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The pharmacogenomics of vincristine-induced peripheral neuropathy in pediatric acute lymphoblastic leukemia patients in Serbia
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Vincristine (VCR) is one of the key drugs in current treatment protocols for pediatric acute
lymphoblastic leukemia (ALL). By destabilization of microtubules, VCR arrests cells in metaphase,
inducing apoptosis of malignant ...
Covid-19 disease severity associated with vitamin d related genetic Variants
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
COVID-19 pandemic has proved to be an unrelenting health threat for more than a year now. The
emerging amount of data indicates that vitamin D could be important for clinical presentation of
COVID-19. Here, we investigated ...
Functional characterization of novel variants in the dnai1 gene in a patient with primary ciliary dyskinesia
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Primary ciliary dyskinesia (PCD) is a rare motor ciliopathy, which predominantly affects the lungs and
reproductive organs. PCD has a heterogeneous genetic basis, and it is necessary to analyze more than
40 causative ...
Β-glucosidase b from microbacterium sp. Bg28 as a biofilm control agent In food processing environment
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
About one in ten people contract a foodborne illness within a year. Children under the age of five are
the most affected, with 125,000 deaths each year. Many of the foodborne illness outbreaks can be
linked to the presence ...
Improving the diagnostics of rare lung disorders using a uniquely designed pipeline for analysis of ngs data
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Rare lung diseases (RLDs) are a group of diseases that individually affect one in 2,000 people, with an
estimate that about 80% of RLDs have a genetic origin. Despite the variations among RLDs in clinical
characteristics ...
Pharmacogenomics and pharmacotranscriptomics of acute leukemia in children: a path to personalized medicine
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Personalized medicine is focused on research disciplines which contribute to the individualization of
therapy, like pharmacogenomics and pharmacotranscriptomics. Acute lymphoblastic leukemia (ALL) is
the most common ...
High-risk population screening for fabry disease in patients with chronic renal failure of unknown etiology
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Fabry disease (FD) is a rare X-linked disorder caused by variants in the GLA gene leading to the
deficiency of lysosomal α-galactosidase-A and progressive accumulation of globotriaosylceramide
affecting the heart, nervous ...
Seed priming enhances tolerance and accumulation of heavy metals in cd hyperaccumulator silene sendtneri through changes in gene expression
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
To improve our understanding of the molecular mechanisms underlying seed priming, RNA
transcriptome analysis was performed using primed and non-primed seeds of Silene sendtneri. Seed
priming was performed by submerging ...
Genomics as a basis for precision medicine
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Although medicine always aimed to be personalized, true implementation of personalized medicine in
health care practice has started recently. Fascinating progress of molecular genetics has strongly
contributed to this ...
Mutation rates of 22 autosomal STR LOCI in a European population from central Balkan, Republic of Serbia
(Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo, 2023)
Analysis of short tandem repeats (STRs) is a tool for human DNA identification, including paternity
and criminal investigations. Locus-specific STR mutation rates are critical for interpretation of DNA
identification in ...