post-genomic era, the rapid evolution of high-throughput genotyping technologies and the increased pace of production of genetic research data, are continually prompting the development of appropriate informatics ...
Computer analysis of glioma gene network structure
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Computer analysis of disease susceptibility genes using online bioinformatics tools and
open databases allows the identification of potential target genes for therapy. In the
course of this study we reconstructed the ...
Modulating Horizontal Gene Transfer through Bistability in the Dynamics of Bacterial Restriction-Modification Systems
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Restriction-modification (R-M) systems consist of genes encoding restriction enzyme
and methyltransferase, often co-expressed with a specialized regulator (C protein).
These systems tightly regulate their function through ...
In silico pre-selection of β-glucosidase gene for heterologous recombinant expression
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Biofilms are ubiquitous in nature, and the food industry is vulnerable to the risks posed by
biofilm formation. Not only do they interfere with the food production process, but they also
pose a public health threat. ...
Development of hybrid and optimized deep learning classifiers for speech recognition in tracheostomy patients: a case study
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
The ability of a machine or program to recognize words spoken aloud and translate
them into legible text is known as speech recognition and has gained a lot of attention
in the last decade especially in healthcare to ...