Search
Now showing items 1-10 of 13
Macrophage migration inhibitory factor (MIF) enhances palmitic acid-and glucose-induced murine beta cell dysfunction and destruction in vitro
(Taylor & Francis Ltd, Abingdon, 2012)
Although several reports suggest a potentially deleterious role of macrophage migration inhibitory factor (MIF) in type 2 diabetes (T2D) pathology, it is still unclear how this pro-inflammatory cytokine acts on pancreatic ...
Ekspresija Bcl2 gena kod pacijenata sa hroničnom limfocitnom leukemijom / Expression of the Bcl2 gene in chronic lymphocytic leukaemia patients
(Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac, 2015)
Hronična limfocitna leukemija (HLL) se manifestuje kao klonska ekspanzija zrelih B limfocita, čija se akumulacija pripisuje prvenstveno poremećajima procesa apoptoze. U HLL su uočene genetičke promene i aberantna ekspresija ...
Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis
(Wiley, Hoboken, 2012)
As a result of chronic exposure to high levels of free fatty acids, glucose and inflammatory mediators beta-cell apoptosis occurs at the end stage of obesity-associated type 2 diabetes (T2D). One potentially deleterious ...
Molekularni markeri poremećaja koagulacije, inflamacije, apoptoze, formiranja i remodelovanja koštanog tkiva kod Leg-Kalve-Pertesove bolesti / Molecular markers of impaired coagulation, inflammation, apoptosis, formation and bone remodeling processes in Legg-Calve-Perthes disease
(Univerzitet u Beogradu, Biološki fakultet, 2015)
Leg-Kalve-Pertesova (LKP) bolest je idiopatska avaskularna osteonekroza epifize femura. Etiologija ove bolesti je nepoznata. Uprkos 100 godina istraživanja mehanizma njene patofiziologije i detaljnog opisivanja kliniĉkih ...
Genomski profil pacijenata dečijeg uzrasta sa hepatičnim glikogenozama: korelacija genotipa i fenotipa i funkcionalna karakterizacija novih varijanti / Genomic profiling of pediatric patients with liver glycogenosis: genotype-phenotype correlation and functional characterization of novel variants
(Univerzitet u Beogradu, Biološki fakultet, 2019)
Bolesti koje nastaju usled naslednog enzimskog poremećaja u sintezi ili razgradnji glikogena i koje primarno pogađaju jetru i bubrege, nazivaju se hepatične glikogenoze. Glikogenoza tip I (GSD tip I) je jedan od najčešćih ...
Molekularni mehanizmi patogeneze mijeloproliferativnih neoplazija : poremećaj ekspresije gena uključenih u proliferaciju i apoptozu / Molecular mechanisms of pathogenesis of myeloproliferative neoplasms: deregulation of genes involved in cell proliferation and apoptosis
(Univerzitet u Beogradu, Biološki fakultet, 2012)
Mijeloproliferativne neoplazije (MPN) su hronični hematološki maligniteti koji se odlikuju autonomnom proliferacijom opredeljenih progenitora hematopoeze i aberantnom aktivacijom tirozin kinaznih signalnih puteva u kombinaciji ...
In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells
(Taylor & Francis Inc, Philadelphia, 2011)
The NO-derivative of the HIV protease inhibitor saquinavir (Saq-NO) is a nontoxic variant of the parental drug with enhanced anticancer activity on several cell lines. However, it is still unclear whether the p53 status ...
Multiple antimelanoma potential of dry olive leaf extract
(Wiley, Hoboken, 2011)
Various constituents of the olive tree (Olea europaea) have been traditionally used in the treatment of infection, inflammation, prevention of chronic diseases, cardiovascular disorders and cancer. The anticancer potential ...
ALPHA-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)
(Maik Nauka/Interperiodica/Springer, New York, 2016)
Alpha-1-antitrypsin (AAT), an acute phase protein, is the principal circulatory anti-protease. This multifunctional protein is encoded by the SERPINA1 gene. Although AAT was recognised as a potential tumour marker, its ...
New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis
(Nature Publishing Group, London, 2011)
A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main ...