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Crosstalk between SOX Genes and Long Non-Coding RNAs in Glioblastoma
(International Journal of Molecular SciencesInternational Journal of Molecular Sciences, 2023)
Glioblastoma (GBM) continues to be the most devastating primary brain malignancy. Despite significant advancements in understanding basic GBM biology and enormous efforts in developing new therapeutic approaches, the ...
The Role of SOX Transcription Factors in Ageing and Age-Related Diseases
(International Journal of Molecular SciencesInternational Journal of Molecular Sciences, 2023)
The quest for eternal youth and immortality is as old as humankind. Ageing is an inevitable physiological process accompanied by many functional declines that are driving factors for age-related diseases. Stem cell exhaustion ...
Germline Variants in Cancer Predisposition Genes in Pediatric Patients with Central Nervous System Tumors
(International Journal of Molecular Sciences, 2023)
Central nervous system (CNS) tumors comprise around 20% of childhood malignancies. Germline variants in cancer predisposition genes (CPGs) are found in approximately 10% of pediatric patients with CNS tumors. This study ...
RclS Sensor Kinase Modulates Virulence of Pseudomonas capeferrum
(MDPI, Basel, 2022)
Signal transduction systems are the key players of bacterial adaptation and survival. The orthodox two-component signal transduction systems perceive diverse environmental stimuli and their regulatory response leads to ...
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin
(International Journal of Molecular SciencesInternational Journal of Molecular Sciences, 2023)
The quest for sustainable biomaterials with excellent biocompatibility and tailorable properties has put polyhydroxyalkanoates (PHAs) into the research spotlight. However, high production costs and the lack of bioactivity ...
Sitagliptin Induces Tolerogenic Human Dendritic Cells
(MDPI, 2023)
Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time the effect of ...
Small Cellular Particles from European Spruce Needle Homogenate
(MDPI, 2023)
Small cellular particles (SCPs) are being considered for their role in cell-to-cell communication. We harvested and characterized SCPs from spruce needle homogenate. SCPs were isolated by differential ultracentrifugation. ...
Can Pharmacogenetic Variants in TPMT, MTHFR and SLCO1B1 Genes Be Used as Potential Markers of Outcome Prediction in Systemic Sclerosis Patients?
(International Journal of Molecular SciencesInternational Journal of Molecular Sciences, 2023)
Systemic sclerosis (SSc) is a rare connective tissue disorder with highest morbidity and mortality among rheumatologic diseases. Disease progression is highly heterogeneous between patients, implying a strong need for ...
A Machine-Learning-Based Approach to Prediction of Biogeographic Ancestry within Europe
(International Journal of Molecular Sciences, 2023)
Data obtained with the use of massive parallel sequencing (MPS) can be valuable in population genetics studies. In particular, such data harbor the potential for distinguishing samples from different populations, especially ...
Pomegranate Peel Extract Differently Modulates Gene Expression in Gingiva-Derived Mesenchymal Stromal Cells under Physiological and Inflammatory Conditions
(International Journal of Molecular SciencesInternational Journal of Molecular Sciences, 2023)
Pomegranate has shown a favorable effect on gingivitis/periodontitis, but the mechanisms involved are poorly understood. The aim of this study was to test the effect of pomegranate peel extract (PoPEx) on gingiva-derived ...