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Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy
(European Journal of Medicinal ChemistryEuropean Journal of Medicinal ChemistryEuropean Journal of Medicinal Chemistry, 2023)
Novel bacterial topoisomerase inhibitors (NBTIs) are new promising antimicrobials for the treatment of multidrug-resistant bacterial infections. In recent years, many new NBTIs have been discovered, however most of them ...
Marker porekla kao adut u forenzičkim analizama DNK u kompleksnim slučajevima iz perspektive Y hromozoma / Lineage marker as a key player in complex forensic cases from the perspective of Y chromosome
(Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo, 2022)
Kako se Y hromozom kroz generacije ne menja rekombinacijama, prenosi se uglavnom nepromenjen
sa oca na sina. Haplotipovi dobijeni kombinovanom analizom kratkih tandemskih ponovaka na Y hromozomu
imaju široku primenu u ...
Investigation of the role of the glucose-6-phosphate translocase in the activation of autophagy and glycogen-selective autophagy in glycogen storage disease type IB patients
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Glycogen storage disease type Ib (GSD-Ib) is characterized by a deficiency of glucose-6-
phosphate translocase (G6PT) encoded by the SLC37A4 gene, affecting glucose homeostasis and disrupting autophagy. ...
Violacein enhances the cytotoxic effect of commonly used chemotherapeutics on rhabdomyosarcoma cells
(Belgrade : Serbian Association on for Cancer Research, 2023)
Investigati on of natural compounds showing specific toxicity to tumor cells aims to improve the efficacy
of available therapies. Our previous research demonstrated the cytotoxic acti vity of the bacterial pigment ...
The story of the SOX genes: for better or for worse…
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
The SOX genes encode a group of transcription factors showing diverse expression patterns during de- velopment and acting as key regulators of diverse cellular processes. SOX transcription factors are in- volved in multiple ...
Late-stage diversification of bacterial natural products through biocatalysis
(Frontiers, 2024)
Bacterial natural products (BNPs) have been and still are very important sources of leads for drug development and chemical novelty. The possibility to perform late-stage diversification of these biomolecules is an attractive ...
The influence of Wilms' tumor 1 gene expression level on prognosis and risk stratification of acute promyelocytic leukemia patients
(Wiley, Hoboken, 2020)
Introduction Patients with acute promyelocytic leukemia (APL) are characterized by the highest expression of Wilms' tumor 1 (WT1) gene compared with other subtypes of acute myeloid leukemia, and yet this molecular marker ...
Precision medicine and COVID-19: Importance of host genome profiling
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: The clinical picture and the course of the disease in COVID-19 patients, caused by coronavirus SARS-CoV-2, vary from asymptomatic to fatal outcome. As the same agent cause the disease, the
individual genomic ...
Varijante i transkripcija gena koji kodiraju komponente leptinskog signalnog puta, inflamacije i antioksidativne zaštite u patogenezi multiple skleroze
(Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo, 2023)
Multipla skleroza (MS) je hronična autoimunska bolest centralnog nervnog sistema (CNS) čiji osnovni
patogenetski mehanizmi obuhvataju neuroinflamaciju, demijelinizaciju i neurodegeneraciju. Glavno
patofiziološko obeležje ...
THE IMPACT OF NEXT-GENERATION SEQUENCING ON DIAGNOSIS AND TREATMENT OF RARE DISEASES
(Macedonian Academy of Sciences and Arts, 2023)
Introduction: Rare diseases are heterogeneous group of diseases, with one common characteristics, a
prevalence less than 1 in 2000 people. Vast majority of them are monogenic and finding pathogenic genetic
variants is ...