TY  - JOUR
AU  - Senćanski, Milan
AU  - Glišić, Sanja
AU  - Kubale, Valentina
AU  - Cotman, Marko
AU  - Mavri, Janez
AU  - Vrecl, Milka
PY  - 2024
UR  - https://www.mdpi.com/2218-273X/14/4/423
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2342
AB  - This study assessed the suitability of the complementarity-determining region 2 (CDR2) of the nanobody (Nb) as a template for the derivation of nanobody-derived peptides (NDPs) targeting active-state β2-adrenergic receptor (β2AR) conformation. Sequences of conformationally selective Nbs favoring the agonist-occupied β2AR were initially analyzed by the informational spectrum method (ISM). The derived NDPs in complex with β2AR were subjected to protein–peptide docking, molecular dynamics (MD) simulations, and metadynamics-based free-energy binding calculations. Computational analyses identified a 25-amino-acid-long CDR2-NDP of Nb71, designated P4, which exhibited the following binding free-energy for the formation of the β2AR:P4 complex (ΔG = −6.8 ± 0.8 kcal/mol or a Ki = 16.5 μM at 310 K) and mapped the β2AR:P4 amino acid interaction network. In vitro characterization showed that P4 (i) can cross the plasma membrane, (ii) reduces the maximum isoproterenol-induced cAMP level by approximately 40% and the isoproterenol potency by up to 20-fold at micromolar concentration, (iii) has a very low affinity to interact with unstimulated β2AR in the cAMP assay, and (iv) cannot reduce the efficacy and potency of the isoproterenol-mediated β2AR/β-arrestin-2 interaction in the BRET2-based recruitment assay. In summary, the CDR2-NDP, P4, binds preferentially to agonist-activated β2AR and disrupts Gαs-mediated signaling.
PB  - MDPI
T2  - Biomolecules
T2  - Biomolecules
T1  - Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the β2-Adrenergic Receptor (β2AR)
IS  - 4
SP  - 423
VL  - 14
DO  - 10.3390/biom14040423
ER  - 

@article{
author = "Senćanski, Milan and Glišić, Sanja and Kubale, Valentina and Cotman, Marko and Mavri, Janez and Vrecl, Milka",
year = "2024",
abstract = "This study assessed the suitability of the complementarity-determining region 2 (CDR2) of the nanobody (Nb) as a template for the derivation of nanobody-derived peptides (NDPs) targeting active-state β2-adrenergic receptor (β2AR) conformation. Sequences of conformationally selective Nbs favoring the agonist-occupied β2AR were initially analyzed by the informational spectrum method (ISM). The derived NDPs in complex with β2AR were subjected to protein–peptide docking, molecular dynamics (MD) simulations, and metadynamics-based free-energy binding calculations. Computational analyses identified a 25-amino-acid-long CDR2-NDP of Nb71, designated P4, which exhibited the following binding free-energy for the formation of the β2AR:P4 complex (ΔG = −6.8 ± 0.8 kcal/mol or a Ki = 16.5 μM at 310 K) and mapped the β2AR:P4 amino acid interaction network. In vitro characterization showed that P4 (i) can cross the plasma membrane, (ii) reduces the maximum isoproterenol-induced cAMP level by approximately 40% and the isoproterenol potency by up to 20-fold at micromolar concentration, (iii) has a very low affinity to interact with unstimulated β2AR in the cAMP assay, and (iv) cannot reduce the efficacy and potency of the isoproterenol-mediated β2AR/β-arrestin-2 interaction in the BRET2-based recruitment assay. In summary, the CDR2-NDP, P4, binds preferentially to agonist-activated β2AR and disrupts Gαs-mediated signaling.",
publisher = "MDPI",
journal = "Biomolecules, Biomolecules",
title = "Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the β2-Adrenergic Receptor (β2AR)",
number = "4",
pages = "423",
volume = "14",
doi = "10.3390/biom14040423"
}

Senćanski, M., Glišić, S., Kubale, V., Cotman, M., Mavri, J.,& Vrecl, M.. (2024). Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the β2-Adrenergic Receptor (β2AR). in Biomolecules
MDPI., 14(4), 423.
https://doi.org/10.3390/biom14040423

Senćanski M, Glišić S, Kubale V, Cotman M, Mavri J, Vrecl M. Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the β2-Adrenergic Receptor (β2AR). in Biomolecules. 2024;14(4):423.
doi:10.3390/biom14040423 .

Senćanski, Milan, Glišić, Sanja, Kubale, Valentina, Cotman, Marko, Mavri, Janez, Vrecl, Milka, "Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the β2-Adrenergic Receptor (β2AR)" in Biomolecules, 14, no. 4 (2024):423,
https://doi.org/10.3390/biom14040423 . .

TY  - CHAP
AU  - Bubić, Maja
AU  - Živković, Maja
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2250
AB  - Povećana konzumacija fruktoze kroz industrijsku hranu doprinosi razvoju metaboličkog sindroma (MetS)
koji prati hronična inflamacija niskog intenziteta, oksidativni stres i aktivacija renin-angiotenzin sistema (RAS).
Orasi su bogat izvor antioksidanasa i polinezasićenih n-3 masnih kiselina sa antiinflamatornim efektima.
Na životinjskom modelu MetS-a je pokazano da suplementacija orasima ima zaštitni efekat na srce kroz
smanjenje odnosa n-6/n-3 masnih kiselina i povećanje nivoa angiotenzin konvertujućeg enzima 2 (ACE2),
kardioprotektivne komponente RAS-a. Orasi u srcu deluju protektivno i na antioksidativnu osu SIRT1-
FoxO3a-MnSOD/katalaza, koja je kompromitovana ishranom bogatom fruktozom. Ulogu negativnih regulatora
ove ose, Nox4 i ChREBP, u srcu treba dodatno ispitati kako bi se utvrdio njihov potencijal u nutritivnoj
terapiji.
Dosadašnja istraživanja su potvrdila korisne efekte konzumacije oraha na kardiometaboličko zdravlje i
predložila molekularne mehanizme u srcu koji leže u osnovi njihovih antiinflamatornih i antioksidativnih
efekata koji mogu poništiti štetne efekte ishrane bogate fruktozom. Translacioni potencijal istraživanja
ukazuje na mogućnost razvoja novih, nefarmakoloških pristupa u terapiji kardiometaboličkih bolesti.
AB  - Increased fructose intake via industrial food is associated with metabolic syndrome (MetS) which is characterized
by chronic low-intensity inflammation, oxidative stress and activation of the renin-angiotensin
system (RAS). Walnuts are a rich source of antioxidants and polyunsaturated n-3 fatty acids that exert antiinflammatory
effects.
Walnut supplementation in an animal model of MetS has been shown to have a protective effect on the
heart through a reduction of n-6/n-3 fatty acid ratio and an increase of angiotensin-converting enzyme 2
(ACE2) level, a cardioprotective component of the RAS. Walnut consumption also showed a protective effect
on the antioxidative axis SIRT1-FoxO3a-MnSOD/catalase in the heart, which was compromised by
fructose-rich diet. The role of the negative regulators of this axis, Nox4 and ChREBP, in the heart should be
further investigated to determine their nutritional therapy potential.
Previous studies confirmed the beneficial effects of walnut consumption on cardiometabolic health and
proposed the molecular mechanisms underlying their anti-inflammatory and antioxidative effects in the
heart, which could reverse the harmful effects of fructose-rich diet. The translational potential of the research
indicates the possibility for development of novel, nutritional, non-pharmacological approaches in
cardiometabolic disease therapy.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - Trendovi u molekularnoj Biologiji
T1  - Antioksidativni i antiinflamatorni efekti suplementacije orasima (Juglans regia L.) na srce u metaboličkom sindromu izazvanom ishranom bogatom fruktozom
T1  - Antioxidative and antiinflamatory effects of walnut supplementation (Juglans regia L.)on heart with fructose-rich diet-induced metabolic syndrome
EP  - 121
IS  - 3
SP  - 106
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2250
ER  - 

@inbook{
author = "Bubić, Maja and Živković, Maja",
year = "2023",
abstract = "Povećana konzumacija fruktoze kroz industrijsku hranu doprinosi razvoju metaboličkog sindroma (MetS)
koji prati hronična inflamacija niskog intenziteta, oksidativni stres i aktivacija renin-angiotenzin sistema (RAS).
Orasi su bogat izvor antioksidanasa i polinezasićenih n-3 masnih kiselina sa antiinflamatornim efektima.
Na životinjskom modelu MetS-a je pokazano da suplementacija orasima ima zaštitni efekat na srce kroz
smanjenje odnosa n-6/n-3 masnih kiselina i povećanje nivoa angiotenzin konvertujućeg enzima 2 (ACE2),
kardioprotektivne komponente RAS-a. Orasi u srcu deluju protektivno i na antioksidativnu osu SIRT1-
FoxO3a-MnSOD/katalaza, koja je kompromitovana ishranom bogatom fruktozom. Ulogu negativnih regulatora
ove ose, Nox4 i ChREBP, u srcu treba dodatno ispitati kako bi se utvrdio njihov potencijal u nutritivnoj
terapiji.
Dosadašnja istraživanja su potvrdila korisne efekte konzumacije oraha na kardiometaboličko zdravlje i
predložila molekularne mehanizme u srcu koji leže u osnovi njihovih antiinflamatornih i antioksidativnih
efekata koji mogu poništiti štetne efekte ishrane bogate fruktozom. Translacioni potencijal istraživanja
ukazuje na mogućnost razvoja novih, nefarmakoloških pristupa u terapiji kardiometaboličkih bolesti., Increased fructose intake via industrial food is associated with metabolic syndrome (MetS) which is characterized
by chronic low-intensity inflammation, oxidative stress and activation of the renin-angiotensin
system (RAS). Walnuts are a rich source of antioxidants and polyunsaturated n-3 fatty acids that exert antiinflammatory
effects.
Walnut supplementation in an animal model of MetS has been shown to have a protective effect on the
heart through a reduction of n-6/n-3 fatty acid ratio and an increase of angiotensin-converting enzyme 2
(ACE2) level, a cardioprotective component of the RAS. Walnut consumption also showed a protective effect
on the antioxidative axis SIRT1-FoxO3a-MnSOD/catalase in the heart, which was compromised by
fructose-rich diet. The role of the negative regulators of this axis, Nox4 and ChREBP, in the heart should be
further investigated to determine their nutritional therapy potential.
Previous studies confirmed the beneficial effects of walnut consumption on cardiometabolic health and
proposed the molecular mechanisms underlying their anti-inflammatory and antioxidative effects in the
heart, which could reverse the harmful effects of fructose-rich diet. The translational potential of the research
indicates the possibility for development of novel, nutritional, non-pharmacological approaches in
cardiometabolic disease therapy.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj Biologiji",
booktitle = "Antioksidativni i antiinflamatorni efekti suplementacije orasima (Juglans regia L.) na srce u metaboličkom sindromu izazvanom ishranom bogatom fruktozom, Antioxidative and antiinflamatory effects of walnut supplementation (Juglans regia L.)on heart with fructose-rich diet-induced metabolic syndrome",
pages = "121-106",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2250"
}

Bubić, M.,& Živković, M.. (2023). Antioksidativni i antiinflamatorni efekti suplementacije orasima (Juglans regia L.) na srce u metaboličkom sindromu izazvanom ishranom bogatom fruktozom. in Trendovi u molekularnoj Biologiji
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(3), 106-121.
https://hdl.handle.net/21.15107/rcub_imagine_2250

Bubić M, Živković M. Antioksidativni i antiinflamatorni efekti suplementacije orasima (Juglans regia L.) na srce u metaboličkom sindromu izazvanom ishranom bogatom fruktozom. in Trendovi u molekularnoj Biologiji. 2023;(3):106-121.
https://hdl.handle.net/21.15107/rcub_imagine_2250 .

Bubić, Maja, Živković, Maja, "Antioksidativni i antiinflamatorni efekti suplementacije orasima (Juglans regia L.) na srce u metaboličkom sindromu izazvanom ishranom bogatom fruktozom" in Trendovi u molekularnoj Biologiji, no. 3 (2023):106-121,
https://hdl.handle.net/21.15107/rcub_imagine_2250 .

TY  - CONF
AU  - Stevanović, Kristina
AU  - Senćanski, Milan
AU  - Perović, Vladimir
AU  - Glišić, Sanja
PY  - 2023
UR  - https://www.chem.bg.ac.rs/pz/news1.py?q=3820&l=1
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2206
AB  - The NOD-like receptor pyrin domain-containing protein 3 (NLRP3), an important
intracellular sensor in the innate immune system, detects a plethora of exogenous and
endogenous stimuli, leading to inflammasome formation and caspase-1 activation. More
recently, it emerged as an attractive drug target due to abnormal NLRP3 inflammasome
activation implicated in many acute and chronic diseases (including diabetes,
atherosclerosis, metabolic syndrome, cardiovascular, and neurodegenerative diseases)
[1]. Several direct NLRP3 inhibitors that block its ATPase activity by keeping it in
closed conformation have been reported [1,2]. Some of them have entered clinical trials,
but still, none of them is FDA approved.
A powerful strategy in identifying potential NLRP3 inhibitors can be in silico drug
repurposing of compounds with already known safety profiles. In this study, we
performed a virtual screening protocol that considers both long- and short-range
interactions between molecules. First, the Informational spectrum method developed for
small molecules was applied for searching the Drugbank database. Selected candidates
were filtered by successive cross-correlation spectra analysis. Finally, after molecular
docking, we identified the most promising candidate and proposed it for further
experimental testing.
PB  - 9th Conference of Young Chemists of Serbia
C3  - 9th Conference of Young Chemists of Serbia
T1  - Identification of the new candidate NLRP3 inhibitor using combined computational approach
SP  - 50
SP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2206
ER  - 

@conference{
author = "Stevanović, Kristina and Senćanski, Milan and Perović, Vladimir and Glišić, Sanja",
year = "2023",
abstract = "The NOD-like receptor pyrin domain-containing protein 3 (NLRP3), an important
intracellular sensor in the innate immune system, detects a plethora of exogenous and
endogenous stimuli, leading to inflammasome formation and caspase-1 activation. More
recently, it emerged as an attractive drug target due to abnormal NLRP3 inflammasome
activation implicated in many acute and chronic diseases (including diabetes,
atherosclerosis, metabolic syndrome, cardiovascular, and neurodegenerative diseases)
[1]. Several direct NLRP3 inhibitors that block its ATPase activity by keeping it in
closed conformation have been reported [1,2]. Some of them have entered clinical trials,
but still, none of them is FDA approved.
A powerful strategy in identifying potential NLRP3 inhibitors can be in silico drug
repurposing of compounds with already known safety profiles. In this study, we
performed a virtual screening protocol that considers both long- and short-range
interactions between molecules. First, the Informational spectrum method developed for
small molecules was applied for searching the Drugbank database. Selected candidates
were filtered by successive cross-correlation spectra analysis. Finally, after molecular
docking, we identified the most promising candidate and proposed it for further
experimental testing.",
publisher = "9th Conference of Young Chemists of Serbia",
journal = "9th Conference of Young Chemists of Serbia",
title = "Identification of the new candidate NLRP3 inhibitor using combined computational approach",
pages = "50-50",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2206"
}

Stevanović, K., Senćanski, M., Perović, V.,& Glišić, S.. (2023). Identification of the new candidate NLRP3 inhibitor using combined computational approach. in 9th Conference of Young Chemists of Serbia
9th Conference of Young Chemists of Serbia., 50.
https://hdl.handle.net/21.15107/rcub_imagine_2206

Stevanović K, Senćanski M, Perović V, Glišić S. Identification of the new candidate NLRP3 inhibitor using combined computational approach. in 9th Conference of Young Chemists of Serbia. 2023;:50.
https://hdl.handle.net/21.15107/rcub_imagine_2206 .

Stevanović, Kristina, Senćanski, Milan, Perović, Vladimir, Glišić, Sanja, "Identification of the new candidate NLRP3 inhibitor using combined computational approach" in 9th Conference of Young Chemists of Serbia (2023):50,
https://hdl.handle.net/21.15107/rcub_imagine_2206 .

TY  - JOUR
AU  - Marković, Zoran
AU  - Mišović, Aleksandra
AU  - Zmejkoski, Danica
AU  - Zdravković, Nemanja
AU  - Kovač, Janez
AU  - Bajuk-Bogdanović, Danica
AU  - Milivojević, Dušan
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Pavlović, Vladimir
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://www.mdpi.com/2079-6382/12/5/919
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1892
AB  - Nowadays, it is a great challenge to develop new medicines for treating various infectious diseases. The treatment of these diseases is of utmost interest to further prevent the development of multi-drug resistance in different pathogens. Carbon quantum dots, as a new member of the carbon nanomaterials family, can potentially be used as a highly promising visible-light-triggered antibacterial agent. In this work, the results of antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots are presented. Carbon quantum dots (CQDs) were synthesized from citric acid by a pyrolysis procedure and irradiated by gamma rays at different doses (25, 50, 100 and 200 kGy). Structure, chemical composition and optical properties were investigated by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Vis spectrometry and photoluminescence. Structural analysis showed that CQDs have a spherical-like shape and dose-dependent average diameters and heights. Antibacterial tests showed that all irradiated dots had antibacterial activity but CQDs irradiated with dose of 100 kGy had antibacterial activity against all seven pathogen-reference bacterial strains. Gamma-ray-modified CQDs did not show any cytotoxicity toward human fetal-originated MRC-5 cells. Moreover, fluorescence microscopy showed excellent cellular uptake of CQDs irradiated with doses of 25 and 200 kGy into MRC-5 cells.
T2  - Antibiotics
T1  - Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria
IS  - 5
SP  - 919
VL  - 12
DO  - 10.3390/antibiotics12050919
ER  - 

@article{
author = "Marković, Zoran and Mišović, Aleksandra and Zmejkoski, Danica and Zdravković, Nemanja and Kovač, Janez and Bajuk-Bogdanović, Danica and Milivojević, Dušan and Mojsin, Marija and Stevanović, Milena and Pavlović, Vladimir and Todorović Marković, Biljana",
year = "2023",
abstract = "Nowadays, it is a great challenge to develop new medicines for treating various infectious diseases. The treatment of these diseases is of utmost interest to further prevent the development of multi-drug resistance in different pathogens. Carbon quantum dots, as a new member of the carbon nanomaterials family, can potentially be used as a highly promising visible-light-triggered antibacterial agent. In this work, the results of antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots are presented. Carbon quantum dots (CQDs) were synthesized from citric acid by a pyrolysis procedure and irradiated by gamma rays at different doses (25, 50, 100 and 200 kGy). Structure, chemical composition and optical properties were investigated by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Vis spectrometry and photoluminescence. Structural analysis showed that CQDs have a spherical-like shape and dose-dependent average diameters and heights. Antibacterial tests showed that all irradiated dots had antibacterial activity but CQDs irradiated with dose of 100 kGy had antibacterial activity against all seven pathogen-reference bacterial strains. Gamma-ray-modified CQDs did not show any cytotoxicity toward human fetal-originated MRC-5 cells. Moreover, fluorescence microscopy showed excellent cellular uptake of CQDs irradiated with doses of 25 and 200 kGy into MRC-5 cells.",
journal = "Antibiotics",
title = "Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria",
number = "5",
pages = "919",
volume = "12",
doi = "10.3390/antibiotics12050919"
}

Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919.
https://doi.org/10.3390/antibiotics12050919

Marković Z, Mišović A, Zmejkoski D, Zdravković N, Kovač J, Bajuk-Bogdanović D, Milivojević D, Mojsin M, Stevanović M, Pavlović V, Todorović Marković B. Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics. 2023;12(5):919.
doi:10.3390/antibiotics12050919 .

Marković, Zoran, Mišović, Aleksandra, Zmejkoski, Danica, Zdravković, Nemanja, Kovač, Janez, Bajuk-Bogdanović, Danica, Milivojević, Dušan, Mojsin, Marija, Stevanović, Milena, Pavlović, Vladimir, Todorović Marković, Biljana, "Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria" in Antibiotics, 12, no. 5 (2023):919,
https://doi.org/10.3390/antibiotics12050919 . .

TY  - DATA
AU  - Marković, Zoran
AU  - Budimir, Milica
AU  - Danko, Martin
AU  - Milivojević, Dušan
AU  - Kubat, Pavel
AU  - Zmejkoski, Danica
AU  - Pavlović, Vladimir
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://www.beilstein-journals.org/bjnano/articles/14/17
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1894
AB  - Figure S1: (a) TEM micrograph of CQDs, (b) top view AFM image of CQDs, (c) height profile of CQDs, and (d) particle size distribution of CQDs.
T2  - Beilstein Journal of Nanotechnology
T2  - Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.
T1  - Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17
EP  - 174
IS  - 1
SP  - 165
VL  - 14
DO  - 10.3762/bjnano.14.17
ER  - 

@misc{
author = "Marković, Zoran and Budimir, Milica and Danko, Martin and Milivojević, Dušan and Kubat, Pavel and Zmejkoski, Danica and Pavlović, Vladimir and Mojsin, Marija and Stevanović, Milena and Todorović Marković, Biljana",
year = "2023",
abstract = "Figure S1: (a) TEM micrograph of CQDs, (b) top view AFM image of CQDs, (c) height profile of CQDs, and (d) particle size distribution of CQDs.",
journal = "Beilstein Journal of Nanotechnology, Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.",
title = "Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17",
pages = "174-165",
number = "1",
volume = "14",
doi = "10.3762/bjnano.14.17"
}

Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17. in Beilstein Journal of Nanotechnology, 14(1), 165-174.
https://doi.org/10.3762/bjnano.14.17

Marković Z, Budimir M, Danko M, Milivojević D, Kubat P, Zmejkoski D, Pavlović V, Mojsin M, Stevanović M, Todorović Marković B. Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17. in Beilstein Journal of Nanotechnology. 2023;14(1):165-174.
doi:10.3762/bjnano.14.17 .

Marković, Zoran, Budimir, Milica, Danko, Martin, Milivojević, Dušan, Kubat, Pavel, Zmejkoski, Danica, Pavlović, Vladimir, Mojsin, Marija, Stevanović, Milena, Todorović Marković, Biljana, "Supplementary data for the article: Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174. https://doi.org/10.3762/bjnano.14.17" in Beilstein Journal of Nanotechnology, 14, no. 1 (2023):165-174,
https://doi.org/10.3762/bjnano.14.17 . .

TY  - CHAP
AU  - Miletić Vukajlović, Jadranka
AU  - Drakulić, Dunja
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2255
AB  - Parkinsonova bolest (PB) je kompleksno progresivno neurodegenerativno oboljenje sa nerazjašnjenom
etiopatogenezom. Odlikuje je, između ostalog, narušena struktura i funkcija komponenti dopaminskog sistema
u delu mozga u kome se nalaze centri za izvođenje voljnih pokreta, kogniciju i pamćenje, dok su na
ćelijskom nivo karakteristične neuroinflamacija, narušavanje strukture i funkcija mnogih organela uključujući
mitohondrije, lizozome ili transportne vezikule, poremećen redoks status, nepravilno savijanje proteina
koje uslovljava njihovo neadekvatno funkcionisanje, stvaranje unutarćelijskih depozita različitih
supstanci (molekula/jona). Obično se manifestuje kombinacijom niza motornih i nemotornih simptoma,
uključujući tremor pri mirovanju, usporenost i osiromašenost pokreta (bradikinezija), ukočenost mišića
(rigidnost) ruku, nogu i vrata, gubitak posturalnih refleksa, fleksibilan položaj tela, kao i konstipacija, urinarna
disfunkcija, impotencija, poremećaji faza sna, prekomerna dnevna pospanost, nemogućnost gutanja
pljuvačke, znojenje, mučnina, anksioznost, apatija, depresija, demencija. Dijagnostikovanje PB se vrši
posredno na osnovu prisustva minimum dva motorna simptoma i adekvatan odgovor na antiparkinson
terapiju, a sa sigurnošću se potvrđuje tek post-mortem analizama utvrđivanjem postojanja karakterističnih
patohistoloških promena u različitim regionima mozga. Kao potencijalni uzročnici njenog nastanka i
progresije izdvajaju se genski faktori, faktori spoljašnje sredine, kao i njihovo međusobno delovanje. Izazovi
PB su ne samo nemogućnost ranog uspostavljanja dijagnoze, poteškoće u procenjivanju toka bolesti,
identifikacija potencijalnih biomarkera i signalnih puteva koji su uključeni u patogenezu, njihova uloga
u kliničkoj prezentaciji bolesti, već i terapija. Iako se ovo hronično oboljenje leči različitim lekovima (farmakoterapija),
hirurškim zahvatima, i potpornim, komplementarnim i alternativnim terapijama, ni jedan
od navedenih vidova terapije ne omogućava potpuno ozdravljenje već kontrolu simptoma radi što dužeg
nezavisnog funkcionisanja obolelih.
AB  - Parkinson’s disease (PD) is a complex progressive neurodegenerative disease with uncertain etiopathogenesis.
Among others, it is characterized by impaired structure and function of components of the dopamine
system in regions of the brain responsible for performing voluntary movements, cognition and
memory; neuroinflammation; disruption of structure and function of various organelles including mitochondria,
lysosomes or transport vesicles, disturbed redox status, misfolding of proteins, intracellular deposition
of various substances (molecules/ions). Usually PD is manifested by a combination of several
motor and non-motor symptoms, including resting tremor, slowness of movement and speed (bradykinesia),
stiffness of arms, legs and neck muscles (rigidity), loss of postural reflexes, flexible body position,
along with constipation, urinary dysfunction, impotence, sleep disorders, excessive daytime sleepiness,
inability to swallow saliva, sweating, nausea, anxiety, apathy, depression, dementia. Diagnosing is performed
indirectly based on the presence of at least two motor symptoms and an adequate response to antiparkinsonian
therapy, while it can be confirmed with certainty only by post-mortem analysis according
to the existence of characteristic pathohistological changes in different regions of the brain. In PD pathogenesis
the relative contribution of genes, environmental/lifestyle factors, as well as their specific interactions
has been recognized. The challenges of PD are not only the impossibility of early diagnosis,
difficulties in assessing the course of the disease, the identification of potential biomarkers and signaling
pathways involved in pathogenesis, their role in the clinical presentation of the disease, but also the therapy.
Although the PD patients are treated with various drugs (pharmacotherapy), surgical interventions,
and supportive, complementary and alternative therapies, none of the mentioned types of therapy provide
the healing but they enable the control of the symptoms for the longest possible independent functioning
of the patients.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - Trendovi u molekularnoj Biologiji
T1  - Parkinsonova bolest – dokle se stiglo?
T1  - Parkinson’s disease – state of the art
EP  - 203
IS  - 3
SP  - 184
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2255
ER  - 

@inbook{
author = "Miletić Vukajlović, Jadranka and Drakulić, Dunja",
year = "2023",
abstract = "Parkinsonova bolest (PB) je kompleksno progresivno neurodegenerativno oboljenje sa nerazjašnjenom
etiopatogenezom. Odlikuje je, između ostalog, narušena struktura i funkcija komponenti dopaminskog sistema
u delu mozga u kome se nalaze centri za izvođenje voljnih pokreta, kogniciju i pamćenje, dok su na
ćelijskom nivo karakteristične neuroinflamacija, narušavanje strukture i funkcija mnogih organela uključujući
mitohondrije, lizozome ili transportne vezikule, poremećen redoks status, nepravilno savijanje proteina
koje uslovljava njihovo neadekvatno funkcionisanje, stvaranje unutarćelijskih depozita različitih
supstanci (molekula/jona). Obično se manifestuje kombinacijom niza motornih i nemotornih simptoma,
uključujući tremor pri mirovanju, usporenost i osiromašenost pokreta (bradikinezija), ukočenost mišića
(rigidnost) ruku, nogu i vrata, gubitak posturalnih refleksa, fleksibilan položaj tela, kao i konstipacija, urinarna
disfunkcija, impotencija, poremećaji faza sna, prekomerna dnevna pospanost, nemogućnost gutanja
pljuvačke, znojenje, mučnina, anksioznost, apatija, depresija, demencija. Dijagnostikovanje PB se vrši
posredno na osnovu prisustva minimum dva motorna simptoma i adekvatan odgovor na antiparkinson
terapiju, a sa sigurnošću se potvrđuje tek post-mortem analizama utvrđivanjem postojanja karakterističnih
patohistoloških promena u različitim regionima mozga. Kao potencijalni uzročnici njenog nastanka i
progresije izdvajaju se genski faktori, faktori spoljašnje sredine, kao i njihovo međusobno delovanje. Izazovi
PB su ne samo nemogućnost ranog uspostavljanja dijagnoze, poteškoće u procenjivanju toka bolesti,
identifikacija potencijalnih biomarkera i signalnih puteva koji su uključeni u patogenezu, njihova uloga
u kliničkoj prezentaciji bolesti, već i terapija. Iako se ovo hronično oboljenje leči različitim lekovima (farmakoterapija),
hirurškim zahvatima, i potpornim, komplementarnim i alternativnim terapijama, ni jedan
od navedenih vidova terapije ne omogućava potpuno ozdravljenje već kontrolu simptoma radi što dužeg
nezavisnog funkcionisanja obolelih., Parkinson’s disease (PD) is a complex progressive neurodegenerative disease with uncertain etiopathogenesis.
Among others, it is characterized by impaired structure and function of components of the dopamine
system in regions of the brain responsible for performing voluntary movements, cognition and
memory; neuroinflammation; disruption of structure and function of various organelles including mitochondria,
lysosomes or transport vesicles, disturbed redox status, misfolding of proteins, intracellular deposition
of various substances (molecules/ions). Usually PD is manifested by a combination of several
motor and non-motor symptoms, including resting tremor, slowness of movement and speed (bradykinesia),
stiffness of arms, legs and neck muscles (rigidity), loss of postural reflexes, flexible body position,
along with constipation, urinary dysfunction, impotence, sleep disorders, excessive daytime sleepiness,
inability to swallow saliva, sweating, nausea, anxiety, apathy, depression, dementia. Diagnosing is performed
indirectly based on the presence of at least two motor symptoms and an adequate response to antiparkinsonian
therapy, while it can be confirmed with certainty only by post-mortem analysis according
to the existence of characteristic pathohistological changes in different regions of the brain. In PD pathogenesis
the relative contribution of genes, environmental/lifestyle factors, as well as their specific interactions
has been recognized. The challenges of PD are not only the impossibility of early diagnosis,
difficulties in assessing the course of the disease, the identification of potential biomarkers and signaling
pathways involved in pathogenesis, their role in the clinical presentation of the disease, but also the therapy.
Although the PD patients are treated with various drugs (pharmacotherapy), surgical interventions,
and supportive, complementary and alternative therapies, none of the mentioned types of therapy provide
the healing but they enable the control of the symptoms for the longest possible independent functioning
of the patients.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj Biologiji",
booktitle = "Parkinsonova bolest – dokle se stiglo?, Parkinson’s disease – state of the art",
pages = "203-184",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2255"
}

Miletić Vukajlović, J.,& Drakulić, D.. (2023). Parkinsonova bolest – dokle se stiglo?. in Trendovi u molekularnoj Biologiji
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(3), 184-203.
https://hdl.handle.net/21.15107/rcub_imagine_2255

Miletić Vukajlović J, Drakulić D. Parkinsonova bolest – dokle se stiglo?. in Trendovi u molekularnoj Biologiji. 2023;(3):184-203.
https://hdl.handle.net/21.15107/rcub_imagine_2255 .

Miletić Vukajlović, Jadranka, Drakulić, Dunja, "Parkinsonova bolest – dokle se stiglo?" in Trendovi u molekularnoj Biologiji, no. 3 (2023):184-203,
https://hdl.handle.net/21.15107/rcub_imagine_2255 .

TY  - JOUR
AU  - Marković, Zoran
AU  - Budimir, Milica
AU  - Danko, Martin
AU  - Milivojević, Dušan
AU  - Kubat, Pavel
AU  - Zmejkoski, Danica
AU  - Pavlović, Vladimir
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://www.beilstein-journals.org/bjnano/articles/14/17
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1889
AB  - Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their
unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon
quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared
carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the
results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these
dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark
cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as
probes for bioimaging.
T2  - Beilstein Journal of Nanotechnology
T2  - Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.
T1  - Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine
EP  - 174
IS  - 1
SP  - 165
VL  - 14
DO  - 10.3762/bjnano.14.17
ER  - 

@article{
author = "Marković, Zoran and Budimir, Milica and Danko, Martin and Milivojević, Dušan and Kubat, Pavel and Zmejkoski, Danica and Pavlović, Vladimir and Mojsin, Marija and Stevanović, Milena and Todorović Marković, Biljana",
year = "2023",
abstract = "Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their
unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon
quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared
carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the
results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these
dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark
cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as
probes for bioimaging.",
journal = "Beilstein Journal of Nanotechnology, Beilstein Journal of NanotechnologyBeilstein J. Nanotechnol.",
title = "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine",
pages = "174-165",
number = "1",
volume = "14",
doi = "10.3762/bjnano.14.17"
}

Marković, Z., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V., Mojsin, M., Stevanović, M.,& Todorović Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174.
https://doi.org/10.3762/bjnano.14.17

Marković Z, Budimir M, Danko M, Milivojević D, Kubat P, Zmejkoski D, Pavlović V, Mojsin M, Stevanović M, Todorović Marković B. Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology. 2023;14(1):165-174.
doi:10.3762/bjnano.14.17 .

Marković, Zoran, Budimir, Milica, Danko, Martin, Milivojević, Dušan, Kubat, Pavel, Zmejkoski, Danica, Pavlović, Vladimir, Mojsin, Marija, Stevanović, Milena, Todorović Marković, Biljana, "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine" in Beilstein Journal of Nanotechnology, 14, no. 1 (2023):165-174,
https://doi.org/10.3762/bjnano.14.17 . .

TY  - JOUR
AU  - Milić, Petar
AU  - Rajković, Katarina
AU  - Nikolić, Goran
AU  - Jeremić, Sanja
AU  - Đurašević, Mirjana
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0263876223000618
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1922
AB  - The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.
T2  - Chemical Engineering Research and Design
T2  - Chemical Engineering Research and DesignChemical Engineering Research and Design
T1  - Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology
EP  - 445
SP  - 439
VL  - 191
DO  - 10.1016/j.cherd.2023.01.051
ER  - 

@article{
author = "Milić, Petar and Rajković, Katarina and Nikolić, Goran and Jeremić, Sanja and Đurašević, Mirjana",
year = "2023",
abstract = "The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.",
journal = "Chemical Engineering Research and Design, Chemical Engineering Research and DesignChemical Engineering Research and Design",
title = "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology",
pages = "445-439",
volume = "191",
doi = "10.1016/j.cherd.2023.01.051"
}

Milić, P., Rajković, K., Nikolić, G., Jeremić, S.,& Đurašević, M.. (2023). Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design, 191, 439-445.
https://doi.org/10.1016/j.cherd.2023.01.051

Milić P, Rajković K, Nikolić G, Jeremić S, Đurašević M. Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design. 2023;191:439-445.
doi:10.1016/j.cherd.2023.01.051 .

Milić, Petar, Rajković, Katarina, Nikolić, Goran, Jeremić, Sanja, Đurašević, Mirjana, "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology" in Chemical Engineering Research and Design, 191 (2023):439-445,
https://doi.org/10.1016/j.cherd.2023.01.051 . .

TY  - JOUR
AU  - Milić, Petar
AU  - Rajković, Katarina
AU  - Nikolić, Goran
AU  - Jeremić, Sanja
AU  - Đurašević, Mirjana
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S0263876223000618
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1888
AB  - The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.
T2  - Chemical Engineering Research and Design
T2  - Chemical Engineering Research and DesignChemical Engineering Research and Design
T1  - Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology
EP  - 445
SP  - 439
VL  - 191
DO  - 10.1016/j.cherd.2023.01.051
ER  - 

@article{
author = "Milić, Petar and Rajković, Katarina and Nikolić, Goran and Jeremić, Sanja and Đurašević, Mirjana",
year = "2023",
abstract = "The aims of this research were preparation of Juglans nigra husk extracts by employing an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. Extracts from J. nigra L. fresh husk were prepared using ethanol (70%, v/v) as a solvent, at different extraction temperatures: 15, 30 and 40 °C, and extraction times: 5, 15, 30, 60 and 80 min. The content of minerals in ethanol extracts was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The response surface methodology (RSM) was developed to evaluate the effect of two extraction factors as well as to optimize the extraction variables for each mineral individually. The RSM models pointed out 40 °C temperature and extraction time in the range 77–80 min as optimal conditions for extraction of macro- and micro-elements. Results of RSM optimization showed the relative order of maximum obtained yield of macro-elements: K>P>S>Ca>Mg and maximum yield of micro-elements was Si>Zn>Sr>Cu.",
journal = "Chemical Engineering Research and Design, Chemical Engineering Research and DesignChemical Engineering Research and Design",
title = "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology",
pages = "445-439",
volume = "191",
doi = "10.1016/j.cherd.2023.01.051"
}

Milić, P., Rajković, K., Nikolić, G., Jeremić, S.,& Đurašević, M.. (2023). Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design, 191, 439-445.
https://doi.org/10.1016/j.cherd.2023.01.051

Milić P, Rajković K, Nikolić G, Jeremić S, Đurašević M. Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology. in Chemical Engineering Research and Design. 2023;191:439-445.
doi:10.1016/j.cherd.2023.01.051 .

Milić, Petar, Rajković, Katarina, Nikolić, Goran, Jeremić, Sanja, Đurašević, Mirjana, "Preparation of Juglans nigra L. husk extracts by applying an ultrasonic-assisted extraction method and process optimization of minerals extraction using response surface methodology" in Chemical Engineering Research and Design, 191 (2023):439-445,
https://doi.org/10.1016/j.cherd.2023.01.051 . .

TY  - DATA
AU  - Marković, Zoran
AU  - Mišović, Aleksandra
AU  - Zmejkoski, Danica
AU  - Zdravković, Nemanja
AU  - Kovač, Janez
AU  - Bajuk-Bogdanović, Danica
AU  - Milivojević, Dušan
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Pavlović, Vladimir
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1895
AB  - Figure S1. TEM micrographs a) CQD_25, b) CQD_50,c) CQD_100, and d) CQD_200 samples, respectively.
T2  - Antibiotics
T1  - Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919
IS  - 5
SP  - 919
VL  - 12
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1895
ER  - 

@misc{
author = "Marković, Zoran and Mišović, Aleksandra and Zmejkoski, Danica and Zdravković, Nemanja and Kovač, Janez and Bajuk-Bogdanović, Danica and Milivojević, Dušan and Mojsin, Marija and Stevanović, Milena and Pavlović, Vladimir and Todorović Marković, Biljana",
year = "2023",
abstract = "Figure S1. TEM micrographs a) CQD_25, b) CQD_50,c) CQD_100, and d) CQD_200 samples, respectively.",
journal = "Antibiotics",
title = "Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919",
number = "5",
pages = "919",
volume = "12",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1895"
}

Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919. in Antibiotics, 12(5), 919.
https://hdl.handle.net/21.15107/rcub_imagine_1895

Marković Z, Mišović A, Zmejkoski D, Zdravković N, Kovač J, Bajuk-Bogdanović D, Milivojević D, Mojsin M, Stevanović M, Pavlović V, Todorović Marković B. Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919. in Antibiotics. 2023;12(5):919.
https://hdl.handle.net/21.15107/rcub_imagine_1895 .

Marković, Zoran, Mišović, Aleksandra, Zmejkoski, Danica, Zdravković, Nemanja, Kovač, Janez, Bajuk-Bogdanović, Danica, Milivojević, Dušan, Mojsin, Marija, Stevanović, Milena, Pavlović, Vladimir, Todorović Marković, Biljana, "Supplementary data for the article:Marković, Z., Mišović, A., Zmejkoski, D., Zdravković, N., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V.,& Todorović Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919" in Antibiotics, 12, no. 5 (2023):919,
https://hdl.handle.net/21.15107/rcub_imagine_1895 .

TY  - JOUR
AU  - Petrović, Suzana
AU  - Božinović, Nevena
AU  - Rajić, Vladimir
AU  - Stanisavljević Ninković, Danijela
AU  - Kisić, Danilo
AU  - Stevanović, Milena
AU  - Stratakis, Emmanuel
PY  - 2023
UR  - https://www.mdpi.com/2079-6412/13/6/1107
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1908
AB  - Arranged patterns obtained via ultrafast laser processing on the surface of Ti/Cu/Ti/Si and Ti/Zr/Ti/Si thin-film systems are reported. Two differently designed multilayer thin films Ti/Cu/Ti/Si and Ti/Zr/Ti/Si were deposited on silicon using the ion sputtering method. The bioactive surfaces of these systems involve the formation of laser-induced periodic surface structures (LIPSS) in each of the laser-written lines of mesh patterns on 5 × 5 mm areas. The formation of nano- and micro-patterns with an ultra-thin oxide film on the surfaces was used to observe the effects of morphology and proliferation of the MRC-5 cell culture line. To determine whether Ti-based thin films have a toxic effect on living cells, an MTT assay was performed. The relative cytotoxic effect, as a percentage of surviving cells, showed that there was no difference in cell number between the Ti-based thin films and the control cells. There was also no difference in the viability of the MRC-5 cells, except for the Ti/Cu/Ti/Si system, where there was a slight 10% decrease in cell viability.
T2  - Coatings
T2  - Coatings
T1  - Cell Response on Laser-Patterned Ti/Zr/Ti and Ti/Cu/Ti Multilayer Systems
IS  - 6
SP  - 1107
VL  - 13
DO  - 10.3390/coatings13061107
ER  - 

@article{
author = "Petrović, Suzana and Božinović, Nevena and Rajić, Vladimir and Stanisavljević Ninković, Danijela and Kisić, Danilo and Stevanović, Milena and Stratakis, Emmanuel",
year = "2023",
abstract = "Arranged patterns obtained via ultrafast laser processing on the surface of Ti/Cu/Ti/Si and Ti/Zr/Ti/Si thin-film systems are reported. Two differently designed multilayer thin films Ti/Cu/Ti/Si and Ti/Zr/Ti/Si were deposited on silicon using the ion sputtering method. The bioactive surfaces of these systems involve the formation of laser-induced periodic surface structures (LIPSS) in each of the laser-written lines of mesh patterns on 5 × 5 mm areas. The formation of nano- and micro-patterns with an ultra-thin oxide film on the surfaces was used to observe the effects of morphology and proliferation of the MRC-5 cell culture line. To determine whether Ti-based thin films have a toxic effect on living cells, an MTT assay was performed. The relative cytotoxic effect, as a percentage of surviving cells, showed that there was no difference in cell number between the Ti-based thin films and the control cells. There was also no difference in the viability of the MRC-5 cells, except for the Ti/Cu/Ti/Si system, where there was a slight 10% decrease in cell viability.",
journal = "Coatings, Coatings",
title = "Cell Response on Laser-Patterned Ti/Zr/Ti and Ti/Cu/Ti Multilayer Systems",
number = "6",
pages = "1107",
volume = "13",
doi = "10.3390/coatings13061107"
}

Petrović, S., Božinović, N., Rajić, V., Stanisavljević Ninković, D., Kisić, D., Stevanović, M.,& Stratakis, E.. (2023). Cell Response on Laser-Patterned Ti/Zr/Ti and Ti/Cu/Ti Multilayer Systems. in Coatings, 13(6), 1107.
https://doi.org/10.3390/coatings13061107

Petrović S, Božinović N, Rajić V, Stanisavljević Ninković D, Kisić D, Stevanović M, Stratakis E. Cell Response on Laser-Patterned Ti/Zr/Ti and Ti/Cu/Ti Multilayer Systems. in Coatings. 2023;13(6):1107.
doi:10.3390/coatings13061107 .

Petrović, Suzana, Božinović, Nevena, Rajić, Vladimir, Stanisavljević Ninković, Danijela, Kisić, Danilo, Stevanović, Milena, Stratakis, Emmanuel, "Cell Response on Laser-Patterned Ti/Zr/Ti and Ti/Cu/Ti Multilayer Systems" in Coatings, 13, no. 6 (2023):1107,
https://doi.org/10.3390/coatings13061107 . .

TY  - CHAP
AU  - Kolić, Ivana
AU  - Stojković, Ljiljana
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2254
AB  - Multipla skleroza (MS) je hronična autoimunska bolest centralnog nervnog sistema (CNS) čiji osnovni
patogenetski mehanizmi obuhvataju neuroinflamaciju, demijelinizaciju i neurodegeneraciju. Glavno
patofiziološko obeležje MS je hiperaktivacija određenih komponenti imunskog sistema, koja dovodi do
nastajanja i akumulacije strukturno-funkcionalnih oštećenja CNS kao posledice hronične inflamacije i
oksidativnog stresa. Adipocitokin i hormon leptin potencijalni je molekularni marker MS, budući da
učestvuje u patogenezi ove bolesti delovanjem na regulaciju imunskog i odgovora na oksidativni stres.
Varijante i promene u transkripciji gena koji kodiraju komponente leptinskog signalnog puta, i sa njima
povezane komponente inflamacije i antioksidativne zaštite, asocirane su sa nastankom i/ili kliničkim tokom
MS kao i odgovorom na terapiju. Danas u Srbiji ima preko 9000 obolelih od MS, a samo 1 od 10 pacijenata
dobija trenutno dostupnu konvencionalnu imunomodulatornu terapiju. Mogućnost modulisanja nivoa
cirkulišućeg leptina sugeriše njegov potencijalni značaj u budućem razvoju personalizovanog pristupa u
lečenju MS baziranog na poboljšavanju efekata ili supstituciji postojeće konvencionalne terapije.
AB  - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) with underlying
pathogenetic mechanisms that include neuroinflammation, demyelination and neurodegeneration.
The main pathophysiological feature of MS is the hyperactivation of certain immune system components,
which leads to formation and accumulation of structural and functional damage in the CNS as a result
of chronic inflammation and oxidative stress. The adipocytokine and hormone leptin is a potential molecular
marker of MS, since it participates in the pathogenesis of this disease by acting on the regulation of
immune system and response to oxidative stress. Variants and transcriptional changes of genes coding
for components of the leptin signaling pathway, and associated components of inflammation and antioxidant
protection, are associated with the onset and/or clinical course of MS as well as response to therapy.
Today, there are over 9,000 MS patients in Serbia, and only 1 out of 10 patients receives currently available
conventional immunomodulatory therapy. The possibility of modulating the level of circulating leptin
suggests its potential importance in the future development of a personalized approach in treatment of
MS based on improving the effects or substituting the existing conventional therapy.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - Trendovi u molekularnoj Biologiji
T1  - Varijante i transkripcija gena koji kodiraju komponente leptinskog signalnog puta, inflamacije i antioksidativne zaštite u patogenezi multiple skleroze
EP  - 183
IS  - 3
SP  - 168
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2254
ER  - 

@inbook{
author = "Kolić, Ivana and Stojković, Ljiljana",
year = "2023",
abstract = "Multipla skleroza (MS) je hronična autoimunska bolest centralnog nervnog sistema (CNS) čiji osnovni
patogenetski mehanizmi obuhvataju neuroinflamaciju, demijelinizaciju i neurodegeneraciju. Glavno
patofiziološko obeležje MS je hiperaktivacija određenih komponenti imunskog sistema, koja dovodi do
nastajanja i akumulacije strukturno-funkcionalnih oštećenja CNS kao posledice hronične inflamacije i
oksidativnog stresa. Adipocitokin i hormon leptin potencijalni je molekularni marker MS, budući da
učestvuje u patogenezi ove bolesti delovanjem na regulaciju imunskog i odgovora na oksidativni stres.
Varijante i promene u transkripciji gena koji kodiraju komponente leptinskog signalnog puta, i sa njima
povezane komponente inflamacije i antioksidativne zaštite, asocirane su sa nastankom i/ili kliničkim tokom
MS kao i odgovorom na terapiju. Danas u Srbiji ima preko 9000 obolelih od MS, a samo 1 od 10 pacijenata
dobija trenutno dostupnu konvencionalnu imunomodulatornu terapiju. Mogućnost modulisanja nivoa
cirkulišućeg leptina sugeriše njegov potencijalni značaj u budućem razvoju personalizovanog pristupa u
lečenju MS baziranog na poboljšavanju efekata ili supstituciji postojeće konvencionalne terapije., Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) with underlying
pathogenetic mechanisms that include neuroinflammation, demyelination and neurodegeneration.
The main pathophysiological feature of MS is the hyperactivation of certain immune system components,
which leads to formation and accumulation of structural and functional damage in the CNS as a result
of chronic inflammation and oxidative stress. The adipocytokine and hormone leptin is a potential molecular
marker of MS, since it participates in the pathogenesis of this disease by acting on the regulation of
immune system and response to oxidative stress. Variants and transcriptional changes of genes coding
for components of the leptin signaling pathway, and associated components of inflammation and antioxidant
protection, are associated with the onset and/or clinical course of MS as well as response to therapy.
Today, there are over 9,000 MS patients in Serbia, and only 1 out of 10 patients receives currently available
conventional immunomodulatory therapy. The possibility of modulating the level of circulating leptin
suggests its potential importance in the future development of a personalized approach in treatment of
MS based on improving the effects or substituting the existing conventional therapy.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj Biologiji",
booktitle = "Varijante i transkripcija gena koji kodiraju komponente leptinskog signalnog puta, inflamacije i antioksidativne zaštite u patogenezi multiple skleroze",
pages = "183-168",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2254"
}

Kolić, I.,& Stojković, L.. (2023). Varijante i transkripcija gena koji kodiraju komponente leptinskog signalnog puta, inflamacije i antioksidativne zaštite u patogenezi multiple skleroze. in Trendovi u molekularnoj Biologiji
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(3), 168-183.
https://hdl.handle.net/21.15107/rcub_imagine_2254

Kolić I, Stojković L. Varijante i transkripcija gena koji kodiraju komponente leptinskog signalnog puta, inflamacije i antioksidativne zaštite u patogenezi multiple skleroze. in Trendovi u molekularnoj Biologiji. 2023;(3):168-183.
https://hdl.handle.net/21.15107/rcub_imagine_2254 .

Kolić, Ivana, Stojković, Ljiljana, "Varijante i transkripcija gena koji kodiraju komponente leptinskog signalnog puta, inflamacije i antioksidativne zaštite u patogenezi multiple skleroze" in Trendovi u molekularnoj Biologiji, no. 3 (2023):168-183,
https://hdl.handle.net/21.15107/rcub_imagine_2254 .

TY  - CHAP
AU  - Kuveljić, Jovana
AU  - Djurić, Tamara
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2251
AB  - Gen za regulator protein fosfataze i aktina 1 (eng. protein phosphatase and actin regulator 1, PHACTR1) je
ušao u žižu interesovanja kada je u studijama asocijacije na celokupnom genomu pokazao značajnu
povezanost sa različitim fenotipovima kardiovaskularnih bolesti (KVB). Nekoliko validacionih studija je istaklo
uticaj varijanti gena PHACTR1 na koronarnu bolest, infarkt miokarda, kalcifikaciju arterija i disekciju
cervikalnih arterija. Vodeća varijanta rs9349379 je pokazala protektivan ili štetan efekat na KVB, jasno
definišući podelu na bolesti u čijoj osnovi je ateroskleroza i one do kojih dovode drugi procesi. U srpskoj
populaciji, analiziran je haplotipski efekat tri varijante gena PHACTR1, rs9349379 A/G, rs2026458 C/T i
rs2876300 A/G, na aterosklerozu karotidnih i koronarnih arterija, kao i njihov efekat na transkripciju gena
PHACTR1 u karotidnom plaku i mononuklearnim ćelijama periferne krvi. Na ovom polju se vodi
dugogodišnja polemika oko toga da li je varijanta rs9349379 povezana sa KVB preko funkcionalnog uticaja
na PHACTR1 ili na gen za endotelin 1, EDN1. U funkcionalnim studijama je predloženo nekoliko mehanizama
delovanja PHACTR1 na kardiovaskularni sistem imajući u vidu da interaguje sa dva esencijalna
ćelijska proteina, protein fosfatazom 1 i G-aktinom. U ovom radu dat je pregled dosadašnjih istraživanja
PHACTR1 u KVB.
AB  - Protein phosphatase and actin regulator 1 (PHACTR1) gene entered the spotlight when it showed a significant
association with various phenotypes of cardiovascular diseases (CVD) in genome-wide association
studies. Several validation studies have highlighted the impact of PHACTR1 variants on coronary artery
disease, myocardial infarction, arterial calcification, and cervical artery dissection. The leading PHACTR1
variant rs9349379 showed a protective or pathogenic effect on CVD, clearly defining the division into atherosclerosis-
based diseases and those caused by other processes. In Serbian population, analysis has been
conducted on haplotype effect of three PHACTR1 gene variants, rs9349379 A/G, rs2026458 C/T and
rs2876300 A/G, on carotid and coronary atherosclerosis, as well as their effect on PHACTR1 mRNA level in
carotid plaque tissue and peripheral blood mononuclear cells. However, there is a long-standing controversy
about whether the rs9349379 variant is associated with CVD through a functional effect on PHACTR1
or on the endothelin 1 gene, EDN1. Several mechanisms of action of PHACTR1 on the cardiovascular system
have been proposed in functional studies, considering that it interacts with two essential cellular proteins,
protein phosphatase 1 and G-actin. This paper provides an overview of the up to date research
conducted on the PHACTR1 in CVD.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - PHACTR1 in cardiovascular diseases: from genome-wide association studies to functional studies
T1  - PHACTR1 u kardiovaskularnim bolestima: od studija asocijacije na celokupnom genomu do funkcionalnih studija
EP  - 137
IS  - 3
SP  - 122
UR  - https://hdl.handle.net/21.15107/rcub_imagine_2251
ER  - 

@inbook{
author = "Kuveljić, Jovana and Djurić, Tamara",
year = "2023",
abstract = "Gen za regulator protein fosfataze i aktina 1 (eng. protein phosphatase and actin regulator 1, PHACTR1) je
ušao u žižu interesovanja kada je u studijama asocijacije na celokupnom genomu pokazao značajnu
povezanost sa različitim fenotipovima kardiovaskularnih bolesti (KVB). Nekoliko validacionih studija je istaklo
uticaj varijanti gena PHACTR1 na koronarnu bolest, infarkt miokarda, kalcifikaciju arterija i disekciju
cervikalnih arterija. Vodeća varijanta rs9349379 je pokazala protektivan ili štetan efekat na KVB, jasno
definišući podelu na bolesti u čijoj osnovi je ateroskleroza i one do kojih dovode drugi procesi. U srpskoj
populaciji, analiziran je haplotipski efekat tri varijante gena PHACTR1, rs9349379 A/G, rs2026458 C/T i
rs2876300 A/G, na aterosklerozu karotidnih i koronarnih arterija, kao i njihov efekat na transkripciju gena
PHACTR1 u karotidnom plaku i mononuklearnim ćelijama periferne krvi. Na ovom polju se vodi
dugogodišnja polemika oko toga da li je varijanta rs9349379 povezana sa KVB preko funkcionalnog uticaja
na PHACTR1 ili na gen za endotelin 1, EDN1. U funkcionalnim studijama je predloženo nekoliko mehanizama
delovanja PHACTR1 na kardiovaskularni sistem imajući u vidu da interaguje sa dva esencijalna
ćelijska proteina, protein fosfatazom 1 i G-aktinom. U ovom radu dat je pregled dosadašnjih istraživanja
PHACTR1 u KVB., Protein phosphatase and actin regulator 1 (PHACTR1) gene entered the spotlight when it showed a significant
association with various phenotypes of cardiovascular diseases (CVD) in genome-wide association
studies. Several validation studies have highlighted the impact of PHACTR1 variants on coronary artery
disease, myocardial infarction, arterial calcification, and cervical artery dissection. The leading PHACTR1
variant rs9349379 showed a protective or pathogenic effect on CVD, clearly defining the division into atherosclerosis-
based diseases and those caused by other processes. In Serbian population, analysis has been
conducted on haplotype effect of three PHACTR1 gene variants, rs9349379 A/G, rs2026458 C/T and
rs2876300 A/G, on carotid and coronary atherosclerosis, as well as their effect on PHACTR1 mRNA level in
carotid plaque tissue and peripheral blood mononuclear cells. However, there is a long-standing controversy
about whether the rs9349379 variant is associated with CVD through a functional effect on PHACTR1
or on the endothelin 1 gene, EDN1. Several mechanisms of action of PHACTR1 on the cardiovascular system
have been proposed in functional studies, considering that it interacts with two essential cellular proteins,
protein phosphatase 1 and G-actin. This paper provides an overview of the up to date research
conducted on the PHACTR1 in CVD.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "PHACTR1 in cardiovascular diseases: from genome-wide association studies to functional studies",
booktitle = "PHACTR1 u kardiovaskularnim bolestima: od studija asocijacije na celokupnom genomu do funkcionalnih studija",
pages = "137-122",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2251"
}

Kuveljić, J.,& Djurić, T.. (2023). PHACTR1 u kardiovaskularnim bolestima: od studija asocijacije na celokupnom genomu do funkcionalnih studija. in PHACTR1 in cardiovascular diseases: from genome-wide association studies to functional studies
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(3), 122-137.
https://hdl.handle.net/21.15107/rcub_imagine_2251

Kuveljić J, Djurić T. PHACTR1 u kardiovaskularnim bolestima: od studija asocijacije na celokupnom genomu do funkcionalnih studija. in PHACTR1 in cardiovascular diseases: from genome-wide association studies to functional studies. 2023;(3):122-137.
https://hdl.handle.net/21.15107/rcub_imagine_2251 .

Kuveljić, Jovana, Djurić, Tamara, "PHACTR1 u kardiovaskularnim bolestima: od studija asocijacije na celokupnom genomu do funkcionalnih studija" in PHACTR1 in cardiovascular diseases: from genome-wide association studies to functional studies, no. 3 (2023):122-137,
https://hdl.handle.net/21.15107/rcub_imagine_2251 .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kováčová, Mária
AU  - Jeremić, Sanja 
AU  - Nagy, Štefan
AU  - Milivojević, Dušan D.
AU  - Kubat, Pavel
AU  - Kleinová, Angela
AU  - Budimir, Milica D.
AU  - Mojsin, Marija
AU  - Stevanović, Milena 
AU  - Annušová, Adriana
AU  - Špitalský, Zdeno
AU  - Todorović Marković, Biljana M.
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1667
AB  - Development of new types of antimicrobial coatings is of utmost importance due to increasing problems with pathogen transmission from various infectious surfaces to human beings. In this study, new types of highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots are presented. Detailed structural, optical, antimicrobial, and cytotoxic investigations of these composites were conducted. Low-power blue light triggered the composites to eradicate Escherichia coli in 30 min, whereas the same effect toward Staphylococcus aureus was reached after 60 min. These composites also show low toxicity against MRC-5 cells. In this way, RF-CPD composites can be used for sterilization of highly touched objects in the healthcare industry.
T2  - Nanomaterials
T2  - Nanomaterials
T1  - Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots
IS  - 22
SP  - 4070
VL  - 12
DO  - 10.3390/nano12224070
ER  - 

@article{
author = "Marković, Zoran M. and Kováčová, Mária and Jeremić, Sanja  and Nagy, Štefan and Milivojević, Dušan D. and Kubat, Pavel and Kleinová, Angela and Budimir, Milica D. and Mojsin, Marija and Stevanović, Milena  and Annušová, Adriana and Špitalský, Zdeno and Todorović Marković, Biljana M.",
year = "2022",
abstract = "Development of new types of antimicrobial coatings is of utmost importance due to increasing problems with pathogen transmission from various infectious surfaces to human beings. In this study, new types of highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots are presented. Detailed structural, optical, antimicrobial, and cytotoxic investigations of these composites were conducted. Low-power blue light triggered the composites to eradicate Escherichia coli in 30 min, whereas the same effect toward Staphylococcus aureus was reached after 60 min. These composites also show low toxicity against MRC-5 cells. In this way, RF-CPD composites can be used for sterilization of highly touched objects in the healthcare industry.",
journal = "Nanomaterials, Nanomaterials",
title = "Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots",
number = "22",
pages = "4070",
volume = "12",
doi = "10.3390/nano12224070"
}

Marković, Z. M., Kováčová, M., Jeremić, S., Nagy, Š., Milivojević, D. D., Kubat, P., Kleinová, A., Budimir, M. D., Mojsin, M., Stevanović, M., Annušová, A., Špitalský, Z.,& Todorović Marković, B. M.. (2022). Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots. in Nanomaterials, 12(22), 4070.
https://doi.org/10.3390/nano12224070

Marković ZM, Kováčová M, Jeremić S, Nagy Š, Milivojević DD, Kubat P, Kleinová A, Budimir MD, Mojsin M, Stevanović M, Annušová A, Špitalský Z, Todorović Marković BM. Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots. in Nanomaterials. 2022;12(22):4070.
doi:10.3390/nano12224070 .

Marković, Zoran M., Kováčová, Mária, Jeremić, Sanja , Nagy, Štefan, Milivojević, Dušan D., Kubat, Pavel, Kleinová, Angela, Budimir, Milica D., Mojsin, Marija, Stevanović, Milena , Annušová, Adriana, Špitalský, Zdeno, Todorović Marković, Biljana M., "Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots" in Nanomaterials, 12, no. 22 (2022):4070,
https://doi.org/10.3390/nano12224070 . .

TY  - CHAP
AU  - Guševac Stojanović, Ivana
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1820
AB  - Poremećena moždana cirkulacija, koja je karakteristična za starenje i mnoga cerebrovaskularna i/ili
neurodegenerativna oboljenja, povezuje se sa prooksidativnim i proapoptotskim promenama mnogobrojnih
biomolekula, uključujući lipide, proteine i DNK, i narušavanjem strukture i funkcije ćelija prečeone
moždane kore (PFC) i hipokampusa (HIPP). Do sada je testiran efekat brojnih jedinjenja da bi se ublažile
posledice narušenog protoka krvi kroz moždano tkivo, ali adekvatna terapija još uvek nije dostupna. Ipak,
kao jedan od mogućih terapeutika, izdvaja se steroidni hormon, progesteron (pregn-4-en-3,20-dion, P4),
za kojeg je pokazano da ispoljava zaštitne efekte u mnogim životinjskim eksperimentalnim modelima kojima
se oponašaju pojedini aspekti poremećaja strukture i funkcije moždanih ćelija primećeni kod starijih
ljudi i obolelih od cerebrovaskularnih i/ili neurodegenerativnih bolesti. Stoga, fokus ovog rada je pružanje
mogućnosti boljeg razumevanja molekulskih mehanizama delovanja P4 u mozgu u fiziološkom stanju,
kao i terapijskog potencijala koji iskazuje u animalnim modelima cerebrovaskularnih i neurodegenerativnih
bolesti, sa posebnim osvrtom na trajnu moždanu hipoperfuziju (MH) gde pokazuje regionalno-specifično
dejstvo. Iako se P4, za sada, u humanoj populaciji pokazao kao neadekvatan terapeutik u lečenju
patološkog stanja povezanog sa poremećenom moždanom cirkulacijom, dodatne kliničke studije bi obezbedile
saznanja o efektu ovog potentnog neurosteroida kod obolelih od drugih cerebrovaskularnih i/ili
neurodegenerativnih bolesti, dok bi u slučaju ohrabrujućih rezultata, P4 terapija mogla znatno olakšati
kvalitet života obolelih.
AB  - Disturbed cerebral circulation, characteristic for aging and many cerebrovascular and/or neurodegenerative
diseases, is associated with prooxidative and proapoptotic changes of various biomolecules, including
lipids, proteins and DNA, and with compromised cell structure and function in prefrontal cortex
(PFC) and hippocampus (HIPP). Numerous compounds, until today, have been tested to alleviate the outcomes
of impaired blood flow through brain tissue, but adequate therapy is not yet available. However, one
of the possible therapeutics is singled out, the steroid hormone, progesterone (pregn-4-en-3,20-dione,
P4), which has been shown to exert protective effects in many animal experimental models that mimic certain
aspects of brain structural and functional changes observed in the elderly and those suffering from
cerebrovascular and/or neurodegenerative diseases. Therefore, this paper is focused on providing a better
understanding of physiological P4-mediated brain molecular mechanisms, as well as its therapeutic
potential in animal models of cerebrovascular and neurodegenerative diseases with the emphasis on permanent
cerebral hypoperfusion (CH) where the regional-specific response is observed. Although P4 is
shown as inadequate for treating a pathological condition associated with disturbed cerebral circulation,
additional clinical studies would provide insights into the potential therapeutic capacity of this potent neurosteroid
in other cerebrovascular and/or neurodegenerative diseases and conditions. In the case of encouraging
results, P4 therapy could significantly improve the quality of patients’ life.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - Trendovi u molekularnoj Biologiji
T1  - Neuroprotektivni potencijal progesterona
T1  - Neuroprotective progesterone potential
EP  - 185
IS  - 2
SP  - 168
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1820
ER  - 

@inbook{
author = "Guševac Stojanović, Ivana and Drakulić, Dunja",
year = "2022",
abstract = "Poremećena moždana cirkulacija, koja je karakteristična za starenje i mnoga cerebrovaskularna i/ili
neurodegenerativna oboljenja, povezuje se sa prooksidativnim i proapoptotskim promenama mnogobrojnih
biomolekula, uključujući lipide, proteine i DNK, i narušavanjem strukture i funkcije ćelija prečeone
moždane kore (PFC) i hipokampusa (HIPP). Do sada je testiran efekat brojnih jedinjenja da bi se ublažile
posledice narušenog protoka krvi kroz moždano tkivo, ali adekvatna terapija još uvek nije dostupna. Ipak,
kao jedan od mogućih terapeutika, izdvaja se steroidni hormon, progesteron (pregn-4-en-3,20-dion, P4),
za kojeg je pokazano da ispoljava zaštitne efekte u mnogim životinjskim eksperimentalnim modelima kojima
se oponašaju pojedini aspekti poremećaja strukture i funkcije moždanih ćelija primećeni kod starijih
ljudi i obolelih od cerebrovaskularnih i/ili neurodegenerativnih bolesti. Stoga, fokus ovog rada je pružanje
mogućnosti boljeg razumevanja molekulskih mehanizama delovanja P4 u mozgu u fiziološkom stanju,
kao i terapijskog potencijala koji iskazuje u animalnim modelima cerebrovaskularnih i neurodegenerativnih
bolesti, sa posebnim osvrtom na trajnu moždanu hipoperfuziju (MH) gde pokazuje regionalno-specifično
dejstvo. Iako se P4, za sada, u humanoj populaciji pokazao kao neadekvatan terapeutik u lečenju
patološkog stanja povezanog sa poremećenom moždanom cirkulacijom, dodatne kliničke studije bi obezbedile
saznanja o efektu ovog potentnog neurosteroida kod obolelih od drugih cerebrovaskularnih i/ili
neurodegenerativnih bolesti, dok bi u slučaju ohrabrujućih rezultata, P4 terapija mogla znatno olakšati
kvalitet života obolelih., Disturbed cerebral circulation, characteristic for aging and many cerebrovascular and/or neurodegenerative
diseases, is associated with prooxidative and proapoptotic changes of various biomolecules, including
lipids, proteins and DNA, and with compromised cell structure and function in prefrontal cortex
(PFC) and hippocampus (HIPP). Numerous compounds, until today, have been tested to alleviate the outcomes
of impaired blood flow through brain tissue, but adequate therapy is not yet available. However, one
of the possible therapeutics is singled out, the steroid hormone, progesterone (pregn-4-en-3,20-dione,
P4), which has been shown to exert protective effects in many animal experimental models that mimic certain
aspects of brain structural and functional changes observed in the elderly and those suffering from
cerebrovascular and/or neurodegenerative diseases. Therefore, this paper is focused on providing a better
understanding of physiological P4-mediated brain molecular mechanisms, as well as its therapeutic
potential in animal models of cerebrovascular and neurodegenerative diseases with the emphasis on permanent
cerebral hypoperfusion (CH) where the regional-specific response is observed. Although P4 is
shown as inadequate for treating a pathological condition associated with disturbed cerebral circulation,
additional clinical studies would provide insights into the potential therapeutic capacity of this potent neurosteroid
in other cerebrovascular and/or neurodegenerative diseases and conditions. In the case of encouraging
results, P4 therapy could significantly improve the quality of patients’ life.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj Biologiji",
booktitle = "Neuroprotektivni potencijal progesterona, Neuroprotective progesterone potential",
pages = "185-168",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1820"
}

Guševac Stojanović, I.,& Drakulić, D.. (2022). Neuroprotektivni potencijal progesterona. in Trendovi u molekularnoj Biologiji
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(2), 168-185.
https://hdl.handle.net/21.15107/rcub_imagine_1820

Guševac Stojanović I, Drakulić D. Neuroprotektivni potencijal progesterona. in Trendovi u molekularnoj Biologiji. 2022;(2):168-185.
https://hdl.handle.net/21.15107/rcub_imagine_1820 .

Guševac Stojanović, Ivana, Drakulić, Dunja, "Neuroprotektivni potencijal progesterona" in Trendovi u molekularnoj Biologiji, no. 2 (2022):168-185,
https://hdl.handle.net/21.15107/rcub_imagine_1820 .

TY  - CHAP
AU  - Zarić Kontić, Marina
AU  - Martinović, Jelena
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1821
AB  - Moždana ishemija/reperfuzija (I/R), redukovan i ponovno uspostavljen protok krvi kroz mozak,
predstavlja karakteristiku cerebro-vaskularnih oboljenja kao što su moždani udar i tranzitorni ishemijski
atak. Izučavanje I/R na životinjskim modelima značajno je za razumevanje same patogeneze i
potencijalnih terapeutika među kojima je svoje mesto našao i neurosteroid dehidroepiandrosteron
(DHEA). DHEA može ostvarivati svoje neurobiološko dejstvo direktno vezivanjem za različite receptore
ili indirektno putem metabolita ili intermedijera metabolickog puta. Mnogobrojne studije su pokazale
njegov neuroprotektivan učinak u različitim patologijama centralnog nervnog sistema među kojima
je svoje mesto zauzela i moždana I/R. U ovom radu osvrnućemo se na direktno delovanje DHEA u
tretmanu ishemičnih stanja pružajući uvid u različite efekte koji su do sada pokazani u životinjskim
modelima I/R kao i potencijalni značaj u modernoj medicini.
AB  - Cerebral ischemia/reperfusion (I/R), reduced and re-established blood flow through the brain,
represents characteristic of cerebrovascular diseases such as stroke and transient ischemic attack. I/R
animal models enable understanding the pathogenesis itself as well as potential therapeutics, among
which the neurosteroid dehydroepiandrosterone (DHEA) has found its place. DHEA can exert its neurobiological
action directly by binding to various receptors or indirectly through metabolites or metabolic
pathway intermediates. Numerous studies have shown its neuroprotective effect in various
pathologies of the central nervous system, among which the cerebral I/R has taken its place. In this
paper, we will focus on the direct actions of DHEA in the treatment of ischemic conditions, providing
insight into the various effects shown so far in animal I/R models as well as potential significance in
modern medicine.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - Trendovi u molekularnoj Biologiji
T1  - Uloga dehidroepiandrosterona u moždanoj ishemiji/reperfuziji
T1  - Effect of dehydroepiandrosterone on cerebral ischemia/reperfusion
EP  - 204
IS  - 2
SP  - 186
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1821
ER  - 

@inbook{
author = "Zarić Kontić, Marina and Martinović, Jelena",
year = "2022",
abstract = "Moždana ishemija/reperfuzija (I/R), redukovan i ponovno uspostavljen protok krvi kroz mozak,
predstavlja karakteristiku cerebro-vaskularnih oboljenja kao što su moždani udar i tranzitorni ishemijski
atak. Izučavanje I/R na životinjskim modelima značajno je za razumevanje same patogeneze i
potencijalnih terapeutika među kojima je svoje mesto našao i neurosteroid dehidroepiandrosteron
(DHEA). DHEA može ostvarivati svoje neurobiološko dejstvo direktno vezivanjem za različite receptore
ili indirektno putem metabolita ili intermedijera metabolickog puta. Mnogobrojne studije su pokazale
njegov neuroprotektivan učinak u različitim patologijama centralnog nervnog sistema među kojima
je svoje mesto zauzela i moždana I/R. U ovom radu osvrnućemo se na direktno delovanje DHEA u
tretmanu ishemičnih stanja pružajući uvid u različite efekte koji su do sada pokazani u životinjskim
modelima I/R kao i potencijalni značaj u modernoj medicini., Cerebral ischemia/reperfusion (I/R), reduced and re-established blood flow through the brain,
represents characteristic of cerebrovascular diseases such as stroke and transient ischemic attack. I/R
animal models enable understanding the pathogenesis itself as well as potential therapeutics, among
which the neurosteroid dehydroepiandrosterone (DHEA) has found its place. DHEA can exert its neurobiological
action directly by binding to various receptors or indirectly through metabolites or metabolic
pathway intermediates. Numerous studies have shown its neuroprotective effect in various
pathologies of the central nervous system, among which the cerebral I/R has taken its place. In this
paper, we will focus on the direct actions of DHEA in the treatment of ischemic conditions, providing
insight into the various effects shown so far in animal I/R models as well as potential significance in
modern medicine.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj Biologiji",
booktitle = "Uloga dehidroepiandrosterona u moždanoj ishemiji/reperfuziji, Effect of dehydroepiandrosterone on cerebral ischemia/reperfusion",
pages = "204-186",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1821"
}

Zarić Kontić, M.,& Martinović, J.. (2022). Uloga dehidroepiandrosterona u moždanoj ishemiji/reperfuziji. in Trendovi u molekularnoj Biologiji
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(2), 186-204.
https://hdl.handle.net/21.15107/rcub_imagine_1821

Zarić Kontić M, Martinović J. Uloga dehidroepiandrosterona u moždanoj ishemiji/reperfuziji. in Trendovi u molekularnoj Biologiji. 2022;(2):186-204.
https://hdl.handle.net/21.15107/rcub_imagine_1821 .

Zarić Kontić, Marina, Martinović, Jelena, "Uloga dehidroepiandrosterona u moždanoj ishemiji/reperfuziji" in Trendovi u molekularnoj Biologiji, no. 2 (2022):186-204,
https://hdl.handle.net/21.15107/rcub_imagine_1821 .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Stanisavljević, Nemanja
AU  - Todorovic Vukotić, Nevena
AU  - Novović, Katarina
AU  - Zakula, Jelena J.
AU  - Stanković, Dalibor
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1584
AB  - The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix
DO  - 10.1080/14786419.2022.2095380
ER  - 

@article{
author = "Đorđević, Neda O. and Stanisavljević, Nemanja and Todorovic Vukotić, Nevena and Novović, Katarina and Zakula, Jelena J. and Stanković, Dalibor and Pajović, Snežana B.",
year = "2022",
abstract = "The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix",
doi = "10.1080/14786419.2022.2095380"
}

Đorđević, N. O., Stanisavljević, N., Todorovic Vukotić, N., Novović, K., Zakula, J. J., Stanković, D.,& Pajović, S. B.. (2022). Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research
Taylor & Francis Ltd, Abingdon..
https://doi.org/10.1080/14786419.2022.2095380

Đorđević NO, Stanisavljević N, Todorovic Vukotić N, Novović K, Zakula JJ, Stanković D, Pajović SB. Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research. 2022;.
doi:10.1080/14786419.2022.2095380 .

Đorđević, Neda O., Stanisavljević, Nemanja, Todorovic Vukotić, Nevena, Novović, Katarina, Zakula, Jelena J., Stanković, Dalibor, Pajović, Snežana B., "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix" in Natural Product Research (2022),
https://doi.org/10.1080/14786419.2022.2095380 . .

TY  - JOUR
AU  - Krkobabić, Ana
AU  - Marković, Darka
AU  - Kovacević, Aleksandar
AU  - Tadić, Vanja
AU  - Radoicić, Marija
AU  - Barudzija, Tatjana
AU  - Ilić-Tomić, Tatjana
AU  - Radetić, Maja
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1552
AB  - The aim of this study was to develop antimicrobial nanocomposite textile material comprising of Cu-based nanostructures synthesized on oxidized cotton fabric using Arctostaphylos uva-ursi (L.) Spreng., Ericaceae (bearberry leaves) as a green reducing agent for adsorbed Cu2+-ions. In order to provide sufficient number of carboxyl groups for complexation with Cu2+-ions a two-step oxidation process with NaIO4 and NaClO2 was carried out. The influence of NaIO4 concentration on content of carboxyl groups and Cu-based nanoparticles was studied by FTIR and AAS. HPLC analysis identified the gallic acid known as a reducing agent in bearberry leaves extract. FESEM and XRD analyses revealed that using bearberry leaves extract and gallic acid solution as reducing agents led to a formation of spherical Cu2O/CuO nanoparticles and CuO nanosheets, respectively. These nanoparticles and nanosheets provided excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. Cytotoxicity on human keratinocyte cells was shown to depend on their copper content.
PB  - Korean Fiber Soc, Seoul
T2  - Fibers and Polymers
T1  - Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract
EP  - 966
IS  - 4
SP  - 954
VL  - 23
DO  - 10.1007/s12221-022-4639-5
ER  - 

@article{
author = "Krkobabić, Ana and Marković, Darka and Kovacević, Aleksandar and Tadić, Vanja and Radoicić, Marija and Barudzija, Tatjana and Ilić-Tomić, Tatjana and Radetić, Maja",
year = "2022",
abstract = "The aim of this study was to develop antimicrobial nanocomposite textile material comprising of Cu-based nanostructures synthesized on oxidized cotton fabric using Arctostaphylos uva-ursi (L.) Spreng., Ericaceae (bearberry leaves) as a green reducing agent for adsorbed Cu2+-ions. In order to provide sufficient number of carboxyl groups for complexation with Cu2+-ions a two-step oxidation process with NaIO4 and NaClO2 was carried out. The influence of NaIO4 concentration on content of carboxyl groups and Cu-based nanoparticles was studied by FTIR and AAS. HPLC analysis identified the gallic acid known as a reducing agent in bearberry leaves extract. FESEM and XRD analyses revealed that using bearberry leaves extract and gallic acid solution as reducing agents led to a formation of spherical Cu2O/CuO nanoparticles and CuO nanosheets, respectively. These nanoparticles and nanosheets provided excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. Cytotoxicity on human keratinocyte cells was shown to depend on their copper content.",
publisher = "Korean Fiber Soc, Seoul",
journal = "Fibers and Polymers",
title = "Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract",
pages = "966-954",
number = "4",
volume = "23",
doi = "10.1007/s12221-022-4639-5"
}

Krkobabić, A., Marković, D., Kovacević, A., Tadić, V., Radoicić, M., Barudzija, T., Ilić-Tomić, T.,& Radetić, M.. (2022). Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract. in Fibers and Polymers
Korean Fiber Soc, Seoul., 23(4), 954-966.
https://doi.org/10.1007/s12221-022-4639-5

Krkobabić A, Marković D, Kovacević A, Tadić V, Radoicić M, Barudzija T, Ilić-Tomić T, Radetić M. Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract. in Fibers and Polymers. 2022;23(4):954-966.
doi:10.1007/s12221-022-4639-5 .

Krkobabić, Ana, Marković, Darka, Kovacević, Aleksandar, Tadić, Vanja, Radoicić, Marija, Barudzija, Tatjana, Ilić-Tomić, Tatjana, Radetić, Maja, "Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract" in Fibers and Polymers, 23, no. 4 (2022):954-966,
https://doi.org/10.1007/s12221-022-4639-5 . .

TY  - JOUR
AU  - Milenković, Mila
AU  - Misović, Aleksandra
AU  - Jovanović, Dragana
AU  - Popović Bijelić, Ana
AU  - Ciasca, Gabriele
AU  - Romano, Sabrina
AU  - Bonasera, Aurelio
AU  - Mojsin, Marija
AU  - Pejić, Jelena
AU  - Stevanović, Milena
AU  - Jovanović, Svetlana
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1457
AB  - Nowadays, a larger number of aggressive and corrosive chemical reagents as well as toxic solvents are used to achieve structural modification and cleaning of the final products. These lead to the production of residual, waste chemicals, which are often reactive, cancerogenic, and toxic to the environment. This study shows a new approach to the modification of graphene quantum dots (GQDs) using gamma irradiation where the usage of reagents was avoided. We achieved the incorporation of S and N atoms in the GQD structure by selecting an aqueous solution of L-cysteine as an irradiation medium. GQDs were exposed to gamma-irradiation at doses of 25, 50 and 200 kGy. After irradiation, the optical, structural, and morphological properties, as well as the possibility of their use as an agent in bioimaging and photodynamic therapy, were studied. We measured an enhanced quantum yield of photoluminescence with the highest dose of 25 kGy (21.60%). Both S- and N-functional groups were detected in all gamma-irradiated GQDs: amino, amide, thiol, and thione. Spin trap electron paramagnetic resonance showed that GQDs irradiated with 25 kGy can generate singlet oxygen upon illumination. Bioimaging on HeLa cells showed the best visibility for cells treated with GQDs irradiated with 25 kGy, while cytotoxicity was not detected after treatment of HeLa cells with gamma-irradiated GQDs.
PB  - MDPI, Basel
T2  - Nanomaterials
T1  - Facile Synthesis of L-Cysteine Functionalized Graphene Quantum Dots as a Bioimaging and Photosensitive Agent
IS  - 8
SP  - 1879
VL  - 11
DO  - 10.3390/nano11081879
ER  - 

@article{
author = "Milenković, Mila and Misović, Aleksandra and Jovanović, Dragana and Popović Bijelić, Ana and Ciasca, Gabriele and Romano, Sabrina and Bonasera, Aurelio and Mojsin, Marija and Pejić, Jelena and Stevanović, Milena and Jovanović, Svetlana",
year = "2021",
abstract = "Nowadays, a larger number of aggressive and corrosive chemical reagents as well as toxic solvents are used to achieve structural modification and cleaning of the final products. These lead to the production of residual, waste chemicals, which are often reactive, cancerogenic, and toxic to the environment. This study shows a new approach to the modification of graphene quantum dots (GQDs) using gamma irradiation where the usage of reagents was avoided. We achieved the incorporation of S and N atoms in the GQD structure by selecting an aqueous solution of L-cysteine as an irradiation medium. GQDs were exposed to gamma-irradiation at doses of 25, 50 and 200 kGy. After irradiation, the optical, structural, and morphological properties, as well as the possibility of their use as an agent in bioimaging and photodynamic therapy, were studied. We measured an enhanced quantum yield of photoluminescence with the highest dose of 25 kGy (21.60%). Both S- and N-functional groups were detected in all gamma-irradiated GQDs: amino, amide, thiol, and thione. Spin trap electron paramagnetic resonance showed that GQDs irradiated with 25 kGy can generate singlet oxygen upon illumination. Bioimaging on HeLa cells showed the best visibility for cells treated with GQDs irradiated with 25 kGy, while cytotoxicity was not detected after treatment of HeLa cells with gamma-irradiated GQDs.",
publisher = "MDPI, Basel",
journal = "Nanomaterials",
title = "Facile Synthesis of L-Cysteine Functionalized Graphene Quantum Dots as a Bioimaging and Photosensitive Agent",
number = "8",
pages = "1879",
volume = "11",
doi = "10.3390/nano11081879"
}

Milenković, M., Misović, A., Jovanović, D., Popović Bijelić, A., Ciasca, G., Romano, S., Bonasera, A., Mojsin, M., Pejić, J., Stevanović, M.,& Jovanović, S.. (2021). Facile Synthesis of L-Cysteine Functionalized Graphene Quantum Dots as a Bioimaging and Photosensitive Agent. in Nanomaterials
MDPI, Basel., 11(8), 1879.
https://doi.org/10.3390/nano11081879

Milenković M, Misović A, Jovanović D, Popović Bijelić A, Ciasca G, Romano S, Bonasera A, Mojsin M, Pejić J, Stevanović M, Jovanović S. Facile Synthesis of L-Cysteine Functionalized Graphene Quantum Dots as a Bioimaging and Photosensitive Agent. in Nanomaterials. 2021;11(8):1879.
doi:10.3390/nano11081879 .

Milenković, Mila, Misović, Aleksandra, Jovanović, Dragana, Popović Bijelić, Ana, Ciasca, Gabriele, Romano, Sabrina, Bonasera, Aurelio, Mojsin, Marija, Pejić, Jelena, Stevanović, Milena, Jovanović, Svetlana, "Facile Synthesis of L-Cysteine Functionalized Graphene Quantum Dots as a Bioimaging and Photosensitive Agent" in Nanomaterials, 11, no. 8 (2021):1879,
https://doi.org/10.3390/nano11081879 . .

TY  - JOUR
AU  - Mihaljević, Marina
AU  - Franić, Dusanka
AU  - Soldatović, Ivan
AU  - Lukić, Iva
AU  - Andrić-Petrović, Sanja
AU  - Mirjanić, Tijana
AU  - Stanković, Biljana
AU  - Zukić, Branka
AU  - Zeljić, Katarina
AU  - Gašić, Vladimir
AU  - Novaković, Ivana
AU  - Pavlović, Sonja
AU  - Adžić, Miroslav
AU  - Marić, Nadja P.
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1451
AB  - Hypothalamic-pituitary-adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5 methylation in subjects with different genetic liability for psychosis. A total of 144 participants were included in the study: 48 patients with psychotic disorders, 50 unaffected siblings, and 46 healthy controls. CT was assessed by Childhood Trauma Questionnaire. The FKBP5 rs1360780 was genotyped and FKBP5 methylation analyses were performed using bisulfite conversion followed by Sanger sequencing at three CpG sites in intron 7. Mixed linear model was used to assess group differences depending on rs1360780 T allele and CT. Results showed a significant T allele-dependent decrease of FKBP5 methylation in patients compared to unaffected siblings and controls. Effect of interaction between T allele and CT exposure on FKBP5 demethylation was found in controls. No effect of both risk factors (T allele and CT) on FKBP5 methylation level was found in unaffected siblings. We confirmed previous evidence of the association between the FKBP5 rs1360780 T allele, CT, and decreased FKBP5 methylation in intron 7. Allele-specific FKBP5 demethylation found in patients could shed a light on altered HPA axis activity in a subgroup of patients related to stress-induced psychosis. FKBP5 methylation and potential protective mechanisms in unaffected siblings after trauma exposure require further investigation.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Psychoneuroendocrinology
T1  - The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls
VL  - 128
DO  - 10.1016/j.psyneuen.2021.105205
ER  - 

@article{
author = "Mihaljević, Marina and Franić, Dusanka and Soldatović, Ivan and Lukić, Iva and Andrić-Petrović, Sanja and Mirjanić, Tijana and Stanković, Biljana and Zukić, Branka and Zeljić, Katarina and Gašić, Vladimir and Novaković, Ivana and Pavlović, Sonja and Adžić, Miroslav and Marić, Nadja P.",
year = "2021",
abstract = "Hypothalamic-pituitary-adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5 methylation in subjects with different genetic liability for psychosis. A total of 144 participants were included in the study: 48 patients with psychotic disorders, 50 unaffected siblings, and 46 healthy controls. CT was assessed by Childhood Trauma Questionnaire. The FKBP5 rs1360780 was genotyped and FKBP5 methylation analyses were performed using bisulfite conversion followed by Sanger sequencing at three CpG sites in intron 7. Mixed linear model was used to assess group differences depending on rs1360780 T allele and CT. Results showed a significant T allele-dependent decrease of FKBP5 methylation in patients compared to unaffected siblings and controls. Effect of interaction between T allele and CT exposure on FKBP5 demethylation was found in controls. No effect of both risk factors (T allele and CT) on FKBP5 methylation level was found in unaffected siblings. We confirmed previous evidence of the association between the FKBP5 rs1360780 T allele, CT, and decreased FKBP5 methylation in intron 7. Allele-specific FKBP5 demethylation found in patients could shed a light on altered HPA axis activity in a subgroup of patients related to stress-induced psychosis. FKBP5 methylation and potential protective mechanisms in unaffected siblings after trauma exposure require further investigation.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Psychoneuroendocrinology",
title = "The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls",
volume = "128",
doi = "10.1016/j.psyneuen.2021.105205"
}

Mihaljević, M., Franić, D., Soldatović, I., Lukić, I., Andrić-Petrović, S., Mirjanić, T., Stanković, B., Zukić, B., Zeljić, K., Gašić, V., Novaković, I., Pavlović, S., Adžić, M.,& Marić, N. P.. (2021). The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls. in Psychoneuroendocrinology
Pergamon-Elsevier Science Ltd, Oxford., 128.
https://doi.org/10.1016/j.psyneuen.2021.105205

Mihaljević M, Franić D, Soldatović I, Lukić I, Andrić-Petrović S, Mirjanić T, Stanković B, Zukić B, Zeljić K, Gašić V, Novaković I, Pavlović S, Adžić M, Marić NP. The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls. in Psychoneuroendocrinology. 2021;128.
doi:10.1016/j.psyneuen.2021.105205 .

Mihaljević, Marina, Franić, Dusanka, Soldatović, Ivan, Lukić, Iva, Andrić-Petrović, Sanja, Mirjanić, Tijana, Stanković, Biljana, Zukić, Branka, Zeljić, Katarina, Gašić, Vladimir, Novaković, Ivana, Pavlović, Sonja, Adžić, Miroslav, Marić, Nadja P., "The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls" in Psychoneuroendocrinology, 128 (2021),
https://doi.org/10.1016/j.psyneuen.2021.105205 . .