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Is miR-133a marker of progressive chronic kidney disease?
dc.creator | Stopić, Bojan | |
dc.creator | Dragičević, Sandra | |
dc.creator | Medić Brkić. Branislava | |
dc.creator | Nikolić, Aleksandra | |
dc.creator | Budisavljević, Sreten | |
dc.creator | Marković Nikolić, Natasa | |
dc.creator | Dimković, Nada | |
dc.date.accessioned | 2023-10-03T10:59:21Z | |
dc.date.available | 2023-10-03T10:59:21Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0931-0509 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/2080 | |
dc.description.abstract | Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular (CV) disease and numerous risk factor have been implicated to play a role. Recent studies have shown that the levels of various microRNAs in the serum of patients with CKD have been altered and there are reports that miR-133a serum levels correlated with left ventricular hypertrophy in hemodialysis patients.The aim of this study was to investigate association between circulating miR-133a levels and development of de novo CV events in patients with CKD stage 3-5HD.METHODS: This study included 51 patients with diagnosed CKD and 7 healthy individuals as controls. According to the estimated glomerular filtration ratio (eGFR) patients were divided into three equal subgroups (n=17): patients with CKD stage 3b, 4, and 5HD. The level of miR-133a was measured in serum by quantitative real-time PCR. Echo parameters were measured by cardiac ultrasound at the beginning and after 12 months of follow-up. The following CV events were reported during 18 months of follow-up: cardiac death, myocardial infarction, cerebrovascular insult, exacerbation of existing and newly discovered angina pectoris and peripheral arterial disease. | |
dc.publisher | Oxford University Press | |
dc.rights | openAccess | |
dc.source | Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress Abstracts | |
dc.title | Is miR-133a marker of progressive chronic kidney disease? | |
dc.type | conferenceObject | en |
dc.rights.license | ARR | |
dc.citation.issue | Supplement_1 | |
dc.citation.spage | FP177 | |
dc.citation.volume | 34 | |
dc.identifier.doi | 10.1093/ndt/gfz106.FP177 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/402640/FP177Is_miR-133a_marker_pub_2019.pdf | |
dc.type.version | publishedVersion |