TY  - JOUR
AU  - Krkobabić, Ana
AU  - Radetić, Maja
AU  - Zille, Andrea
AU  - Ribeiro, Ana Isabel
AU  - Tadić, Vanja
AU  - Ilić-Tomić, Tatjana
AU  - Marković, Darka
PY  - 2024
UR  - https://www.mdpi.com/1420-3049/29/7/1447
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2335
AB  - The syntheses of Ag-based nanoparticles (NPs) with the assistance of plant extracts have been shown to be environmentally benign and cost-effective alternatives to conventional chemical syntheses. This study discusses the application of Paliurus spina-christi, Juglans regia, Humulus lupulus, and Sambucus nigra leaf extracts for in situ synthesis of Ag-based NPs on cotton fabric modified with citric acid. The presence of NPs with an average size ranging from 57 to 99 nm on the fiber surface was confirmed by FESEM. XPS analysis indicated that metallic (Ag0) and/or ionic silver (Ag2O and AgO) appeared on the surface of the modified cotton. The chemical composition, size, shape, and amounts of synthesized NPs were strongly dependent on the applied plant extract. All fabricated nanocomposites exhibited excellent antifungal activity against yeast Candida albicans. Antibacterial activity was significantly stronger against Gram-positive bacteria Staphylococcus aureus than Gram-negative bacteria Escherichia coli. In addition, 99% of silver was retained on the samples after 24 h of contact with physiological saline solution, implying a high stability of nanoparticles. Cytotoxic activity towards HaCaT and MRC5 cells was only observed for the sample synthetized in the presence of H. lupulus extract. Excellent antimicrobial activity and non-cytotoxicity make the developed composites efficient candidates for medicinal applications.
PB  - MDPI
T2  - Molecules
T2  - Molecules
T1  - Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies
IS  - 7
SP  - 1447
VL  - 29
DO  - 10.3390/molecules29071447
ER  - 

@article{
author = "Krkobabić, Ana and Radetić, Maja and Zille, Andrea and Ribeiro, Ana Isabel and Tadić, Vanja and Ilić-Tomić, Tatjana and Marković, Darka",
year = "2024",
abstract = "The syntheses of Ag-based nanoparticles (NPs) with the assistance of plant extracts have been shown to be environmentally benign and cost-effective alternatives to conventional chemical syntheses. This study discusses the application of Paliurus spina-christi, Juglans regia, Humulus lupulus, and Sambucus nigra leaf extracts for in situ synthesis of Ag-based NPs on cotton fabric modified with citric acid. The presence of NPs with an average size ranging from 57 to 99 nm on the fiber surface was confirmed by FESEM. XPS analysis indicated that metallic (Ag0) and/or ionic silver (Ag2O and AgO) appeared on the surface of the modified cotton. The chemical composition, size, shape, and amounts of synthesized NPs were strongly dependent on the applied plant extract. All fabricated nanocomposites exhibited excellent antifungal activity against yeast Candida albicans. Antibacterial activity was significantly stronger against Gram-positive bacteria Staphylococcus aureus than Gram-negative bacteria Escherichia coli. In addition, 99% of silver was retained on the samples after 24 h of contact with physiological saline solution, implying a high stability of nanoparticles. Cytotoxic activity towards HaCaT and MRC5 cells was only observed for the sample synthetized in the presence of H. lupulus extract. Excellent antimicrobial activity and non-cytotoxicity make the developed composites efficient candidates for medicinal applications.",
publisher = "MDPI",
journal = "Molecules, Molecules",
title = "Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies",
number = "7",
pages = "1447",
volume = "29",
doi = "10.3390/molecules29071447"
}

Krkobabić, A., Radetić, M., Zille, A., Ribeiro, A. I., Tadić, V., Ilić-Tomić, T.,& Marković, D.. (2024). Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies. in Molecules
MDPI., 29(7), 1447.
https://doi.org/10.3390/molecules29071447

Krkobabić A, Radetić M, Zille A, Ribeiro AI, Tadić V, Ilić-Tomić T, Marković D. Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies. in Molecules. 2024;29(7):1447.
doi:10.3390/molecules29071447 .

Krkobabić, Ana, Radetić, Maja, Zille, Andrea, Ribeiro, Ana Isabel, Tadić, Vanja, Ilić-Tomić, Tatjana, Marković, Darka, "Plant-Assisted Synthesis of Ag-Based Nanoparticles on Cotton: Antimicrobial and Cytotoxicity Studies" in Molecules, 29, no. 7 (2024):1447,
https://doi.org/10.3390/molecules29071447 . .

TY  - JOUR
AU  - Prlainović, Nevena
AU  - Milovanović, Jelena
AU  - Milašinović, Nikola
AU  - Bezbradica, Dejan
AU  - Mijin, Dušan
PY  - 2024
UR  - https://doiserbia.nb.rs/Article.aspx?ID=0367-598X2400003P
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2311
AB  - Lipase-catalyzed organic reactions have been widely practiced in the past three decades. Especially interesting are insoluble/immobilized forms due to providing a possibility of facile use and recyclability, thus reducing process costs, and making the procedure more environmentally friendly. Carbon-based supports have been extensively exploited for this purpose, because of neutral and biodegradable nature and thermal and chemical stability. Their high specific surface area, characteristic surface morphology and lower mass transfer resistances play a vital role in the performance of the attached enzyme. This review paper presents an overview of the main aspects of lipase immobilized on multi-walled carbon nanotubes (MWCNTs). Moreover, different immobilization strategies to achieve a biocatalyst with improved performances are discussed. Furthermore, as lipases are considered to have high commercial worth for synthesis of valuable organic molecules, the second part of the paper is dedicated to the overview of the most important industrial sectors in which these nanobiocatalysts have been used. In specific, applications in biodiesel production, flavour ester synthesis and racemization are summarized.
AB  - Lipaze su poslednjih decenija široko rasprostanjeni katalizatoriu raznovrsnim organskim reakcijama. Posebno su interesantne u imobilisanom/nerastvornom obliku jer je na ovaj način olakšana njihova upotreba uz mogućnost recikliranja i ponovne upotrebe čime se smanjuju troškovi samog procesa i postupak je ekološki prihvatljiviji. Kao nosači za vezivanje nanomaterijali na bazi ugljenika, posebno ugljenične nanocevi, su našli primenu zbog svojih izuzetnih fizičkih, mehaničkih i hemijskih svojstava. Njihova velika specifična površina, karakteristična površinska morfologija i smanjen otpor prenosu mase igraju vitalnu ulogu u performansama vezanog enzima. Ovaj pregledni rad predstavlja prikaz glavnih aspekata lipaze imobilisane na višeslojne ugljenične nanocevi i različitih strategija imobilizacije za dobijanje biokatalizatora sa poboljšanim svojstvima. Takođe, kako su lipaze enzimi od velikog komercijalnog značaja za organsku sintezu i primenu u biotehnologiji, drugi deo rada posvećen je pregledu najvažnijih industrijskih sektora u kojima su ovi nanobiokatalizatori našli primenu. Shodno tome, dat je pregled proizvodnje biodizela, mirisnih estara i racemizacije
PB  - Association of the Chemical Engineers of Serbia
T2  - Hemijska industrija
T2  - Hemijska industrija
T1  - Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update
T1  - Višeslojne ugljenične nanocevi kao nosač lipaze za organsku sintezu: pregled najnovijih trendova
IS  - n/a
DO  - 10.2298/HEMIND230614003P
ER  - 

@article{
author = "Prlainović, Nevena and Milovanović, Jelena and Milašinović, Nikola and Bezbradica, Dejan and Mijin, Dušan",
year = "2024",
abstract = "Lipase-catalyzed organic reactions have been widely practiced in the past three decades. Especially interesting are insoluble/immobilized forms due to providing a possibility of facile use and recyclability, thus reducing process costs, and making the procedure more environmentally friendly. Carbon-based supports have been extensively exploited for this purpose, because of neutral and biodegradable nature and thermal and chemical stability. Their high specific surface area, characteristic surface morphology and lower mass transfer resistances play a vital role in the performance of the attached enzyme. This review paper presents an overview of the main aspects of lipase immobilized on multi-walled carbon nanotubes (MWCNTs). Moreover, different immobilization strategies to achieve a biocatalyst with improved performances are discussed. Furthermore, as lipases are considered to have high commercial worth for synthesis of valuable organic molecules, the second part of the paper is dedicated to the overview of the most important industrial sectors in which these nanobiocatalysts have been used. In specific, applications in biodiesel production, flavour ester synthesis and racemization are summarized., Lipaze su poslednjih decenija široko rasprostanjeni katalizatoriu raznovrsnim organskim reakcijama. Posebno su interesantne u imobilisanom/nerastvornom obliku jer je na ovaj način olakšana njihova upotreba uz mogućnost recikliranja i ponovne upotrebe čime se smanjuju troškovi samog procesa i postupak je ekološki prihvatljiviji. Kao nosači za vezivanje nanomaterijali na bazi ugljenika, posebno ugljenične nanocevi, su našli primenu zbog svojih izuzetnih fizičkih, mehaničkih i hemijskih svojstava. Njihova velika specifična površina, karakteristična površinska morfologija i smanjen otpor prenosu mase igraju vitalnu ulogu u performansama vezanog enzima. Ovaj pregledni rad predstavlja prikaz glavnih aspekata lipaze imobilisane na višeslojne ugljenične nanocevi i različitih strategija imobilizacije za dobijanje biokatalizatora sa poboljšanim svojstvima. Takođe, kako su lipaze enzimi od velikog komercijalnog značaja za organsku sintezu i primenu u biotehnologiji, drugi deo rada posvećen je pregledu najvažnijih industrijskih sektora u kojima su ovi nanobiokatalizatori našli primenu. Shodno tome, dat je pregled proizvodnje biodizela, mirisnih estara i racemizacije",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija, Hemijska industrija",
title = "Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update, Višeslojne ugljenične nanocevi kao nosač lipaze za organsku sintezu: pregled najnovijih trendova",
number = "n/a",
doi = "10.2298/HEMIND230614003P"
}

Prlainović, N., Milovanović, J., Milašinović, N., Bezbradica, D.,& Mijin, D.. (2024). Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update. in Hemijska industrija
Association of the Chemical Engineers of Serbia.(n/a).
https://doi.org/10.2298/HEMIND230614003P

Prlainović N, Milovanović J, Milašinović N, Bezbradica D, Mijin D. Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update. in Hemijska industrija. 2024;(n/a).
doi:10.2298/HEMIND230614003P .

Prlainović, Nevena, Milovanović, Jelena, Milašinović, Nikola, Bezbradica, Dejan, Mijin, Dušan, "Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update" in Hemijska industrija, no. n/a (2024),
https://doi.org/10.2298/HEMIND230614003P . .

TY  - JOUR
AU  - Babić Radić, Marija
AU  - Filipović, Vuk
AU  - Vuković, Jovana
AU  - Vukomanović, Marija
AU  - Ilić-Tomić, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2023
UR  - https://www.mdpi.com/2073-4360/15/7/1643
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1799
AB  - The idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33–65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.
T2  - Polymers
T2  - Polymers
T1  - 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform
IS  - 7
SP  - 1643
VL  - 15
DO  - 10.3390/polym15071643
ER  - 

@article{
author = "Babić Radić, Marija and Filipović, Vuk and Vuković, Jovana and Vukomanović, Marija and Ilić-Tomić, Tatjana and Nikodinović-Runić, Jasmina and Tomić, Simonida",
year = "2023",
abstract = "The idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33–65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.",
journal = "Polymers, Polymers",
title = "2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform",
number = "7",
pages = "1643",
volume = "15",
doi = "10.3390/polym15071643"
}

Babić Radić, M., Filipović, V., Vuković, J., Vukomanović, M., Ilić-Tomić, T., Nikodinović-Runić, J.,& Tomić, S.. (2023). 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform. in Polymers, 15(7), 1643.
https://doi.org/10.3390/polym15071643

Babić Radić M, Filipović V, Vuković J, Vukomanović M, Ilić-Tomić T, Nikodinović-Runić J, Tomić S. 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform. in Polymers. 2023;15(7):1643.
doi:10.3390/polym15071643 .

Babić Radić, Marija, Filipović, Vuk, Vuković, Jovana, Vukomanović, Marija, Ilić-Tomić, Tatjana, Nikodinović-Runić, Jasmina, Tomić, Simonida, "2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform" in Polymers, 15, no. 7 (2023):1643,
https://doi.org/10.3390/polym15071643 . .

TY  - JOUR
AU  - Salević-Jelić, Ana
AU  - Lević, Steva
AU  - Stojanović, Dušica
AU  - Jeremić, Sanja
AU  - Miletić, Dunja
AU  - Pantić, Milena
AU  - Pavlović, Vladimir
AU  - Ignjatović, Ivana Sredović
AU  - Uskoković, Petar
AU  - Nedović, Viktor
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S2214289423000042
UR  - https://doi.org/10.1016/j.fpsl.2023.101027
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1921
AB  - This study aimed to develop active, biodegradable materials for food packaging by incorporating sage extract (SE) within a zein-gelatin blend by electrospinning and solvent casting. The fabrication techniques, SE incorporation, and its content (5, 10% w/w) determined the materials’ properties. Electrospinning produced 0.36–0.53 mm thick, non-transparent fibrous mats (mean fiber diameter 1.12–1.36 µm). Solvent casting generated 0.34–0.41 mm thick, transparent continuous films. The analysis indicated the constituents’ compatibility, homogenous dispersion, and efficient SE incorporation without strong chemical interactions and phase separation. The solvent-cast films presented more ordered structures, higher mechanical resistance, elongation, and water vapor barrier performance than the electrospun mats. The SE-incorporating formulations showed phenolics’ delivery ability to food simulants influenced by structure, SE content, and media polarity. The electrospun mats expressed higher DPPH• radicals’ inhibition, while the solvent-cast films showed stronger Staphylococcus aureus and Escherichia coli growth inhibition, increased by SE incorporation. All formulations showed rapid complete bio-disintegration in compost (18–25 days).
T2  - Food Packaging and Shelf Life
T2  - Food Packaging and Shelf LifeFood Packaging and Shelf Life
T1  - Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization
SP  - 101027
VL  - 35
DO  - 10.1016/j.fpsl.2023.101027
ER  - 

@article{
author = "Salević-Jelić, Ana and Lević, Steva and Stojanović, Dušica and Jeremić, Sanja and Miletić, Dunja and Pantić, Milena and Pavlović, Vladimir and Ignjatović, Ivana Sredović and Uskoković, Petar and Nedović, Viktor",
year = "2023",
abstract = "This study aimed to develop active, biodegradable materials for food packaging by incorporating sage extract (SE) within a zein-gelatin blend by electrospinning and solvent casting. The fabrication techniques, SE incorporation, and its content (5, 10% w/w) determined the materials’ properties. Electrospinning produced 0.36–0.53 mm thick, non-transparent fibrous mats (mean fiber diameter 1.12–1.36 µm). Solvent casting generated 0.34–0.41 mm thick, transparent continuous films. The analysis indicated the constituents’ compatibility, homogenous dispersion, and efficient SE incorporation without strong chemical interactions and phase separation. The solvent-cast films presented more ordered structures, higher mechanical resistance, elongation, and water vapor barrier performance than the electrospun mats. The SE-incorporating formulations showed phenolics’ delivery ability to food simulants influenced by structure, SE content, and media polarity. The electrospun mats expressed higher DPPH• radicals’ inhibition, while the solvent-cast films showed stronger Staphylococcus aureus and Escherichia coli growth inhibition, increased by SE incorporation. All formulations showed rapid complete bio-disintegration in compost (18–25 days).",
journal = "Food Packaging and Shelf Life, Food Packaging and Shelf LifeFood Packaging and Shelf Life",
title = "Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization",
pages = "101027",
volume = "35",
doi = "10.1016/j.fpsl.2023.101027"
}

Salević-Jelić, A., Lević, S., Stojanović, D., Jeremić, S., Miletić, D., Pantić, M., Pavlović, V., Ignjatović, I. S., Uskoković, P.,& Nedović, V.. (2023). Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization. in Food Packaging and Shelf Life, 35, 101027.
https://doi.org/10.1016/j.fpsl.2023.101027

Salević-Jelić A, Lević S, Stojanović D, Jeremić S, Miletić D, Pantić M, Pavlović V, Ignjatović IS, Uskoković P, Nedović V. Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization. in Food Packaging and Shelf Life. 2023;35:101027.
doi:10.1016/j.fpsl.2023.101027 .

Salević-Jelić, Ana, Lević, Steva, Stojanović, Dušica, Jeremić, Sanja, Miletić, Dunja, Pantić, Milena, Pavlović, Vladimir, Ignjatović, Ivana Sredović, Uskoković, Petar, Nedović, Viktor, "Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization" in Food Packaging and Shelf Life, 35 (2023):101027,
https://doi.org/10.1016/j.fpsl.2023.101027 . .

TY  - JOUR
AU  - Salević-Jelić, Ana
AU  - Lević, Steva
AU  - Stojanović, Dušica
AU  - Jeremić, Sanja
AU  - Miletić, Dunja
AU  - Pantić, Milena
AU  - Pavlović, Vladimir
AU  - Ignjatović, Ivana Sredović
AU  - Uskoković, Petar
AU  - Nedović, Viktor
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S2214289423000042
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1887
UR  - https://doi.org/10.1016/j.fpsl.2023.101027
AB  - This study aimed to develop active, biodegradable materials for food packaging by incorporating sage extract (SE) within a zein-gelatin blend by electrospinning and solvent casting. The fabrication techniques, SE incorporation, and its content (5, 10% w/w) determined the materials’ properties. Electrospinning produced 0.36–0.53 mm thick, non-transparent fibrous mats (mean fiber diameter 1.12–1.36 µm). Solvent casting generated 0.34–0.41 mm thick, transparent continuous films. The analysis indicated the constituents’ compatibility, homogenous dispersion, and efficient SE incorporation without strong chemical interactions and phase separation. The solvent-cast films presented more ordered structures, higher mechanical resistance, elongation, and water vapor barrier performance than the electrospun mats. The SE-incorporating formulations showed phenolics’ delivery ability to food simulants influenced by structure, SE content, and media polarity. The electrospun mats expressed higher DPPH• radicals’ inhibition, while the solvent-cast films showed stronger Staphylococcus aureus and Escherichia coli growth inhibition, increased by SE incorporation. All formulations showed rapid complete bio-disintegration in compost (18–25 days).
T2  - Food Packaging and Shelf Life
T2  - Food Packaging and Shelf LifeFood Packaging and Shelf Life
T1  - Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization
SP  - 101027
VL  - 35
DO  - 10.1016/j.fpsl.2023.101027
ER  - 

@article{
author = "Salević-Jelić, Ana and Lević, Steva and Stojanović, Dušica and Jeremić, Sanja and Miletić, Dunja and Pantić, Milena and Pavlović, Vladimir and Ignjatović, Ivana Sredović and Uskoković, Petar and Nedović, Viktor",
year = "2023",
abstract = "This study aimed to develop active, biodegradable materials for food packaging by incorporating sage extract (SE) within a zein-gelatin blend by electrospinning and solvent casting. The fabrication techniques, SE incorporation, and its content (5, 10% w/w) determined the materials’ properties. Electrospinning produced 0.36–0.53 mm thick, non-transparent fibrous mats (mean fiber diameter 1.12–1.36 µm). Solvent casting generated 0.34–0.41 mm thick, transparent continuous films. The analysis indicated the constituents’ compatibility, homogenous dispersion, and efficient SE incorporation without strong chemical interactions and phase separation. The solvent-cast films presented more ordered structures, higher mechanical resistance, elongation, and water vapor barrier performance than the electrospun mats. The SE-incorporating formulations showed phenolics’ delivery ability to food simulants influenced by structure, SE content, and media polarity. The electrospun mats expressed higher DPPH• radicals’ inhibition, while the solvent-cast films showed stronger Staphylococcus aureus and Escherichia coli growth inhibition, increased by SE incorporation. All formulations showed rapid complete bio-disintegration in compost (18–25 days).",
journal = "Food Packaging and Shelf Life, Food Packaging and Shelf LifeFood Packaging and Shelf Life",
title = "Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization",
pages = "101027",
volume = "35",
doi = "10.1016/j.fpsl.2023.101027"
}

Salević-Jelić, A., Lević, S., Stojanović, D., Jeremić, S., Miletić, D., Pantić, M., Pavlović, V., Ignjatović, I. S., Uskoković, P.,& Nedović, V.. (2023). Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization. in Food Packaging and Shelf Life, 35, 101027.
https://doi.org/10.1016/j.fpsl.2023.101027

Salević-Jelić A, Lević S, Stojanović D, Jeremić S, Miletić D, Pantić M, Pavlović V, Ignjatović IS, Uskoković P, Nedović V. Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization. in Food Packaging and Shelf Life. 2023;35:101027.
doi:10.1016/j.fpsl.2023.101027 .

Salević-Jelić, Ana, Lević, Steva, Stojanović, Dušica, Jeremić, Sanja, Miletić, Dunja, Pantić, Milena, Pavlović, Vladimir, Ignjatović, Ivana Sredović, Uskoković, Petar, Nedović, Viktor, "Biodegradable and active zein-gelatin-based electrospun mats and solvent-cast films incorporating sage extract: Formulation and comparative characterization" in Food Packaging and Shelf Life, 35 (2023):101027,
https://doi.org/10.1016/j.fpsl.2023.101027 . .

TY  - JOUR
AU  - Radonjić, Mia
AU  - Petrović, Jelena
AU  - Milivojević, Milena
AU  - Stevanović, Milena
AU  - Stojkovska, Jasmina
AU  - Obradović, Bojana
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1594
AB  - A multidisciplinary approach based on experiments and mathematical modeling was used in biomimetic system development for three-dimensional (3D) cultures of cancer cells. Specifically, two cancer cell lines, human embryonic teratocarcinoma NT2/D1 and rat glioma C6, were immobilized in alginate microbeads and microfibers, respectively, and cultured under static and flow conditions in perfusion bioreactors. At the same time, chemical engineering methods were applied to explain the obtained results. The superficial medium velocity of 80 mu m s(-1) induced lower viability of NT2/D1 cells in superficial microbead zones, implying adverse effects of fluid shear stresses estimated as similar to 67 mPa. On the contrary, similar velocity (100 mu m s(-1)) enhanced the proliferation of C6 glioma cells within microfibers compared to static controls. An additional study of silver release from nanocomposite Ag/honey/alginate microfibers under perfusion indicated that the medium partially flows through the hydrogel (interstitial velocity of similar to 10 nm s(-1)). Thus, a diffusion-advection-reaction model described the mass transport to immobilized cells within microfibers. Substances with diffusion coefficients of similar to 10(-)(19)-10(-11) m(2) s(-)(1) are sufficiently supplied by diffusion only, while those with significantly lower diffusivities (similar to 10(-1)(9) m(2) s(-1)) require additional convective transport. The present study demonstrates the selection and contribution of chemical engineering methods in tumor model system development.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Chemical engineering methods in analyses of 3d cancer cell cultures: hydrodynamic and mass transport considerations
EP  - 223
IS  - 3
SP  - 211
VL  - 28
DO  - 10.2298/CICEQ210607033R
ER  - 

@article{
author = "Radonjić, Mia and Petrović, Jelena and Milivojević, Milena and Stevanović, Milena and Stojkovska, Jasmina and Obradović, Bojana",
year = "2022",
abstract = "A multidisciplinary approach based on experiments and mathematical modeling was used in biomimetic system development for three-dimensional (3D) cultures of cancer cells. Specifically, two cancer cell lines, human embryonic teratocarcinoma NT2/D1 and rat glioma C6, were immobilized in alginate microbeads and microfibers, respectively, and cultured under static and flow conditions in perfusion bioreactors. At the same time, chemical engineering methods were applied to explain the obtained results. The superficial medium velocity of 80 mu m s(-1) induced lower viability of NT2/D1 cells in superficial microbead zones, implying adverse effects of fluid shear stresses estimated as similar to 67 mPa. On the contrary, similar velocity (100 mu m s(-1)) enhanced the proliferation of C6 glioma cells within microfibers compared to static controls. An additional study of silver release from nanocomposite Ag/honey/alginate microfibers under perfusion indicated that the medium partially flows through the hydrogel (interstitial velocity of similar to 10 nm s(-1)). Thus, a diffusion-advection-reaction model described the mass transport to immobilized cells within microfibers. Substances with diffusion coefficients of similar to 10(-)(19)-10(-11) m(2) s(-)(1) are sufficiently supplied by diffusion only, while those with significantly lower diffusivities (similar to 10(-1)(9) m(2) s(-1)) require additional convective transport. The present study demonstrates the selection and contribution of chemical engineering methods in tumor model system development.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Chemical engineering methods in analyses of 3d cancer cell cultures: hydrodynamic and mass transport considerations",
pages = "223-211",
number = "3",
volume = "28",
doi = "10.2298/CICEQ210607033R"
}

Radonjić, M., Petrović, J., Milivojević, M., Stevanović, M., Stojkovska, J.,& Obradović, B.. (2022). Chemical engineering methods in analyses of 3d cancer cell cultures: hydrodynamic and mass transport considerations. in Chemical Industry & Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 28(3), 211-223.
https://doi.org/10.2298/CICEQ210607033R

Radonjić M, Petrović J, Milivojević M, Stevanović M, Stojkovska J, Obradović B. Chemical engineering methods in analyses of 3d cancer cell cultures: hydrodynamic and mass transport considerations. in Chemical Industry & Chemical Engineering Quarterly. 2022;28(3):211-223.
doi:10.2298/CICEQ210607033R .

Radonjić, Mia, Petrović, Jelena, Milivojević, Milena, Stevanović, Milena, Stojkovska, Jasmina, Obradović, Bojana, "Chemical engineering methods in analyses of 3d cancer cell cultures: hydrodynamic and mass transport considerations" in Chemical Industry & Chemical Engineering Quarterly, 28, no. 3 (2022):211-223,
https://doi.org/10.2298/CICEQ210607033R . .

TY  - JOUR
AU  - Tomsić, Brigita
AU  - Marković, Darka
AU  - Janković, Vukašin
AU  - Simoncić, Barbara
AU  - Nikodinović-Runić, Jasmina
AU  - Ilić-Tomić, Tatjana
AU  - Radetić, Maja
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1539
AB  - Sustainable biodegradation of cellulose fibers is critical for composting after the end of a product's life. In this study, we aimed at investigating the effect of in situ synthesized CuO/Cu2O nanoparticles (NPs) with biocidal concentration on the biodegradation behavior of cotton fibers pretreated with 1,2,3,4-butanetetracarboxylic acid (BTCA) and succinic acid (SUC). Biodegradation of the fibers was evaluated by soil burial tests in garden soil and in model compost after different soil burial times. The results showed that the application of BTCA, SUC, and CuO/Cu2O NPs did not affect the hydrophilicity of the samples and allowed a smooth biodegradation process. The morphological and chemical changes during biodegradation, evaluated by FESEM and FTIR analyses, showed that the presence of CuO/Cu2O NPs slightly hindered biodegradation of the fibers after 18 days in soil. However, biodegradation was much faster in the model compost, where all samples, regardless of their chemical modification, almost completely degraded after only 11 days. Intense microbial growth on the surface of all samples after nine days of burial in garden soil and model compost was confirmed by the presence of proteins produced by the microorganisms. The total number of microorganisms in the garden soil remained almost unchanged and increased in the model compost after the burial test. The only exception was the sample with the highest concentration of CuO/Cu2O NPs, which caused a reduction in microbial growth but not complete growth inhibition. These results clearly showed that during material degradation, the cellulosic material supporting microbial growth prevailed over the suppression of microbial growth by CuO/Cu2O NPs.
PB  - Springer, Dordrecht
T2  - Cellulose
T1  - Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids
EP  - 302
IS  - 1
SP  - 287
VL  - 29
DO  - 10.1007/s10570-021-04296-6
ER  - 

@article{
author = "Tomsić, Brigita and Marković, Darka and Janković, Vukašin and Simoncić, Barbara and Nikodinović-Runić, Jasmina and Ilić-Tomić, Tatjana and Radetić, Maja",
year = "2022",
abstract = "Sustainable biodegradation of cellulose fibers is critical for composting after the end of a product's life. In this study, we aimed at investigating the effect of in situ synthesized CuO/Cu2O nanoparticles (NPs) with biocidal concentration on the biodegradation behavior of cotton fibers pretreated with 1,2,3,4-butanetetracarboxylic acid (BTCA) and succinic acid (SUC). Biodegradation of the fibers was evaluated by soil burial tests in garden soil and in model compost after different soil burial times. The results showed that the application of BTCA, SUC, and CuO/Cu2O NPs did not affect the hydrophilicity of the samples and allowed a smooth biodegradation process. The morphological and chemical changes during biodegradation, evaluated by FESEM and FTIR analyses, showed that the presence of CuO/Cu2O NPs slightly hindered biodegradation of the fibers after 18 days in soil. However, biodegradation was much faster in the model compost, where all samples, regardless of their chemical modification, almost completely degraded after only 11 days. Intense microbial growth on the surface of all samples after nine days of burial in garden soil and model compost was confirmed by the presence of proteins produced by the microorganisms. The total number of microorganisms in the garden soil remained almost unchanged and increased in the model compost after the burial test. The only exception was the sample with the highest concentration of CuO/Cu2O NPs, which caused a reduction in microbial growth but not complete growth inhibition. These results clearly showed that during material degradation, the cellulosic material supporting microbial growth prevailed over the suppression of microbial growth by CuO/Cu2O NPs.",
publisher = "Springer, Dordrecht",
journal = "Cellulose",
title = "Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids",
pages = "302-287",
number = "1",
volume = "29",
doi = "10.1007/s10570-021-04296-6"
}

Tomsić, B., Marković, D., Janković, V., Simoncić, B., Nikodinović-Runić, J., Ilić-Tomić, T.,& Radetić, M.. (2022). Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids. in Cellulose
Springer, Dordrecht., 29(1), 287-302.
https://doi.org/10.1007/s10570-021-04296-6

Tomsić B, Marković D, Janković V, Simoncić B, Nikodinović-Runić J, Ilić-Tomić T, Radetić M. Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids. in Cellulose. 2022;29(1):287-302.
doi:10.1007/s10570-021-04296-6 .

Tomsić, Brigita, Marković, Darka, Janković, Vukašin, Simoncić, Barbara, Nikodinović-Runić, Jasmina, Ilić-Tomić, Tatjana, Radetić, Maja, "Biodegradation of cellulose fibers functionalized with CuO/Cu2O nanoparticles in combination with polycarboxylic acids" in Cellulose, 29, no. 1 (2022):287-302,
https://doi.org/10.1007/s10570-021-04296-6 . .

TY  - JOUR
AU  - Ponjavić, Marijana
AU  - Nikolić, Marija S.
AU  - Jevtić, Sanja
AU  - Jeremić, Sanja
AU  - Đokić, Lidija
AU  - Donlagić, Jasna
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1580
AB  - The present study reports the potential application of star-shaped poly(epsilon-caprolactones) with different number of arms as new drug delivery matrix. Linear and star-shaped PCL ibuprofen loaded microspheres were prepared using oil-in-water (o/w) solvent evaporation technique and characterized with FTIR, DSC, XRD and SEM analysis. High yield, encapsulation efficiency and drug loadings were obtained for all microspheres. FTIR analysis revealed the existence of interactions between polymer matrix and drug, while the DSC analysis suggested that drug was encapsulated in an amorphous form. SEM analysis confirmed that regular, spherical in shape star-shaped microspheres, with diameter between 80 and 90 mu n, were obtained, while quite larger microspheres, 110 mu m, were prepared from linear PCL. The advantage of using starshaped PCL microspheres instead of linear PCL was seen from drug release profiles which demonstrated higher amount of drug released from star-shaped polymer matrix as a consequence of their branched, flexible structure. Microspheres prepared from the polymers with the most branched structure showed the highest amount of the released drug after 24 h. Finally, cytotoxicity tests, performed using normal human fibroblasts (MRCS), indicated the absence of cytotoxicity at lower concentrations of microspheres proving the great potential of star-shaped PCL systems in comparison to linear ones.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers
DO  - 10.2298/JSC220202032P
ER  - 

@article{
author = "Ponjavić, Marijana and Nikolić, Marija S. and Jevtić, Sanja and Jeremić, Sanja and Đokić, Lidija and Donlagić, Jasna",
year = "2022",
abstract = "The present study reports the potential application of star-shaped poly(epsilon-caprolactones) with different number of arms as new drug delivery matrix. Linear and star-shaped PCL ibuprofen loaded microspheres were prepared using oil-in-water (o/w) solvent evaporation technique and characterized with FTIR, DSC, XRD and SEM analysis. High yield, encapsulation efficiency and drug loadings were obtained for all microspheres. FTIR analysis revealed the existence of interactions between polymer matrix and drug, while the DSC analysis suggested that drug was encapsulated in an amorphous form. SEM analysis confirmed that regular, spherical in shape star-shaped microspheres, with diameter between 80 and 90 mu n, were obtained, while quite larger microspheres, 110 mu m, were prepared from linear PCL. The advantage of using starshaped PCL microspheres instead of linear PCL was seen from drug release profiles which demonstrated higher amount of drug released from star-shaped polymer matrix as a consequence of their branched, flexible structure. Microspheres prepared from the polymers with the most branched structure showed the highest amount of the released drug after 24 h. Finally, cytotoxicity tests, performed using normal human fibroblasts (MRCS), indicated the absence of cytotoxicity at lower concentrations of microspheres proving the great potential of star-shaped PCL systems in comparison to linear ones.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers",
doi = "10.2298/JSC220202032P"
}

Ponjavić, M., Nikolić, M. S., Jevtić, S., Jeremić, S., Đokić, L.,& Donlagić, J.. (2022). Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd..
https://doi.org/10.2298/JSC220202032P

Ponjavić M, Nikolić MS, Jevtić S, Jeremić S, Đokić L, Donlagić J. Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers. in Journal of the Serbian Chemical Society. 2022;.
doi:10.2298/JSC220202032P .

Ponjavić, Marijana, Nikolić, Marija S., Jevtić, Sanja, Jeremić, Sanja, Đokić, Lidija, Donlagić, Jasna, "Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers" in Journal of the Serbian Chemical Society (2022),
https://doi.org/10.2298/JSC220202032P . .

TY  - JOUR
AU  - Matijašević, Danka
AU  - Pantić, Milena
AU  - Stanisavljević, Nemanja
AU  - Jevtić, Sanja
AU  - Rajić, Nevenka
AU  - Lević, Steva
AU  - Nedović, Viktor
AU  - Nikšić, Miomir
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1565
AB  - Research background. In the recent years, considerable attention has been given to selenium status since its deficiency is linked with various disorders and affects at least 13 % of world population. Additionally, mushrooms are known to possess pronounced capacity for absorption of various micronutrients, including Se, from soil/substrate. Here, we investigate the possibility of using Se-rich zeolitic tuff as a supplement for production of selenized mushroom. Furthermore, the impact of the enrichment on the activity of antioxidant enzymes and biological potential of Coriolus versicolor medicinal mushroom is studied. Experimental approach. Se(IV)- and Se(VI)-modified natural zeolitic tuff from the Serbian deposit Zlatokop was used as supplement for mushroom cultivation. To examine the effectiveness of selenium enrichment, we determined total selenium with inductively coupled plasma mass spectrometry (ICP-MS), together with the activity of antioxidant enzymes in fresh fruiting bodies and biological potential of methanolic extracts. Antioxidant activity was evaluated using the appropriate tests for: inhibition of lipid peroxidation, DPPH free radical scavenging assay, Fe(III)-reducing antioxidant power assay and ability of chelating Fe2+ ions. The antibacterial activity against foodborne pathogens was measured by broth microdilution assay. Additionally, chemical composition of the prepared extracts was studied using UV-Vis and Fourier transform infrared (FTIR) spectroscopy. Results and conclusions. Content of selenium detected in biofortified C. versicolor was even 470 times higher than in control on dry mass basis ((140.7 +/- 3.8) vs (0.3 +/- 0.1) mu g/g), proving that Se-rich zeolitic tuff is an excellent supplement for mushroom production. Furthermore, the results of monitoring the activity of antioxidant enzymes revealed that most of the Se-enriched mushrooms exhibited higher superoxide dismutase (SOD) and cata lase (CAT) and lower glutathione peroxidase (GSH-Px) activities than control. Due to higher amounts of enzymes, which can quickly catalyze the reduction of superoxide radicals, the quality of selenium-enriched mushrooms is preserved for a longer period of time. Investigation of biological potential indicated that Se-enriched mushroom methanolic extracts, generally, expressed enhanced antioxidant properties. Additionally, extracts showed antibacterial activity against all tested pathogenic microorganisms. Novelty and scientific contribution. Cultivation of mushrooms on Se-enriched zeolitic tuff is a new technological approach for obtaining Se-fortified food/supplements with enhanced antioxidant and antibacterial activities.
PB  - Faculty Food Technology Biotechnology, Zagreb
T2  - Food Technology and Biotechnology
T1  - Coriolus versicolor Mushroom Grown on Selenium-Rich Zeolitic Tuff as a Potential Novel Food Supplement
EP  - 79
IS  - 1
SP  - 67
VL  - 60
DO  - 10.17113/ftb.60.01.22.7172
ER  - 

@article{
author = "Matijašević, Danka and Pantić, Milena and Stanisavljević, Nemanja and Jevtić, Sanja and Rajić, Nevenka and Lević, Steva and Nedović, Viktor and Nikšić, Miomir",
year = "2022",
abstract = "Research background. In the recent years, considerable attention has been given to selenium status since its deficiency is linked with various disorders and affects at least 13 % of world population. Additionally, mushrooms are known to possess pronounced capacity for absorption of various micronutrients, including Se, from soil/substrate. Here, we investigate the possibility of using Se-rich zeolitic tuff as a supplement for production of selenized mushroom. Furthermore, the impact of the enrichment on the activity of antioxidant enzymes and biological potential of Coriolus versicolor medicinal mushroom is studied. Experimental approach. Se(IV)- and Se(VI)-modified natural zeolitic tuff from the Serbian deposit Zlatokop was used as supplement for mushroom cultivation. To examine the effectiveness of selenium enrichment, we determined total selenium with inductively coupled plasma mass spectrometry (ICP-MS), together with the activity of antioxidant enzymes in fresh fruiting bodies and biological potential of methanolic extracts. Antioxidant activity was evaluated using the appropriate tests for: inhibition of lipid peroxidation, DPPH free radical scavenging assay, Fe(III)-reducing antioxidant power assay and ability of chelating Fe2+ ions. The antibacterial activity against foodborne pathogens was measured by broth microdilution assay. Additionally, chemical composition of the prepared extracts was studied using UV-Vis and Fourier transform infrared (FTIR) spectroscopy. Results and conclusions. Content of selenium detected in biofortified C. versicolor was even 470 times higher than in control on dry mass basis ((140.7 +/- 3.8) vs (0.3 +/- 0.1) mu g/g), proving that Se-rich zeolitic tuff is an excellent supplement for mushroom production. Furthermore, the results of monitoring the activity of antioxidant enzymes revealed that most of the Se-enriched mushrooms exhibited higher superoxide dismutase (SOD) and cata lase (CAT) and lower glutathione peroxidase (GSH-Px) activities than control. Due to higher amounts of enzymes, which can quickly catalyze the reduction of superoxide radicals, the quality of selenium-enriched mushrooms is preserved for a longer period of time. Investigation of biological potential indicated that Se-enriched mushroom methanolic extracts, generally, expressed enhanced antioxidant properties. Additionally, extracts showed antibacterial activity against all tested pathogenic microorganisms. Novelty and scientific contribution. Cultivation of mushrooms on Se-enriched zeolitic tuff is a new technological approach for obtaining Se-fortified food/supplements with enhanced antioxidant and antibacterial activities.",
publisher = "Faculty Food Technology Biotechnology, Zagreb",
journal = "Food Technology and Biotechnology",
title = "Coriolus versicolor Mushroom Grown on Selenium-Rich Zeolitic Tuff as a Potential Novel Food Supplement",
pages = "79-67",
number = "1",
volume = "60",
doi = "10.17113/ftb.60.01.22.7172"
}

Matijašević, D., Pantić, M., Stanisavljević, N., Jevtić, S., Rajić, N., Lević, S., Nedović, V.,& Nikšić, M.. (2022). Coriolus versicolor Mushroom Grown on Selenium-Rich Zeolitic Tuff as a Potential Novel Food Supplement. in Food Technology and Biotechnology
Faculty Food Technology Biotechnology, Zagreb., 60(1), 67-79.
https://doi.org/10.17113/ftb.60.01.22.7172

Matijašević D, Pantić M, Stanisavljević N, Jevtić S, Rajić N, Lević S, Nedović V, Nikšić M. Coriolus versicolor Mushroom Grown on Selenium-Rich Zeolitic Tuff as a Potential Novel Food Supplement. in Food Technology and Biotechnology. 2022;60(1):67-79.
doi:10.17113/ftb.60.01.22.7172 .

Matijašević, Danka, Pantić, Milena, Stanisavljević, Nemanja, Jevtić, Sanja, Rajić, Nevenka, Lević, Steva, Nedović, Viktor, Nikšić, Miomir, "Coriolus versicolor Mushroom Grown on Selenium-Rich Zeolitic Tuff as a Potential Novel Food Supplement" in Food Technology and Biotechnology, 60, no. 1 (2022):67-79,
https://doi.org/10.17113/ftb.60.01.22.7172 . .

TY  - JOUR
AU  - Krkobabić, Ana
AU  - Marković, Darka
AU  - Kovacević, Aleksandar
AU  - Tadić, Vanja
AU  - Radoicić, Marija
AU  - Barudzija, Tatjana
AU  - Ilić-Tomić, Tatjana
AU  - Radetić, Maja
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1552
AB  - The aim of this study was to develop antimicrobial nanocomposite textile material comprising of Cu-based nanostructures synthesized on oxidized cotton fabric using Arctostaphylos uva-ursi (L.) Spreng., Ericaceae (bearberry leaves) as a green reducing agent for adsorbed Cu2+-ions. In order to provide sufficient number of carboxyl groups for complexation with Cu2+-ions a two-step oxidation process with NaIO4 and NaClO2 was carried out. The influence of NaIO4 concentration on content of carboxyl groups and Cu-based nanoparticles was studied by FTIR and AAS. HPLC analysis identified the gallic acid known as a reducing agent in bearberry leaves extract. FESEM and XRD analyses revealed that using bearberry leaves extract and gallic acid solution as reducing agents led to a formation of spherical Cu2O/CuO nanoparticles and CuO nanosheets, respectively. These nanoparticles and nanosheets provided excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. Cytotoxicity on human keratinocyte cells was shown to depend on their copper content.
PB  - Korean Fiber Soc, Seoul
T2  - Fibers and Polymers
T1  - Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract
EP  - 966
IS  - 4
SP  - 954
VL  - 23
DO  - 10.1007/s12221-022-4639-5
ER  - 

@article{
author = "Krkobabić, Ana and Marković, Darka and Kovacević, Aleksandar and Tadić, Vanja and Radoicić, Marija and Barudzija, Tatjana and Ilić-Tomić, Tatjana and Radetić, Maja",
year = "2022",
abstract = "The aim of this study was to develop antimicrobial nanocomposite textile material comprising of Cu-based nanostructures synthesized on oxidized cotton fabric using Arctostaphylos uva-ursi (L.) Spreng., Ericaceae (bearberry leaves) as a green reducing agent for adsorbed Cu2+-ions. In order to provide sufficient number of carboxyl groups for complexation with Cu2+-ions a two-step oxidation process with NaIO4 and NaClO2 was carried out. The influence of NaIO4 concentration on content of carboxyl groups and Cu-based nanoparticles was studied by FTIR and AAS. HPLC analysis identified the gallic acid known as a reducing agent in bearberry leaves extract. FESEM and XRD analyses revealed that using bearberry leaves extract and gallic acid solution as reducing agents led to a formation of spherical Cu2O/CuO nanoparticles and CuO nanosheets, respectively. These nanoparticles and nanosheets provided excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. Cytotoxicity on human keratinocyte cells was shown to depend on their copper content.",
publisher = "Korean Fiber Soc, Seoul",
journal = "Fibers and Polymers",
title = "Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract",
pages = "966-954",
number = "4",
volume = "23",
doi = "10.1007/s12221-022-4639-5"
}

Krkobabić, A., Marković, D., Kovacević, A., Tadić, V., Radoicić, M., Barudzija, T., Ilić-Tomić, T.,& Radetić, M.. (2022). Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract. in Fibers and Polymers
Korean Fiber Soc, Seoul., 23(4), 954-966.
https://doi.org/10.1007/s12221-022-4639-5

Krkobabić A, Marković D, Kovacević A, Tadić V, Radoicić M, Barudzija T, Ilić-Tomić T, Radetić M. Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract. in Fibers and Polymers. 2022;23(4):954-966.
doi:10.1007/s12221-022-4639-5 .

Krkobabić, Ana, Marković, Darka, Kovacević, Aleksandar, Tadić, Vanja, Radoicić, Marija, Barudzija, Tatjana, Ilić-Tomić, Tatjana, Radetić, Maja, "Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract" in Fibers and Polymers, 23, no. 4 (2022):954-966,
https://doi.org/10.1007/s12221-022-4639-5 . .

TY  - JOUR
AU  - Assaleh, Mohamed H.
AU  - Jeremić, Sanja
AU  - Cvijeti, Ilija
AU  - Marinkovi, Aleksandar
AU  - Prlainovi, Nevena
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1601
AB  - Antimicrobial-resistance (AMR) has become the greatest concern and highly challenging issue when treating nosocomial infections. The exigency to develop new potent compounds continues to increase worldwide, whereby derivatives of natural products are becoming more attractive. In the present pa-per, the microbiological assessment of a series of 12 cinnamide hydrazides, four of them completely novel, against clinically relevant pathogens has discovered several derivatives with promising in vitro activities against Acinetobacter baumannii, one of the most dreaded opportunistic pathogens in hospi-tals. The compounds were synthesized by combining one of three different natural acids (cinnamic, 4-chloro or 4-methoxy) with four monothiocarbohydrazones (MTCHs) -an important class of synthetic organic molecules. Their structure was confirmed by elemental microanalysis, as well as ATR-FTIR, H-1 and C-13 NMR spectra, with the addition of 2D NMR spectra for novel compounds. The hybrids of cinnamic acids and pyridine derivatives are particularly active compounds with the lowest MIC50 value of 10.4 mu M for p-chloro cinnamic acid and acetyl pyridine derivatives. An alignment-independent 3D QSAR model identified pharmacophoric hotspots and suggested several structural modifications that might improve the potency of this class of compounds against A. baumannii. The compounds are strong iron-chelating agents forming complexes with a stability constant between 10 7 and 10 9 . The synthesized derivatives represent a promising class of antibacterial compounds with activities comparable to the commonly used antibiotics.
PB  - Elsevier, Amsterdam
T2  - Journal of Molecular Structure
T1  - In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens
VL  - 1262
DO  - 10.1016/j.molstruc.2022.133016
ER  - 

@article{
author = "Assaleh, Mohamed H. and Jeremić, Sanja and Cvijeti, Ilija and Marinkovi, Aleksandar and Prlainovi, Nevena",
year = "2022",
abstract = "Antimicrobial-resistance (AMR) has become the greatest concern and highly challenging issue when treating nosocomial infections. The exigency to develop new potent compounds continues to increase worldwide, whereby derivatives of natural products are becoming more attractive. In the present pa-per, the microbiological assessment of a series of 12 cinnamide hydrazides, four of them completely novel, against clinically relevant pathogens has discovered several derivatives with promising in vitro activities against Acinetobacter baumannii, one of the most dreaded opportunistic pathogens in hospi-tals. The compounds were synthesized by combining one of three different natural acids (cinnamic, 4-chloro or 4-methoxy) with four monothiocarbohydrazones (MTCHs) -an important class of synthetic organic molecules. Their structure was confirmed by elemental microanalysis, as well as ATR-FTIR, H-1 and C-13 NMR spectra, with the addition of 2D NMR spectra for novel compounds. The hybrids of cinnamic acids and pyridine derivatives are particularly active compounds with the lowest MIC50 value of 10.4 mu M for p-chloro cinnamic acid and acetyl pyridine derivatives. An alignment-independent 3D QSAR model identified pharmacophoric hotspots and suggested several structural modifications that might improve the potency of this class of compounds against A. baumannii. The compounds are strong iron-chelating agents forming complexes with a stability constant between 10 7 and 10 9 . The synthesized derivatives represent a promising class of antibacterial compounds with activities comparable to the commonly used antibiotics.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Molecular Structure",
title = "In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens",
volume = "1262",
doi = "10.1016/j.molstruc.2022.133016"
}

Assaleh, M. H., Jeremić, S., Cvijeti, I., Marinkovi, A.,& Prlainovi, N.. (2022). In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens. in Journal of Molecular Structure
Elsevier, Amsterdam., 1262.
https://doi.org/10.1016/j.molstruc.2022.133016

Assaleh MH, Jeremić S, Cvijeti I, Marinkovi A, Prlainovi N. In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens. in Journal of Molecular Structure. 2022;1262.
doi:10.1016/j.molstruc.2022.133016 .

Assaleh, Mohamed H., Jeremić, Sanja, Cvijeti, Ilija, Marinkovi, Aleksandar, Prlainovi, Nevena, "In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens" in Journal of Molecular Structure, 1262 (2022),
https://doi.org/10.1016/j.molstruc.2022.133016 . .

TY  - JOUR
AU  - Janković, Vukašin
AU  - Marković, Darka
AU  - Nikodinović-Runić, Jasmina
AU  - Radetić, Maja
AU  - Ilic-Tomic, Tatjana
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1665
AB  - Given the environmental burden of textile industry, especially of dyeing processes and the volume of synthetic dyes and surfactants, the intensive development of the greener approaches is under way. Herein, an environmentaly-friendly dyeing of polyamide (PA) and PA/Elastane (PA/EA) knits using live bacterial approach in water environment, completely eliminating usage of textile auxiliaries is described. A total of 12 pigment-producing Streptomyces strains were isolated and purified from soil and rizoshere or bark of smoke tree Cotinus coggygria samples. The antibacterial, antifungal and cytotoxic effects of crude bacterial extracts were tested. Antimicrobial effect was obtained by the majority of extracts but only two streptomycetes extracts, 11–5 and BPS51, showed moderate cytotoxicity against HaCaT human cell line. This was the reason to select 11–5 and BPS51 strains for the dyeing of the textile materials. Excellent properties of dyeing wool, silk and PA are achieved initially using live cultures, and the bioprocess is optimized on commercial PA and PA/EA knits used for stockings production. Satisfactory coloration of both knits is achieved with dynamic conditions (culture shaking at 180 rpm over 5–14 days at 30 ºC) giving the best coloration results, except in the case of the PA sample dyed with a bacterial strain 11–5. The prolongation of dyeing time leads to higher color yields independently of fabric and bacteria strain. Although the color differences between the samples before and after washing are observed, washing fastness after three washing cycles can be considered as satisfactory.
T2  - World Journal of Microbiology and Biotechnology
T2  - World Journal of Microbiology and BiotechnologyWorld J Microbiol Biotechnol
T1  - Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains
IS  - 1
SP  - 32
VL  - 39
DO  - 10.1007/s11274-022-03473-4
ER  - 

@article{
author = "Janković, Vukašin and Marković, Darka and Nikodinović-Runić, Jasmina and Radetić, Maja and Ilic-Tomic, Tatjana",
year = "2022",
abstract = "Given the environmental burden of textile industry, especially of dyeing processes and the volume of synthetic dyes and surfactants, the intensive development of the greener approaches is under way. Herein, an environmentaly-friendly dyeing of polyamide (PA) and PA/Elastane (PA/EA) knits using live bacterial approach in water environment, completely eliminating usage of textile auxiliaries is described. A total of 12 pigment-producing Streptomyces strains were isolated and purified from soil and rizoshere or bark of smoke tree Cotinus coggygria samples. The antibacterial, antifungal and cytotoxic effects of crude bacterial extracts were tested. Antimicrobial effect was obtained by the majority of extracts but only two streptomycetes extracts, 11–5 and BPS51, showed moderate cytotoxicity against HaCaT human cell line. This was the reason to select 11–5 and BPS51 strains for the dyeing of the textile materials. Excellent properties of dyeing wool, silk and PA are achieved initially using live cultures, and the bioprocess is optimized on commercial PA and PA/EA knits used for stockings production. Satisfactory coloration of both knits is achieved with dynamic conditions (culture shaking at 180 rpm over 5–14 days at 30 ºC) giving the best coloration results, except in the case of the PA sample dyed with a bacterial strain 11–5. The prolongation of dyeing time leads to higher color yields independently of fabric and bacteria strain. Although the color differences between the samples before and after washing are observed, washing fastness after three washing cycles can be considered as satisfactory.",
journal = "World Journal of Microbiology and Biotechnology, World Journal of Microbiology and BiotechnologyWorld J Microbiol Biotechnol",
title = "Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains",
number = "1",
pages = "32",
volume = "39",
doi = "10.1007/s11274-022-03473-4"
}

Janković, V., Marković, D., Nikodinović-Runić, J., Radetić, M.,& Ilic-Tomic, T.. (2022). Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains. in World Journal of Microbiology and Biotechnology, 39(1), 32.
https://doi.org/10.1007/s11274-022-03473-4

Janković V, Marković D, Nikodinović-Runić J, Radetić M, Ilic-Tomic T. Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains. in World Journal of Microbiology and Biotechnology. 2022;39(1):32.
doi:10.1007/s11274-022-03473-4 .

Janković, Vukašin, Marković, Darka, Nikodinović-Runić, Jasmina, Radetić, Maja, Ilic-Tomic, Tatjana, "Eco-friendly dyeing of polyamide and polyamide-elastane knits with living bacterial cultures of two Streptomyces sp. strains" in World Journal of Microbiology and Biotechnology, 39, no. 1 (2022):32,
https://doi.org/10.1007/s11274-022-03473-4 . .

TY  - JOUR
AU  - Kramar, Ana D.
AU  - Ilić-Tomić, Tatjana
AU  - Ladarević, Jelena M.
AU  - Nikodinović-Runić, Jasmina
AU  - Kostić, Mirjana M.
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1497
AB  - Halochromic (pH-responsive) material was obtained by dyeing functionalized viscose fabric with a crude extract from Streptomyces sp. strain NP4. The functionalization of the fabric before dyeing was performed to make cellulose susceptible to coloration with NP4 extract. Two combined pre-treatment steps were used, oxidation to obtain dialdehyde cellulose and chitosan deposition after oxidation. Chitosan was deposited onto untreated fabric as well, while only oxidized viscose was also investigated for dyeing. Functionalization by both protocols made viscose susceptible to dyeing with the notion that the deposition of chitosan onto oxidized viscose produced the darkest shade on the material. Dyed fabrics showed visual pH responsiveness in the range pH 4-10, with a color change from pink to red (pH 4-pH 7) and a major color change from red to blue (pH 7-pH 10) whereby fabric was tested and could withstand 10 color-changing cycles. Cytotoxicity assay confirmed the non-toxic nature of dyed material, which indicates its possible use as wound dressing's indicators.
PB  - Springer, Dordrecht
T2  - Cellulose
T1  - Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4
EP  - 8784
IS  - 13
SP  - 8771
VL  - 28
DO  - 10.1007/s10570-021-04071-7
ER  - 

@article{
author = "Kramar, Ana D. and Ilić-Tomić, Tatjana and Ladarević, Jelena M. and Nikodinović-Runić, Jasmina and Kostić, Mirjana M.",
year = "2021",
abstract = "Halochromic (pH-responsive) material was obtained by dyeing functionalized viscose fabric with a crude extract from Streptomyces sp. strain NP4. The functionalization of the fabric before dyeing was performed to make cellulose susceptible to coloration with NP4 extract. Two combined pre-treatment steps were used, oxidation to obtain dialdehyde cellulose and chitosan deposition after oxidation. Chitosan was deposited onto untreated fabric as well, while only oxidized viscose was also investigated for dyeing. Functionalization by both protocols made viscose susceptible to dyeing with the notion that the deposition of chitosan onto oxidized viscose produced the darkest shade on the material. Dyed fabrics showed visual pH responsiveness in the range pH 4-10, with a color change from pink to red (pH 4-pH 7) and a major color change from red to blue (pH 7-pH 10) whereby fabric was tested and could withstand 10 color-changing cycles. Cytotoxicity assay confirmed the non-toxic nature of dyed material, which indicates its possible use as wound dressing's indicators.",
publisher = "Springer, Dordrecht",
journal = "Cellulose",
title = "Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4",
pages = "8784-8771",
number = "13",
volume = "28",
doi = "10.1007/s10570-021-04071-7"
}

Kramar, A. D., Ilić-Tomić, T., Ladarević, J. M., Nikodinović-Runić, J.,& Kostić, M. M.. (2021). Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4. in Cellulose
Springer, Dordrecht., 28(13), 8771-8784.
https://doi.org/10.1007/s10570-021-04071-7

Kramar AD, Ilić-Tomić T, Ladarević JM, Nikodinović-Runić J, Kostić MM. Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4. in Cellulose. 2021;28(13):8771-8784.
doi:10.1007/s10570-021-04071-7 .

Kramar, Ana D., Ilić-Tomić, Tatjana, Ladarević, Jelena M., Nikodinović-Runić, Jasmina, Kostić, Mirjana M., "Halochromic cellulose textile obtained via dyeing with biocolorant isolated from Streptomyces sp. strain NP4" in Cellulose, 28, no. 13 (2021):8771-8784,
https://doi.org/10.1007/s10570-021-04071-7 . .

TY  - JOUR
AU  - Dimitrijević, Silvana B.
AU  - Alagić, Sladana
AU  - Pavlović, Sonja
AU  - Stanković, Biljana
AU  - Kotur, Nikola
AU  - Ivanović, Aleksandra
AU  - Dimitrijević, Stevan P.
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1480
AB  - The study presents the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay results on human erythroleukemia K562 cell line to compare the toxicity of electrolytes based on the mercaptotriazole gold complex (Au-MT) and gold potassium cyanide. Solutions immediately after mixing and after three months at different concentrations were compared, with a prolonged aging period, to a year, for the electrolytes at pH = 9. Lower toxicity of new organic gold complex at pH = 4, 7, and 12 than of alkaline cyanide electrolyte, but higher at pH = 2, was determined. The solution of the Au-MT at pH = 9 had comparable, but lower cell toxicity in the whole investigated period.
PB  - Elsevier, Amsterdam
T2  - Journal of the Indian Chemical Society
T1  - Cytotoxicity of the gold complex based on mercaptotriazole - A comparison with the conventional cyanide electrolyte
IS  - 11
VL  - 98
DO  - 10.1016/j.jics.2021.100219
ER  - 

@article{
author = "Dimitrijević, Silvana B. and Alagić, Sladana and Pavlović, Sonja and Stanković, Biljana and Kotur, Nikola and Ivanović, Aleksandra and Dimitrijević, Stevan P.",
year = "2021",
abstract = "The study presents the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay results on human erythroleukemia K562 cell line to compare the toxicity of electrolytes based on the mercaptotriazole gold complex (Au-MT) and gold potassium cyanide. Solutions immediately after mixing and after three months at different concentrations were compared, with a prolonged aging period, to a year, for the electrolytes at pH = 9. Lower toxicity of new organic gold complex at pH = 4, 7, and 12 than of alkaline cyanide electrolyte, but higher at pH = 2, was determined. The solution of the Au-MT at pH = 9 had comparable, but lower cell toxicity in the whole investigated period.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of the Indian Chemical Society",
title = "Cytotoxicity of the gold complex based on mercaptotriazole - A comparison with the conventional cyanide electrolyte",
number = "11",
volume = "98",
doi = "10.1016/j.jics.2021.100219"
}

Dimitrijević, S. B., Alagić, S., Pavlović, S., Stanković, B., Kotur, N., Ivanović, A.,& Dimitrijević, S. P.. (2021). Cytotoxicity of the gold complex based on mercaptotriazole - A comparison with the conventional cyanide electrolyte. in Journal of the Indian Chemical Society
Elsevier, Amsterdam., 98(11).
https://doi.org/10.1016/j.jics.2021.100219

Dimitrijević SB, Alagić S, Pavlović S, Stanković B, Kotur N, Ivanović A, Dimitrijević SP. Cytotoxicity of the gold complex based on mercaptotriazole - A comparison with the conventional cyanide electrolyte. in Journal of the Indian Chemical Society. 2021;98(11).
doi:10.1016/j.jics.2021.100219 .

Dimitrijević, Silvana B., Alagić, Sladana, Pavlović, Sonja, Stanković, Biljana, Kotur, Nikola, Ivanović, Aleksandra, Dimitrijević, Stevan P., "Cytotoxicity of the gold complex based on mercaptotriazole - A comparison with the conventional cyanide electrolyte" in Journal of the Indian Chemical Society, 98, no. 11 (2021),
https://doi.org/10.1016/j.jics.2021.100219 . .

TY  - JOUR
AU  - Ponjavić, Marijana
AU  - Nikolić, Marija S.
AU  - Stevanović, Sanja
AU  - Nikodinović-Runić, Jasmina
AU  - Jeremić, Sanja
AU  - Pavić, Aleksandar
AU  - Đonlagić, Jasna
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1354
AB  - Star-shaped polymers of biodegradable aliphatic polyester, poly(epsilon-caprolactone), PCL, with different number of arms (three, four, and six) were synthesized by ring-opening polymerization initiated by multifunctional alcohols used as cores. As potential biomaterials, synthesized star-shaped poly(epsilon-caprolactone)s,sPCL, were thoroughly characterized in terms of their degradation under different pH conditions and in respect to their cytotoxicity. The in vitro degradation was performed in phosphate buffer (pH 7.4) and hydrochloric acid solution (pH 1.0) over 5 weeks. Degradation ofsPCL films was followed by the weight loss measurements, GPC, FTIR, and AFM analysis. While the most of the samples were stable against the abiotic hydrolysis at pH 7.4 after 5 weeks of degradation, degradation was significantly accelerated in the acidic medium. Degradation rate of polymer films was affected by the polymer architecture and molecular weight. The molecular weight profiles during the degradation revealed random chain scission of the ester bonds indicating bulk degradation mechanism of hydrolysis at pH 7.4, while acidic hydrolysis proceeded through the bulk degradation associated with surface erosion, confirmed by AFM. The in vitro toxicity tests, cytotoxicity applying normal human fibroblasts (MRC5) and embryotoxicity assessment (using zebra fish model,Danio rerio), suggested those polymeric materials as suitable for biomedical application.
PB  - Sage Publications Ltd, London
T2  - Journal of Bioactive and Compatible Polymers
T1  - Hydrolytic degradation of star-shaped poly(epsilon-caprolactone)s with different number of arms and their cytotoxic effects
EP  - 537
IS  - 6
SP  - 517
VL  - 35
DO  - 10.1177/0883911520951826
ER  - 

@article{
author = "Ponjavić, Marijana and Nikolić, Marija S. and Stevanović, Sanja and Nikodinović-Runić, Jasmina and Jeremić, Sanja and Pavić, Aleksandar and Đonlagić, Jasna",
year = "2020",
abstract = "Star-shaped polymers of biodegradable aliphatic polyester, poly(epsilon-caprolactone), PCL, with different number of arms (three, four, and six) were synthesized by ring-opening polymerization initiated by multifunctional alcohols used as cores. As potential biomaterials, synthesized star-shaped poly(epsilon-caprolactone)s,sPCL, were thoroughly characterized in terms of their degradation under different pH conditions and in respect to their cytotoxicity. The in vitro degradation was performed in phosphate buffer (pH 7.4) and hydrochloric acid solution (pH 1.0) over 5 weeks. Degradation ofsPCL films was followed by the weight loss measurements, GPC, FTIR, and AFM analysis. While the most of the samples were stable against the abiotic hydrolysis at pH 7.4 after 5 weeks of degradation, degradation was significantly accelerated in the acidic medium. Degradation rate of polymer films was affected by the polymer architecture and molecular weight. The molecular weight profiles during the degradation revealed random chain scission of the ester bonds indicating bulk degradation mechanism of hydrolysis at pH 7.4, while acidic hydrolysis proceeded through the bulk degradation associated with surface erosion, confirmed by AFM. The in vitro toxicity tests, cytotoxicity applying normal human fibroblasts (MRC5) and embryotoxicity assessment (using zebra fish model,Danio rerio), suggested those polymeric materials as suitable for biomedical application.",
publisher = "Sage Publications Ltd, London",
journal = "Journal of Bioactive and Compatible Polymers",
title = "Hydrolytic degradation of star-shaped poly(epsilon-caprolactone)s with different number of arms and their cytotoxic effects",
pages = "537-517",
number = "6",
volume = "35",
doi = "10.1177/0883911520951826"
}

Ponjavić, M., Nikolić, M. S., Stevanović, S., Nikodinović-Runić, J., Jeremić, S., Pavić, A.,& Đonlagić, J.. (2020). Hydrolytic degradation of star-shaped poly(epsilon-caprolactone)s with different number of arms and their cytotoxic effects. in Journal of Bioactive and Compatible Polymers
Sage Publications Ltd, London., 35(6), 517-537.
https://doi.org/10.1177/0883911520951826

Ponjavić M, Nikolić MS, Stevanović S, Nikodinović-Runić J, Jeremić S, Pavić A, Đonlagić J. Hydrolytic degradation of star-shaped poly(epsilon-caprolactone)s with different number of arms and their cytotoxic effects. in Journal of Bioactive and Compatible Polymers. 2020;35(6):517-537.
doi:10.1177/0883911520951826 .

Ponjavić, Marijana, Nikolić, Marija S., Stevanović, Sanja, Nikodinović-Runić, Jasmina, Jeremić, Sanja, Pavić, Aleksandar, Đonlagić, Jasna, "Hydrolytic degradation of star-shaped poly(epsilon-caprolactone)s with different number of arms and their cytotoxic effects" in Journal of Bioactive and Compatible Polymers, 35, no. 6 (2020):517-537,
https://doi.org/10.1177/0883911520951826 . .

TY  - JOUR
AU  - Stojkovska, Jasmina
AU  - Zvicer, Jovana
AU  - Milivojević, Milena
AU  - Petrović, Isidora
AU  - Stevanović, Milena
AU  - Obradović, Bojana
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1363
AB  - Development of drugs is a complex, time- and cost-consuming process due to the lack of standardized and reliable characterization techniques and models. Traditionally, drug screening is based on in vitro analysis using two-dimensional (2D) cell cultures followed by in vivo animal testing. Unfortunately, application of the obtained results to humans in about 90 % of cases fails. Therefore, it is important to develop and improve cell-based systems that can mimic the in vivo-like conditions to provide more reliable results. In this paper, we present development and validation of a novel, user-friendly perfusion bioreactor system for single use aimed for cancer research, drug screening, anti-cancer drug response studies, biomaterial characterization, and tissue engineering. Simple design of the perfusion bioreactor provides direct medium flow at physiological velocities (100-250 mu m s(-1)) through samples of different sizes and shapes. Biocompatibility of the bioreactor was confirmed in short term cultivation studies of cervical carcinoma SiHa cells immobilized in alginate microfibers under continuous medium flow. The results have shown preserved cell viability indicating that the perfusion bioreactor in conjunction with alginate hydrogels as cell carriers could be potentially used as a tool for controlled anti-cancer drug screening in a 3D environment.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska Industrija
T1  - Validation of a novel perfusion bioreactor system in cancer research
EP  - 196
IS  - 3
SP  - 187
VL  - 74
DO  - 10.2298/HEMIND200329015S
ER  - 

@article{
author = "Stojkovska, Jasmina and Zvicer, Jovana and Milivojević, Milena and Petrović, Isidora and Stevanović, Milena and Obradović, Bojana",
year = "2020",
abstract = "Development of drugs is a complex, time- and cost-consuming process due to the lack of standardized and reliable characterization techniques and models. Traditionally, drug screening is based on in vitro analysis using two-dimensional (2D) cell cultures followed by in vivo animal testing. Unfortunately, application of the obtained results to humans in about 90 % of cases fails. Therefore, it is important to develop and improve cell-based systems that can mimic the in vivo-like conditions to provide more reliable results. In this paper, we present development and validation of a novel, user-friendly perfusion bioreactor system for single use aimed for cancer research, drug screening, anti-cancer drug response studies, biomaterial characterization, and tissue engineering. Simple design of the perfusion bioreactor provides direct medium flow at physiological velocities (100-250 mu m s(-1)) through samples of different sizes and shapes. Biocompatibility of the bioreactor was confirmed in short term cultivation studies of cervical carcinoma SiHa cells immobilized in alginate microfibers under continuous medium flow. The results have shown preserved cell viability indicating that the perfusion bioreactor in conjunction with alginate hydrogels as cell carriers could be potentially used as a tool for controlled anti-cancer drug screening in a 3D environment.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska Industrija",
title = "Validation of a novel perfusion bioreactor system in cancer research",
pages = "196-187",
number = "3",
volume = "74",
doi = "10.2298/HEMIND200329015S"
}

Stojkovska, J., Zvicer, J., Milivojević, M., Petrović, I., Stevanović, M.,& Obradović, B.. (2020). Validation of a novel perfusion bioreactor system in cancer research. in Hemijska Industrija
Savez hemijskih inženjera, Beograd., 74(3), 187-196.
https://doi.org/10.2298/HEMIND200329015S

Stojkovska J, Zvicer J, Milivojević M, Petrović I, Stevanović M, Obradović B. Validation of a novel perfusion bioreactor system in cancer research. in Hemijska Industrija. 2020;74(3):187-196.
doi:10.2298/HEMIND200329015S .

Stojkovska, Jasmina, Zvicer, Jovana, Milivojević, Milena, Petrović, Isidora, Stevanović, Milena, Obradović, Bojana, "Validation of a novel perfusion bioreactor system in cancer research" in Hemijska Industrija, 74, no. 3 (2020):187-196,
https://doi.org/10.2298/HEMIND200329015S . .

TY  - JOUR
AU  - Marković, Darka
AU  - Tseng, Hsiang-Han
AU  - Nunney, Tim
AU  - Radoicić, Marija
AU  - Ilić-Tomić, Tatjana
AU  - Radetić, Maja
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1351
AB  - The objective of this study was to develop novel antimicrobial nanocomposite material based on polypropylene (PP) non-woven fabric, biopolymer alginate and copper oxides nanoparticles. In order to introduce polar groups onto the surface of PP fibers necessary for binding of alginate, non-woven fabric was activated by corona discharge. Carboxylate groups of alginate were further utilized for binding of Cu2+-ions which were reduced with sodium borohydride as a conventional and ascorbic acid as a green reducing agent. Characteristic morphological and chemical changes induced by corona activation and alginate impregnation were confirmed by FTIR, XPS and FESEM analyses. AAS measurements showed that the amounts of generated nanoparticles depend on applied reducing agent and the concentration of precursor salt. XPS analysis suggested that nanoparticles were mixture of copper (I) and (II) oxides. XPS depth profiling gave an exceptional insight into chemical changes within the thin layer on the fiber surface and formation of certain interfaces induced by each treatment. All fabricated nanocomposites provided excellent antimicrobial activity against Gram-negative bacteria E. coli, Gram-positive bacteria S. aureus and yeast C. albicans. The cytotoxicity assay indicated that maximum amount of Cu2+-ions released from synthetized nanocomposite within 24 h was not cytotoxic to human keratinocyte (HaCaT) cells.
PB  - Elsevier, Amsterdam
T2  - Applied Surface Science
T1  - Novel antimicrobial nanocomposite based on polypropylene non-woven fabric, biopolymer alginate and copper oxides nanoparticles
VL  - 527
DO  - 10.1016/j.apsusc.2020.146829
ER  - 

@article{
author = "Marković, Darka and Tseng, Hsiang-Han and Nunney, Tim and Radoicić, Marija and Ilić-Tomić, Tatjana and Radetić, Maja",
year = "2020",
abstract = "The objective of this study was to develop novel antimicrobial nanocomposite material based on polypropylene (PP) non-woven fabric, biopolymer alginate and copper oxides nanoparticles. In order to introduce polar groups onto the surface of PP fibers necessary for binding of alginate, non-woven fabric was activated by corona discharge. Carboxylate groups of alginate were further utilized for binding of Cu2+-ions which were reduced with sodium borohydride as a conventional and ascorbic acid as a green reducing agent. Characteristic morphological and chemical changes induced by corona activation and alginate impregnation were confirmed by FTIR, XPS and FESEM analyses. AAS measurements showed that the amounts of generated nanoparticles depend on applied reducing agent and the concentration of precursor salt. XPS analysis suggested that nanoparticles were mixture of copper (I) and (II) oxides. XPS depth profiling gave an exceptional insight into chemical changes within the thin layer on the fiber surface and formation of certain interfaces induced by each treatment. All fabricated nanocomposites provided excellent antimicrobial activity against Gram-negative bacteria E. coli, Gram-positive bacteria S. aureus and yeast C. albicans. The cytotoxicity assay indicated that maximum amount of Cu2+-ions released from synthetized nanocomposite within 24 h was not cytotoxic to human keratinocyte (HaCaT) cells.",
publisher = "Elsevier, Amsterdam",
journal = "Applied Surface Science",
title = "Novel antimicrobial nanocomposite based on polypropylene non-woven fabric, biopolymer alginate and copper oxides nanoparticles",
volume = "527",
doi = "10.1016/j.apsusc.2020.146829"
}

Marković, D., Tseng, H., Nunney, T., Radoicić, M., Ilić-Tomić, T.,& Radetić, M.. (2020). Novel antimicrobial nanocomposite based on polypropylene non-woven fabric, biopolymer alginate and copper oxides nanoparticles. in Applied Surface Science
Elsevier, Amsterdam., 527.
https://doi.org/10.1016/j.apsusc.2020.146829

Marković D, Tseng H, Nunney T, Radoicić M, Ilić-Tomić T, Radetić M. Novel antimicrobial nanocomposite based on polypropylene non-woven fabric, biopolymer alginate and copper oxides nanoparticles. in Applied Surface Science. 2020;527.
doi:10.1016/j.apsusc.2020.146829 .

Marković, Darka, Tseng, Hsiang-Han, Nunney, Tim, Radoicić, Marija, Ilić-Tomić, Tatjana, Radetić, Maja, "Novel antimicrobial nanocomposite based on polypropylene non-woven fabric, biopolymer alginate and copper oxides nanoparticles" in Applied Surface Science, 527 (2020),
https://doi.org/10.1016/j.apsusc.2020.146829 . .